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Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive–compulsive disorder: proton magnetic resonance spectroscopy

Published online by Cambridge University Press:  17 October 2016

Shin-Eui Park
Affiliation:
Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea
Nam-Gil Choi
Affiliation:
Department of Radiology, DongShin University, Naju, Republic of Korea
Gwang-Woo Jeong*
Affiliation:
Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea
*
Professor Gwang-Woo Jeong, Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, # 42 Jebongro, Dong-gu, Gwangju 501-757, Republic of Korea. Tel: +82 62 220 5881; Fax: +82 62 226 4380; E-mail: gwjeong@jnu.ac.kr

Abstract

Objective

Proton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive–compulsive disorder (OCD).

Methods

In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1H-MRS.

Results

The metabolic concentration of myo-inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in N-acetylaspartate, choline, lactate and lipid between the two groups.

Conclusion

These findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC.

Type
Original Articles
Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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