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8 - Nonlinear model regression and optimization

Published online by Cambridge University Press:  05 June 2012

Michael R. King
Affiliation:
Cornell University, New York
Nipa A. Mody
Affiliation:
Cornell University, New York
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Summary

Introduction

Mathematical modeling is used to analyze and quantify physical, biological, and technological processes. You may ask, “What is modeling and what purpose does a model serve in scientific research or in industrial design?” Experimental investigation generates a set of data that describes the nature of a process. The quantitative trend in the data, which describes system behavior as a function of one or more variables, can be fitted to a mathematical function that is believed to represent adequately the relationship between the observations and the independent variables. Fitting a model to data involves determining the “best-fit” values of the parameters of the model.

A mathematical model can be of two types.

  1. (1) A model formulated from physical laws is called a mechanistic model. A model of this type, if formulated correctly, provides insight into the nature of the process. The model parameters can represent physical, chemical, biological, or economic properties of the process.

  2. (2) An empirical model, on the other hand, is not derived from natural laws. It is constructed to match the shape or form of the data, but it does not explain the origin of the trend. Therefore, the parameters of an empirical model do not usually correspond to physical properties of the system.

Mechanistic models of scientific processes generate new insights into the mechanisms by which the processes occur and proceed in nature or in a man-made system. A mathematical model is almost always an incomplete or imperfect description of the system.

Type
Chapter
Information
Numerical and Statistical Methods for Bioengineering
Applications in MATLAB
, pp. 480 - 538
Publisher: Cambridge University Press
Print publication year: 2010

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References

Boal, J. H., Plessinger, M. A., Reydt, C., and Miller, R. K. (1997) Pharmacokinetic and Toxicity Studies of AZT (Zidovudine) Following Perfusion of Human Term Placenta for 14 Hours. Toxicol. Appl. Pharmacol., 143, 13–21.CrossRefGoogle ScholarPubMed
Edgar, T. F., and Himmelblau, D. M. (1988) Optimization of Chemical Processes (New York: McGraw-Hill).Google Scholar
Fournier, R. L. (2007) Basic Transport Phenomena in Biomedical Engineering (New York: Taylor & Francis).Google Scholar
Nauman, B. E. (2002) Chemical Reactor Design, Optimization, and Scaleup (New York: McGraw-Hill).Google Scholar
Rao, S. S. (2002) Applied Numerical Methods for Engineers and Scientists (Upper Saddle River, NJ: Prentice Hall).Google Scholar
Saltzman, W. M. (2001) Drug Delivery: Engineering Principles for Drug Therapy (New York: Oxford University Press).Google Scholar

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