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  • Cited by 4
  • Print publication year: 1999
  • Online publication date: March 2010

13 - Behavioral Analogies of Short Lead Interval Startle Inhibition

Summary

ABSTRACT

Short lead interval startle inhibition is widely viewed as reflecting a low-level inhibitory/sensorimotor gating mechanism that serves to protect the processing of a lead stimulus from the potentially disruptive impact of a startleeliciting stimulus. However, despite the acceptance of this view, it has received little empirical attention, and hence the significance of startle inhibition for cognition is not well understood. This chapter explores the cognitive significance of startle inhibition by comparing it with five behavioral cognitive/clinical measures that have an “inhibition-based” theoretical interpretation: attentional blink, negative priming, backward masking, perseverative responding on the Wisconsin Card Sorting Test, and thought disorder as reflected by the Ego Impairment Index. In each case, we explore the possibility that the behavioral and startle measures reflect a common underlying inhibitory process, comparing each measure to startle inhibition in terms of similarities and differences relating to experimental procedures, time course, critical stimulus characteristics, and patterns of response in normal and pathological subject groups.

Introduction

One reason for psychology's increasing interest in startle modification measures is their hypothesized reflection of cognitive processing, particularly in the case of the short lead interval measures. As reviewed earlier in this book (Chapters 3, 7, and 11), the dominant theoretical interpretations of short lead interval startle inhibition are (1) that it reflects a low-level inhibitory mechanism protective of lead stimulus processing (e.g., Graham, 1975, 1980) and (2) that it also reflects a more general inhibitory process, termed sensorimotor gating, a critical component of intact cognitive processing that involves the ability to filter or screen out irrelevant sensory, motor, or cognitive information in the early stages of information processing (e.g., Braff & Geyer, 1990; Geyer, Swerdlow, Mansbach, & Braff, 1990; Cadenhead, Geyer, & Braff, 1993).