Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-23T15:32:54.463Z Has data issue: false hasContentIssue false

Chapter 18 - Imprinting

from Section 6: - Genetics

Published online by Cambridge University Press:  06 July 2010

By
Sayeda Abu-Amero  and
Gudrun E. Moore
Edited by
Robert Pijnenborg ,
Ivo Brosens  and
Roberto Romero
Robert Pijnenborg
Affiliation:
University Hospital Gasthuisberg, Leuven
Ivo Brosens
Affiliation:
Leuven Institute for Fertility and Embryology
Roberto Romero
Affiliation:
National Institute of Child Health and Human Development, Detroit
Get access

Summary

This chapter discusses specific imprinted genes or imprinted regions known to be imprinted in the human placenta with an effect on fetal growth and development. IGFII is a growth-promoting protein active during gestation and was the first imprinted gene to be described which is common to mouse and man. H19 contains a germline DMR which acts as an ICR regulating its expression as well as imprinted genes in the cluster. Plekstrin homology-like domain family A member 2 (PHLDA2) is most highly expressed in the trophoblast of placenta and additionally in bronchial epithelium cells, liver, and prostate. Mesoderm-specific transcript (MEST) localizes to human chromosome 7q32 and was the first imprinted gene identified on chromosome 7, and is expressed in all major fetal tissues including placental trophoblast and endothelium. Imprinted genes are most highly expressed during fetal development and growth with some involved in early postnatal growth.

Keywords

deciduochorial naturedefinitive placentafirst trimesterO2 deliverypregnancymaterno-fetal exchangemammalian fetusgestational sacsecond trimestersuteroplacental circulation
Type
Chapter
Information
Placental Bed Disorders
Basic Science and its Translation to Obstetrics
 , pp. 183 - 194
Publisher: Cambridge University Press
Print publication year: 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×