Skip to main content Accessibility help
×
Home

Brain activation measured using functional magnetic resonance imaging during the Tower of London task

  • Inge-Andre Rasmussen (a1), Ida Kristin Antonsen (a1), Erik Magnus Berntsen (a1), Jian Xu (a1), Jim Lagopoulos (a2) (a3) (a4) and Asta Kristine Håberg (a1)...

Abstract

Background:

Individuals with traumatic brain injury (TBI) often suffer from a number of enduring cognitive impairments such as in attention, memory, speed of processing information and dual-task performance.

Objective:

The aim of this study was to assess the patterns of regional brain activation in response to the Tower of London (ToL) task in a group of patients suffering from chronic TBI using functional magnetic resonance imaging (fMRI).

Methods:

fMRI was performed during performance of the ToL planning task in 10 patients suffering from severe TBI and in 10 age- and sex-matched controls using a 3 T magnetic resonance scanner.

Results:

Performance data showed no difference in response accuracy between the TBI group and the healthy control group. Statistical parametric brain maps showed that the TBI group activates larger and additional areas of the cerebral cortex than the healthy control group both for tasks and for a subtraction contrast between the tasks.

Conclusions:

The results of this study are interpreted as a cortical reorganization inside the executive system of vigilance and working memory in patients with TBI. Both parietal and frontal areas are recruited to compensate for damaged brain tissue.

Copyright

Corresponding author

Dr Inge-Andre Rasmussen Jr, Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim 7006, Norway. Tel: +61 2 93822998; Fax: +61 2 96591033; E-mail: inge.rasmussen@ntnu.no

References

Hide All
1.Blatter, DD, Bigler, ED, Gale, SDet al. MR-based brain and cerebrospinal fluid measurement after traumatic brain injury: correlation with neuropsychological outcome. AJNR Am J Neuroradiol 1997;18:110.
2.Dikmen, SS, Ross, BL, Machamer, JE, Temkin, NR. One year psychosocial outcome in head injury. J Int Neuropsychol Soc 1995;1:6777.
3.Richardson, J. Clinical and neuropsychological aspects of closed head injury. London, UK: Taylor and Francis, 1990.
4.Sarno, MT, Buonaguro, A, Levita, E. Characteristics of verbal impairment in closed head injured patients. Arch Phys Med Rehabil 1986;67:400405.
5.van Zomeren, AH, van den Burg, W. Residual complaints of patients two years after severe head injury. J Neurol Neurosurg Psychiatr 1985;48:2128.
6.Vilkki, J. Cognitive flexibility and mental programming after closed head injuries and anterior or posterior cerebral excisions. Neuropsychologia 1992;30:807814.
7.Shallice, T, Burgess, PW. Deficits in strategy application following frontal lobe damage in man. Brain 1991;114:727741.
8.Walsh, K. Understanding brain damage. New York: Churchill Livingstone, 1985.
9.Cockburn, J. Performance on the Tower of London test after severe head injury. J Int Neuropsychol Soc 1995;1:537544.
10.Anzai, Y, Simon, HA. The theory of learning by doing. Psychol Rev 1979;86:124140.
11.Shallice, T. Specific impairments of planning. Philos Trans R Soc Lond B Biol Sci 1982;298:199209.
12.Shallice, T. From neuropsychology to mental structure. Cambridge, UK: Cambridge University Press, 1988.
13.Brouwer, WH, Schmidt, I, Vanier, M, Velten, JC, Wever, AME, Van Zomeren, AH. The relation between severity of closed head injury (CHI) and executive function: an inverse U-shaped function? Int Neuropsychol Soc 1994; Angers, France; 1994.
14.Owen, AM, Downes, JJ, Sahakian, BJ, Polkey, CE, Robbins, TW. Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 1990;28:10211034.
15.Ponsford, J, Kinsella, G. Attentional deficits following closed-head injury. J Clin Exp Neuropsychol 1992;14:822838.
16.Talairach, J, Tournoux, P. Co-planar stereotaxic atlas of the human brain: three-dimensional proportional system. 1988. Thieme Medical, New York.
17.Kriegeskorte, N, Goebel, R. An efficient algorithm for topologically correct segmentation of the cortical sheet in anatomical MR volumes. Neuroimage 2001;14:329346.
18.Dale, AM, Fischl, B, Sereno, MI. Cortical surface-based analysis – I. Segmentation and surface reconstruction. Neuroimage 1999;9:179194.
19.Friston, KJ, Holmes, AP, Poline, JBet al. Analysis of fMRI time-series revisited. Neuroimage 1995;2:4553.
20.Baker, SC, Rogers, RD, Owen, AMet al. Neural systems engaged by planning: a PET study of the Tower of London task. Neuropsychologia 1996;34:515526.
21.Dagher, A, Owen, AM, Boecker, H, Brooks, DJ. The role of the striatum and hippocampus in planning: a PET activation study in Parkinson’s disease. Brain 2001;124:10201032.
22.Fincham, JM, Carter, CS, Van Veen, V, Stenger, VA, Anderson, JR. Neural mechanisms of planning: a computational analysis using event-related fMRI. Proc Natl Acad Sci U S A 2002;99:33463351.
23.Owen, AM, Doyon, J, Dagher, A, Sadikot, A, Evans, AC. Abnormal basal ganglia outflow in Parkinson’s disease identified with PET. Implications for higher cortical functions. Brain 1998;121:949965.
24.Rasser, PE, Johnston, P, Lagopoulos, Jet al. Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching. Neuroimage 2005;26:941951.
25.Schall, U, Johnston, P, Lagopoulos, Jet al. Functional brain maps of Tower of London performance: a positron emission tomography and functional magnetic resonance imaging study. Neuroimage 2003;20:11541161.
26.van den Heuvel, OA, Groenewegen, HJ, Barkhof, F, Lazeron, RH, Van Dyck, R, Veltman, DJ. Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of Tower of London task. Neuroimage 2003;18:367374.
27.Morris, RG, Ahmed, S, Syed, GM, Toone, BK. Neural correlates of planning ability – frontal-lobe activation during the Tower of London test. Neuropsychologia 1993;31:13671378.
28.Robertson, EM, Tormos, JM, Maeda, F, Pascual-Leone, A. The role of the dorsolateral prefrontal cortex during sequence learning is specific for spatial information. Cereb Cortex 2001;11:628635.
29.Funahashi, S, Bruce, CJ, Goldmanrakic, PS. Mnemonic coding of visual space in the monkeys dorsolateral prefrontal cortex. J Neurophysiol 1989;61:331349.
30.Petrides, M. Dissociable roles of mid-dorsolateral prefrontal and anterior inferotemporal cortex in visual working memory. J Neurosci 2000;20:74967503.
31.Owen, AM. Cognitive planning in humans: neuropsychological, neuroanatomical and neuropharmacological perspectives. Prog Neurobiol 1997;53:431.
32.Christodoulou, C, DeLuca, J, Ricker, JHet al. Functional magnetic resonance imaging of working memory impairment after traumatic brain injury. J Neurol Neurosurg Psychiatr 2001;71:161168.
33.Perlstein, WM, Cole, MA, Demery, JAet al. Parametric manipulation of working memory load in traumatic brain injury: behavioral and neural correlates. J Int Neuropsychol Soc 2004;10:724741.
34.Scheibel, RS, Pearson, DA, Faria, LPet al. An fMRI study of executive functioning after severe diffuse TBI. Brain Inj 2003;17:919930.
35.Seidman, LJ, Breiter, HC, Goodman, JM, Goldstein, JM, Woodruff, PWR, Rosen, BR. A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands. Neuropsychology 1998;12:505518.
36.McAllister, TW, Saykin, AJ, Flashman, LAet al. Brain activation during working memory 1 month after mild traumatic brain injury – a functional MRI study. Neurology 1999;53:13001308.

Keywords

Related content

Powered by UNSILO

Brain activation measured using functional magnetic resonance imaging during the Tower of London task

  • Inge-Andre Rasmussen (a1), Ida Kristin Antonsen (a1), Erik Magnus Berntsen (a1), Jian Xu (a1), Jim Lagopoulos (a2) (a3) (a4) and Asta Kristine Håberg (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.