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14 - Cardiac and Haemodynamic Function

from Section 2 - Targeting Effects

Published online by Cambridge University Press:  03 December 2019

By
Kai Kuck ,
Natalie Silverton  and
Michael K. Cahalan
Edited by
Pedro L. Gambús  and
Jan F. A. Hendrickx
Pedro L. Gambús
Affiliation:
Hospital Clinic de Barcelona, Spain
Jan F. A. Hendrickx
Affiliation:
Aalst General Hospital, Belgium
Get access

Summary

In Europe, approximately 30% of surgeries are performed in patients with cardiovascular comorbidities and up to 42% of intraoperative complications are cardiac related [4]. Often, the anaesthesiologist needs to intervene to maintain haemodynamic function and prevent perioperative complications.

Type
Chapter
Information
Personalized Anaesthesia
Targeting Physiological Systems for Optimal Effect
 , pp. 206 - 221
Publisher: Cambridge University Press
Print publication year: 2020

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References

Katzung, BG: Basic and Clinical Pharmacology, 5th ed. Norwalk, Conn.: Appleton and Lange, 1992, xiii, 1017.Google Scholar
Crystal, GJ, Heerdt, PM: Cardiovascular physiology: integrative function. In: Hemmings, HC, Egan, TD, eds. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. London: Elsevier Health Sciences: 2013, 253–71.Google Scholar
Cannesson, M, Pestel, G, Ricks, C, Hoeft, A, Perel, A: Hemodynamic monitoring and management in patients undergoing high risk surgery: a survey among North American and European anesthesiologists. Crit. Care. 2011; 15 (4): R197.Google Scholar
Longrois, D, Hoeft, A, De Hert, S: European Society of Cardiology/European Society of Anaesthesiology guidelines on non-cardiac surgery: cardiovascular assessment and management: A short explanatory statement from the European Society of Anaesthesiology members who participated in the European Task Force. Eur.J.Anaesthesiol. 2014; 31 (10): 513–16.Google Scholar
Wynne, J, Mann, T, Alpert, JS, Green, LH, Grossman, W: Hemodynamic effects of nitrous oxide administered during cardiac catheterization. JAMA. 1980; 243 (14): 1440–2.CrossRefGoogle ScholarPubMed
Malan, TP, Jr., DiNardo, JA, Isner, RJ, Frink, EJ, Jr., Goldberg, M, Fenster, PE, et al: Cardiovascular effects of sevoflurane compared with those of isoflurane in volunteers. Anesthesiology. 1995; 83 (5): 918–28.Google Scholar
Cahalan, MK, Weiskopf, RB, Eger, EI, 2nd, Yasuda, N, Ionescu, P, Rampil, IJ, et al: Hemodynamic effects of desflurane/nitrous oxide anesthesia in volunteers. Anesth.Analg. 1991; 73 (2): 157–64.CrossRefGoogle ScholarPubMed
Tatara, T: Context-sensitive fluid therapy in critical illness. J. Intens.Care. 2016; 4: 20.Google Scholar
Cannesson, M, Gan, TJ. PRO: Perioperative goal-directed fluid therapy is an essential element of an enhanced recovery protocol. Anesth.Analg. 2016; 122 (5): 1258–60.CrossRefGoogle ScholarPubMed
Myburgh, JA, Mythen, MG: Resuscitation fluids. N.Engl.J.Med. 2013; 369 (13): 1243–51.CrossRefGoogle ScholarPubMed
Hamilton, MA, Cecconi, M, Rhodes, A: A systematic review and meta-analysis on the use of preemptive hemodynamic intervention to improve postoperative outcomes in moderate and high-risk surgical patients. Anesth.Analg. 2011; 112 (6): 1392–402.CrossRefGoogle ScholarPubMed
Bennett-Guerrero, E, Welsby, I, Dunn, TJ, Young, LR, Wahl, TA, Diers, TL, et al: The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization after routine, moderate-risk, elective surgery. Anesth.Analg. 1999; 89 (2): 514–19.Google Scholar
Lobo, SM, Rezende, E, Knibel, MF, Silva, NB, Paramo, JA, Nacul, FE, et al: Early determinants of death due to multiple organ failure after noncardiac surgery in high-risk patients. Anesth.Analg. 2011; 112 (4): 877–83.Google Scholar
Grocott, MP, Mythen, MG, Gan, TJ: Perioperative fluid management and clinical outcomes in adults. Anesth.Analg. 2005; 100 (4): 1093–106.CrossRefGoogle ScholarPubMed
Jarisch, A: Kreislauffragen. Deutsche Med Wochenschr. 1928; 29: 1211–13.Google Scholar
Lewington, S, Clarke, R, Qizilbash, N, Peto, R, Collins, R: Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002; 360 (9349): 1903–13.Google Scholar
Varon, J, Marik, PE: Perioperative hypertension management. Vasc.Health.Risk.Manag. 2008; 4 (3): 615–27.Google Scholar
Chobanian, AV, Bakris, GL, Black, HR, Cushman, WC, Green, LA, Izzo, JL Jr., et al: Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003; 42 (6): 1206–52.Google Scholar
Howell, SJ, Sear, JW, Foex, P: Hypertension, hypertensive heart disease and perioperative cardiac risk. Br.J.Anaesth. 2004; 92 (4): 570–83.Google Scholar
Sanders, RD: How important is peri-operative hypertension? Anaesthesia. 2014; 69 (9): 948–53.Google Scholar
Bijker, JB, van Klei, WA, Kappen, TH, van Wolfswinkel, L, Moons, KG, Kalkman, CJ: Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection. Anesthesiology. 2007; 107 (2): 213–20.CrossRefGoogle ScholarPubMed
Kristensen, SD, Knuuti, J, Saraste, A, Anker, S, Botker, HE, De Hert, S, et al: ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur.J.Anaesthesiol. 2014; 31 (10): 517–73.Google Scholar
Lonjaret, L, Lairez, O, Minville, V, Geeraerts, T: Optimal perioperative management of arterial blood pressure. Integr. Blood Press.Control. 2014; 7: 49–59.Google Scholar
Walsh, M, Devereaux, PJ, Garg, AX, Kurz, A, Turan, A, Rodseth, RN, et al: Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: toward an empirical definition of hypotension. Anesthesiology. 2013; 119 (3): 507–15.Google Scholar
Grocott, MP, Dushianthan, A, Hamilton, MA, Mythen, MG, Harrison, D, Rowan, K, et al: Perioperative increase in global blood flow to explicit defined goals and outcomes after surgery: a Cochrane Systematic Review. Br.J.Anaesth. 2013; 111 (4): 535–48.CrossRefGoogle ScholarPubMed
Dellinger, RP, Levy, MM, Rhodes, A, Annane, D, Gerlach, H, Opal, SM, et al: Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit.Care.Med. 2013; 41 (2): 580–637.Google Scholar
Scali, S, Bertges, D, Neal, D, Patel, V, Eldrup-Jorgensen, J, Cronenwett, J, et al: Heart rate variables in the Vascular Quality Initiative are not reliable predictors of adverse cardiac outcomes or mortality after major elective vascular surgery. J.Vasc.Surg. 2015; 62 (3): 710–20.e9.Google Scholar
Waldron, N, Miller, T, Gan, T: Endpoints of goal-directed therapy in the OR and in the ICU. In: Cannesson, M, Pearse, R, eds. Perioperative Hemodynamic Monitoring and Goal Directed Therapy: From Theory to Practice. Cambridge: Cambridge University Press, 2014, 372–90.Google Scholar
Shoemaker, WC, Montgomery, ES, Kaplan, E, Elwyn, DH: Physiologic patterns in surviving and nonsurviving shock patients. Use of sequential cardiorespiratory variables in defining criteria for therapeutic goals and early warning of death.Arch. Surg. (Chicago, Ill: 1960). 1973; 106 (5): 630–6.CrossRefGoogle ScholarPubMed
Lobo, SM, de Oliveira, NE: Clinical review: what are the best hemodynamic targets for noncardiac surgical patients? Crit.Care. 2013; 17 (2): 210.Google Scholar
Pearse, R, Dawson, D, Fawcett, J, Rhodes, A, Grounds, RM, Bennett, ED: Changes in central venous saturation after major surgery, and association with outcome. Crit.Care. 2005; 9 (6): R694–9.Google ScholarPubMed
Collaborative Study Group on Perioperative Scv OM. Multicentre study on peri- and postoperative central venous oxygen saturation in high-risk surgical patients. Crit.Care. 2006; 10 (6): R158.Google Scholar
Tseng, GS, Wall, MH: Endpoints of resuscitation: what are they anyway? Semin.Cardiothorac.Vasc.Anesth. 2014; 18 (4): 352–62.CrossRefGoogle ScholarPubMed
Vallet, B, Blanloeil, Y, Cholley, B, Orliaguet, G, Pierre, S, Tavernier, B, et al: Guidelines for perioperative haemodynamic optimization. Ann.Fr.Anesth.Reanim. 2013; 32 (10): e151–8.Google Scholar
Cannesson, M: Arterial pressure variation and goal-directed fluid therapy. J.Cardiothorac.Vasc.Anesth. 2010; 24 (3): 487–97.Google Scholar
Monnet, X, Dres, M, Ferre, A, Le Teuff, G, Jozwiak, M, Bleibtreu, A, et al: Prediction of fluid responsiveness by a continuous non-invasive assessment of arterial pressure in critically ill patients: comparison with four other dynamic indices. Br.J.Anaesth. 2012; 109 (3): 330–8.CrossRefGoogle ScholarPubMed
Mireles, SA, Jaffe, RA, Drover, DR, Brock-Utne, JG: A poor correlation exists between oscillometric and radial arterial blood pressure as measured by the Philips MP90 monitor. J.Clin.Monit.Comput. 2009; 23 (3): 169–74.Google Scholar
Ribezzo, S, Spina, E, Di Bartolomeo, S, Sanson, G: Noninvasive techniques for blood pressure measurement are not a reliable alternative to direct measurement: a randomized crossover trial in ICU. Scient.World.J. 2014: 353628.Google Scholar
Meng, X, Zang, G, Fan, L, Zheng, L, Dai, J, Wang, X, et al: Non-invasive monitoring of blood pressure using the Philips Intellivue MP50 monitor cannot replace invasive blood pressure techniques in surgery patients under general anesthesia. Exp.Ther.Med. 2013; 6 (1): 9–14.Google Scholar
Wax, DB, Lin, HM, Leibowitz, AB: Invasive and concomitant noninvasive intraoperative blood pressure monitoring: observed differences in measurements and associated therapeutic interventions. Anesthesiology. 2011; 115 (5): 973–8.Google Scholar
Kim, SH, Lilot, M, Sidhu, KS, Rinehart, J, Yu, Z, Canales, C, et al: Accuracy and precision of continuous noninvasive arterial pressure monitoring compared with invasive arterial pressure: a systematic review and meta-analysis. Anesthesiology. 2014; 120 (5): 1080–97.Google Scholar
Marik, PE, Cavallazzi, R: Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense. Crit. Care.Med. 2013; 41 (7): 1774–81.CrossRefGoogle Scholar
Harvey, S, Stevens, K, Harrison, D, Young, D, Brampton, W, McCabe, C, et al: An evaluation of the clinical and cost-effectiveness of pulmonary artery catheters in patient management in intensive care: a systematic review and a randomised controlled trial. Health. Technol.Assess. 2006; 10 (29): iii–iv, ix–xi, 1–133.Google Scholar
Rajaram, SS, Desai, NK, Kalra, A, Gajera, M, Cavanaugh, SK, Brampton, W, et al: Pulmonary artery catheters for adult patients in intensive care. Cochrane.Database.Syst.Rev. 2013; 2: CD003408.Google Scholar
Marik, PE: Obituary: pulmonary artery catheter 1970 to 2013. Ann.Intensive Care. 2013; 3 (1): 38.CrossRefGoogle ScholarPubMed
Schwann, NM, Hillel, Z, Hoeft, A, Barash, P, Mohnle, P, Miao, Y, et al: Lack of effectiveness of the pulmonary artery catheter in cardiac surgery. Anesth.Analg. 2011; 113 (5): 994–1002.CrossRefGoogle ScholarPubMed
Kuper, M, Gold, SJ, Callow, C, Quraishi, T, King, S, Mulreany, A, et al: Intraoperative fluid management guided by oesophageal Doppler monitoring. BMJ. 2011; 342: d3016.Google Scholar
Fellahi, JL, Fischer, MO: Electrical bioimpedance cardiography: an old technology with new hopes for the future. J.Cardiothorac.Vasc.Anesth. 2014; 28 (3): 755–60.Google Scholar
Peyton, PJ, Chong, SW: Minimally invasive measurement of cardiac output during surgery and critical care: a meta-analysis of accuracy and precision. Anesthesiology. 2010; 113 (5): 1220–35.Google Scholar
Critchley, LA, Critchley, JA: A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques. J.Clin.Monit.Comput. 1999; 15 (2): 85–91.Google Scholar
Schloglhofer, T, Gilly, H, Schima, H: Semi-invasive measurement of cardiac output based on pulse contour: a review and analysis. Can.J.Anaesth. 2014; 61 (5): 452–79.Google Scholar
Ameloot, K, Palmers, PJ, Malbrain, ML: The accuracy of noninvasive cardiac output and pressure measurements with finger cuff: a concise review. Curr.Opin.Crit.Care. 2015; 21 (3): 232–9.Google Scholar
Jozwiak, M, Teboul, JL, Monnet, X. Extravascular lung water in critical care: recent advances and clinical applications. Ann.Intens.Care. 2015; 5 (1): 38.Google Scholar
Marik, PE, Cavallazzi, R, Vasu, T, Hirani, A: Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature. Crit.Care.Med. 2009; 37 (9): 2642–7.Google Scholar
Dueck, MH, Klimek, M, Appenrodt, S, Weigand, C, Boerner, U: Trends but not individual values of central venous oxygen saturation agree with mixed venous oxygen saturation during varying hemodynamic conditions. Anesthesiology. 2005; 103 (2): 249–57.Google Scholar
Thavasothy, M, Broadhead, M, Elwell, C, Peters, M, Smith, M: A comparison of cerebral oxygenation as measured by the NIRO 300 and the INVOS 5100 Near-Infrared Spectrophotometers. Anaesthesia. 2002; 57 (10): 999–1006.Google Scholar
Denault, A, Deschamps, A, Murkin, JM: A proposed algorithm for the intraoperative use of cerebral near-infrared spectroscopy. Semin.Cardiothorac.Vasc.Anesth. 2007; 11 (4): 274–81.Google Scholar
Ghosh, A, Elwell, C, Smith, M: Review article: cerebral near-infrared spectroscopy in adults: a work in progress. Anesth.Analg. 2012; 115 (6): 1373–83.Google Scholar
Skarvan, K, Lambert, A, Filipovic, M, Seeberger, M: Reference values for left ventricular function in subjects under general anaesthesia and controlled ventilation assessed by two-dimensional transoesophageal echocardiography. Eur.J.Anaesthesiol. 2001; 18 (11): 713–22.Google Scholar
Pai, RG, Bodenheimer, MM, Pai, SM, Koss, JH, Adamick, RD: Usefulness of systolic excursion of the mitral anulus as an index of left ventricular systolic function. Am.J.Cardiol. 1991; 67 (2): 222–4.Google Scholar
Yamada, H, Oki, T, Mishiro, Y, Tabata, T, Abe, M, Onose, Y, et al: Effect of aging on diastolic left ventricular myocardial velocities measured by pulsed tissue Doppler imaging in healthy subjects. J.Am.Soc.Echocardiogr. 1999; 12 (7): 574–81.Google Scholar
Alam, M, Wardell, J, Andersson, E, Samad, BA, Nordlander, R: Effects of first myocardial infarction on left ventricular systolic and diastolic function with the use of mitral annular velocity determined by pulsed wave doppler tissue imaging. J.Am.Soc.Echocardiogr. 2000; 13 (5): 343–52.Google Scholar
Gorcsan, J, 3rd, Strum, DP, Mandarino, WA, Gulati, VK, Pinsky, MR: Quantitative assessment of alterations in regional left ventricular contractility with color-coded tissue Doppler echocardiography. Comparison with sonomicrometry and pressure-volume relations. Circulation. 1997; 95 (10): 2423–33.Google Scholar
Ama, R, Segers, P, Roosens, C, Claessens, T, Verdonck, P, Poelaert, J: The effects of load on systolic mitral annular velocity by tissue Doppler imaging. Anesth.Analg. 2004; 99 (2): 332–8.Google Scholar
Vinereanu, D, Khokhar, A, Tweddel, AC, Cinteza, M, Fraser, AG: Estimation of global left ventricular function from the velocity of longitudinal shortening. Echocardiogr. 2002; 19 (3): 177–85.Google Scholar
Sevimli, S, Arslan, S, Gundogdu, F, Aksakal, E, Buyukkaya, E, Tas, H, et al: Can transesophageal pulse-wave tissue Doppler imaging be used to evaluate left ventricular function? Echocardiogr. 2007; 24 (9): 946–54.Google Scholar
Zehender, M, Kasper, W, Kauder, E, Schonthaler, M, Geibel, A, Olschewski, M, et al: Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction. N.Engl.J.Med. 1993; 328 (14): 981–8.Google Scholar
Cameli, M, Righini, FM, Lisi, M, Bennati, E, Navarri, R, Lunghetti, S, et al: Comparison of right versus left ventricular strain analysis as a predictor of outcome in patients with systolic heart failure referred for heart transplantation. Am.J.Cardiol. 2013; 112 (11): 1778–84.CrossRefGoogle ScholarPubMed
Park, SJ, Park, JH, Lee, HS, Kim, MS, Park, YK, Park, Y, et al: Impaired RV global longitudinal strain is associated with poor long-term clinical outcomes in patients with acute inferior STEMI. JACC.Cardiovasc.Imaging. 2015; 8 (2): 161–9.Google Scholar
Haddad, F, Denault, AY, Couture, P, Cartier, R, Pellerin, M, Levesque, S, et al: Right ventricular myocardial performance index predicts perioperative mortality or circulatory failure in high-risk valvular surgery. J.Am.Soc.Echocardiogr. 2007; 20 (9): 1065–72.Google Scholar
Maslow, AD, Regan, MM, Panzica, P, Heindel, S, Mashikian, J, Comunale, ME: Precardiopulmonary bypass right ventricular function is associated with poor outcome after coronary artery bypass grafting in patients with severe left ventricular systolic dysfunction. Anesth.Analg. 2002; 95 (6): 1507–18.Google Scholar
Ternacle, J, Berry, M, Cognet, T, Kloeckner, M, Damy, T, Monin, JL, et al: Prognostic value of right ventricular two-dimensional global strain in patients referred for cardiac surgery. J.Am.Soc.Echocardiogr. 2013; 26 (7): 721–6.Google Scholar
Rudski, LG, Lai, WW, Afilalo, J, Hua, L, Handschumacher, MD, Chandrasekaran, K, et al: Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J.Am.Soc.Echocardiogr. 2010; 23 (7): 685–713; quiz 86–8.Google Scholar
Lang, RM, Badano, LP, Mor-Avi, V, Afilalo, J, Armstrong, A, Ernande, L, et al: Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J.Am.Soc.Echocardiogr. 2015; 28 (1): 1–39.e14.Google Scholar
Focardi, M, Cameli, M, Carbone, SF, Massoni, A, De Vito, R, Lisi, M, et al: Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparison with cardiac magnetic resonance. Eur.Heart.Cardiovasc.Imaging. 2015; 16 (1): 47–52.Google Scholar
Tamborini, G, Muratori, M, Brusoni, D, Celeste, F, Maffessanti, F, Caiani, EG, et al: Is right ventricular systolic function reduced after cardiac surgery? A two- and three-dimensional echocardiographic study. Eur.J.Echocardiogr. 2009; 10 (5): 630–4.Google Scholar
Blessberger, H, Binder, T: Two dimensional speckle tracking echocardiography: clinical applications. Heart. 2010; 96 (24): 2032–40.Google ScholarPubMed
Blessberger, H, Binder, T: Non-invasive imaging: Two dimensional speckle tracking echocardiography: basic principles. Heart. 2010; 96 (9): 716–22.Google ScholarPubMed
Leibundgut, G, Rohner, A, Grize, L, Bernheim, A, Kessel-Schaefer, A, Bremerich, J, et al: Dynamic assessment of right ventricular volumes and function by real-time three-dimensional echocardiography: a comparison study with magnetic resonance imaging in 100 adult patients. J.Am.Soc.Echocardiogr. 2010; 23 (2): 116–26.Google Scholar
Fusini, L, Tamborini, G, Gripari, P, Maffessanti, F, Mazzanti, V, Muratori, M, et al: Feasibility of intraoperative three-dimensional transesophageal echocardiography in the evaluation of right ventricular volumes and function in patients undergoing cardiac surgery. J.Am.Soc.Echocardiogr. 2011; 24 (8): 868–77.Google Scholar
Bowman, RJ, Westenskow, DR: A microcomputer-based fluid infusion system for the resuscitation of burn patients. IEEE.Trans.Biomed.Eng. 1981; 28 (6): 475–9.Google Scholar
Rinehart, J, Alexander, B, Le Manach, Y, Hofer, C, Tavernier, B, Kain, ZN, et al: Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: an in silico simulation study. Crit.Care. 2011; 15 (6): R278.Google Scholar
Keogh, BE, Jacobs, J, Royston, D, Taylor, KM: Microprocessor-controlled hemodynamics: a step towards improved efficiency and safety. J.Cardiothorac.Anesth. 1989; 3 (1): 4–9.Google Scholar
Rinehart, J, Liu, N, Alexander, B, Cannesson, M: Review article: closed-loop systems in anesthesia: is there a potential for closed-loop fluid management and hemodynamic optimization? Anesth.Analg. 2012; 114 (1): 130–43.Google Scholar
Ketteler, T, Krahwinkel, W, Wolfertz, J, Godke, J, Hoffmeister, T, Scheuble, L, et al: Arbutamine stress echocardiography. Eur.Heart.J. 1997; 18 Suppl D: D24–30.Google Scholar
Kuck, K, Johnson, KB: The three laws of autonomous and closed-loop systems in anesthesia. Anesth.Analg. 2017; 124 (2): 377–80.Google Scholar
Drews, FA, Westenskow, DR: The right picture is worth a thousand numbers: data displays in anesthesia. Hum.Factors. 2006; 48 (1): 59–71.CrossRefGoogle Scholar
Blike, GT, Surgenor, SD, Whalen, K, Jensen, J: Specific elements of a new hemodynamics display improves the performance of anesthesiologists. J.Clin.Monit.Comput. 2000; 16 (7): 485–91.Google Scholar
Agutter, J, Drews, F, Syroid, N, Westenskow, D, Albert, R, Strayer, D, et al: Evaluation of graphic cardiovascular display in a high-fidelity simulator. Anesth.Analg. 2003; 97 (5): 1403–13.Google Scholar
Guyton, AC, Coleman, TG, Granger, HJ: Circulation: overall regulation. Annu.Rev.Physiol. 1972; 34: 13–46.Google Scholar
Smith, BW, Andreassen, S, Shaw, GM, Jensen, PL, Rees, SE, Chase, JG: Simulation of cardiovascular system diseases by including the autonomic nervous system into a minimal model. Comput.Methods.Programs. Biomed. 2007; 86 (2): 153–60.Google Scholar
Blike, GT, Surgenor, SD, Whalen, K: A graphical object display improves anesthesiologists’ performance on a simulated diagnostic task. J.Clin.Monit.Comput. 1999; 15 (1): 37–44.Google Scholar
Billard, V: Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs: from modeling to clinical use. F1000Res. 2015; 4.Google Scholar
Gorges, M, Westenskow, DR, Kuck, K, Orr, JA: A tool predicting future mean arterial blood pressure values improves the titration of vasoactive drugs. J.Clin.Monit.Comput. 2010; 24 (3): 223–35.Google Scholar
Patel, S: Cardiovascular effects of intravenous anesthetics. Int.Anesthesiol.Clin. 2002; 40 (1): 15–33.Google Scholar
Doenicke, A, Angster, R, Mayer, M, Adams, HA, Grillenberger, G, Nebauer, AE: The action of S-(+)-ketamine on serum catecholamine and cortisol. A comparison with ketamine racemate. Der.Anästhesist. 1992; 41 (10): 597–603.Google Scholar
Ogura, T, Egan, TD: Opioid agonists and anagonists. In: Hemmings, HC, Egan, TD, eds. Pharmacology and Physiology for Anesthesia : Foundations and Clinical Application. London: Elsevier Health Sciences, 2013, 253–71.Google Scholar
Zimmerman, J, Cahalan, M: Vasopressors and inotropes. In: Hemmings, HC, Egan, TD, eds. Pharmacology and Physiology for Anesthesia : Foundations and Clinical Application. London: Elsevier Health Sciences, 2013, 390–404.CrossRefGoogle Scholar
Shipley, JB, Tolman, D, Hastillo, A, Hess, ML: Milrinone: basic and clinical pharmacology and acute and chronic management. Am.J.Med.Sci. 1996; 311 (6): 286–91.Google Scholar
Figgitt, DP, Gillies, PS, Goa, KL: Levosimendan. Drugs. 2001; 61 (5): 613–27; discussion 28–9.Google Scholar
Sear, JW: Antihypertensive drugs and vasodilators. In: Hemmings, HC, Egan, TD, eds. Pharmacology and Physiology for Anesthesia : Foundations and Clinical Application. London: Elsevier Health Sciences, 2013, 405–25.Google Scholar
Mitchell, A, Buhrmann, S, Opazo Saez, A, Rushentsova, U, Schafers, RF, Philipp, T, et al: Clonidine lowers blood pressure by reducing vascular resistance and cardiac output in young, healthy males. Cardiovasc. Drugs.Ther. 2005; 19 (1): 49–55.Google Scholar
Fontana, F, Allaria, B, Brunetti, B, Arienta, R, Favaro, M, Trivellato, A, et al: Cardiac and circulatory response to the intravenous administration of urapidil during general anaesthesia. Drugs.Exp.Clin.Res. 1990; 16 (6): 315–18.Google Scholar
Boldt, J, Schindler, E, Wollbruck, M, Gorlach, G, Hempelmann, G: Cardiorespiratory response of intravenous angiotensin-converting enzyme inhibitor enalaprilat in hypertensive cardiac surgery patients. J.Cardiothorac.Vasc.Anesth. 1995; 9(1): 44–9.Google Scholar
Wagner, F, Yeter, R, Bisson, S, Siniawski, H, Hetzer, R: Beneficial hemodynamic and renal effects of intravenous enalaprilat following coronary artery bypass surgery complicated by left ventricular dysfunction. Crit.Care.Med. 2003; 31 (5): 1421–8.Google Scholar
Harrison, TK, Goldhaber-Fiebert, S: Generic events. In: Gaba, DM, Fish, KJ, Howard, SK, Burden, A, eds. Crisis Management in Anesthesiology. 2nd ed. London: Elsevier Health Sciences, 2014, 88–136.Google Scholar
Steyn, J, Dorfling, J: Cardiovascular events. In: Gaba, DM, Fish, KJ, Howard, SK, Burden, A, eds. Crisis Management in Anesthesiology. 2nd ed. London: Elsevier Health Sciences, 2014, 137–72.Google Scholar

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