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New Challenges to Health
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Book description

Viruses continually evolve and adapt, posing new threats to health. This book discusses the ecology of viruses with particular emphasis on the emergence of devastating haemorrhagic disease, and reviews the molecular and cell biological basis of the pathogenesis of several virus diseases. An introduction is given to the mathematical analysis of recurrent epidemic virus disease, such as measles. Neurological and psychological disease is discussed in relation to the pathological mechanisms that may underlie prion disease (such as new variant CJD) and to the possible virus involvement in human psychiatric illness. Virus infections that have come to prominence recently (HIV, bunyaviruses, morbilliviruses and caliciviruses) or that remain a threat (influenza and hepatitis viruses) are discussed. There are also chapters on new and potential niches for virus infections in the immunocompromised, and the problem of the emergence of antiviral drug resistance in viruses for which therapies exist.

Reviews

‘… an excellent reference for students and researchers alike and scores well on topicality, authoritativeness and accuracy …’

P. Roy Source: Journal of Epidemiology

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Contents

  • 9 - Structure–function analysis of prion protein
    pp 179-194
    • By Charles Weissmann, MRC Prion Unit/Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK, Doron Shmerling, MRC Prion Unit/Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK, Current address: Core Technologies Dept, Novartis Pharma AG, 4002 Basel, Switzerland., Daniela Rossi, MRC Prion Unit/Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK, Antonio Cozzio, MRC Prion Unit/Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK, Current address: Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA., Ivan Hegyi, Institut für Neuropathologie, Universitätsspital Zürich, 8091 Zürich, Switzerland, Marek Fischer, MRC Prion Unit/Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK, Current address: Dept für Innere Medizin, Abt. für Infektionskrankheiten, Universitätsspital Zürich, Zürich 8091, Switzerland., Rainer Leimeroth, MRC Prion Unit/Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK, Current address: Dept of Cell Biology, ETH, Hönggerberg, 8093 Zürich, Switzerland., Eckhard Flechsig, MRC Prion Unit/Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK

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