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  • Cited by 2
  • Edited by Stephen A. Schey, Department of Haematology, King’s College Hospital, London , Kwee L. Yong, Department of Haematology, University College Hospital, London , Robert Marcus, Department of Haematology, King’s College Hospital, London , Kenneth C. Anderson, Dana-Farber Cancer Institute, Boston

Book description

Myeloma is the second-most common hematologic cancer, accounting for approximately 1 percent of all cancers and 2 percent of all deaths from cancer. In recent years there have been major and significant advances in the diagnosis, imaging, molecular pathogenesis, and therapy of myeloma. This book describes these advances in a single, practical volume, placing them in the context of daily clinical practice. Different myeloma subtypes are discussed in individual chapters, integrating etiology, pathogenesis, molecular pathology, histology, and therapy in a single place for each condition. The book begins by discussing epidemiology, imaging techniques, pathogenesis, and other general considerations. Conditions covered in detail include multiple myeloma, POEMS syndrome, Castleman's syndrome, Waldenstrom's macroglobulinemia, amyloidosis and MGUS. Featuring color illustrations, and written and edited by leading authorities in the field, Myeloma provides readers with the information they need to diagnose and manage these complex disorders.

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  • Frontmatter
    pp i-iv
  • Contents
    pp v-vi
  • List of contributors
    pp vii-x
  • Section 1 - Overview of myeloma
  • 1 - Epidemiology of myeloma
    pp 1-10
  • 2 - Diagnosis of myeloma and related plasma cell disorders
    pp 11-27
  • 3 - Imaging of myeloma
    pp 28-38
  • Section 2 - Biological basis for targeted therapies in myeloma
  • 4 - Cell cycle regulation and myeloma precursor cells
    pp 39-47
  • 6 - The myeloma bone marrow environment and survival signaling
    pp 64-83
  • 7 - Immune dysfunction in multiple myeloma
    pp 84-95
  • 9 - Principles of pathway directed therapy
    pp 110-120
  • Section 3 - Myeloma: clinical entities
  • 13 - Solitary bone and extra-medullary plasmacytoma
    pp 167-173
  • 14 - Amyloidosis
    pp 174-189
  • 15 - Waldenstrom’s macroglobulinemia/lymphoplasmacytic lymphoma
    pp 190-215
  • 16 - Castleman’s disease
    pp 216-224
  • Section 4 - Supportive therapies
  • 20 - The management of infection in myeloma
    pp 276-287
  • Index
    pp 288-296


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