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Acta Neuropsychiatrica Acta Neuropsychiatrica

Article contents

Gene polymorphisms and response to transcranial direct current stimulation for auditory verbal hallucinations in schizophrenia

Published online by Cambridge University Press:  21 March 2018

Harleen Chhabra ,
Venkataram Shivakumar ,
Manjula Subbanna ,
Sunil V. Kalmady ,
Anushree Bose ,
Sri Mahavir Agarwal ,
Vanteemar S. Sreeraj Open the ORCID record for Vanteemar S. Sreeraj in new tab/window[Opens in a new window] ,
Damodharan Dinakaran ,
Janardhanan C. Narayanaswamy ,
Monojit Debnath  and
Ganesan Venkatasubramanian
Harleen Chhabra
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Venkataram Shivakumar
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Manjula Subbanna
Affiliation:
Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Department of Human Genetics, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Sunil V. Kalmady
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Anushree Bose
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Sri Mahavir Agarwal
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Vanteemar S. Sreeraj
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Damodharan Dinakaran
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Janardhanan C. Narayanaswamy
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Monojit Debnath
Affiliation:
Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Department of Human Genetics, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Ganesan Venkatasubramanian
Affiliation:
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Corresponding
E-mail address:
venkat.nimhans@gmail.com
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Abstract

Objective

Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia.

Methods

Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS. The COMT (rs4680) and NRG1 (rs35753505) genotypes were determined. The COMT genotypes were categorised into Val group (GG; n=15) and Met group (GG/AG; n=17) and NRG1 genotypes were categorised into AA group (n=12) and AG/GG group (n=20).

Results

The reduction in auditory hallucination sub-scale score was significantly affected by COMT-GG genotype [Time×COMT interaction: F(1,28)=10.55, p=0.003, ɳ2=0.27]. Further, COMT-GG effect was epistatically influenced by the co-occurrence of NRG1-AA genotype [Time×COMT×NRG1 interaction: F(1,28)=8.09, p=0.008, ɳ2=0.22]. Irrespective of genotype, females showed better tDCS response than males [Time×Sex interaction: F(1,21)=4.67, p=0.04, ɳ2=0.18].

Conclusion

COMT-GG and NRG1-AA genotypes aid the tDCS-induced improvement in AVHs in schizophrenia patients. Our preliminary observations need replication and further systematic research to understand the neuroplastic gene determinants that modulate the effect of tDCS.

Keywords

hallucinations genes schizophrenia tDCS
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 30 , Issue 4 , August 2018 , pp. 218 - 225
Copyright
© Scandinavian College of Neuropsychopharmacology 2018 

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References

1. Lewis, DA Moghaddam, B (2006) Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch Neurol 63, 1372–1376.CrossRefGoogle ScholarPubMed
2. Tsai, G Coyle, JT (2002) Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 42, 165–179.CrossRefGoogle Scholar
3. Balu, DT Coyle, JT (2011) Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev 35, 848–870.CrossRefGoogle ScholarPubMed
4. Voineskos, D, Rogasch, NC, Rajji, TK, Fitzgerald, PB Daskalakis, ZJ (2013) A review of evidence linking disrupted neural plasticity to schizophrenia. Can J Psychiatry 58, 86–92.CrossRefGoogle Scholar
5. Bose, A, Shivakumar, V, Narayanaswamy, JC, Nawani, H, Subramaniam, A, Agarwal, SM, Chhabra, H, Kalmady, SV Venkatasubramanian, G (2014) Insight facilitation with add-on tDCS in schizophrenia. Schizophr Res 156, 63–65.CrossRefGoogle Scholar
6. Agarwal, SM, Shivakumar, V, Bose, A, Subramaniam, A, Nawani, H, Chhabra, H, Kalmady, SV, Narayanaswamy, JC Venkatasubramanian, G (2013) Transcranial direct current stimulation in schizophrenia – a review. Clin Psychopharmacol Neurosci 11, 118–125.CrossRefGoogle Scholar
7. Brunelin, J, Mondino, M, Gassab, L, Haesebaert, F, Gaha, L, Suaud-Chagny, MF, Saoud, M, Mechri, A Poulet, E (2012) Examining transcranial direct-current stimulation (tDCS) as a treatment for hallucinations in schizophrenia. Am J Psychiatry 169, 719–724.CrossRefGoogle Scholar
8. Fritsch, B, Reis, J, Martinowich, K, Schambra, HM, Ji, Y, Cohen, LG Lu, B (2010) Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron 66, 198–204.CrossRefGoogle ScholarPubMed
9. Bikson, M, Inoue, M, Akiyama, H, Deans, JK, Fox, JE, Miyakawa, H Jefferys, JG (2004) Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro. J Physiol 557(Pt 1):175–190.CrossRefGoogle ScholarPubMed
10. Hasan, A, Nitsche, MA, Rein, B, Schneider-Axmann, T, Guse, B, Gruber, O, Falkai, P Wobrock, T (2011) Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation. Behavioural Brain Research 224, 15–22.CrossRefGoogle ScholarPubMed
11. Nitsche, M AA, Liebetanz, D, Lang, N, Tergau, F Paulus, W (2007) Induction and modulation of neuroplasticity by transcranial direct current stimulation. In: Marcolin MA and Padberg F editors Transcranial brain stimulation for treatment of psychiatric disorders Adv Biol Psychiatrvol.23 Basel: Kargerp. 172–186.CrossRefGoogle Scholar
12. Nitsche, MA Paulus, W (2001) Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 57, 1899–1901.CrossRefGoogle ScholarPubMed
13. Krause, B, Marquez-Ruiz, J Kadosh, RC (2013) The effect of transcranial direct current stimulation: a role for cortical excitation/inhibition balance? Front Hum Neurosci 7, 602.CrossRefGoogle ScholarPubMed
14. Antal, A, Paulus, W Nitsche, MA (2011) Electrical stimulation and visual network plasticity. Restor Neurol Neurosci. [Review] 29, 365–374.Google ScholarPubMed
15. Monte-Silva, K, Kuo, MF, Hessenthaler, S, Fresnoza, S, Liebetanz, D, Paulus, W Nitsche, MA (2013) Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation. Brain Stimul 6, 424–432.CrossRefGoogle ScholarPubMed
16. Nawani, H, Bose, A, Agarwal, SM, Shivakumar, V, Chhabra, H, Subramaniam, A, Kalmady, S, Narayanaswamy, JC Venkatasubramanian, G (2014) Modulation of corollary discharge dysfunction in schizophrenia by tDCS: preliminary evidence. Brain Stimul 7, 486–488.CrossRefGoogle ScholarPubMed
17. Kirimoto, H, Ogata, K, Onishi, H, Oyama, M, Goto, Y Tobimatsu, S (2011) Transcranial direct current stimulation over the motor association cortex induces plastic changes in ipsilateral primary motor and somatosensory cortices. Clin Neurophysiol 122, 777–783.CrossRefGoogle ScholarPubMed
18. Lang, N, Siebner, HR, Ward, NS, Lee, L, Nitsche, MA, Paulus, W, Rothwell, JC, Lemon, RN Frackowiak, RS (2005) How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? Eur J Neurosci 22, 495–504.CrossRefGoogle ScholarPubMed
19. Venkatakrishnan, A Sandrini, M (2012) Combining transcranial direct current stimulation and neuroimaging: novel insights in understanding neuroplasticity. J Neurophysiol 107, 1–4.CrossRefGoogle ScholarPubMed
20. Mei, L Xiong, WC (2008) Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci 9, 437–452.CrossRefGoogle Scholar
21. Ho, BC, Wassink, TH, O’Leary, DS, Sheffield, VC Andreasen, NC (2005) Catechol-o-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow. Mol Psychiatry 10, 287–298.CrossRefGoogle ScholarPubMed
22. Bray, NJ, Buckland, PR, Williams, NM, Williams, HJ, Norton, N, Owen, MJ O'Donovan, MC (2003) A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 73, 152–161.CrossRefGoogle ScholarPubMed
23. Shifman, S, Bronstein, M, Sternfeld, M, Pisante-Shalom, A, Lev-Lehman, E, Weizman, A, Reznik, I, Spivak, B, Grisaru, N, Karp, L, Schiffer, R, Kotler, M, Strous, RD, Swartz-Vanetik, M, Knobler, HY, Shinar, E, Beckmann, JS, Yakir, B, Risch, N, Zak, NB Darvasi, A (2002) A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 71, 1296–1302.CrossRefGoogle Scholar
24. Akil, M, Kolachana, BS, Rothmond, DA, Hyde, TM, Weinberger, DR Kleinman, JE (2003) Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 23, 2008–2013.CrossRefGoogle ScholarPubMed
25. Opgen-Rhein, C, Neuhaus, AH, Urbanek, C, Hahn, E, Sander, T Dettling, M (2008) Executive attention in schizophrenic males and the impact of COMT Val108/158Met genotype on performance on the attention network test. Schizophr Bull 34, 1231–1239.CrossRefGoogle ScholarPubMed
26. Quednow, BB, Wagner, M, Mossner, R, Maier, W Kuhn, KU (2010) Sensorimotor gating of schizophrenia patients depends on catechol o-methyltransferase Val158Met polymorphism. Schizophr Bull 36, 341–346.CrossRefGoogle ScholarPubMed
27. Haraldsson, HM, Ettinger, U, Magnusdottir, BB, Sigmundsson, T, Sigurdsson, E, Ingason, A Petursson, H (2010) Catechol-o-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia. Schizophr Bull 36, 157–164.CrossRefGoogle Scholar
28. Witte, AV, Kurten, J, Jansen, S, Schirmacher, A, Brand, E, Sommer, J Floel, A (2012) Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity. J Neurosci 32, 4553–4561.CrossRefGoogle ScholarPubMed
29. Nieratschker, V, Kiefer, C, Giel, K, Kruger, R Plewnia, C (2015) The COMT Val/Met polymorphism modulates effects of tDCS on response inhibition. Brain Stimul 8, 283–288.CrossRefGoogle ScholarPubMed
30. Plewnia, C, Zwissler, B, Langst, I, Maurer, B, Giel, K Kruger, R (2013) Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism. Cortex 49, 1801–1807.CrossRefGoogle ScholarPubMed
31. Shivakumar, V, Chhabra, H, Subbanna, M, Agarwal, SM, Bose, A, Kalmady, SV, Narayanaswamy, JC, Debnath, M Venkatasubramanian, G (2015) Effect of tDCS on auditory hallucinations in schizophrenia: influence of catechol-o-methyltransferase (COMT) Val158Met polymorphism. Asian J Psychiatr 16, 75–77.CrossRefGoogle ScholarPubMed
32. Yang, JZ, Si, TM, Ruan, Y, Ling, YS, Han, YH, Wang, XL, Zhou, M, Zhang, HY, Kong, QM, Liu, C, Zhang, DR, Yu, YQ, Liu, SZ, Ju, GZ, Shu, L, Ma, DL Zhang, D (2003) Association study of neuregulin 1 gene with schizophrenia. Mol Psychiatry 8, 706–709.CrossRefGoogle ScholarPubMed
33. Kukshal, P, Bhatia, T, Bhagwat, AM, Gur, RE, Gur, RC, Deshpande, SN, Nimgaonkar, VL Thelma, BK (2013) Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample. Schizophr Res 144, 24–30.CrossRefGoogle Scholar
34. Kurnianingsih, YA, Kuswanto, CN, McIntyre, RS, Qiu, A, Ho, BC Sim, K (2011) Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder. J Neural Transm 118, 1621–1639.CrossRefGoogle ScholarPubMed
35. Krug, A, Markov, V, Eggermann, T, Krach, S, Zerres, K, Stocker, T, Shah, NJ, Schneider, F, Nothen, MM, Treutlein, J, Rietschel, M Kircher, T (2008) Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals. Neuroimage 42, 1569–1576.CrossRefGoogle Scholar
36. Thirunavukkarasu, P, Vijayakumari, AA, John, JP, Halahalli, HN, Paul, P, Sen, S, Purushottam, M Jain, S (2014) An exploratory association study of the influence of dysbindin and neuregulin polymorphisms on brain morphometry in patients with schizophrenia and healthy subjects from South India. Asian J Psychiatr 10, 62–68.CrossRefGoogle ScholarPubMed
37. Yokley, JL, Prasad, KM, Chowdari, KV, Talkowski, ME, Wood, J, Gur, RC, Gur, RE, Almasy, L, Nimgaonkar, VL Pogue-Geile, MF (2012) Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families. Psychiatr Genet 22, 70–81.CrossRefGoogle ScholarPubMed
38. Kircher, T, Thienel, R, Wagner, M, Reske, M, Habel, U, Kellermann, T, Frommann, I, Schwab, S, Wolwer, W, von Wilmsdorf, M, Braus, DF, Schmitt, A, Rapp, A, Stocker, T, Shah, NJ, Henn, FA, Sauer, H, Gaebel, W, Maier, W Schneider, F (2009) Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas. Eur Arch Psychiatry Clin Neurosci 259, 72–79.CrossRefGoogle ScholarPubMed
39. Prata, DP, Breen, G, Osborne, S, Munro, J, Clair, D Collier, DA (2009) An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis. Psychiatr Genet 19, 113–116.CrossRefGoogle ScholarPubMed
40. Nawaz, R, Asif, H, Khan, A, Ishtiaq, H, Shad, F Siddiqui, S (2014) Drugs Targeting SNPrs35753505 of the NRG1 gene may prevent the association of schizophrenia in a Pakistani population. CNS Neurol Disord Drug Targets 13, 1604–1614.CrossRefGoogle Scholar
41. Georgieva, L, Dimitrova, A, Ivanov, D, Nikolov, I, Williams, NM, Grozeva, D, Zaharieva, I, Toncheva, D, Owen, MJ, Kirov, G O'Donovan, MC (2008) Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia. Biol Psychiatry 64, 419–427.CrossRefGoogle Scholar
42. Nickl-Jockschat, T, Stocker, T, Krug, A, Markov, V, Huang, R, Schneider, F, Habel, U, Eickhoff, SB, Zerres, K, Nothen, MM, Treutlein, J, Rietschel, M, Shah, NJ Kircher, T (2014) A neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects. Brain Behav 4, 215–226.CrossRefGoogle ScholarPubMed
43. Yeganeh-Doost, P, Gruber, O, Falkai, P Schmitt, A (2011) The role of the cerebellum in schizophrenia: from cognition to molecular pathways. Clinics (Sao Paulo) 66(Suppl. 1):71–77.CrossRefGoogle ScholarPubMed
44. Haddock, G, McCarron, J, Tarrier, N Faragher, EB (1999) Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychol Med 29, 879–889.CrossRefGoogle Scholar
45. Oldfield, RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9(1):97–113.CrossRefGoogle ScholarPubMed
46. Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R Dunbar, GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl. 20):22–33. quiz 4–57.Google ScholarPubMed
47. Brunoni, AR, Amadera, J, Berbel, B, Volz, MS, Rizzerio, BG Fregni, F (2011) A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int J Neuropsychopharmacol 14, 1133–1145.CrossRefGoogle ScholarPubMed
48. Cools, R D’Esposito, M (2011) Inverted-U-shaped dopamine actions on human working memory and cognitive control. Biol Psychiatry 69, e113–e125.CrossRefGoogle ScholarPubMed
49. Munafo, MR, Attwood, AS Flint, J (2008) Neuregulin 1 genotype and schizophrenia. Schizophr Bull 34, 9–12.CrossRefGoogle Scholar
50. Gong, YG, Wu, CN, Xing, QH, Zhao, XZ, Zhu, J He, L (2009) A two-method meta-analysis of neuregulin 1(NRG1) association and heterogeneity in schizophrenia. Schizophr Res 111, 109–114.CrossRefGoogle Scholar
51. Ledonne, A, Nobili, A, Latagliata, EC, Cavallucci, V, Guatteo, E, Puglisi-Allegra, S, D'Amelio, M Mercuri, NB (2015) Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry 20, 959–973.CrossRefGoogle ScholarPubMed
52. Neddens, J, Vullhorst, D, Paredes, D Buonanno, A (2009) Neuregulin links dopaminergic and glutamatergic neurotransmission to control hippocampal synaptic plasticity. Commun Integr Biol 2, 261–264.CrossRefGoogle ScholarPubMed
53. Roy, K, Murtie, JC, El-Khodor, BF, Edgar, N, Sardi, SP, Hooks, BM, Benoit-Marand, M, Chen, C, Moore, H, O'Donnell, P, Brunner, D Corfas, G (2007) Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc Natl Acad Sci USA 104, 8131–8136.CrossRefGoogle ScholarPubMed
54. Teo, JT, Bentley, G, Lawrence, P, Soltesz, F, Miller, S, Wille, D, McHugh, S, Dodds, C, Lu, B, Croft, RJ, Bullmore, ET Nathan, PJ (2014) Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism. Int J Neuropsychopharmacol 17, 705–713.CrossRefGoogle ScholarPubMed
55. Brunoni, AR, Kemp, AH, Shiozawa, P, Cordeiro, Q, Valiengo, LC, Goulart, AC, Coprerski, B, Lotufo, PA, Brunoni, D, Perez, AB, Fregni, F Bensenor, IM (2013) Impact of 5-HTTLPR and BDNF polymorphisms on response to sertraline versus transcranial direct current stimulation: implications for the serotonergic system. Eur Neuropsychopharmacol 23, 1530–1540.CrossRefGoogle ScholarPubMed
56. Rroji, O, van Kuyck, K, Nuttin, B Wenderoth, N (2015) Anodal tDCS over the primary motor cortex facilitates long-term memory formation reflecting use-dependent plasticity. PLoS One 10, e0127270.CrossRefGoogle ScholarPubMed
57. Nitsche, MA, Fricke, K, Henschke, U, Schlitterlau, A, Liebetanz, D, Lang, N, Henning, S, Tergau, F Paulus, W (2003) Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J Physiol 553(Pt 1):293–301.CrossRefGoogle ScholarPubMed
58. Polania, R, Paulus, W, Antal, A Nitsche, MA (2011) Introducing graph theory to track for neuroplastic alterations in the resting human brain: a transcranial direct current stimulation study. Neuroimage 54, 2287–2296.CrossRefGoogle ScholarPubMed
59. Hunter, MA, Coffman, BA, Trumbo, MC Clark, VP (2013) Tracking the neuroplastic changes associated with transcranial direct current stimulation: a push for multimodal imaging. Front Hum Neurosci 7, 495.Google ScholarPubMed
60. Pena-Gomez, C, Sala-Lonch, R, Junque, C, Clemente, IC, Vidal, D, Bargallo, N, Falcon, C, Valls-Sole, J, Pascual-Leone, A Bartres-Faz, D (2012) Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI. Brain Stimul 5, 252–263.CrossRefGoogle ScholarPubMed
61. Kunze, T, Hunold, A, Haueisen, J, Jirsa, V Spiegler, A (2016) Transcranial direct current stimulation changes resting state functional connectivity: a large-scale brain network modeling study. Neuroimage 140, 174–187.CrossRefGoogle ScholarPubMed
62. Rizos, EN, Michalopoulou, PG, Siafakas, N, Stefanis, N, Douzenis, A, Rontos, I, Laskos, E, Kastania, A, Zoumpourlis, V Lykouras, L (2010) Association of serum brain-derived neurotrophic factor and duration of untreated psychosis in first-episode patients with schizophrenia. Neuropsychobiology 62, 87–90.CrossRefGoogle ScholarPubMed

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