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A comparison of the symptomatic profile between two consecutive depressive episodes in patients with bipolar disorder type I

Published online by Cambridge University Press:  24 June 2014

Marcia B De Macedo-Soares ,
Elisa Brietzke ,
Rodrigo Da Silva Dias ,
Tiago Mendonça ,
Camila Moreira  and
Beny Lafer
Marcia B De Macedo-Soares*
Affiliation:
Bipolar Disorder Program, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil
Elisa Brietzke
Affiliation:
Bipolar Disorder Program, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil
Rodrigo Da Silva Dias
Affiliation:
Bipolar Disorder Program, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil
Tiago Mendonça
Affiliation:
Bipolar Disorder Program, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil
Camila Moreira
Affiliation:
Bipolar Disorder Program, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil
Beny Lafer
Affiliation:
Bipolar Disorder Program, Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil
*
Marcia Britto de Macedo-Soares, Bipolar Disorders Program, Institute of Psychiatry, University of São Paulo Medical School, R. Tabapuã 821/55, São Paulo 04533-013, Brazil. Tel/Fax: +55 11 30799519; E-mail: mbmacedosoares@gmail.com
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Abstract

de Macedo-Soares MB, Brietzke E, da Silva Dias R, Mendonca T, Moreira C, Lafer B. A comparison of the symptomatic profile between two consecutive depressive episodes in patients with bipolar disorder type I.

Objective:

To compare the variability of patterns of depressive symptoms between two consecutive depressive episodes in patients with bipolar disorder type I.

Methods:

Review of prospectively collected data from 136 subjects of an out-patient bipolar unit from 1997 to 2007. Binomial statistics was used for the analysis of Hamilton Depression Rating Scale (HDRS)-31 items of the first and second episodes, and the correlation of the HDRS-31 item scores of both episodes was determined using the Spearman coefficient.

Results:

Ten depressive symptoms showed a significant correlation between index and subsequent episodes: psychological anxiety, somatic anxiety, somatic symptoms, diurnal variation, paranoid symptoms, obsessive and compulsive symptoms, hypersomnia, loss of appetite and helplessness. Only four symptoms were stable in both statistical tests: paranoid symptoms, obsessive–compulsive symptoms, loss of appetite and hypersomnia.

Conclusions:

Paranoid and obsessive–compulsive symptoms, loss of appetite and hypersomnia tended to be found in successive episodes. However, the moderate correlations of the symptoms across two depressive recurrences suggested that clinical presentations in bipolar depression may not be predicted by symptom profiles presented in previous episodes.

Keywords

bipolar disorderbipolar depressionsymptomatologyconsistency
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 22 , Issue 6 , December 2010 , pp. 280 - 283
Copyright
Copyright © 2010 John Wiley & Sons A/S

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