Skip to main content Accessibility help
×
Home

Information:

  • Access

Actions:

      • Send article to Kindle

        To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

        Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

        Find out more about the Kindle Personal Document Service.

        10-04 Identifying markers of negative mood: the gender-specific influence of COMT and MAO-A polymorphisms on emotion processing
        Available formats
        ×

        Send article to Dropbox

        To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

        10-04 Identifying markers of negative mood: the gender-specific influence of COMT and MAO-A polymorphisms on emotion processing
        Available formats
        ×

        Send article to Google Drive

        To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

        10-04 Identifying markers of negative mood: the gender-specific influence of COMT and MAO-A polymorphisms on emotion processing
        Available formats
        ×
Export citation

Background:

Our integrative neuroscience model of emotion processing proposes that the effects of genetic polymorphisms on emotional function and risk for disorders of negative affect may vary with gender. The COMT Met allele has been related to anxiety traits (in women), while MAO-A genotypes have been linked to anxiety and phobic disorders (in women) and increased aggression (in men). Using a facial emotion perception task, we examined the role of neuroimaging endophenotypes in the association between COMT, MAO-A and negative mood, and the moderating effects of gender.

Methods:

About 273 healthy subjects from the Brain Resource International Database provided data from cheek swabs (for genotyping). We assessed mood and temperament (using DASS and NEO), and emotion-related brain function (using event-related potential recording).

Results:

COMT heterozygotes (V/M) were associated with higher neuroticism, and reduced and delayed neural responses to emotion in women. By contrast, while the MAO-A genotype showed no direct effects on negative mood, the high-activity alleles were associated with faster and greater responses to emotion in men.

Conclusions:

The gender-related dissociation in the impact of COMT and MAO-A on emotion processing and negative mood suggests that these variants contribute to the differential expression of mood disorders in men and women. Integrative genotype-endophenotype makers may offer promise as a tool to aid in early identification of vulnerability to mood disorder and the selection of optimal treatments.