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  • Print publication year: 2015
  • Online publication date: April 2015

Chapter 20 - Neuropsychological issues in MRI-negative focal epilepsy surgery: evaluation and outcomes


1. Meador KJ, Loring DW, Flanigin HF. History of epilepsy surgery. Journal of Epilepsy. 1989;2:21–5.
2. Penfield W, Flanigin H. Surgical therapy of temporal lobe seizures. Transactions of the American Neurological Association. 1950;51:146–9.
3. Penfield W, Flanigin H. Epilepsy and the Functional Anatomy of the Human Brain. Boston: Little, Brown, & Company; 1954.
4. Wada J, Rasmussen T. Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance: Experimental and clinical observations. Online article: http://wwwc3hu/~mavideg/jns/1-4-prev1html. 1960;17:266–82.
5. Milner B. Psychological deficits produced by temporal lobe excision. In Solomon HC, Cobb S, Penfield W, editors. The Brain and Human Behavior: Proceedings of the Association for Research in Nervous and Mental Disease. Baltimore: The Williams and Wilkins Company; 1958.
6. Milner B, Branch C, Rasmussen T. Study of short-term memory after intracarotid injection of sodium amytal. Transactions of the American Neurological Association. 1962;87:224–6.
7. Engel JJ. Surgical Treatment of the Epilepsies. New York: Raven; 1993.
8. Duncan JS. Neuroimaging methods to evaluate the etiology and consequences of epilepsy. Epilepsy Research. 2002;50:131–40.
9. Engel JJ. Surgery for seizures. New England Journal of Medicine. 1996;334:647–52.
10. Gilliam F, Kanner AM. Treatment of depressive disorders in epilepsy patients. Epilepsy & Behavior. 2002;3(5, Supplement 1):2–9.
11. Helmstaedter C, Kurthen M, Lux S, Reuber M, Elger CE. Chronic epilepsy and cognition: A longitudinal study in temporal lobe epilepsy. Annals of Neurology. 2003;54(4):425–32.
12. Hermann B, Seidenberg M, Lee EJ, Chan F, Rutecki P. Cognitive phenotypes in temporal lobe epilepsy. Journal of the International Neuropsychological Society. 2007;13:12–20.
13. Jacoby A, Baker GA, Steen N, Potts P, Chadwick DW. The clincial course of epilepsy and it psychosocial correlates: Findings from a U.K. community study. Epilepsia. 1996;32(2):148–61.
14. Wiebe S, Blume WT, Girvin JP, Eliasziw M. Effectiveness and safety of epilepsy surgery: What is the evidence? CNS Spectrum. 2004;9:120–2, 126–32.
15. Wiebe SB, Girvin JP, Eliasziw M. A randomized controlled trial of surgery for temporal-lobe epilepsy. New England Journal of Medicine. 2001;345:311–18.
16. Engel JJ, Wiebe S, French J, Sperling M, Williamson P, Spencer D, Gummit R, Zahn C, Westbrook E, Enos B. Practice parameter: Temporal lobe and localized neocortical resections for epilepsy. Neurology. 2003;60:538–47.
17. Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: A systematic review and meta-analysis. Brain. 2005;128(Pt. 5):1188–98.
18. McGonigal A, Bartolomei F, Regis J, Guye M, Gavaret M, Trebuchon-Da Fonseca A, et al. Stereoelectroencephalography in presurgical assessment of MRI-negative epilepsy. Brain. 2007;130(Pt. 12):3169–83.
19. Bell ML, Rao S, So EL. Epilepsy surgery outcomes in temporal lobe epilepsy with a normal MRI. Epilepsia. 2009;50:2053–60.
20. McIntosh AM, Wilson SJ, Berkovic SF. Stereoencephalography in presurgical assessment of MRI-negative epilepsy. Brain. 2007;130:3169–83.
21. Radhakrishnan K, So EL, Sibert PL, Jack CR Jr, Cascino GD, Sharbrough FW, et al. Predictors of outcome of anterior temporal lobectomy for intractable epilepsy: A multivariate study. Neurology. 1998;51:465–71.
22. Dulay MF, Busch RM. Prediction of neuropsychological outcome after resection of temporal and extratemporal seizure foci. Neurosurgical Focus. 2012;32(3):E4.
23. Lin TW, de Aburto MA, Dahlbom M, Huang LL, Marvi MM, Tang M, et al. Predicting seizure-free status for temporal lobe epilepsy patients undergoing surgery: Prognostic value of quantifying maximal metabolic asymmetry extending over a specified proportion of the temporal lobe. Journal of Nuclear Medicine. 2007;48(5):776–82.
24. Loring DW, Meador KJ, Lee GP, Smith JR. Structural versus functional prediction of memory change following anterior temporal lobectomy. Epilepsy & Behavior. 2004;5(2):264–8.
25. Loring DW, Lee GP, Martin RC, Meador KJ. Verbal and visual memory index discrepancies from the Wechsler Memory Scale – revised: Cautions in interpretation. Psychological assessment. A Journal of Consulting and Clinical Psychology. 1989;1(3):198–202.
26. Milner B. Visual recognition and recall after right temporal-lobe excision in man. Neuropsychologia. 1968;6(3):191–209.
27. Saykin AJ, Stafiniak P, Robinson LJ, Flannery KA, Gur RC, O’Connor MJ, et al. Language before and after temporal lobectomy: Specificity of acute changes and relation to early risk factors. Epilepsia. 1995;33(11):1071–7.
28. Martin RC, Loring DW, Meador KJ, Lee GP. The effects of lateralized temporal lobe dysfunction on formal and semantic word fluency. Neuropsychologia. 1990;28:823–9.
29. Drane DL, Ojemann GA, Aylward E, Ojemann JG, Johnson LC, Silbergeld DL, et al. Category-specific naming and recognition deficits in temporal lobe epilepsy. Neuropsychologia. 2008;46(5):1242–55.
30. Glosser G, Salvucci AE, Chiaravalloti ND. Naming and recognizing famous faces in temporal lobe epilepsy. Neurology. 2003;61:81–6.
31. Seidenberg M, Hermann B, Wyler AR, Davies K, Dohan JFC, Leveroni C. Neuropsychological outcome following anterior temporal lobectomy in patients with and without the syndrome of mesial temporal lobe epilepsy. Neuropsychology. 1998;12(2):303–16.
32. Chelune GJ. Hippocampal adequacy versus functional reserve: Predicting memory functions following temporal lobectomy. Archives of Clinical Neuropsychology. 1995;10(5):413–32.
33. Drane DL. Neuropsychological evaluation of the epilepsy surgery patient. In Barr B, Morrison C, editors. Handbook of the Neuropsychology of Epilepsy. New York: Springer; in press.
34. Schoenberg MR, Werz MA, Drane DL. Epilepsy and seizures. In Scott MRSJ, editor. Black Book of Neuropsychology. New York: Springer; 2011. pp. 423–519.
35. Jokeit H, Seitz R, Markowitsch H, Neumann N, Witte O, Ebner A. Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. Brain. 1997;120:2283–94.
36. Concha L, Beaulieu C, Gross DW. Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy. Annals of Neurology. 2005;57:188–96.
37. Hermann B, Seidenberg M, Bell B, Rutecki P, Sheth RD, Wendt G, et al. Extratemporal quantitative MR volumetrics and neuropsychological status in temporal lobe epilepsy. Journal of the International Neuropsychological Society. 2003;9(3):353–62.
38. McDonald CR, Bauer RM, Grande L, Gilmore R, Roper S. The role of the frontal lobes in memory: Evidence from unilateral frontal resections for relief of intractable epilepsy. Archives of Clinical Neuropsychology. 2001;16:571–85.
39. Nolan MA, Redoblado MA, Lah S, Sabaz M, Lawson JA, Cunningham AM, et al. Memory function in childhood epilepsy syndromes. Journal of Paediatric Child Health. 2004;40:20–7.
40. Pigott S, Milner B. Memory for different aspects of complex visual scenes after unilateral temporal- or frontal-lobe resection. Neuropsychologia. 1993;31(1):1–15.
41. Milner B, Petrides M, Smith ML. Frontal lobes and the temporal organization of memory. Human Neurobiology. 1985;4:137–42.
42. Milner B, Corsi P, Leonard G. Frontal-lobe contribution to recency judgments. Neuropsychologia. 1991;29:601–18.
43. Drane DL, Lee GP, Cech H, Huthwaite JS, Ojemann GA, Ojemann JG, et al. Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset. Epilepsy & Behavior. 2006;9(2):339–44.
44. Drane DL, Ojemann JG, Phatak V, Loring DW, Gross RE, Hebb AO, et al. Famous face identification in temporal lobe epilepsy: Support for a multimodal integration model of semantic memory. Cortex. 2013;49:1648–67.
45. Martin RC, Sawrie SM, Edwards R, Roth DL, Faught E, Kuzniecky RI, et al. Investigation of executive function change following anterior temporal lobectomy: Selective normalization of verbal fluency. Neuropsychology. 2000;14(2):501–8.
46. Saling MM. Verbal memory in mesial temporal lobe epilepsy: Beyond material specificity. Brain. 2009;132:570–82.
47. Helmstaedter C, Grunwald T, Lehnertz K, Gleissner U, Elger CE. Differential involvement of left temporolateral and temporomesial structures in verbal declarative learning and memory: Evidence from temporal lobe epilepsy. Brain and Cognition. 1997;35(1):110–31.
48. Drane DL, Loring DL, Voets NL, Price M, Gross RE, Willie JT, et al., editors. MRI-guided laser ablation of hippocampus leads to better cognitive outcome than standard temporal lobe resection for the treatment of epilepsy. Montreal, Canada: International League Against Epilepsy; 2013.
49. Damasio H, Grabowski TJ, Tranel D, Hichwa RD, Damasio A. A neural basis for lexical retrieval. Nature. 1996;380:499–505.
50. Hamberger MJ, Seidel WT, McKhann GM 2nd, Goodman RR. Hippocampal removal affects visual but not auditory naming. Neurology. 2010;74(19):1488–93.
51. Benke T, Kuen E, Schwarz M, Walser G. Proper name retrieval in temporal lobe epilepsy: Naming of famous faces and landmarks. Epilepsy & Behavior. 2013;27:371–7.
52. Helmstaedter C, Kemper B, Elger CE. Neuropsychological aspects of frontal lobe epilepsy. Neuropsychologia. 1996;34(5):399–406.
53. Nishida T, Kudo T, Nakamura F, Yoshimura M, Matsuda K, Yagi K. Postictal mania associated with frontal lobe epilepsy. Epilepsy & Behavior. 2005;6:102–10.
54. McDonald CR, Delis DC, Norman MA, Wetter SR, Tecoma ES, Iragui VJ. Response inhibition and set shifting in patients with frontal lobe epilepsy or temporal lobe epilepsy. Epilepsy & Behavior. 2005;7:438–46.
55. Upton D, Thompson PJ. General neuropsychological characteristics of frontal lobe epilepsy. Epilepsy Research. 1996;23:169–77.
56. Rzezak P, Fuentes D, Guimaraes CA, Thome-Souza S, Kuczynski E, Li LM, et al. Frontal lobe dysfunction in children with temporal lobe epilepsy. Pediatric Neurology. 2007;37(3):176–85.
57. Salanova V, Andermann F, Rasmussen T, Olivier A, Quesney LF. Parietal lobe epilepsy: Clinical manifestations and outcomes in 82 patients treated surgically between 1929 and 1988. Brain 1995;118:607–27.
58. Blume WT, Wiebe S, Tapsell LM. Occipital epilepsy: Lateral versus mesial. Brain 2005;128:1209–25.
59. Chilosi AM, Brovedani P, Moscatelli M, Bonanni P, Guerrini R. Neuropsychological findings in idiopathic occipital lobe epilepsies. Epilepsia. 2006;47:76–8.
60. Helmstaedter C, Petzoid I, Bien CG. The cognitive consequence of resecting nonlesional tissues in epilepsy surgery-results from MRI- and histopathology-negative patients with temporal lobe epilepsy. Epilepsia. 2011;52(8):1402–8.
61. Helmstaedter C, Richter S, Roske S, Oltmanns F, Schramm J, Lehmann TN. Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material-specific memory in patients with mesial temporal lobe epilepsy. Epilepsia. 2008;49(1):88–97.
62. Immonen A, Jutila L, Muraja-Murro A, Mervaala E. Long-term epilepsy surgery outcomes in patients with MRI-negative temporal lobe epilepsy. Epilepsia. 2010;51(11):2260–9.
63. Helmstaedter C, Gleibner U, Zentner J, Elger CE. Neuropsychological consequences of epilepsy surgery in frontal lobe epilepsy. Neuropsychologia. 1998;36(4):333–41.
64. Lendt M, Gleissner U, Helmstaedter C, Sassen R, Clusmann H, Elger CE. Neuropsychological outcome in children after frontal lobe epilepsy surgery. Epilepsy & Behavior. 2002;3:51–9.
65. Davis KL, Murro AM, Park YD, Lee GP, Cohen MJ, Smith JR. Posterior quadrant epilepsy surgery: Predictors of outcome. Seizure. 2012;21(9):722–8.
66. Lippe S, Bulteau C, Dorfmuller G, Audren F, Delalande O, Jambaque I. Cognitive outcome of parietooccipital resection in children with epilepsy. Epilepsia. 2010;51(10):2047–57.
67. Luerding R, Boesebeck F, Ebner A. Cognitive changes after epilepsy surery in the posterior cortex. Journal of Neurology, Neurosurgery and Psychiatry. 2004;75(4):583–7.
68. Potter JL, Shefft BK, Beebe DW, Howe SR, Yeh HS, Privitiera MD. Presurgical neuropsychological testing predicts cognitive and seizure outcomes after anterior temporal lobectomy. Epilepsy & Behavior. 2009;16:246–53.
69. Sawrie SM, Martin RC, Gilliam FG, Roth DL, Faught E, Kuzniecky R. Contribution of neuropsychological data to the prediction of temporal lobe epilepsy surgery outcome. Epilepsia. 1998;39(3):319–25.
70. Téllez-Zenteno JD, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: A systematic review and meta-analysis. Brain. 2005;128:1188–98.
71. Loring DW, Meador KJ, Lee GP, Nichols ME, King DW, Gallagher BB, et al. Wada memory performance predicts seizure outcome following anterior temporal lobectomy. Neurology. 1994;44:2322–4.
72. Hennessy MJ, Elwes RD, Honavar M, Rabe-Hesketh S, Binnie CD, Polkey CE. Predictors of outcome and pathological considerations in the surgical treatment of intractable epilepsy associated with temporal lobe lesions. Journal of Neurology, Neurosurgery, and Psychiatry. 2001;70:450–8.
73. Lieb JP, Raousch R, Engel J Jr, et al. Changes in intelligence following temporal lobectomy: Relationship to EEG activity, seizure relief, and pathology. Epilepsia. 1982;23:1–13.
74. Dodrill CB, Wilkus RJ, Ojemann GA, Ward AA, Wyler AR, van Belle G, Tamas L. Multidisciplinary prediction of seizure relief from cortical resection surgery. Annals of Neurology. 1986;20:2–12.
75. Hermann B, Loring DW. Improving neuropsychological outcomes from epilepsy surgery. Epilepsy & Behavior. 2008;13:5–6.
76. Yucus C, Tranel D. Preserved proper naming following left anterior temporal lobectomy is associated with early age of seizure onset. Epilepsia. 2007;48(12):2241–52.
77. Loring DL, Meador KJ. The Wada test: Current perspectives and applications. In Barr W, Morrison C, editors. Handbook of the Neuropsychology of Epilepsy. New York: Springer; in press.
78. Loring DL, Bowden SC, Lee GP, Meador KJ. Diagnostic utility of Wada memory assymetries: Sensitivity, specificity, and likelihood ratio characterization. Neuropsychology. 2009;23:687–93.