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Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

  • Kyoko Hasebe (a1), Laura Gray (a1) (a2), Chiara Bortolasci (a1) (a3), Bruna Panizzutti (a4), Mohammadreza Mohebbi (a5), Srisaiyini Kidnapillai (a1), Briana Spolding (a1), Ken Walder (a1), Michael Berk (a2) (a5) (a6) (a7), Gin Malhi (a8), Seetal Dodd (a5) (a6) (a7) and Olivia M. Dean (a2) (a5) (a6)...



This study aimed to explore effects of adjunctive N-acetylcysteine (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression.


We embarked on a 12-week clinical trial of NAC (2000 mg/day compared with placebo) as an adjunctive treatment for unipolar depression. A follow-up visit was conducted 4 weeks following the completion of treatment. We collected serum samples at baseline and the end of the treatment phase (week 12) to determine changes in interleukin-6 (IL6), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following NAC treatment.


NAC treatment significantly improved depressive symptoms on the Montgomery–Asberg Depression Rating Scale (MADRS) over 16 weeks of the trial. Serum levels of IL6 were associated with reductions of MADRS scores independent of treatment response. However, we found no significant changes in IL6, CRP and BDNF levels following NAC treatment.


Overall, this suggests that our results failed to support the hypothesis that IL6, CRP and BDNF are directly involved in the therapeutic mechanism of NAC in depression. IL6 may be a useful marker for future exploration of treatment response.


Corresponding author

Dr. Olivia M. Dean, School of Medicine, IMPACT Strategic Research Centre, Deakin University, Barwon Health, Geelong, Australia. Tel: +61 (0)3 4215 3300; Fax: +61 (0)3 4215 3491; E-mail:


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Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

  • Kyoko Hasebe (a1), Laura Gray (a1) (a2), Chiara Bortolasci (a1) (a3), Bruna Panizzutti (a4), Mohammadreza Mohebbi (a5), Srisaiyini Kidnapillai (a1), Briana Spolding (a1), Ken Walder (a1), Michael Berk (a2) (a5) (a6) (a7), Gin Malhi (a8), Seetal Dodd (a5) (a6) (a7) and Olivia M. Dean (a2) (a5) (a6)...


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