Skip to main content Accessibility help
×
Home

Association between metabolic syndrome and cognitive decline: a systematic review of prospective population-based studies

  • Zilong Hao (a1), Bo Wu (a1), Deren Wang (a1) and Ming Liu (a1)

Extract

Objective: The association between metabolic syndrome (MS) and the risk of cognitive impairment or dementia remains unclear. In this article, we systematically review studies on the risk of cognitive disorders in patients with MS to determine the strength of the association between MS and cognitive decline.

Methods: Electronic databases through December 2009 were searched to identify prospective population-based studies that examined the association between MS and risk of cognitive disorders. Two reviewers used a standardised form to collect data and assess eligibility. The quality of study was assessed by the Newcastle–Ottawa Scale.

Results: We found nine eligible studies that involve 19 876 participants. All studies but two indicate that MS is associated with cognitive decline (from one-fold to more than two-fold increase in risk). It seems that MS may be associated with cognitive impairment (positive results in three of five) and vascular dementia (positive results in two of three), whereas three studies involving patients with Alzheimer's disease (AD) did not find the association between MS and AD. When examining the association of the individual risk factors of the MS and cognition in seven eligible studies, glucose (three studies) and hypertension (three studies) showed positive results associated with cognitive decline.

Conclusion: The MS may be associated with cognitive impairment and vascular dementia but not for AD, which need to be further investigated with high-quality studies.

Copyright

Corresponding author

Professor Ming Liu, Stroke Clinical Research Unit, Department of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041 Sichuan Province, P. R. China. Tel/fax: +86 28 85423551; E-mail: wyplmh@hotmail.com

References

Hide All
1.Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:24862497.
2.Ford, ES.Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the US. Diabetes Care 2005;28:27452749.
3.Hildrum, B, Mykletun, A, Hole, T, Midthjell, K, Dahl, AA.Age-specific prevalence of the metabolic syndrome defined by the International Diabetes Federation and the National Cholesterol Education Program: the Norwegian HUNT 2 study. BMC Public Health 2007;7:220.
4.Razay, G, Vreugdenhil, A, Wilcock, G.The metabolic syndrome and Alzheimer disease. Arch Neurol 2007;64: 9396.
5.Galassi, A, Reynolds, K, He, J.Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med 2006;119:812819.
6.Li, W, Ma, D, Liu, M et al. Association between metabolic syndrome and risk of stroke: a meta-analysis of cohort studies. Cerebrovasc Dis 2008;25:539547.
7.Biessels, GJ, Staekenborg, S, Brunner, E, Brayne, C, Scheltens, P.Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 2006;5:6474.
8.Qiu, C, Winblad, B, Fratiglioni, L.The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 2005;4:487499.
9.Kivipelto, M, Ngandu, T, Fratiglioni, L et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 2005;62:15561560.
10.Yaffe, K.Metabolic syndrome and cognitive disorders: is the sum greater than its parts? Alzheimer Dis Assoc Disord 2007;21:167171.
11.Vanhanen, M, Koivisto, K, Moilanen, L et al. Association of metabolic syndrome with Alzheimer disease: a population-based study. Neurology 2006;67:843847.
12.Dik, MG, Jonker, C, Comijs, HC et al. Contribution of metabolic syndrome components to cognition in older individuals. Diabetes Care 2007;30:26552660.
13.Gatto, NM, Henderson, VW, St John, JA, McCleary, C, Hodis, HN, Mack, WJ.Metabolic syndrome and cognitive function in healthy middle-aged and older adults without diabetes. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2008;15:627641.
14.Laudisio, A, Marzetti, E, Pagano, F et al. Association of metabolic syndrome with cognitive function: the role of sex and age. Clin Nutr 2008;27:747754.
15.Liu, CY, Zhou, HD, Xu, ZQ, Zhang, WW, Li, XY, Zhao, J.Metabolic syndrome and cognitive impairment amongst elderly people in Chinese population: a cross-sectional study. Eur J Neurol 2009;16:10221027.
16.Roberts, RO, Geda, YE, Knopman, DS et al. Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: a population-based study. Alzheimer Dis Assoc Disord 2010;24:1118.
17.Kuusisto, J, Koivisto, K, Mykkanen, L et al. Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study. BMJ 1997;315:10451049.
18.Lee, KS, Jang, Y, Chung, YK, Chung, JH, Oh, BH, Hong, CH.Relationship between the diagnostic components of metabolic syndrome (MS) and cognition by ApoE genotype in the elderly. Arch Gerontol Geriatr 2010;50:6972.
19.Kalmijn, S, Foley, D, White, L et al. Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol 2000;20:22552260.
20.Yaffe, K, Kanaya, A, Lindquist, K et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 2004;292:22372242.
21.Yaffe, K, Weston, AL, Blackwell, T, Krueger, KA.The metabolic syndrome and development of cognitive impairment among older women. Arch Neurol 2009;66:324328.
22.Akbaraly, TN, Kivimaki, M, Shipley, MJ et al. Metabolic syndrome over 10 years and cognitive functioning in late mid life: the Whitehall II study. Diabetes Care 2010;33:8489.
23.Muller, M, Tang, MX, Schupf, N, Manly, JJ, Mayeux, R, Luchsinger, JA.Metabolic syndrome and dementia risk in a multiethnic elderly cohort. Dement Geriatr Cogn Disord 2007;24:185192.
24.van den Berg, E, Biessels, GJ, de Craen, AJ, Gussekloo, J, Westendorp, RG.The metabolic syndrome is associated with decelerated cognitive decline in the oldest old. Neurology 2007;69:979985.
25.Wells, GA, Shea, B, O'Connell, D et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-analyses. URL http://wwwohrica/programs/clinical_epidemiology/oxfordhtm (accessed on August 2009).
26.Yaffe, K, Haan, M, Blackwell, T, Cherkasova, E, Whitmer, RA, West, N.Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc 2007;55:758762.
27.Komulainen, P, Lakka, TA, Kivipelto, M et al. Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women. Dement Geriatr Cogn Disord 2007;23:2934.
28.Raffaitin, C, Gin, H, Empana, JP et al. Metabolic˜syndrome and risk for incident Alzheimer's disease or vascular dementia: the three-city study. Diabetes Care 2009;32:169174.
29.Knopman, DS, Mosley, TH, Catellier, DJ, Coker, LH.Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI study. Alzheimers Dement 2009;5:207214.
30.Segura, B, Jurado, MA, Freixenet, N, Albuin, C, Muniesa, J, Junque, C.Mental slowness and executive dysfunctions in patients with metabolic syndrome. Neurosci Lett 2009;462:4953.
31.Ho, RC, Niti, M, Yap, KB, Kua, EH, Ng, TP.Metabolic syndrome and cognitive decline in Chinese older adults: Results from the Singapore longitudinal ageing studies. Am J Geriatr Psychiatry 2008;16:519522.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed