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5 - The behavioral correlates of testosterone

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5.7 References

AbdelgadirSE, RoselliCE, ChoateJVA, ReskoJA (1999) Androgen receptor messenger ribonucleic acid in brains and pituitaries of male rhesus monkeys: studies on distribution, hormonal control, and relationship to luteinizing hormone secretion. Biol Reprod 60:1251–1256
AlderE, CookA, DavidsonD, WestC, BancroftJ (1986) Hormones, mood and sexuality in lactating women. Brit J Psychiat 148:74–79
AlexanderGM, SherwinBB (1993) Sex steroids, sexual behavior, and selection attention for erotic stimuli in women using oral contraceptives. Psychoneuroendocrinology 18:91–102
AlmeidaOP, YeapBB, HankeyGJ, JamrozikK, FlickerL (2008) Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry 65:283–289
AmiazR, SeidmanSN (2008) Testosterone and depression in men. Curr Opin Endocrinol Diabet Obes 15:278–28
AndersenML, GuindaliniC, Santos-SilvaR, BittencourtLRA, TufikS (2010) Androgen receptor CAG repeat polymorphism is not associated with erectile dysfunction complaints, gonadal steroids and sleep parameters: data from a population-based survey. J Androl 32:524–529
AndersonRA, BancroftJ, WuFCW (1992) The effects of exogenous testosterone on sexuality and mood of normal men. J Clin Endocr Metab 75:1503–1507
AndersonRA, MartinCW, KungA, EveringtonD, PunTC, TanKCB, BancroftJ, SundaramK, Moo-YoungAJ, BairdDT (1999) 7α-Methyl-19-Nortestosterone (MENT) maintains sexual behavior and mood in hypogonadal men. J Clin Endocr Metab 84:3556–3562
AppeltH, StraussB (1986) The psychoendocrinology of female sexuality: a research project. German J Psychol 10:143–156
AzizA, BramstromM, BergquistC, SilverstolpeG (2005) Perimenopausal androgen decline after oophorectomy does not influence sexuality or psychological wellbeing. Fert Steril 83:1021–1028
BagatellCJ, HeimanJR, RivierJE, BremnerWJ (1994a) Effects of endogenous testosterone and estradiol on sexual behavior in normal young men. J Clin Endocr Metab 78:711–716
BagatellCJ, HeimanJR, MatsumotoAM, RivierJE, BremnerWJ (1994b) Metabolic and behavioral effects of high-dose exogenous testosterone in healthy men. J Clin Endocr Metab 79:561–567
BaischerW, KoinigG, HartmannB, HuberJ, LangerG (1995) Hypothalamic-pituitary-gonadal axis in depressed premenopausal women: elevated blood testosterone concentrations compared to normal controls. Psychoneuroendocrinology 20:553–559
BancroftJ (1989) Human Sexuality and its Problems, 2nd edn. Churchill Livingstone, Edinburgh
BancroftJ (1993) The premenstrual syndrome – a reappraisal of the concept and the evidence. Psychol Med Suppl 24:1–47
BancroftJ (1995) Are the effects of androgens on male sexuality noradrenergically mediated? Some consideration of the human. Neurosci Biobehav Rev 19:325–330
BancroftJ (2002) Sexual effects of androgens in women: Some theoretical considerations. Fert Steril 77 (Suppl 4):S55–S59
BancroftJ (2003) Androgens and sexual function in men and women. In: BremnerW, BagatellC (eds) Androgens in Health and Disease. Humana Press, Totowa, NJ, pp 259–290
BancroftJ (2009) Human Sexuality and its Problems, 3rd edn. Churchill Livingstone, Edinburgh
BancroftJ, CawoodEHH (1996) Androgens and the menopause: a study of 40 to 60 year old women. Clin Endocrinol 45:577–587
BancroftJ, GrahamCA (2011) The varied nature of women's sexuality: unresolved issues and a theoretical approach. Horm Behav 59:717–729
BancroftJ, SartoriusN (1990) The effects of oral contraceptives on well-being and sexuality. Oxford Rev Reprod Biol 12:57–92
BancroftJ, DavidsonDW, WarnerP, TyrerG (1980) Androgens and sexual behaviour in women using oral contraceptives. Clin Endocrinol 12:327–340
BancroftJ, SandersD, DavidsonD, WarnerP (1983) Mood, sexuality, hormones and the menstrual cycle III. Sexuality and the role of androgens. Psychosom Med 45:509–516
BancroftJ, SherwinB, AlexanderGM, DavidsonDW, WalkerA (1991) Oral contraceptives, androgens, and the sexuality of young women. II. The role of androgens. Arch Sex Behav 20:121–135
BancroftJ, LoftusJ, LongJS (2003) Distress about sex: a national survey of women in heterosexual relationships. Arch Sex Behav 32:193–208
Barrett-ConnorE, von MühlenDG, Kritz-SilversteinD (1999) Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study. J Clin Endocr Metab 84:573–577
BeckAT, WardCH, MendelsonM, MockJ, ErbaughJ (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571
BehreHM, BöckersA, SchlingheiderA, NieschlagE (1994) Sustained suppression of serum LH, FSH and testosterone and increase of high-density lipoprotein cholesterol by daily injections of the GnRH antagonist cetrorelix over 8 days in normal men. Clin Endocrinol 40:241–248
BellRJ, DonathS, DavisonSL, DavisSR (2006) Endogenous androgen levels and well-being: differences between premenopausal and postmenopausal women. Menopause 13:65–71
BelleroseSB, BinikYM (1993) Body image and sexuality in oophorectomized women. Arch Sex Behav 22:435–460
BlackburnIM, LoudonJB, AshworthCM (1977) A new scale for measuring mania. Psychol Med 7:453–458
BlochM, SchmidtPJ, SuT-P, TobinMB, RubinowDR (1998) Pituitary-adrenal hormones and testosterone across the menstrual cycle in women with premenstrual syndrome and controls. Biol Psychiat 43:897–903
BookAS, StarzykKB, QuinseyVL (2001) The relationship between testosterone and aggression: a meta-analysis. Aggress Violent Behav 6:579–599
BoydRA, ZegaracEA, PosvarEL, FlackMR (2001) Minimal androgenic activity of a new oral contraceptive containing norethindrone acetate and graduated doses of ethinyl estradiol. Contraception 63:71–76
BraunsteinGD, SundwallDA, KatzM, ShifrenJL, BusterJE, SimonJA, BachmanG, AguirreOA, LucasJD, RodenbergC, BuchA, WattsNB (2005) Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women. Arch Intern Med 165:1582–1589
BrombergerJT, SchottLL, KravitzHM, SowersM, AvisNE, GoldEB, RandolphJF Jr, MatthewsKA (2010) Longitudinal change in reproductive hormones and depressive symptoms across the menopausal transition. Arch Gen Psychiatry 67:598–607
BrownWA, DavisGH (1975) Serum testosterone and irritability in man. Psychosom Med 37:87
BuenaF, SwerdloffRS, SteinerBS, LutchmansinghP, PetersonMA, PandianMR, GalmariniM, BhasinS (1993) Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range. Fertil Steril 59:1118–1123
BurgerH, HailesJ, NelsonJ, MenelausM (1987) Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women. Brit Med J 294:936–937
BurgerHG, DudleyEC, CuiJ, DennersteinL, HopperJL (2000) A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocr Metab 85:2832–2838
BussAH, DurkeeA (1957) An inventory for assessing different kinds of hostility. J Consult Psychol 21:343–349
BussAH, PerryM (1992) The Aggression Questionnaire. J Personal Soc Psychol 63:452–459
BusterJE, KingsbergSA, AguirreO, BrownC, BreauxJG, BuchA, RodenbergCA, WekselmanK, CassonP (2005) Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 105:944–952
BuvatJ (2003) Androgen therapy with dehydroepiandrosterone. World J Urol 21:346–355
CapraraGV, BarbaranelliC, ComreyAL (1992) A personological approach to the study of aggression. Personality Individ Diff 13:77–84
CaraniC, ScuteriA, MarramaP, BancroftJ (1990) The effects of testosterone administration and visual erotic stimuli on nocturnal penile tumescence in normal men. Horm Behav 24:435–441
CaraniC, GranataARM, BancroftJ, MarramaP (1995) The effects of testosterone replacement on nocturnal penile tumescence and rigidity and erectile response to visual erotic stimuli in hypogonadal men. Psychoneuroendocrinology 20:743–753
CarneyA, BancroftJ, MathewsA (1978) Combination of hormonal and psychological treatment for female sexual unresponsiveness: a comparative study. Brit J Psychiat 132:339–356
CashdanE (1995) Hormones, sex and status in women. Horm Behav 29:354–366
CashdanE (2003) Hormones and competitive aggression in women. Aggress Behav 29:107–115
CawoodEHH, BancroftJ (1996) Steroid hormones, the menopause, sexuality and well-being of women. Psychol Med 26:925–936
ChristiansenK, KnussmanR (1987) Androgen levels and components of aggression in men. Horm Behav 21:170–180
CoenenCMH, ThomasCMG, BormGF, HollandersJMG, RollandR (1996) Changes in androgens during treatment with four low-dose contraceptives. Contraception 53:171–176
Cortés-GallegosV, CastanedaG, AlonsoR, SojoI, CarrancoA, CervantesC, ParraA (1983) Sleep deprivation reduces circulating androgens in healthy men. Arch Androl 10:33–37
CouzinetB, MeduriG, LecceMG, YoungJ, BraillyS, LoosfeltH, MilgromE, SchaisonG (2001) The postmenopausal ovary is not a major androgen-producing gland. J Clin Endocr Metab 86:5060–5066
CrillyRG, MarshallDH, NordinBE (1979) The effect of age on plasma androstenedione concentration in oophorectomised women. Clin Endocrinol 10:199–201
DabbsJM Jr, RubackRB, FradyRl, HopperCH, SgoutasDS (1988) Saliva testosterone and criminal violence among women. Pers Indiv Differ 9:269–275
DarneyPD (1995) The androgenicity of progestins. Am J Med 98 (Suppl 1A):104S–110S
DavidsonJM, CarmagoCA, SmithER (1979) Effects of androgens on sexual behavior of hypogonadal men. J Clin Endocr Metab 48:955–958
DavisAR, CastanoPM (2004) Oral contraceptives and libido in women. Annu Rev Sex Res 15:297–320
DavisS, PapaliaMA, NormanRJ, O'NeillS, RedelmanM, WilliamsonM, StuckeyBG, WlodarczykJ, Gard'nerK, HumberstoneA (2008) Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in pre-menopausal women: a randomized trial. Ann Intern Med 148:569–577
DavisSR, McCloudP, StraussBJG, BurgerH (1995) Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 21:227–236
DavisSR, DavisonSL, DonathS, BellRJ (2005) Circulating androgen levels and self-reported sexual function in women. JAMA 294:91–96
DavisSR, van der MoorenMJ, van LunsenRH, LopesP, RibotC, ReesM, MoufaregeA, RodenbergC, BuchA, PurdieDW (2006) Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause 13:387–396
DavisonSL, BellR, DonathS, MontaltoJG, DavisSR (2005) Androgen levels in adult females: changes with age, menopause and oophorectomy. J Clin Endocr Metab 90:3847–3853
DavisonSL, BellRJ, LaChinaM, HoldenSL, DavisSR (2009) The relationship between self-reported sexual satisfaction and general well-being in women. J Sex Med 6:2690–2697
DerogatisL, RustJ, GolombokS, BouchardC, NachtigallL, RodenbergC, KuznickiJ, McHorneyCA (2004) Validation of the profile of female sexual function (PFSF) in surgically and naturally menopausal women. J Sex Marital Ther 30:25–36
DerogatisLR (1994) Symptom Checklist-90-R: Administration, Scoring, and Procedures Manual. National Computer Systems Inc, Minneapolis, MN
DerogatisLR (1997) The Derogatis Interview for Sexual Functioning (DISF/DISFSR): an introductory report. J Sex Mar Ther 231:291–304
DowMGT, GallagherJ (1989) A controlled study of combined hormonal and psychological treatment for sexual unresponsiveness in women. Brit J Clin Psychol 28:201–212
EhlersCL, RicklerKC, HoveyJE (1980) A possible relationship between plasma testosterone and aggressive behavior in a female outpatient population. In: GirgisM, KilohLG (eds) Limbic Epilepsy and Dyscontrol Syndrome. North Holland Biomedical Press, New York, pp 183–194
ErikksonE, SundbladC, LisjöP, ModighK, AnderschB (1992) Serum levels of androgens are higher in women with premenstrual irritability and dysphoria than in controls. Psychoneuroendocrinology 17:195–204
FarquharCM, SadlerL, HarveyS, McDoudallJ, YazdiG, MeuliK (2002) A prospective study of the short-term outcomes of hysterectomy with and without oophorectomy. Aust N Z J Obstet Gynaecol 42:197–204
Fernandez-GuastiA, KruijverFPM, FodorM, SwaabDF (2000) Sex differences in the distribution of androgen receptors in the human hypothalamus. J Comp Neurol 425:422–435
FinleySK, KritzerMF (1999) Immuno-reactivity for intracellular androgenreceptors in identified subpopulations of neurons, astrocytes and oligodendrocytes in primate prefrontal cortex. J Neurobiol 40:446–457
FrenkenJ, VennixP (1981) Sexuality Experience Scales Manual. Swets and Zeitlinger BV, Zeist, the Netherlands
GarrattA, TorgersonD, WynessJ, HallM, ReidDM (1995) Measuring sexual function in pre menopausal women. Br J Obstet Gynaecol 102:311–316
GladueBA (1991) Aggressive behavioral characteristics, hormones, and sexual orientation in men and women. Aggress Behav 17:313–326
GoldstatR, BrigantiE, TranJ, WolfeR, DavisSR (2003) Transdermal testosterone therapy improves well-being, mood and sexual function in pre-menopausal women. Menopause 10:390–398
GoorenLJG (1988) Hypogonadotropic hypogonadal men respond less well to androgen substitution treatment than hypergonadotropic hypogonadal men. Arch Sex Behav 17:265–270
GorskiRA (2000) Sexual differentiation of the nervous system. In: KandelER, SchwartzJH, JesellTM (eds) Principles of Neural Science, 4th edn. McGraw-Hill, New York, pp 1131–1148
GrahamCA (2010) The DSM diagnostic criteria for Female Sexual Arousal Disorder. Arch Sex Behav 39:240–255
GrahamCA, BancroftJ, DollHA, GrecoT, TannerA (2007) Does oral-contraceptive-induced reduction in free testosterone adversely affect the sexuality or mood of women?Psychoneuroendocrinology 32:246–255
GrayA, JacksonDN, McKinlayJB (1991) The relation between dominance, anger, and hormones in normally aging men: results from the Massachusetts male aging study. Psychosom Med 53:375–385
HamiltonM (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62
HamiltonM (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278–296
HarrisJA (1999) Review and methodological considerations in research on testosterone and aggression. Aggress Viol Behav 4:273–291
HarrisJA, RushtonJP, HampsonE, JacksonDN (1996) Salivary testosterone and self-report aggressive and prosocial personality characteristics in men and women. Aggress Behav 22:313–331
HeathertonTF, PolivyJ (1991) Development and validation of a scale for measuring state self-esteem. J Pers Soc Psychol 60:895–910.
HedricksCA (1994) Female sexual activity across the human menstrual cycle: a biopsychosocial approach. Annu Rev Sex Res 5:122–172
HinesM (2004) Brain Gender. Oxford University Press, Oxford
HuesmannLR, EronLD (1989) Individual differences and the trait of aggression. Europ J Personal 3:95–106
HydeJS (1984) How large are gender differences in aggression? A developmental meta-analysis. Develop Psychol 20:722–736
JanaudA, RouffyJ, UpmalisD, DainM-P (1992) A comparison of lipid and androgen metabolism with triphasic oral contraceptive formations containing norgestimate or levonorgestrel. Acta Obstet Gynecol Scand Suppl 156:33–38
Jung-HoffmanC, KuhlH (1987) Divergent effects of two low-dose oral contraceptives on sex hormone-binding globulin and free testosterone. Amer J Obs Gynecol 156:199–203
KellyDD (1991) Sexual differentiation of the nervous system. In: KandelER, SchwartzJH, JessellTM (eds) Principles of Neural Science. Appleton & Lange, Norwalk, pp 959–973
KingSR (2008) Emerging roles for neurosteroids in sexual behavior and function. Andrologia 29:524–533
KomisarukBR, SansoneG (2003) Neural pathways mediating vaginal function: the vagus nerve and spinal cord oxytocin. Scandinav J Psychol 44:241–250
KomisarukBR, FrangosE, WhippleB (2011) Hysterectomy improves sexual response? Addressing a crucial omission in the literature. J Minim Invas Gyn 18:288–295
KouriEM, LukasSE, PopeHG Jr, OlivaPS (1995) Increased aggressive responding in male volunteers following the administration of gradually increasing doses of testosterone cypionate [published correction appears in Drug Alcohol Depend 1998; 50:255]. Drug Alcohol Depend 40:73–79
KraemerHC, BeckerHB, BrodieHTH, DoeringCH, MoosRH, HamburgDA (1976) Orgasmic frequency and plasma testosterone levels in normal human males. Arch Sex Behav 5:125
KwanM, GreenleafWJ, MannJ, CrapoL, DavidsonJM (1983) The nature of androgen action on male sexuality: a combined laboratory-self-report study on hypogonadal men. J Clin Endocr Metab 57:557–562
LaanE, EveraerdW (1995) Determinants of sexual arousal: psychophysiological theory and data. Annu Rev Sex Res 6:32–76
LangeJD, BrownWA, WinczeJP, ZwickW (1980) Serum testosterone concentration and penile tumescence changes in men. Horm Behav 14:267
LeibenluftE, SchmidtPJ, TurnerEH, DanaceauMA, AshmanSB, WehrTA, RubinowDR (1997) Effects of leuprolide-induced hypogonadism and testosterone replacement on sleep, melatonin and prolactin secretion in men. J Clin Endocr Metab 82:3203–3207
LiuPY, YeeB, WishartSM, JimenezM, JungDG, GrunsteinRR, HandelsmanDJ (2003) The short-term effects of high-dose testosterone on sleep, breathing, and function in older men. J Clin Endocr Metab 88:3605–3613
LloydEA (2005) The Case of the Female Orgasm: Bias in the Science of Evolution. Harvard University Press, Cambridge, MA
LuboshitzkyR, AvivA, HefetzA, HererP, Shen-OrrZ, LavieL, LavieP (2002) Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. J Clin Endocr Metab 87:3394–3398
LuisiM, FranchiF (1980) Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients. J Endocrinol Invest 3:305–308
ManettiGJ, HonigSC (2010) Update on male hormonal contraception: is the vasectomy in jeopardy?Internat J Impot Res 22:159–170
MathewsA, WhiteheadA, KellettJ (1983) Psychological and hormonal factors in the treatment of female sexual dysfunction. Psychol Med 13:83–92
McNairDM, LorrM, DropplemanLF (1992) EdITS Manual for the Profile of Mood States. Educational and Industrial Testing Service, San Diego
Meyer-BahlburgHFL, BakerSW, DolezalC, CarlsonAD, ObeidJSD, NewMI (2003) Long-term outcome in congenital adrenal hyperplasia: gender and sexuality. Endocrinologist 13:227–232
MichaelRP, ReesHD, BonsallRW (1989) Sites in the male primate brain at which testosterone acts as an androgen. Brain Res 502:11–20
MillerKK, SesmiloG, SchillerA, SchoenfeldD, BurtonS, KlibanskiA (2001) Androgen deficiency in women with hypopituitarism. J Clin Endocr Metab 86:561–567
MillerKK, BillerBM, BeauregardC, LipmanJG, JonesJ, SchoenfeldD, ShermanJC, SwearingenB, LoefflerJ, KlibanskiA (2006) Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. J Clin Endocr Metab 91:1683–1690
MintoCL, LiaoKL-M, ConwayGS, CreightonSM (2003) Sexual function in women with complete androgen insensitivity syndrome. Fert Steril 80:157–164
MoneyJ, EhrhardtA (1972) Man and Woman: Boy and Girl. Johns Hopkins Press, Baltimore
MontorsiF, OettelM (2005) Testosterone and sleep-related erections: an overview. J Sex Med 2:771–784
MushayandebvuT, CastracaneVD, GimpelT, AdelT, SantoroN (1996) Evidence for diminished mid-cycle ovarian androgen production in older reproductive aged women. Fert Steril 65:721–723
MyersLS, DixenJ, MorrissetteD, CarmichaelM, DavidsonJM (1990) Effects of estrogen, androgen, and progestin on sexual psychophysiology and behavior in postmenopausal women. J Clin Endocr Metab 70:1124–1131
Nathorst-BöösJ, von SchoultzB, CarlströmK (1993) Elective ovarian removal and estrogen replacement therapy – effects on sexual life, psychological wellbeing and androgen status. J Psychosom Obstet Gynaecol 14:283–293
National Institute for Health and Clinical Excellence (NICE) (2005) Long-Acting Reversible Contraception: The Effective and Appropriate Use of Long-Acting Reversible Contraception. RCOG Press, London
NeaveN, WolfsonS (2003) Testosterone, territoriality, and the ‘home advantage'. Physiol Behav 78:269–275
O'CarrollRE, ShapiroC, BancroftJ (1985) Androgens, behaviour and nocturnal erections in hypogonadal men: the effect of varying the replacement dose. Clin Endocrinol 23:527–538
O'ConnorDB, ArcherJ, WuFCW (2001) Measuring aggression: self-reports, partner reports and responses to provoking scenarios. Aggress Behav 27:79–101
O'ConnorDB, ArcherJ, WuFCW (2004) Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study. J Clin Endocri Metab 89:2837–2845
OlweusD (1975) Development of a Multi-Faceted Aggression Inventory for Boys. Report No. 6. University of Bergen, Bergen, Norway
OlweusD, MattssonA, SchallingD, LowH (1980) Testosterone, aggression, physical, and personality dimensions in normal adolescent males. Psychosom Med 42:253–269
OlweusD, MattssonA, SchallingD, LowH (1988) Circulating testosterone levels and aggression in adolescent males: a causal analysis. Psychosom Med 42:253–269
OrentreichN, BrindJL, RizerRL, VogelmanJH (1984) Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocr Metab 59:551–555
OverallJE, GorhamDR (1962) The Brief Psychiatric Rating Scale. Psychol Res 10:799–812
PanjariM, DavisSR (2010) DHEA for postmenopausal women: a review of the evidence. Maturitas 66:172–179
ParentAS, TeilmannG, JuulA, SkakkebaekNE, ToppariJ, BourguignonJ-P (2003) The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev 24:668–693
ParkK, KangHK, SeoJJ, KimHJ, RyuSB, JeongGW (2001) Blood-oxygenation level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response. Urology 57:1189–1194
ParmeggianaPL, MorrisonAR (1990) Alterations in autonomic functions during sleep. In: LoewyAD, SpyerKM (eds) Central Regulation of Autonomic Functions. Oxford University Press, New York, pp 367–386
PerrinJS, HervéPY, LeonardG, PerronM, PikeGB, PittiotA, RicherL, VeilletteS, PausovaZ, PausT (2008) Growth of white matter in the adolescent brain: role of testosterone and androgen receptor. J Neurosci 28:9519–9524
PopeHG Jr, KouriEM, HudsonJI (2000) Effects of supraphysiological doses of testosterone on mood and aggression in normal men. Arch Gen Psychiatry 57:133–140
PuyL, MacLuskyNJ, BeckerL, KarsanN, TrachtenbergJ, BrownTJ (1995) Immuno-cytochemical detection of androgen receptor in human temporal cortex: characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues. J Steroid Biochem Mol Biol 55:197–209
RabochJ, StarkaL (1973) Reported coital activity of men and levels of plasma testosterone. Arch Sex Behav 2:309
RadloffLS (1977) The CES-D Scale. A self-report depression scale for research in the general population. App Psych Meas 1:385–401
RathusSA (1973) A 30-item schedule for assessing assertive behavior. Behav Ther 4:398–406
RedoutéJ, StoléruS, PugeatM, CostesN, LavenneF, Le BarsD, DechaudH, CinottiL, PujolJF (2005) Brain processing of visual sexual stimuli in treated and untreated hypogonadal patients. Psychoneuroendocrinology, 30:461–482
RileyA, RileyE (2000) Controlled studies on women presenting with sexual drive disorder: I. Endocrine status. J Sex Marital Ther 26:269–283
RogerM, NahoulK, SchollerR, BagrelD (1980) Evolution with ageing of four plasma androgens in postmenopausal women. Maturitas 2:171–177
RommertsFFG (1990) Testosterone: an overview of biosynthesis, transport, metabolism and action. In: NieschlagE, BehreHM (eds) Testosterone: Action, Deficiency, Substitution. Springer-Verlag, Berlin, pp 1–22
RoselliCE, KlostermanS, ReskoJA (2001) Anatomic relationships between aromatase and androgen receptor mRNA expression in the hypothalamus and amygdala of adult male cynomolgus monkeys. J Comp Neurol 439:208–223
RubinH, HensonD, FalvoR, HighR (1979) The relationship between men's endogenous levels of testosterone and their penile responses to erotic stimuli. Behav Res Ther 17:305
SalmimiesP, KockottG, PirkeKM, VogtHJ, SchillWB (1982) Effects of testosterone replacement on sexual behavior in hypogonadal men. Arch Sex Behav 11:345–353
SandblomRE, MatsumotoAM, ScoeneRB, LeeKA, GiblinEC, BremnerWJ, PiersonDJ (1983) Obstructive sleep apnoea induced by testosterone administration. N Engl J Med 308:508–510
SandersSA, GrahamCA, BassJ, BancroftJ (2001) A prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation. Contraception 64:51–58
SarkeyS.AzcoitaI, Garcia-SeguraLM, Garcia-OvejeroD, DonCarlosLL (2008) Classical androgen receptors in non-classical sites in the brain. Horm Behav 53:753–764
SarrieauA, MitchellJB, LalS, OlivierA, QuirionE, MeaneyMJ (1990) Androgen binding sites in human temporal cortex. Neuroendocrinology 51:713–716
SchmidtPJ, BerlinKL, DanaceauMA, NeerenA, HaqMA, RocaCA, RubinowDR (2004) The effects of pharmacologically induced hypogonadism on mood in healthy men. Arch Gen Psychiat 61:997–1004
SchmidtPJ, DalyRC, BlochM, SmithMJ, DanaceauMA, SimpsonSt.CL, MurphyJH, HaqN, RubinowDR (2005) Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiat 62:154–162
Schreiner-EngelP, SchiaviRC, WhiteD, GhizzaniA (1995) Low sexual desire in women: the role of reproductive hormones. Horm Behav 23:221–234
SeigelJM (1986) The multi-dimensional anger inventory. J Personality Soc Psych 51:191–200
SherwinBB (1988) A comparative analysis of the role of androgen in human male and female sexual behavior: behavioral specificity, critical thresholds, and sensitivity. Psychobiology 16:416–425
SherwinBB, GelfandMM (1985a) Sex steroids and affect in the surgical menopause: a double-blind, cross-over study. Psychoneuroendocrinol 10:325–335
SherwinBB, GelfandMM (1985b) Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. Am J Obstet Gynecol 151:153–160
SherwinBB, GelfandMM, BrenderW (1985) Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 47:339–351
ShifrenJL, BraunsteinGD, SimonJA, CassonPR, BusterJE, RedmondGP, BurkiRE, GinsbergES, RosenRC, LeiblumSR, CaramelliKE, MazerNA (2000) Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 343:682–688
ShifrenJL, DavisSR, MoreauM, WaldbaumA, BouchardC, DerogatisL, DerzcoC, BearnsonP, KakosN, O'NeillS, LevineS, WechselmanK, BuchA, RodenbergC, KrollR (2006) Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause 13:770–779
ShoresMM, MoceriVM, SloanKL, AlvinM, MatsumotoMD, KivlahanDR (2005) Low testosterone levels predict incident depressive illness in older men: effects of age and medical morbidity. J Clin Psychiat 66:7–14
SimmonsZL, RoneyJR (2011) Variation in CAG repeat length of the androgen receptor gene predicts variables associated with intrasexual competitiveness in human males. Horm Behav 60:306–312
SimonJ, BraunsteinG, NachtigallL, UtianW, KatzM, MillerS, WaldbaumA, BouchardC, DerzkoC, BuchA, RodenbergC, LucasJ, DavisS (2005) Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 90:5226–5233
SimpsonJA, GangestadSW (1991) Individual differences in sociosexuality – evidence for convergent and discriminant validity. J Pers Soc Psychol 60:870–883
SkakkebaekNE, BancroftJ, DavidsonDW, WarnerP (1981) Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study. Clin Endocrinol 14:49–61
StuartFM, HammondDC, PettMA (1987) Inhibited sexual desire in women. Arch Sex Behav 16:91–106
SuTP, PagliaroM, SchmidtPJ, PickarD, WolkowitzO, RubinowDR (1993) Neuropsychiatric effects of anabolic steroids in male normal volunteers. JAMA 269:2760–2764
SulcováJ, HillM, HamplR, StárkaL (1997) Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects. J Endocrinol 154:57–62
SymonsD (1979) The Evolution of Human Sexuality. Oxford University Press, New York
TaylorJF, RosenRC, LeiblumSR (1994) Self-report assessment of female sexual function: psychometric evaluation of the Brief Index of Sexual Functioning for Women. Arch Sex Behav 23:627–643
TeplinV, VittinghoffE, LinF, LearmanLA, RichterHE, KuppermannM (2007) Oophorectomy in premenopausal women. Health-related quality of life and sexual functioning. Obstet Gynecol 109:347–354
ThorneycroftIH, StanczykFZ, BradshawKD, BallaghSA, NicholsM, WeberME (1999) Effect of low-dose oral contraceptives on androgenic markers and acne. Contraception 60:255–262
ThorntonJW (2001) Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. PNAS 98:5671–5676
TrickerR, CasaburiR, StorerTW, ClevengerB, BermanN, ShiraziA, BhasinS (1996) The effect of supraphysiological doses of testosterone on angry behavior in healthy eugonadal men – a clinical research center study. J Clin Endocr Metab 81:3754–3758
TuitenA, LaanE, PanhuysenG, EveraerdW, de HaanE, KoppeschaarH, VroonP (1996) Discrepancies between genital responses and subjective sexual function during testosterone substitution in women with hypothalamic amenorrhea. Psychosom Med 58:234–241
TuitenA, Van HonkJ, KoppeschaarH, BernaardsC, ThijssenJ, VerbatenR (2000) Time course of effects of testosterone administration on sexual arousal in women. Arch Gen Psychiat 57:149–153
TutTG, GhadessyFJ, TrifiroMA, PinskyI, YongEL (1997) Long polyglutamine tracts in the androgen receptor are associated with reduced transactivation, impaired sperm production, and male infertility. J Clin Endocr Metab 82:3777–3782
VagueJ (1983) Testicular feminization syndrome: an experimental model for the study of hormone action on sexual behavior. Horm Res 18:62–68
Van der PahlenB, LindmanR, SarkolaT, MäkisaloH, ErikssonCJP (2002) An exploratory study on self-evaluated aggression and androgens in women. Aggress Behav 28:273–280
Van der VangeN, BlankensteinMA, KloosterboerHJ, HaspelsAA, ThijssenJH (1990) Effects of seven low-dose combined oral contraceptives on sex hormone binding globulin, corticosteroid binding globulin, total and free testosterone. Contraception 41:345–352
Van GoozenSHM, Cohen-KettenisPT, GoorenLJG, FrijdaNH, Van de PollNE (1995) Gender differences in behaviour: activating effects of cross-sex hormones. Psychoneuroendocrinology 20:343–363
VermeerschH, T'SjoenG, KaufmanJM, VinckeJ, Van HoutteM (2010) Testosterone, androgen receptor gene CAG repeat length, mood and behaviour in adolescent males. Europ J Endocrinol 163:319–328
WalkerPA (1978) The role of antiandrogens in the treatment of sex offenders. In: QuallsCB, WinczeJP, BarlowDH (eds) The Prevention of Sexual Disorders. Plenum, New York, pp 117–136
WeberB, LewickaS, DeuschleM, CollaM, HeuserI (2000) Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 25:765–771
WeinbergerDR, ElvevagB, GieddJN (2005) The Adolescent Brain: A Work in Progress. The National Campaign to Prevent Teen Pregnancy, Washington, DC. Available at: (accessed Jan 16, 2012)
WestbergL, BaghaeiF, RosmondR, HellstrandM, LandénM, JanssonM, HolmG, BjörntorpP, ErikssonE (2001) Polymorphisms of the androgen receptor gene and the estrogen receptor β gene are associated with androgen levels in women. J Clin Endocr Metab 86:2562–2568
WisniewskiAB, MigeonCJ, Meyer-BahlburgHFL, GearhartJP, BerkowitzGD, BrownTR (2000) Complete androgen insensitivity syndrome: long-term medical, surgical and psychosexual outcome. J Clin Endocr Metab 85:2664–2669
YatesWR, PerryPJ, MacIndoeJ, HolmanT, EllingrodV (1999) Psychosexual effects of three doses of testosterone cycling in normal men. Biol Psychiat 45:254–260
YoungRC, BiggsJT, ZieglerVE, MeyerDA (1978) A rating scale for mania: reliability, validity, and sensitivity. Br J Psychiat 133:429–435
ZhouJ, HofmanMA, GoorenLJG, SwaabDF (1995) A sex difference in the human brain and its relation to transexuality. Nature 378:68–70
ZitzmannM, NieschlagE (2001) Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs. Europ J Endocrinol 144:183–197
ZitzmannM, NieschlagE (2003) The CAG repeat polymorphism within the androgen receptor gene and maleness. Int J Androl 26:76–83
ZitzmannM, FaberS, NieschlagE (2006) Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocr Metab 91:4335–4343
ZumoffB, StrainGW, MillerLK, RosnerW (1995) Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocr Metab 80:1429–1430