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  • Print publication year: 2012
  • Online publication date: August 2012

9 - Androgen effects on the skeletal muscle

9.13 References

ArltW, CalliesF, van VlijmenJC, KoehlerI, ReinckeM, BidlingmaierM, HueblerD, OettelM, ErnstM, SchulteHM, AllolioB (1999) Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 341:1013–1020
ArltW, CalliesF, AllolioB (2000) DHEA replacement in women with adrenal insufficiency – pharmacokinetics, bioconversion and clinical effects on well-being, sexuality and cognition. Endocr Res 26:505–511
ArverS, Sinha-HikimI, BeallG, GuerreroM, ShenR, BhasinS (1999) Serum dihydrotestosterone and testosterone concentrations in human immunodeficiency virus-infected men with and without weight loss. J Androl 20:611–618
BachmanE, FengR, TravisonT, LiM, OlbinaG, OstlandV, UlloorJ, ZhangA, BasariaS, GanzT, WestermanM, BhasinS (2010) Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab 95:4743–4747
Barrett-ConnorE, von MuhlenDG, Kritz-SilversteinD (1999) Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study. J Clin Endocrinol Metab 84:573–577
BasariaS, CovielloAD, TravisonTG, StorerTW, FarwellWR, JetteAM, EderR, TennstedtS, UlloorJ, ZhangA, ChoongK, LakshmanKM, MazerNA, MiciekR, KrasnoffJ, ElmiA, KnappPE, BrooksB, ApplemanE, AggarwalS, BhasinG, Hede-BrierleyL, BhatiaA, CollinsL, LeBrasseurN, FioreLD, BhasinS (2010) Adverse events associated with testosterone administration. N Engl J Med 363:109–122
BaumgartnerRN (2000) Body composition in healthy aging. Ann N Y Acad Sci 904:437–448
BaumgartnerRN, KoehlerKM, GallagherD, RomeroL, HeymsfieldSB, RossRR, GarryPJ, LindemanRD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147:755–763
BernsJS, RudnickMR, CohenRM (1992) A controlled trial of recombinant human erythropoietin and nandrolone decanoate in the treatment of anemia in patients on chronic hemodialysis. Clin Nephrol 37:264–267
BhasinS, StorerTW, BermanN, CallegariC, ClevengerB, PhillipsJ, BunnellTJ, TrickerR, ShiraziA, CasaburiR (1996) The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 335:1–7
BhasinS, StorerTW, BermanN, YarasheskiKE, ClevengerB, PhillipsJ, LeeWP, BunnellTJ, CasaburiR (1997) Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. J Clin Endocrinol Metab 82:407–413
BhasinS, StorerTW, Asbel-SethiN, KilbourneA, HaysR, Sinha-HikimI, ShenR, ArverS, BeallG (1998) Effects of testosterone replacement with a nongenital, ransdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. J Clin Endocrinol Metab 83:3155–3162
BhasinS, StorerTW, JavanbakhtM, BermanN, YarasheskiKE, PhillipsJ, DikeM, Sinha-HikimI, ShenR, HaysRD, BeallG (2000) Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. JAMA 283:763–770
BhasinS, WoodhouseL, CasaburiR, SinghAB, BhasinD, BermanN, ChenX, YarasheskiKE, MaglianoL, DzekovC, DzekovJ, BrossR, PhillipsJ, Sinha-HikimI, ShenR, StorerTW (2001) Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 281:E1172–E1181
BhasinS, TaylorWE, SinghR, ArtazaJ, Sinha-HikimI, JasujaR, ChoiH, Gonzalez-CadavidNF (2003) The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci 58:M1103–M1110
BhasinS, WoodhouseL, CasaburiR, SinghAB, MacRP, LeeM, YarasheskiKE, Sinha-HikimI, DzekovC, DzekovJ, MaglianoL, StorerTW (2005) Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab 90:678–688
BhasinS, CalofOM, StorerTW, LeeML, MazerNA, JasujaR, MontoriVM, GaoW, DaltonJT (2006) Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nat Clin Pract Endocrinol Metab 2:146–159
BlackmanMR, SorkinJD, MunzerT, BellantoniMF, Busby-WhiteheadJ, StevensTE, JaymeJ, O'ConnorKG, ChristmasC, TobinJD, StewartKJ, CottrellE, St ClairC, PabstKM, HarmanSM (2002) Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 288:2282–2292
BlancoCE, PopperP, MicevychP (1997) Anabolic-androgenic steroid induced alterations in choline acetyltransferase messenger RNA levels of spinal cord motoneurons in the male rat. Neuroscience 78:873–882
BondanelliM, AmbrosioMR, MarguttiA, FranceschettiP, ZatelliMC, degli UbertiEC (2003) Activation of the somatotropic axis by testosterone in adult men: evidence for a role of hypothalamic growth hormone-releasing hormone. Neuroendocrinology 77:380–387
BrodskyIG, BalagopalP, NairKS (1996) Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men-a clinical research center study. J Clin Endocrinol Metab 81:3469–3475
BuchwaldD, ArgyresS, EasterlingRE, OelshlegelFJ Jr, BrewerGJ, SchoomakerEB, AbbrechtPH, WilliamsGW, WellerJM (1977) Effect of nandrolone decanoate on the anemia of chronic hemodialysis patients. Nephron 18:232–238
CalofOM, SinghAB, LeeML, KennyAM, UrbanRJ, TenoverJL, BhasinS (2005) Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 60:1451–1457
CasaburiR, BhasinS, CosentinoL, PorszaszJ, SomfayA, LewisMI, FournierM, StorerTW (2004) Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 170:870–878
CawthonPM, EnsrudKE, LaughlinGA, CauleyJA, DamTT, Barrett-ConnorE, FinkHA, HoffmanAR, LauE, LaneNE, StefanickML, CummingsSR, OrwollES; Osteoporotic Fractures in Men (MrOS) Research Group (2009) Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study. J Clin Endocrinol Metab 94:3806–3815
ClagueJE, WuFC, HoranMA (1999) Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men. Int J Androl 22:261–265
CoodleyGO, CoodleyMK (1997) A trial of testosterone therapy for HIV-associated weight loss. Aids 11:1347–1352
CoodleyGO, LovelessMO, NelsonHD, CoodleyMK (1994) Endocrine function in the HIV wasting syndrome. J Acquir Immune Defic Syndr 7:46–51
CovielloAD, LakshmanK, MazerNA, BhasinS (2006) Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone. J Clin Endocrinol Metab 91:4669–4675
CovielloAD, KaplanB, LakshmanKM, ChenT, SinghAB, BhasinS (2008) Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab 93:914–919
CrawfordBA, LiuPY, KeanMT, BleaselJF, HandelsmanDJ (2003) Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. J Clin Endocrinol Metab 88:3167–3176
DobsAS, FewWL 3rd, BlackmanMR, HarmanSM, HooverDR, GrahamNM (1996) Serum hormones in men with human immunodeficiency virus-associated wasting. J Clin Endocrinol Metab 81:4108–4112
DobsAS, CofrancescoJ, NoltenWE, DanoffA, AndersonR, HamiltonCD, FeinbergJ, SeekinsD, YangcoB, RhameF (1999) The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection. Am J Med 107:126–132
EakmanGD, DallasJS, PonderSW, KeenanBS (1996) The effects of testosterone and dihydrotestosterone on hypothalamic regulation of growth hormone secretion. J Clin Endocrinol Metab 81:1217–1223
Emmelot-VonkMH, VerhaarHJ, Nakhai PourHR, AlemanA, LockTM, BoschJL, GrobbeeDE, van der SchouwYT (2008) Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA 299:39–52
Fernández-BalsellsMM, MuradMH, LaneM, LampropulosJF, AlbuquerqueF, MullanRJ, AgrwalN, ElaminMB, Gallegos-OrozcoJF, WangAT, ErwinPJ, BhasinS, MontoriVM (2010) Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab 95:2560–2575
FerrandoAA, TiptonKD, DoyleD, PhillipsSM, CortiellaJ, WolfeRR (1998) Testosterone injection stimulates net protein synthesis but not tissue amino acid transport. Am J Physiol 275:E864–E871
FerrandoAA, Sheffield-MooreM, YeckelCW, GilkisonC, JiangJ, AchacosaA, LiebermanSA, TiptonK, WolfeRR, UrbanRJ (2002) Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. Am J Physiol Endocrinol Metab 282:E601–E607
FreemanER, BloomDA, McGuireEJ (2001) A brief history of testosterone. J Urol 165:371–373
GiustinaA, ScalviniT, TassiC, DesenzaniP, PoiesiC, WehrenbergWB, RogolAD, VeldhuisJD (1997) Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone. J Clin Endocrinol Metab 82:1210–1219
GrinspoonS, CorcoranC, LeeK, BurrowsB, HubbardJ, KatznelsonL, WalshM, GuccioneA, CannanJ, HellerH, BasgozN, KlibanskiA (1996) Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. J Clin Endocrinol Metab 81:4051–4058
GrinspoonS, CorcoranC, AskariH, SchoenfeldD, WolfL, BurrowsB, WalshM, HaydenD, ParlmanK, AndersonE, BasgozN, KlibanskiA (1998) Effects of androgen administration in men with the AIDS wasting syndrome. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 129:18–26
GrinspoonS, CorcoranC, StanleyT, BaajA, BasgozN, KlibanskiA (2000) Effects of hypogonadism and testosterone administration on depression indices in HIV-infected men. J Clin Endocrinol Metab 85:60–65
GuptaV, BhasinS, GuoW, SinghR, MikiR, ChauhanP, ChoongK, TchkoniaT, LebrasseurNK, FlanaganJN, HamiltonJA, ViereckJC, NarulaNS, KirklandJL, JasujaR (2009) Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol 296:32–40
JohansenKL (1999) Physical functioning and exercise capacity in patients on dialysis. Adv Ren Replace Ther 6:141–148
JohansenKL, MulliganK, SchambelanM (1999) Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. Jama 281:1275–1281
JohnsK, BeddallMJ, CorrinRC (2005) Anabolic steroids for the treatment of weight loss in HIV-infected individuals. Cochrane Database Syst Rev 19:CD005483
KatznelsonL, FinkelsteinJS, SchoenfeldDA, RosenthalDI, AndersonEJ, KlibanskiA (1996) Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 81:4358–4365
KatznelsonL, RosenthalDI, RosolMS, AndersonEJ, HaydenDL, SchoenfeldDA, KlibanskiA (1998) Using quantitative CT to assess adipose distribution in adult men with acquired hypogonadism. Am J Roentgenol 170:423–427
KennyAM, PrestwoodKM, GrumanCA, MarcelloKM, RaiszLG (2001) Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci 56:M266–M272
KennyAM, BellantonioS, GrumanCA, AcostaRD, PrestwoodKM (2002) Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci 57:M321–M325
KenyonA, KnowltonK, SandifordI, KochFC, LotwinG (1940) A comparative study of the metabolic effects of testosterone propionate in normal men and women and in eunuchoidism. Endocrinology 26:26–45
KhawKT, Barrett-ConnorE (1992) Lower endogenous androgens predict central adiposity in men. Ann Epidemiol 2:675–682
KnappPE, StorerTW, HerbstKL, SinghAB, DzekovC, DzekovJ, LaValleyM, ZhangA, UlloorJ, BhasinS (2008) Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss. Am J Physiol Endocrinol Metab 294:E1135–E1143
KochakianC (1937) Testosterone and testosterone acetate and the protein and energy metabolism of castrate dogs. Endocrinology 21:750–755
KochakianC (1950) Comparison of protein anabolic property of various androgens in the castrated rat. Am J Physiol 60:53–58
KochakianC, MurlinJ (1935) The effect of male hormone on the protein and energy metabolism of castrate dogs. J Nutrition 10:437–459
KongA, EdmondsP (2002) Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis. Lancet Infect Dis 2:692–699
KrasnoffJ, BasariaS, PencinaM, KaurG, CovielloA, VasanR, BhasinS, MurabitoJM (2009) Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study. J Clin Endocrinol Metab 95:2790–2799
LeBrasseurNK, LajevardiN, MiciekR, MazerN, StorerTW, BhasinS (2009) Effects of testosterone therapy on muscle performance and physical function in older men with mobility limitations (The TOM Trial): design and methods. Contemp Clin Trials 30:133–140
LeslieM, ForgerNG, BreedloveSM (1991) Sexual dimorphism and androgen effects on spinal motoneurons innervating the rat flexor digitorum brevis. Brain Res 561:269–273
MacAdamsMR, WhiteRH, ChippsBE (1986) Reduction of serum testosterone levels during chronic glucocorticoid therapy. Ann Intern Med 104:648–651
MargoleseHC (2000) The male menopause and mood: testosterone decline and depression in the aging male—is there a link?J Geriatr Psychiatry Neurol 13:93–101
MaurasN, HayesV, WelchS, RiniA, HelgesonK, DoklerM, VeldhuisJD, UrbanRJ (1998) Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity. J Clin Endocrinol Metab 83:1886–1892
MeltonLJ 3rd, KhoslaS, CrowsonCS, O'ConnorMK, O'FallonWM, RiggsBL (2000a) Epidemiology of sarcopenia. J Am Geriatr Soc 48:625–630
MeltonLJ 3rd, KhoslaS, RiggsBL (2000b) Epidemiology of sarcopenia. Mayo Clin Proc 75 (Suppl):S10–S12; discussion:S12–S13
MorleyJE (2000) Andropause, testosterone therapy, and quality of life in aging men. Cleve Clin J Med 67:880–882
MorleyJE, PerryHM 3rd, KaiserFE, KraenzleD, JensenJ, HoustonK, MattammalM, PerryHM Jr (1993) Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 41:149–152
MorleyJE, KaiserFE, PerryHM 3rd, PatrickP, MorleyPM, StauberPM, VellasB, BaumgartnerRN, GarryPJ (1997) Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 46:410–413
NairKS, RizzaRA, O'BrienP, DhatariyaK, ShortKR, NehraA, VittoneJL, KleeGG, BasuA, BasuR, CobelliC, ToffoloG, Dalla ManC, TindallDJ, MeltonLJ 3rd, SmithGE, KhoslaS, JensenMD (2006) DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 355:1647–1659
NovakA, BrodM, ElbersJ (2002) Andropause and quality of life: findings from patient focus groups and clinical experts. Maturitas 43:231–237
OphoffJ, Van ProeyenK, CallewaertF, De GendtK, De BockK, Vanden BoschA, VerhoevenG, HespelP, VanderschuerenD (2009) Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. Endocrinology 150:3558–3566
OrwollE, LambertLC, MarshallLM, BlankJ, Barrett-ConnorE, CauleyJ, EnsrudK, CummingsSR (2006) Endogenous testosterone levels, physical performance, and fall risk in older men. Arch Intern Med 166:2124–2131
PageST, AmoryJK, BowmanFD, AnawaltBD, MatsumotoAM, BremnerWJ, TenoverJL (2005) Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90:1502–1510
PainterP, JohansenK (1999) Physical functioning in end-stage renal disease. Introduction: a call to activity. Adv Ren Replace Ther 6:107–109
PopeHG Jr, CohaneGH, KanayamaG, SiegelAJ, HudsonJI (2003) Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial. Am J Psychiatry 160:105–111
RabkinJG, RabkinR, WagnerG (1995) Testosterone replacement therapy in HIV illness. Gen Hosp Psychiatry 17:37–42
RabkinJG, FerrandoSJ, WagnerGJ, RabkinR (2000a) DHEA treatment for HIV+ patients: effects on mood, androgenic and anabolic parameters. Psychoneuroendocrinology 25:53–68
RabkinJG, WagnerGJ, RabkinR (2000b) A double-blind, placebo-controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms. Arch Gen Psychiatry 57:141–147; discussion:155–146
ReddyP, WhiteCM, DunnAB, MoynaNM, ThompsonPD (2000) The effect of testosterone on health-related quality of life in elderly males – a pilot study. J Clin Pharm Ther 25:421–426
ReidIR (1987) Serum testosterone levels during chronic glucocorticoid therapy. Ann Intern Med 106:639–640
ReidIR, WattieDJ, EvansMC, StapletonJP (1996) Testosterone therapy in glucocorticoid-treated men. Arch Intern Med 156:1173–1177
RietschelP, CorcoranC, StanleyT, BasgozN, KlibanskiA, GrinspoonS (2000) Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy. Clin Infect Dis 31:1240–1244
RoyTA, BlackmanMR, HarmanSM, TobinJD, SchragerM, MetterEJ (2002) Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men. Am J Physiol Endocrinol Metab 283:E284–E294
SalehianB, JacobsonD, SwerdloffRS, GrafeMR, Sinha-HikimI, McCutchanJA (1999) Testicular pathologic changes and the pituitary-testicular axis during human immunodeficiency virus infection. Endocr Pract 5:1–9
SattlerFR, JaqueSV, SchroederET, OlsonC, DubeMP, MartinezC, BriggsW, HortonR, AzenS (1999) Effects of pharmacological doses of nandrolone decanoate and progressive resistance training in immunodeficient patients infected with human immunodeficiency virus. J Clin Endocrinol Metab 84:1268–1276
SchaapLA, PluijmSM, SmitJH, van SchoorNM, VisserM, GoorenLJ, LipsP (2005) The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women. Clin Endocrinol (Oxf) 63:152–160
ScholsAM, SoetersPB, MostertR, PluymersRJ, WoutersEF (1995) Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med 152:1268–1274
SeidellJC, BjorntorpP, SjostromL, KvistH, SannerstedtR (1990) Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism 39:897–901
SeidmanSN, RabkinJG (1998) Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression. J Affect Disord 48:157–161
SeidmanSN, AraujoAB, RooseSP, McKinlayJB (2001) Testosterone level, androgen receptor polymorphism, and depressive symptoms in middle-aged men. Biol Psychiatry 50:371–376
SeidmanSN, AraujoAB, RooseSP, DevanandDP, XieS, CooperTB, McKinlayJB (2002) Low testosterone levels in elderly men with dysthymic disorder. Am J Psychiatry 159:456–459
SerraC, BhasinS, TangherliniF, BartonER, GannoM, ZhangA, ShanskyJ, VandenburghHH, TravisonTG, JasujaR, MorrisC (2011) The role of GH and IGF-I in mediating anabolic effects of testosterone on androgen-responsive muscle. Endocrinology 152:193–206
Sheffield-MooreM, UrbanRJ, WolfSE, JiangJ, CatlinDH, HerndonDN, WolfeRR, FerrandoAA (1999) Short-term oxandrolone administration stimulates net muscle protein synthesis in young men. J Clin Endocrinol Metab 84:2705–2711
Sheffield-MooreM, Paddon-JonesD, CaspersonSL, GilkisonC, VolpiE, WolfSE, JiangJ, RosenblattJI, UrbanRJ (2006) Androgen therapy induces muscle protein anabolism in older women. J Clin Endocrinol Metab 91:3844–3849
ShifrenJL, BraunsteinGD, SimonJA, CassonPR, BusterJE, RedmondGP, BurkiRE, GinsburgES, RosenRC, LeiblumSR, CaramelliKE, MazerNA (2000) Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 343:682–688
SihR, MorleyJE, KaiserFE, PerryHM 3rd, PatrickP, RossC (1997) Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 82:1661–1667
SinghR, ArtazaJN, TaylorWE, Gonzalez-CadavidNF, BhasinS (2003) Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology 144:5081–5088
SinghR, ArtazaJN, TaylorWE, BragaM, YuanX, Gonzalez-CadavidNF, BhasinS (2006) Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147:141–154
SinghR, BhasinS, BragaM, ArtazaJN, PervinS, TaylorWE, KrishnanV, SinhaSK, RajavashisthTB, JasujaR (2009) Regulation of myogenic differentiation by androgens: cross-talk between androgen receptor/β-catenin and follistatin/TGF-β signaling pathways. Endocrinology 150:1259–1268
Sinha-HikimI, ArtazaJ, WoodhouseL, Gonzalez-CadavidN, SinghAB, LeeMI, StorerTW, CasaburiR, ShenR, BhasinS (2002) Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab 283:E154–E164
Sinha-HikimI, RothSM, LeeMI, BhasinS (2003) Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men. Am J Physiol Endocrinol Metab 285:E197–E205
Sinha-HikimI, TaylorWE, Gonzalez-CadavidNF, ZhengW, BhasinS (2004) Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. J Clin Endocrinol Metab 89:5245–5255
Sinha-HikimI, CornfordM, GaytanH, LeeML, BhasinS (2006) Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab 91:3024–3033
SnyderPJ, PeacheyH, HannoushP, BerlinJA, LohL, LenrowDA, HolmesJH, DlewatiA, SantannaJ, RosenCJ, StromBL (1999a) Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 84:2647–2653
SnyderPJ, PeacheyH, HannoushP, BerlinJA, LohL, HolmesJH, DlewatiA, StaleyJ, SantannaJ, KapoorSC, AttieMF, HaddadJG Jr, StromBL (1999b) Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 84:1966–1972
SnyderPJ, PeacheyH, BerlinJA, HannoushP, HaddadG, DlewatiA, SantannaJ, LohL, LenrowDA, HolmesJH, KapoorSC, AtkinsonLE, StromBL (2000) Effects of testosterone replacement in hypogonadal men. J Clin Endocrinol Metab 85:2670–2677
Srinivas-ShankarU, RobertsSA, ConnollyMJ, O'ConnellMD, AdamsJE, OldhamJA, WuFC (2010) Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 95:639–650
SteidleC, SchwartzS, JacobyK, SebreeT, SmithT, BachandR (2003) AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. J Clin Endocrinol Metab 88:2673–2681
StorerTW, MaglianoL, WoodhouseL, LeeML, DzekovC, DzekovJ, CasaburiR, BhasinS (2003) Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. J Clin Endocrinol Metab 88:1478–1485
StorerTW, WoodhouseL, MaglianoL, SinghAB, DzekovC, DzekovJ, BhasinS (2008) Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men. J Am Geriatr Soc 56:1991–1999
StrawfordA, BarbieriT, Van LoanM, ParksE, CatlinD, BartonN, NeeseR, ChristiansenM, KingJ, HellersteinMK (1999a) Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial. JAMA 281:1282–1290
StrawfordA, BarbieriT, NeeseR, Van LoanM, ChristiansenM, HohR, SathyanG, SkowronskiR, KingJ, HellersteinM (1999b) Effects of nandrolone decanoate therapy in borderline hypogonadal men with HIV-associated weight loss. J Acquir Immune Defic Syndr Hum Retrovirol 20:137–146
TenoverJL (1999) Testosterone replacement therapy in older adult men. Int J Androl 22:300–306
TenoverJL (2000) Experience with testosterone replacement in the elderly. Mayo Clin Proc 75 (Suppl):S77–S81; discussion:S82
TenoverJS (1992) Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 75:1092–1098
TravisonTG, BasariaS, StorerTW, JetteAM, MiciekR, FarwellWR, ChoongK, LakshmanK, MazerNA, CovielloAD, KnappPE, UlloorJ, ZhangA, BrooksB, NguyenAH, EderR, LebrasseurN, ElmiA, ApplemanE, Hede-BrierleyL, BhasinG, BhatiaA, LazzariA, DavisS, NiP, CollinsL, BhasinS (2011) Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation. J Gerontol A Biol Sci Med Sci 66:1090–1099
UrbanRJ, BodenburgYH, GilkisonC, FoxworthJ, CogganAR, WolfeRR, FerrandoA (1995) Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 269:E820–E826
van den BeldAW, de JongFH, GrobbeeDE, PolsHA, LambertsSW (2000) Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276–3282
WagnerGJ, RabkinJG, RabkinR (1998) Testosterone as a treatment for fatigue in HIV+ men. Gen Hosp Psychiatry 20:209–213
WangC, EyreDR, ClarkR, KleinbergD, NewmanC, IranmaneshA, VeldhuisJ, DudleyRE, BermanN, DavidsonT, BarstowTJ, SinowR, AlexanderG, SwerdloffRS (1996a) Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men – a clinical research center study. J Clin Endocrinol Metab 81:3654–3662
WangC, AlexanderG, BermanN, SalehianB, DavidsonT, McDonaldV, SteinerB, HullL, CallegariC, SwerdloffRS (1996b) Testosterone replacement therapy improves mood in hypogonadal men – a clinical research center study. J Clin Endocrinol Metab 81:3578–3583
WangC, SwerdloffRS, IranmaneshA, DobsA, SnyderPJ, CunninghamG, MatsumotoAM, WeberT, BermanN (2000) Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Testosterone Gel Study Group. J Clin Endocrinol Metab 85:2839–2853
WoodhouseLJ, Reisz-PorszaszS, JavanbakhtM, StorerTW, LeeM, ZerounianH, BhasinS (2003) Development of models to predict anabolic response to testosterone administration in healthy young men. Am J Physiol Endocrinol Metab 284:E1009–E1017
WoodhouseLJ, GuptaN, BhasinM, SinghAB, RossR, PhillipsJ, BhasinS (2004) Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men. J Clin Endocrinol Metab 89:718–726
YesalisCE, BahrkeMS (1995) Anabolic-androgenic steroids. Current issues. Sports Med 19:326–340
YesalisCE, KennedyNJ, KopsteinAN, BahrkeMS (1993) Anabolic-androgenic steroid use in the United States. JAMA 270:1217–1221