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Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats

Published online by Cambridge University Press:  07 December 2016

Yavuz Selvi ,
Hasan Serdar Gergerlioglu ,
Nursel Akbaba ,
Mehmet Oz ,
Ali Kandeger ,
Enver Ahmet Demir ,
Fatma Humeyra Yerlikaya  and
Kismet Esra Nurullahoglu-Atalik
Yavuz Selvi*
Affiliation:
Department of Psychiatry, Neuroscience Research Center (SAM) Konya, Selcuk University Medicine Faculty, Konya, Turkey
Hasan Serdar Gergerlioglu
Affiliation:
Department of Psychiatry, Neuroscience Research Center (SAM) Konya, Selcuk University Medicine Faculty, Konya, Turkey
Nursel Akbaba
Affiliation:
Department of Psychiatry, Selcuk University Medicine Faculty, Konya, Turkey
Mehmet Oz
Affiliation:
Department of Physiology, Bozok University Medicine Faculty, Yozgat, Turkey
Ali Kandeger
Affiliation:
Department of Psychiatry, Selcuk University Medicine Faculty, Konya, Turkey
Enver Ahmet Demir
Affiliation:
Department of Physiology, Mustafa Kemal University Medicine Faculty, Hatay, Turkey
Fatma Humeyra Yerlikaya
Affiliation:
Department of Biochemistry, Necmettin Erbakan University Medicine Faculty, Konya, Turkey
Kismet Esra Nurullahoglu-Atalik
Affiliation:
Department of Pharmacology, Necmettin Erbakan University Medicine Faculty, Konya, Turkey
*
Yavuz Selvi, Associate Professor of Psychiatry, Department of Psychiatry, Neuroscience Research Center (SAM) Konya, Selcuk University Medicine Faculty, Konya, Turkey. Tel: +900 332 224 4563; Fax: +900 332 241 6065; E-mail: dryavuzselvi@yahoo.com
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Abstract

Objective

The Western-type diet is associated with an elevated risk of Alzheimer’s disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats.

Methods

In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n=16) and standard housing condition (n=24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid β-peptide (Aβ) (1–40), Aβ(1–42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE.

Results

The EE decreased the Aβ(1–40), Aβ(1–42), APP, and tau levels in high-fat and high-sucrose-fed rats.

Conclusion

This observation shows that EE may rescue diet-induced amyloid and tau pathology.

Keywords

Alzheimer’s diseaseamyloiddiethippocampustau
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 29 , Issue 5 , October 2017 , pp. 291 - 298
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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