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  • Print publication year: 2019
  • Online publication date: July 2019

Chapter 12 - Intracerebral Hemorrhage in the Neurocritical Care Unit


Intracerebral hemorrhage (ICH) is nontraumatic spontaneous bleeding into the brain parenchyma. Annually, approximately 75,000 people in the United States suffer an ICH, which accounts for 10–30% of all stroke cases across different ethnic groups [1–3]. ICH is the most fatal and least treatable form of stroke with one month mortality exceeding 40% [4]. In addition, survivors suffer severe disability [5,6]. Patients with ICH require ICU management and patients cared for in specialized neurologic intensive care units are less likely to die as a result of their ICH [7,8]. Although, compared to ischemic stroke and subarachnoid hemorrhage, the pace of advances in management of ICH has been slow, ongoing trials in minimally invasive surgery and optimal medical management are underway [9,10].

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1.Kase, CS MJ, Caplan, LR. Stroke: Pathophysiology, Diagnosis, and Management. Barnett H MJ, editor. Philadelphia: Churchill Livingstone; 1998.
2.Flaherty, ML, Woo, D, Haverbusch, M et al. (2005). Racial variations in location and risk of intracerebral hemorrhage. Stroke 36(5): 934937.
3.Albers, GW, Amarenco, P, Easton, JD, Sacco, RL, Teal, P (2004). Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126(3 Suppl): 483S-512S.
4.van Asch, CJ, Luitse, MJ, Rinkel, GJ, et al (2010). Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol 9(2): 167176.
5.Qureshi, AI, Tuhrim, S, Broderick, JP, et al. (2001). Spontaneous intracerebral hemorrhage. N Engl J Med 344(19): 14501460.
6.Flaherty, ML, Haverbusch, M, Sekar, P, et al. (2006). Long-term mortality after intracerebral hemorrhage. Neurology 66(8): 11821186.
7.Diringer, MN, Edwards, DF (2001). Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med 29(3): 635640.
8.Mirski, MA, Chang, CW, Cowan, R (2001). Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care. J Neurosurg Anesthesiol 13(2): 8392.
9.Ramanan, M, Shankar, A (2013). Minimally invasive surgery for primary supratentorial intracerebral haemorrhage. J Clin Neurosci 20(12): 16501658.
10.Sakamoto, Y, Koga, M, Yamagami, H, et al. (2013). Systolic blood pressure after intravenous antihypertensive treatment and clinical outcomes in hyperacute intracerebral hemorrhage: the stroke acute management with urgent risk-factor assessment and improvement-intracerebral hemorrhage study. Stroke 44(7): 18461851.
11.Fisher, C (1979). Pathological observations in hypertensive intracerebral hemorrhage. J Neuropathol Exp Neurol 30: 536550.
12.Brott, T, Thalinger, K, Hertzberg, V (1986). Hypertension as a risk factor for spontaneous intracerebral hemorrhage. Stroke 17(6): 10781083.
13.Thrift, AG, McNeil, JJ, Forbes, A, Donnan, GA (1998). Three important subgroups of hypertensive persons at greater risk of intracerebral hemorrhage. Melbourne Risk Factor Study Group. Hypertension 31(6): 12231229.
14.Greenberg, SM, Vonsattel, JP, Stakes, JW, Gruber, M, Finklestein, SP (1993). The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology 43(10): 20732079.
15.Greenberg, SM (1997). Amyloid angiopathy. Neurology 48(1): 291.
16.Woo, D, Broderick, JP (2002). Spontaneous intracerebral hemorrhage: epidemiology and clinical presentation. Neurosurg Clin N Am 13(3): 265279, v.
17.Mayer, SA, Rincon, F (2005). Treatment of intracerebral haemorrhage. Lancet Neurol 4(10): 662672.
18.Greenberg, SM, Vonsattel, JP (1997). Diagnosis of cerebral amyloid angiopathy: sensitivity and specificity of cortical biopsy. Stroke 28(7): 14181422.
19.Charidimou, A, Gang, Q, Werring, DJ (2012). Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatry 83(2): 124137.
20.O’Donnell, HC, Rosand, J, Knudsen, KA, et al. (2000). Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. New Engl J Med 342(4): 240245.
21.Greenberg, SM, Finklestein, SP, Schaefer, PW (1996). Petechial hemorrhages accompanying lobar hemorrhage: detection by gradient-echo MRI. Neurology 46(6): 17511754.
22.Greenberg, SM, Eng, JA, Ning, M, Smith, EE, Rosand, J (2004). Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke 35(6): 14151420.
23.Arakawa, S, Saku, Y, Ibayashi, S, Nagao, T, Fujishima, M (1998). Blood pressure control and recurrence of hypertensive brain hemorrhage. Stroke 29(9): 18061809.
24.Hypertension Detection and Follow-up Program Cooperative Group. (1982). Five-year findings of the hypertension detection and follow-up program. III. Reduction in stroke incidence among persons with high blood pressure. JAMA 247(5): 633638.
25.Hemphill, JC 3rd, Greenberg, SM, Anderson, CS, et al. (2015). Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 46(7): 20322060.
26.Woo, D, Sauerbeck, LR, Kissela, BM, et al. (2002). Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke 33(5): 11901195.
27.Biffi, A, Shulman, JM, Jagiella, JM, et al. (2012). Genetic variation at CR1 increases risk of cerebral amyloid angiopathy. Neurology 78(5): 334341.
28.Biffi, A, Sonni, A, Anderson, CD, et al. (2010). Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 68(6): 934943.
29.Mayer, SA (2003). Ultra-early hemostatic therapy for intracerebral hemorrhage. Stroke 34(1): 224229.
30.Mayer, SA, Lignelli, A, Fink, ME, et al. (1998). Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study. Stroke 29(9): 17911798.
31.Rosand, J, Eskey, C, Chang, Y, et al. (2002). Dynamic single-section CT demonstrates reduced cerebral blood flow in acute intracerebral hemorrhage. Cerebrovasc Dis 14(3–4): 214220.
32.Rosand, J, Eckman, MH, Knudsen, KA, Singer, DE, Greenberg, SM (2004). The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med 164(8): 880884.
33.Broderick, JP, Brott, TG, Duldner, JE, Tomsick, T, Huster, G (1993). Volume of intracerebral hemorrhage: a powerful and easy-to-use predictor of 30-day mortality. Stroke 24(7): 987993.
34.Davis, SM, Broderick, J, Hennerici, M, et al. (2006). Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology 66(8): 11751181.
35.Brott, T, Broderick, J, Kothari, R, et al. (1997). Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 28(1): 15.
36.Flibotte, JJ, Hagan, N, O’Donnell, J, Greenberg, SM, Rosand, J (2004). Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 63(6): 10591064.
37.Gebel, JM Jr., Jauch, EC, Brott, TG, et al. (2002). Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage. Stroke 33(11): 26362641.
38.Xi, G, Wagner, KR, Keep, RF, et al. (1998). Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke 29(12): 25802586.
39.Mayer, SA, Sacco, RL, Shi, T, Mohr, JP (1994). Neurologic deterioration in noncomatose patients with supratentorial intracerebral hemorrhage. Neurology 44(8): 13791384.
40.Levine, JM, Snider, R, Finkelstein, D, et al. (2007). Early edema in warfarin-related intracerebral hemorrhage. Neurocrit Care 7(1): 5863.
41.Power, C, Henry, S, Del Bigio, MR, et al. (2003). Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases. Ann Neurol 53(6): 731742.
42.Zazulia, AR, Diringer, MN, Derdeyn, CP, Powers, WJ (1999). Progression of mass effect after intracerebral hemorrhage. Stroke 30(6): 11671173.
43.Abilleira, S, Montaner, J, Molina, CA, et al. (2003). Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage. J Neurosurg 99(1): 6570.
44.Schellinger, PD, Fiebach, JB, Hoffmann, K, et al. (2003). Stroke MRI in intracerebral hemorrhage: is there a perihemorrhagic penumbra? Stroke 34(7): 16741679.
45.Vermeer, SE, Algra, A, Franke, CL, Koudstaal, PJ, Rinkel, GJ ( 2002). Long-term prognosis after recovery from primary intracerebral hemorrhage. Neurology 59(2): 205209.
46.Fujii, Y, Takeuchi, S, Sasaki, O, Minakawa, T, Tanaka, R (1998). Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage. Stroke 29(6): 11601166.
47.Hemphill, JC 3rd, Bonovich, DC, Besmertis, L, Manley, GT, Johnston, SC (2001). The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 32(4): 891897.
48.Becker, KJ, Baxter, AB, Cohen, WA, et al. (2001). Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies. Neurology 56(6): 766772.
49.Hemphill, JC 3rd, White, DB (2009). Clinical nihilism in neuroemergencies. Emerg Med Clin North Am 27(1): 2737, vii-viii.
50.Rost, NS, Smith, EE, Chang, Y, et al. (2008). Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score. Stroke 39(8): 23042309.
51.Hemphill, JC 3rd, Farrant, M, Neill, TA Jr. (2009). Prospective validation of the ICH Score for 12-month functional outcome. Neurology 73(14): 10881094.
52.Caplan, LR. (2000). Caplan’s Stroke: A Clinical Approach, 3rd edn. Boston: Butterworth-Heinemann.
53.Weisberg, LA (1979). Computerized tomography in intracranial hemorrhage. Arch Neurol 36(7): 422426.
54.Broderick, JP, Brott, TG, Tomsick, T, Barsan, W, Spilker, J (1990). Ultra-early evaluation of intracerebral hemorrhage. J Neurosurg 72(2): 195199.
55.Smith, EE, Rosand, J, Greenberg, SM (2005). Hemorrhagic stroke. Neuroimaging Clin N Am 15(2): 259272, ix.
56.Kothari, RU, Brott, T, Broderick, JP, et al. (1996). The ABCs of measuring intracerebral hemorrhage volumes. Stroke 27(8): 13041305.
57.Huttner, HB, Steiner, T, Hartmann, M, et al. (2006). Comparison of ABC/2 estimation technique to computer-assisted planimetric analysis in warfarin-related intracerebral parenchymal hemorrhage. Stroke 37(2): 404408.
58.Hemphill, JC 3rd, Adeoye, OM, Alexander, DN, et al. (2018). Clinical performance measures for adults hospitalized with intracerebral hemorrhage: performance measures for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 49(7): e243-e261.
59.Zhu, XL, Chan, MS, Poon, WS (1997). Spontaneous intracranial hemorrhage: which patients need diagnostic cerebral angiography? A prospective study of 206 cases and review of the literature. Stroke 28(7): 14061409.
60.McKinney, AM, Palmer, CS, Truwit, CL, Karagulle, A, Teksam, M (2008). Detection of aneurysms by 64-section multidetector CT angiography in patients acutely suspected of having an intracranial aneurysm and comparison with digital subtraction and 3D rotational angiography. AJNR 29(3): 594602.
61.Laissy, JP, Normand, G, Monroc, M, et al. (1991). Spontaneous intracerebral hematomas from vascular causes. Predictive value of CT compared with angiography. Neuroradiology 33(4): 291295.
62.Hino, A, Fujimoto, M, Yamaki, T, Iwamoto, Y, Katsumori, T (1998). Value of repeat angiography in patients with spontaneous subcortical hemorrhage. Stroke 29(12): 25172521.
63.Atlas, SW, Thulburn, KR (2002). Intracranial hemorrhage. In Atlas, SW (ed.) Magnetic Resonance Imaging of the Brain and Spine, 3rd edn. Philadelphia: Lippincott Williams & Wilkins, 773832.
64.Wijman, CA, Venkatasubramanian, C, Bruins, S, Fischbein, N, Schwartz, N (2010). Utility of early MRI in the diagnosis and management of acute spontaneous intracerebral hemorrhage. Cerebrovasc Dis 30(5): 456463.
65.The European Stroke Initiative Writing Committee and the Writing Committee for the EUSI Executive Committee. (2006). Recommendations for the management of intracranial haemorrhage. Part I: spontaneous intracerebral haemorrhage. Cerebrovasc Dis 22(4): 294316.
66.Gujjar, AR, Deibert, E, Manno, EM, Duff, S, Diringer, MN (1998). Mechanical ventilation for ischemic stroke and intracerebral hemorrhage: indications, timing, and outcome. Neurology 51(2): 447451.
67.Walls, RM. Airway. 5th edn. ed. Marx, JA, Harkberger, R.S., Walls, R.M., editor. St. Louis: C.V. Mosby; 2002.
68.Roppolo, LP, Walters, K (2004). Airway management in neurological emergencies. Neurocrit Care 1(4): 405414.
69.Goldstein, JN, Fazen, LE, Snider, R, et al. (2007). Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology 68(12): 889894.
70.Wada, R, Aviv, RI, Fox, AJ, et al. (2007). CT angiography “spot sign” predicts hematoma expansion in acute intracerebral hemorrhage. Stroke 38(4): 12571262.
71.Ott, KH, Kase, CS, Ojemann, RG, Mohr, JP (1974). Cerebellar hemorrhage: diagnosis and treatment. A review of 56 cases. Arch Neurol 31(3): 160167.
72.Zumkeller, M, Höllerhage, HG, Pröschl, M, Dietz, H (1992). The results of surgery for intracerebral hematomas. Neurosurg Rev 15(1): 3336.
73.Kobayashi, S, Sato, A, Kageyama, Y, et al. (1994). Treatment of hypertensive cerebellar hemorrhage--surgical or conservative management? Neurosurgery 34(2): 246250; discussion 250–1.
74.Broderick, JP, Adams, HP Jr., Barsan, W, et al. (1999). Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 30(4): 905915.
75.Mendelow, AD, Gregson, BA, Rowan, EN, et al. (2013). Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet 382(9890): 397408.
76.Mendelow, AD, Gregson, BA, Fernandes, HM, et al. (2005). Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet 365(9457): 387397.
77.Teernstra, OP, Evers, SM, Lodder, J, et al. (2003). Stereotactic treatment of IntraCerebral Hematoma by means of a Plasminogen Activator: a multicenter randomized controlled trial (SICHPA). Stroke 34(4): 968974.
78.Morgan, T, Zuccarello, M, Narayan, R, et al. (2008). Preliminary findings of the minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation (MISTIE) clinical trial. Acta Neurochir Suppl 105: 147151.
79.Auer, LM, Deinsberger, W, Niederkorn, K, et al. (1989). Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma: a randomized study. J Neurosurg 70(4): 530535.
80.Naff, NJ, Hanley, DF, Keyl, PM, et al. (2004). Intraventricular thrombolysis speeds blood clot resolution: results of a pilot, prospective, randomized, double-blind, controlled trial. Neurosurgery 54(3): 577583; discussion 83–4.
81.He, J, Whelton, PK, Vu, B, Klag, MJ (1998). Aspirin and risk of hemorrhagic stroke: a meta-analysis of randomized controlled trials. JAMA 280(22): 19301935.
82.Flaherty, ML, Haverbusch, M, Sekar, P, et al. (2006). Location and outcome of anticoagulant-associated intracerebral hemorrhage. Neurocrit Care 5(3): 197201.
83.Steiner, T, Rosand, J, Diringer, M (2006). Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions. Stroke 37(1): 256262.
84.Goldstein, JN, Thomas, SH, Frontiero, V, et al. (2006). Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage. Stroke 37(1): 151155.
85.Fredriksson, K, Norrving, B, Stromblad, LG (1992). Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke 23(7): 972977.
86.Ansell, J, Hirsh, J, Dalen, J, et al. (2001). Managing oral anticoagulant therapy. Chest 119(1 Suppl): 22S-38S.
87.Sarode, R, Milling, TJ Jr., Refaai, MA, et al. (2013). Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation 128(11): 12341243.
88.Hanley, JP (2004). Warfarin reversal. J Clin Pathol 57(11): 11321139.
89.Fuji, RN, Flagella, M, Baca, M, et al. (2015). Effect of selective LRRK2 kinase inhibition on nonhuman primate lung. Sci Transl Med 7(273): 273ra15.
90.Biffi, A, Kuramatsu, JB, Leasure, A, et al. (2017). Oral anticoagulation and functional outcome after intracerebral hemorrhage. Ann Neurol 82(5): 755765.
91.Connolly, SJ, Ezekowitz, MD, Yusuf, S, et al. (2009). Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361(12): 11391151.
92.Stangier, J (2008). Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet 47(5): 285295.
93.Zhou, W, Schwarting, S, Illanes, S, et al. (2011). Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran. Stroke 42(12): 35943599.
94.Eerenberg, ES, Kamphuisen, PW, Sijpkens, MK, et al. (2011). Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 124(14): 15731579.
95.Eliquis Product Monograph (2011). Available from: (accessed January 2019).
96.Seidl, SE, Potashkin, JA (2011). The promise of neuroprotective agents in Parkinson’s disease. Front Neurol 2: 68.
97.Siegal, DM, Crowther, MA (2013). Acute management of bleeding in patients on novel oral anticoagulants. Eur Heart J 34(7): 489498b.
98.Kaatz, S, Kouides, PA, Garcia, DA, et al. (2012). Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol 87 Suppl 1: S141–5.
99.Connolly, SJ, Eikelboom, J, Joyner, C, et al. (2011). Apixaban in patients with atrial fibrillation. N Engl J Med 364(9): 806817.
100.Mannucci, PM, Remuzzi, G, Pusineri, F, et al. (1983). Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med 308(1): 812.
101.Ohwaki, K, Yano, E, Nagashima, H, et al. (2004). Blood pressure management in acute intracerebral hemorrhage: relationship between elevated blood pressure and hematoma enlargement. Stroke 35(6): 13641367.
102.Jauch, EC, Lindsell, CJ, Adeoye, O, et al. (2006). Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage. Stroke 37(8): 20612065.
103.Qureshi, AI, Mohammad, YM, Yahia, AM, et al. (2005). A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage. J Intensive Care Med 20(1): 3442.
104.Fogelholm, R, Avikainen, S, Murros, K (1997). Prognostic value and determinants of first-day mean arterial pressure in spontaneous supratentorial intracerebral hemorrhage. Stroke 28(7): 13961400.
105.Willmot, M, Leonardi-Bee, J, Bath, PM (2004). High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension 43(1): 1824.
106.Garg, RK, Liebling, SM, Maas, MB, et al. (2012). Blood pressure reduction, decreased diffusion on MRI, and outcomes after intracerebral hemorrhage. Stroke 43(1): 6771.
107.Falcone, GJ, Biffi, A, Devan, WJ, et al. (2012). Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage. Stroke 43(11): 28772883.
108.Prabhakaran, S, Gupta, R, Ouyang, B, et al. (2010). Acute brain infarcts after spontaneous intracerebral hemorrhage: a diffusion-weighted imaging study. Stroke 41(1): 8994.
109.Anderson, CS, Heeley, E, Huang, Y, et al. (2013). Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med 368(25): 23552365.
110.Qureshi, AI, Palesch, YY (2011). Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II: design, methods, and rationale. Neurocrit Care 15(3): 559576.
111.Qureshi, AI, Palesch, YY, Barsan, WG, et al. (2016). Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. N Engl J Med 375(11): 10331043.
112.van den Berghe, G, Wouters, P, Weekers, F, et al. (2001). Intensive insulin therapy in critically ill patients. N Engl J Med 345(19): 13591367.
113.Commichau, C, Scarmeas, N, Mayer, SA (2003). Risk factors for fever in the neurologic intensive care unit. Neurology 60(5): 837841.
114.Schwarz, S, Hafner, K, Aschoff, A, Schwab, S (2000). Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology 54(2): 354361.
115.The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care (2000). Indications for intracranial pressure monitoring. J Neurotrauma 17(6–7): 479491.
116.McKinley, BA, Parmley, CL, Tonneson, AS (1999). Standardized management of intracranial pressure: a preliminary clinical trial. J Trauma 46(2): 271279.
117.Adams, RE, Diringer, MN (1998). Response to external ventricular drainage in spontaneous intracerebral hemorrhage with hydrocephalus. Neurology 50(2): 519523.
118.Goldstein, JN, Greenberg, SM, Rosand, J (2006). Emergency management of intracerebral hemorrhage. Continuum 12(1): 1329.
119.Passero, S, Rocchi, R, Rossi, S, Ulivelli, M, Vatti, G (2002). Seizures after spontaneous supratentorial intracerebral hemorrhage. Epilepsia 43(10): 11751180.
120.Claassen, J, Mayer, SA, Kowalski, RG, Emerson, RG, Hirsch, LJ (2004). Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology 62(10): 17431748.
121.Vespa, PM, O’Phelan, K, Shah, M, et al. (2003). Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology 60(9): 14411446.
122.Naidech, AM, Garg, RK, Liebling, S, et al. (2009). Anticonvulsant use and outcomes after intracerebral hemorrhage. Stroke 40(12): 38103815.
123.Messe, SR, Sansing, LH, Cucchiara, BL, et al. (2009). Prophylactic antiepileptic drug use is associated with poor outcome following ICH. Neurocrit Care 11(1): 3844.
124.Mayer, SA, Brun, NC, Begtrup, K, et al. (2008). Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 358(20): 21272137.
125.Kakkos, SK, Caprini, JA, Geroulakos, G, et al. (2016). Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism. Cochrane Database Syst Rev 9: CD005258.