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  • Print publication year: 2013
  • Online publication date: April 2013

Chapter 13 - Environment and lifestyle effects on fertility


1. MendiolaJ, Torres-CanteroAM, AgarwalA. Lifestyle factors and male infertility: an evidence-based review. Arch Med Sci. 2009;5:S3–S12.
2. KumarDP, SangeethaN. Mitochondrial DNA mutations and male infertility. Indian J Hum Genet. 2009;15(3):93–7.
3. World Health Organization. Tobacco or Health : A Global Status Report. Geneva: WHO; 1997.
4. MostafaT. Cigarette smoking and male infertility. J Adv Res. 2010;1:179–86.
5. KünzleR, MuellerMD, HänggiWet al. Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril. 2003;79(2):287–91.
6. GerhardI, FrohlichE, Eggert-KruseWet al. Relationship of sperm acrosin activity to semen and clinical parameters in infertile patients. Andrologia. 1989;21(2):146–54.
7. SaidTM, RangaG, AgarwalA. Relationship between semen quality and tobacco chewing in men undergoing infertility evaluation. Fertil Steril. 2005;84(3):649–53.
8. Oyeyipo, YinusaR, EmikpeBOet al. Effects of nicotine on sperm characteristics and fertility profile in adult male rats: a possible role of cessation. J Reprod Infertil. 2011;12(3):201–8.
9. KizilerAR, AydemirB, OnaranIet al. High levels of cadmium and lead in seminal fluid and blood of smoking men are associated with high oxidative stress and damage in infertile subjects. Biol Trace Elem Res. 2007;120(1–3):82–91.
10. TelismanS, CvitkovicP, JurasovicJet al. Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men. Environ Health Perspect. 2000;108(1):45–53.
11. ZhangJP, MengQY, WangQet al. Effect of smoking on semen quality of infertile men in Shandong, China. Asian J Androl. 2000;2(2):143–6.
12. DawsonEB, HarrisWA, TeterMCet al. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992;58(5):1034–9.
13. SunJG, JurisicovaA, CasperRF. Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol Reprod. 1997;56(3):602–7.
14. EvensonDP, LarsonKL, JostLK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl. 2002;23(1):25–43.
15. ZavosPM, CorreaJR, AntypasSet al. Effects of seminal plasma from cigarette smokers on sperm viability and longevity. Fertil Steril. 1998;69(3):425–9.
16. MuthusamiKR, ChinnaswamyP. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertil Steril. 2005;84(4):919–24.
17. BrzekA. Alcohol and male fertility (preliminary report). Andrologia. 1987;19(1):32–6.
18. PajarinenJ, KarhunenPJ, SavolainenVet al. Moderate alcohol consumption and disorders of human spermatogenesis. Alcohol Clin Exp Res. 1996;20(2):332–7.
19. BrackenMB, EskenaziB, SachseKet al. Association of cocaine use with sperm concentration, motility, and morphology. Fertil Steril. 1990;53(2):315–22.
20. GeorgeVK, LiH, TelokenCet al. Effects of long-term cocaine exposure on spermatogenesis and fertility in peripubertal male rats. J Urol. 1996;155(1):327–31.
21. FazelipourS, KiaeiS, TootianZ. Adverse effect of heroin hydrochloride on selected male reproductive parameters in mice. Comp Clin Pathol. 2010;19(6):565–9.
22. RagniG, De LauretisL, BestettiOet al. Gonadal function in male heroin and methadone addicts. Int J Androl. 1988;11(2):93–100.
23. MalikSA, KhanC, JabbarAet al. Heroin addiction and sex hormones in males. J Pak Med Assoc. 1992;42(9):210–12.
24. YilmazB, KonarV, KutluSet al. Influence of chronic morphine exposure on serum LH, FSH, testosterone levels, and body and testicular weights in the developing male rat. Arch Androl. 1999;43(3):189–96.
25. CiceroTJ, DavisLA, LaReginaMCet al. Chronic opiate exposure in the male rat adversely affects fertility. Pharmacol Biochem Behav. 2002;72(1–2):157–63.
26. HarclerodeJ. Endocrine effects of marijuana in the male: preclinical studies. NIDA Res Monogr. 1984;44:46–64.
27. HembreeWC, III, NahasGG, ZeidenbergPet al. Changes in human spermatozoa associated with high dose of marihuana smoking. In NahasGG, PatonW D M, editors. Advances in the Biosciences. Vol. 22 & 23. Marihuana: Biological Effects; Analysis, Metabolism, Cellular Responses, Reproduction and Brain. Oxford: Pergamon Press, 1979; 429–39.
28. World Health Organization. Obesity and overweight. 2012; Available from:
29. JensenTK, AnderssonAM, JorgensenNet al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82(4):863–70.
30. World Health Organization, MachA. Turning the tide of malnutrition: responding to the challenge of the 21st century. Geneva: WHO; 2000; Available from:
31. ChavarroJE, TothTL, SadioSMet al. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Hum Reprod. 2008;23(11):2584–90.
32. JensenTK, SwanSH, SkakkebaekNEet al. Caffeine intake and semen quality in a population of 2,554 young Danish men. Am J Epidemiol. 2010;171(8):883–91.
33. LenziA, SgroP, SalaconePet al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril. 2004;81(6):1578–84.
34. McGradyAV. Effects of psychological stress on male reproduction: a review. Arch Androl. 1984;13(1):1–7.
35. EskiocakS, GozenAS, KilicASet al. Association between mental stress & some antioxidant enzymes of seminal plasma. Indian J Med Res. 2005;122(6):491–6.
36. EskiocakS, GozenAS, YaparSBet al. Glutathione and free sulphydryl content of seminal plasma in healthy medical students during and after exam stress. Hum Reprod. 2005;20(9):2595–600.
37. FensterL, KatzDF, WyrobekAJet al. Effects of psychological stress on human semen quality. J Androl. 1997;18(2):194–202.
38. JungA, SchuppeHC. Influence of genital heat stress on semen quality in humans. Andrologia. 2007;39(6):203–15.
39. LueYH, HikimAP, SwerdloffRSet al. Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity. Endocrinology. 1999;140(4):1709–17.
40. ShefiS, TaraporePE, WalshTJet al. Wet heat exposure: a potentially reversible cause of low semen quality in infertile men. Int Braz J Urol. 2007;33(1):50–6; discussion 56–7.
41. TiemessenCH, EversJL, BotsRS. Tight-fitting underwear and sperm quality. Lancet. 1996;347(9018):1844–5.
42. JungA, EberlM, SchillWB. Improvement of semen quality by nocturnal scrotal cooling and moderate behavioural change to reduce genital heat stress in men with oligoasthenoteratozoospermia. Reproduction. 2001;121(4):595–603.
43. RowleyMJ, LeachDR, WarnerGAet al. Effect of graded doses of ionizing radiation on the human testis. Radiat Res. 1974;59(3):665–78.
44. GutschiT, Mohamad Al-AliB, ShamloulRet al. Impact of cell phone use on men’s semen parameters. Andrologia. 2011;43(5):312–16.
45. JurewiczJ, HankeW, RadwanMet al. Environmental factors and semen quality. Int J Occup Med Environ Health. 2009;22(4):305–29.
46. SomersCM. Ambient air pollution exposure and damage to male gametes: human studies and in situ ‘sentinel’ animal experiments. Syst Biol Reprod Med. 2011;57(1–2):63–71.
47. NieuwenhuijsenMJ, ToledanoMB, EatonNEet al. Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: A review. Occup Environ Med. 2000;57(2):73–85.
48. TardiffRG, CarsonML, GinevanME. Updated weight of evidence for an association between adverse reproductive and developmental effects and exposure to disinfection by-products. Regul Toxicol Pharmacol. 2006;45(2):185–205.
49. TothGP, KeltyKC, GeorgeELet al. Adverse male reproductive effects following subchronic exposure of rats to sodium dichloroacetate. Fundam Appl Toxicol. 1992;19(1):57–63.