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Auditory brainstem response (ABR) profiling tests as diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD)

Published online by Cambridge University Press:  14 August 2017

Eva Juselius Baghdassarian Open the ORCID record for Eva Juselius Baghdassarian [Opens in a new window] ,
Maria Nilsson Markhed ,
Eva Lindström ,
Björn M Nilsson  and
Tommy Lewander
Eva Juselius Baghdassarian*
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
Maria Nilsson Markhed
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
Eva Lindström
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
Björn M Nilsson
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
Tommy Lewander
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
*
Eva Juselius Baghdassarian, Department of Neuroscience, Psychiatry, Uppsala University Hospital, Akademiska sjukhuset, 751 85 Uppsala, Sweden. Tel: +46 739891814; E-mail: eva.baghdassarian@neuro.uu.se
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Abstract

Objective

To evaluate the performances of two auditory brainstem response (ABR) profiling tests as potential biomarkers and diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD), respectively, in an investigator-initiated blinded study design.

Method

Male and female patients with schizophrenia (n=26) and adult ADHD (n=24) meeting Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) diagnostic criteria and healthy controls (n=58) comprised the analysis set (n=108) of the total number of study participants (n=119). Coded sets of randomized ABR recordings were analysed by an independent party blinded to clinical diagnoses before a joint code-breaking session.

Results

The ABR profiling test for schizophrenia identified schizophrenia patients versus controls with a sensitivity of 84.6% and a specificity of 93.1%. The ADHD test identified patients with adult ADHD versus controls with a sensitivity of 87.5% and a specificity of 91.4%.

Conclusion

The ABR profiling tests discriminated schizophrenia and ADHD versus healthy controls with high sensitivity and specificity. The methods deserve to be further explored in larger clinical studies including a broad range of psychiatric disorders to determine their utility as potential diagnostic biomarkers.

Keywords

ADHDERPschizophreniapsychiatric disorders
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 30 , Issue 3 , June 2018 , pp. 137 - 147
Copyright
© Scandinavian College of Neuropsychopharmacology 2017 

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