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Immune dysfunction, depression and neurodegeneration

  • B. E. Leonard (a1) (a2) and A. M. Myint (a1)


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2.A-M, Myint, Leonard, BE, Steinbusch, H, Y-K, Kim. Th1, Th2 and Th3 cytokine alterations in major depression. J Affect Dis 2005;88:169173.
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8.Song, C, Leonard, BE.The olfactory bulbectomised rat model of depression. Neurosci Biobehav Rev 2005;29:627647.
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10.Holsboer, F. The rationale for CRH receptor antagonists to treat depression and anxiety. J Psychiat Res 1999;33:181214.
11.Leonard, BE, A-M, Myint. Inflkammation and depression: is there a causal connection with dementia?. Neurotox Res 2006;10:149160.
12.Geerlings, MI, Schoevers, RA, Beckman, AT.Depression and rik of cognitive decline and Alzheimer's disease. Results oftwo prospective community based studies in the Netherlands. Br J Psychiat 2000;176:568575.
13.Chen, P, Ganguli, M, Mulsant, BH, DeKosky, ST.The temporal relationship between depressive symptoms and dementia. Arch Gen Psychiat 1999;56:261266.
14.Nibuya, M, Takahashi, M, Russell, DS, Duman, RS.Repeated stress increases catalytic TrkB mRNA in rat hippocampus. Neurosci Lett 1999;267:8184.
15.A-M, Myint, Y-K, Kim. Cytokine-serotonin interaction through indoleamine dioxygenase: a neurodegenerative hypothesis of depression. Med Hypoth 2003;61:8184.
16.Chiarrugi, A, Calvani, M, Meli, E, Traggiai, F.Synthesis and release of neurotoxic kynurenine metabolites by human monocyte derived macrophages. J Neuroimmunol 2001;120:190198.
17.Guillemin, GJ, Smith, DG, Kerr, SJ, Smythe, GA, Kapoor, V, Armati, PJ. Characterisation of the kymurenine pathway metaboilism in human astrocytes and implications in neuro-pathogenesis. Redox Rep 2000;5:108111.
18.Guillemin, GJ, Kerr, SJ, Smythe, GA, Smith, DG, Kapoor, V, Armali, PJ. Kynurenine pathway metabolism in human astro-cytes: a paradox for neuronal protection. J Neurochem 2001;78:842853.
19.A-M, Myint, Y-K, Kim, Verkerk, R, Scharpe, S, Steinbusch, H, Leonard, BE.Kynurenine pathway in major depression: evidence of impaired neuroprotection. J Affect Dis 2007;98:143151.
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21.Leonard, BE. Inflammation.depression and dementia:are they connected? Neurochem Res 2007;32:17491756.

Immune dysfunction, depression and neurodegeneration

  • B. E. Leonard (a1) (a2) and A. M. Myint (a1)


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