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  • Print publication year: 2006
  • Online publication date: August 2009

7 - Probes of Behaviour Regulation: Olfactory Models in Addiction

from Section I - Neurology, Neurophysiology and Neuropsychology: Olfactory Clues to Brain Development and Disorder

Summary

This chapter shows how olfactory testing could be applied to investigations of orbitofrontal cortex (OFC) function and related behavioural outcomes. It discusses how tasks such as olfactory identification may offer insights into the development and maintenance of substance use disorders (SUD). Although imaging and neuropsychological studies demonstrate abnormalities in OFC function within addicted populations, it is unclear whether these deficits are related to premorbid vulnerability, a direct consequence of chronic exposure to addictive substances, or a combination of both. In humans, there is growing evidence that an earlier onset age of substance abuse may be related to more marked neurobiological and cognitive deficits. Adolescence is a developmental period associated with increased risk-taking and experimentation with drugs, and is also a time of increased vulnerability to the development of SUD. Experimentation with drugs also occurs during a period of substantial brain development and remodelling.
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Olfaction and the Brain
  • Online ISBN: 9780511543623
  • Book DOI: https://doi.org/10.1017/CBO9780511543623
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REFERENCES
Arnett, J. (1992) Reckless behavior in adolscence: a developmental perspective. Dev Rev, 12, 339–73.
Bartzokis, G., Beckson, M., Lu, P. H., et al. (2002) Brain maturation may be arrested in chronic cocaine addicts. Biol Psychiatry, 51, 605–11.
Bartzokis, G., Beckson, M., Lu, P. H., et al. (2004) Cortical gray matter volumes are associated with subjective responses to cocaine infusion. Am J Addict, 13, 64–73.
Bechara, A. & Damasio, H. (2002) Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences. Neuropsychologia, 40, 1675–89.
Bechara, A., Damasio, A. R., Damasio, H., et al. (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50, 7–15.
Bechara, A., Damasio, H., Tranel, D., et al. (1997) Deciding advantageously before knowing the advantageous strategy. Science, 275, 1293–5.
Bechara, A., Dolan, S., Denburg, N., et al. (2001) Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia, 39, 376–89.
Block, J. & Shelder, J. (1990) Adolescent drug use and psychological health: a longitudinal enquiry. Am Psychologist, 45, 612–30.
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., et al. (1997) Acute effects of cocaine on human brain activity and emotion. Neuron, 19, 591–611.
Butter, C. M. (1969) Perseveration in extinction and in discrimination reversal tasks following selective prefrontal ablations in Macaca mulatta. Physiol Behav, 4, 163–71.
Casey, B. J., Giedd, J. N. & Thomas, K. M. (2000) Structural and functional brain development and its relation to cognitive development. Biol Psychol, 54, 241–57.
Childress, A. R., Mozley, P. D., McElgin, W., et al. (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry, 156, 11–18.
Cloninger, C. R., Sigvardsson, S. & Bohman, M. (1998) Childhood personality predicts alcohol abuse in young adults. Alcohol Clin Exp Res, 12, 494–505.
Daglish, M. R., Weinstein, A., Malizia, A. L., et al. (2001) Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects. Am J Psychiatry, 158, 1680–6.
Dawe, S., Gullo, M. J. & Loxton, N. J. (2004) Reward drive and rash impulsiveness as dimensions of impulsivity: implications for substance misuse. Addict Behav, 29, 1389–405.
Bellis, M. D., Clark, D. B., Beers, S. R., et al. (2000) Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry, 157, 737–44.
Dias, R., Robbins, T. W. & Roberts, A. C. (1996) Dissociation in prefrontal cortex of affective and attentional shifts. Nature, 380, 69–72.
Ehrenreich, H., Rinn, T., Kunert, H. J., et al. (1999) Specific attentional dysfunction in adults following early start of cannabis use. Psychopharmacology (Berl), 142, 295–301.
Elliott, R., Friston, K. J. & Dolan, R. J. (2000) Dissociable neural responses in human reward systems. J Neurosci, 20, 6159–65.
Everitt, B. J., Dickinson, A. & Robbins, T. W. (2001a) The neuropsychological basis of addictive behaviour. Brain Res Brain Res Rev, 36, 129–38.
Everitt, B. J., Dickinson, A. & Robbins, T. W. (2001b) The neuropsychological basis of addictive behaviour review. Brain Res Brain Res Rev, 36, 129–38.
Franklin, T. R., Acton, P. D., Maldjian, J. A., et al. (2002) Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry, 51, 134–42.
Garavan, H., Pankiewicz, J., Bloom, A., et al. (2000) Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Am J Psychiatry, 157, 1789–98.
Goldstein, R. Z. & Volkow, N. D. (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry, 159, 1642–52.
Grant, S., Contoreggi, C. & London, E. D. (2000) Drug abusers show impaired performance in a laboratory test of decision making. Neuropsychologia, 38, 1180–7.
Grant, S., London, E. D., Newlin, D. B., et al. (1996) Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci USA, 93, 12040–5.
Henderson, M. J., Galen, L. W. & DeLuca, J. W. (1998) Temperament style and substance abuse characteristics. Subst Abus, 19, 61–70.
Horn, N. R., Dolan, M. C., Elliot, R., et al. (2003) Response inhibition and impulsivity: an fMRI study. Neuropsychologia, 41, 1959–66.
Jentsch, J. D. & Taylor, J. R. (1999) Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology (Berl), 146, 373–90.
Johnston, L. D., O'Malley, P. M. & Bachman, J. G. (2002) Monitoring the future national results on adolescent drug use: Overview of Key Findings, 2001. p. 39. U.S. Department of Health and Human Services Public Health Service National Institutes of Health.
Krawczyk, D. C. (2002) Contributions of the prefrontal cortex to the neural basis of human decision making. Neurosci Biobehav Rev, 26, 631–64.
Kubota, M., Nakazaki, S., Hirai, S., et al. (2001) Alcohol consumption and frontal lobe shrinkage: study of 1432 non-alcoholic subjects. J Neurol Neurosurg Psychiatry, 71, 104–6.
Larsson, M., Finkel, D. & Pederson, N. L. (2000) Odor identification: Influences of age, gender cognition and personality. J Gerontology, 55B (5), 304–10.
Liu, X., Matochik, J. A., Cadet, J. L., et al. (1998) Smaller volume of prefrontal lobe in polysubstance abusers: a magnetic resonance imaging study. Neuropsychopharmacology, 18, 243–52.
London, E. D., Cascella, N. G., Wong, D. F., et al. (1990) Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [fluorine 18]–fluorodeoxyglucose. Arch Gen Psychiatry, 47, 567–74.
Lubman, D. I., Yucel, M. & Pantelis, C. (2004) Addiction, a condition of compulsive behaviour? Neuroimaging and neuropsychological evidence of inhibitory dysregulation. Addiction, 99, 1491–502.
Maas, L. C., Lukas, S. E., Kaufman, M. J., et al. (1998) Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. Am J Psychiatry, 155, 124–6.
Matochik, J. A., London, E. D., Eldreth, D. A., et al. (2003) Frontal cortical tissue composition in abstinent cocaine abusers: a magnetic resonance imaging study. Neuroimage, 19, 1095–102.
McGue, M., Iacono, W. G., Legrand, L. N., et al. (2001) Origins and consequences of age at first drink. I. Associations with substance-use disorders, disinhibitory behavior and psychopathology, and P3 amplitude. Alcohol Clin Exp Res, 25, 1156–65.
Petry, N. M. (2001) Substance abuse, pathological gambling, and impulsiveness. Drug Alcohol Depend, 63, 29–38.
Petry, N. M., Bickel, W. K. & Arnett, M. (1998) Shortened time horizons and insensitivity to future consequences in heroin addicts. Addiction, 93, 729–38.
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., et al. (1997) Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol Clin Exp Res, 21, 521–9.
Pope, H. G. Jr., Gruber, A. J., Hudson, J. I., et al. (2003) Early-onset cannabis use and cognitive deficits: what is the nature of the association?Drug Alcohol Depend, 69, 303–10.
Pujol, J., Soriano-Mas, C., Alonso, P., et al. (2004) Mapping structural brain alterations in obsessive-compulsive disorder. Arch Gen Psychiatry, 61, 720–30.
Robinson, T. E. & Berridge, K. C. (2000) The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction, 95 (Suppl 2), S91–S117.
Rogers, R. D., Everitt, B. J., Baldacchino, A., et al. (1999a) Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology, 20, 322–39.
Rogers, R. D., Owen, A. M., Middleton, H. C., et al. (1999b) Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J Neurosci, 19, 9029–38.
Rolls, E. T., Hornak, J., Wade, D., et al. (1994) Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J Neurol Neurosurg Psychiatry, 57, 1518–24.
Rupp, C. I., Kurz, M., Kemmler, G., et al. (2003) Reduced olfactory sensitivity, discrimination, and identification in patients with alcohol dependence. Alcohol Clin Exp Res, 27, 432–9.
Slotkin, T. A. (2002) Nicotine and the adolescent brain: insights from an animal model. Neurotoxicol Teratol, 24, 369–84.
Spear, L. P. (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev, 24, 417–63.
Tarter, R. E. (2002) Etiology of adolescent substance abuse: a developmental perspective. Am J Addict, 11, 171–91.
Tarter, R., Vanyukov, M., Giancola, P., et al. (1999) Etiology of early age onset substance use disorder: a maturational perspective. Dev Psychopathol, 11, 657–83.
Volkow, N. D. & Fowler, J. S. (2000) Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex, 10, 318–25.
Volkow, N. D., Mullani, N., Gould, K. L., et al. (1988) Cerebral blood flow in chronic cocaine users: a study with positron emission tomography. Br J Psychiatry, 152, 641–8.
Volkow, N. D., Fowler, J. S., Wolf, A. P., et al. (1991) Changes in brain glucose metabolism in cocaine dependence and withdrawal. Am J Psychiatry, 148, 621–6.
Volkow, N. D., Hitzemann, R., Wang, G. J., et al. (1992) Long-term frontal brain metabolic changes in cocaine abusers. Synapse, 11, 184–90.
Volkow, N. D., Gillespie, H., Mullani, N., et al. (1996) Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication. Psychiatry Res, 67, 29–38.
Volkow, N. D., Wang, G. -J., Overall, J. E., et al. (1997) Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification. Alcohol Clin Exp Res, 21, 1278–84.
Volkow, N. D., Wang, G. J., Fowler, J. S., et al. (1999) Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. Am J Psychiatry, 156, 19–26.
Wang, G. J., Volkow, N. D., Fowler, J. S., et al. (1999) Regional brain metabolic activation during craving elicited by recall of previous drug experiences. Life Sci, 64, 775–84.
White, V. (2001a) Australian secondary students' use of alcohol in 1999. Report Monograph Series No. 45.Canberra: National Drug Strategy Unit Commonwealth Department of Health and Aged Care.
White, V. (2001b) Australian secondary students' use of over-the-counter and illicit substances in 1999. Report Monograph series no. 46. Canberra: National Drug Strategy unit, Commonwealth Department of Health and Aged Care.
Wilson, W., Mathew, R., Turkington, T., et al. (2000) Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study. J Addict Dis, 19, 1–22.