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Changes of ultrastructure and downregulation of heat shock protein 70 and fibroblast growth factor 2 in gastric mucosa of rats with depressive-like behaviour

Published online by Cambridge University Press:  24 June 2014

Gonglin Hou ,
Mingming Tang ,
Linlin Yan  and
Mingming Wang
Gonglin Hou*
Affiliation:
Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China
Mingming Tang
Affiliation:
Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China
Linlin Yan
Affiliation:
Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China
Mingming Wang
Affiliation:
Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China
*
Gonglin Hou, Department of psychology, Zhejiang Sci-Tech University, 579# Mailbox, Hangzhou 310018, China. Tel: +86 57186843234; Fax: +86-57188492242 E-mail: gonglinhou@163.com
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Extract

Objective: To understand the underlying mechanism of gastric symptoms in patients with depressive disorder.

Methods: This study tested in the rat depression model evoked with chronic mild stress whether the microstructure gastric mucosa is injured using scanning electronic microscopy and transmission electronic microscopy (TEM). In addition, the expression of heat shock protein 70 (HSP70) and fibroblast growth factor 2 (FGF2) proteins in the gastric mucosa were measured by Western blotting.

Results: We found that the gastric epithelial cells were ruptured and the gastric pits were widened in rats with depression. The amount of mucous granules was also reduced in the surface mucous cells. Moreover, parietal cells became active, and the secretory canaliculi were magnified. Expression of HSP70 and FGF2 was reduced in the gastric mucosa.

Conclusions: These findings suggested that gastric symptoms in rats with depressive-like behaviour were caused by the injury of the gastric mucosa, AQ1 and HSP70 and FGF2 may be key molecules in the pathogenesis.

Keywords

depressionelectronic microscopyfibroblast growth factor 2gastric mucosaheat shock protein 70ultrastructure
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 3 , June 2012 , pp. 160 - 165
Copyright
Copyright © Cambridge University Press 2011

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