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From genomics to proteomics: new directions in molecular neuropsychiatry

Published online by Cambridge University Press:  24 June 2014

Amy F. Eisener ,
Carlos N. Pato ,
Mantosh Dewan  and
Michele T. Pato
Amy F. Eisener
Affiliation:
Center for Psychiatric and Molecular Genetics, Department of Psychiatry, SUNY Upstate Medical University, Syracuse
Carlos N. Pato
Affiliation:
Center for Psychiatric and Molecular Genetics, Department of Psychiatry, SUNY Upstate Medical University, Syracuse Veterans Administration, Medical center Syracuse Center for Neuroscience, Universidade de Coimbra, Portugal
Mantosh Dewan
Affiliation:
Center for Psychiatric and Molecular Genetics, Department of Psychiatry, SUNY Upstate Medical University, Syracuse
Michele T. Pato*
Affiliation:
Center for Psychiatric and Molecular Genetics, Department of Psychiatry, SUNY Upstate Medical University, Syracuse Veterans Administration, Medical center Syracuse Center for Neuroscience, Universidade de Coimbra, Portugal
*
Michele T. Pato MD, Center for Psychiatric and Molecular Genetics, Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA. Tel: (315) 464-3206; Fax: (315) 464-3255; E-mail: cmpato@aol.com
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Abstract

Neuropsychiatry, like many other biomedical sciences, has been revolutionized by the advances in genomic technologies over the years. The advent of PCR (polymerase chain reaction) and the sequencing of the human genome have provided invaluable insights into the molecular genetics of the various psychiatric disorders through the study of candidate genes and linkage analyses. However, biological phenotype is dictated by protein expression, which has been shown to stray from the genetic blueprint designated by the genome. Consequently, the field of proteomics has recently emerged as a powerful means of exploring protein structure, function, and expression patterns. The ability to study disease at the gene and protein levels presents a tremendous opportunity for neuropsychiatric research, particularly in terms of the potential for developing therapeutic agents for novel protein targets.

Keywords

drug discoverygenomicsmolecular geneticspostgenomicsprotein analysisproteomics
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 6 , December 2003 , pp. 388 - 397
Copyright
Copyright © 2003 Blackwell Munksgaard

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