Family members have long provided physical, emotional, and financial assistance to relatives in need of support because of frailty, dementia, disability, and other conditions common in late life. As our country faces an enormous increase in the number of older Americans, the role of family caregivers will become increasingly important. Health care professionals, especially primary care physicians, should identify people in the caregiving role and screen for caregiving stress or burden. It is likewise important to screen for health effects including depression, anxiety, and substance abuse. Informal caregivers—friends and family members—often care for chronically ill older adults, including those who have a diagnosis of dementia. Caregiver stress can cause health issues for caregivers; clinicians are encouraged to use available tools to screen for stress and to link caregivers to local and online resources.