Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-18T22:21:57.209Z Has data issue: false hasContentIssue false

Chapter 11 - The oesophagus, stomach and small bowel

Published online by Cambridge University Press:  05 February 2012

Mazyar Kanani  and
Leanne Harling
Mazyar Kanani
Affiliation:
Children's Hospital, Pittsburgh
Leanne Harling
Affiliation:
Department of Surgery and Cancer, Imperial College London
Get access

Summary

What underlying aetiological factors have been associated with peptic ulcer disease?

Helicobacter pylori infection

Colonizes the entire gastric epithelium and causes increased gastric acid secretion by producing ammonia, which locally suppresses somatostatin inhibition of gastrin release by antral D cells. H. pylori also disrupts mucosal integrity by release of proteases and phospholipases.

Non-steroidal anti-inflammatory drugs (NSAIDs)

Inhibit cyclo-oxygenase and decrease prostoglandin production. Prostaglandins (E type) act to increase both mucosal blood flow and the production of mucus and bicarbonate, which form a protective layer and act as a buffer for gastric acid, respectively. There is a dose-dependent relationship. Selective Cox-2 inhibitors have been shown to lower the risk of gastric ulceration but do not eliminate this risk.

Type
Chapter
Information
MRCS Revision Guide: Trunk and Thorax , pp. 80 - 90
Publisher: Cambridge University Press
Print publication year: 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×