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  • Cited by 27
  • Print publication year: 2006
  • Online publication date: July 2009

4 - Adult Neurogenesis

Summary

ABSTRACT

Contrary to widely held belief, a small number of new neurons are generated in the adult brain and even in the aging brain. Although this adult neurogenesis is minute compared with the vast number of neurons in our brains, and although adult neurogenesis does not lead to substantial regeneration in cases of neuronal loss, the new neurons may serve an important function in learning and memory processes. Adult neurogenesis is neuronal development in nucleo and is controlled by genetic and environmental factors. It exemplifies that, throughout life, brain development is activity and experience dependent, and, more important, that it never ends.

INTRODUCTION

“Adult neurogenesis” is the generation of new nerve cells in the adult brain (Fig. 4.1), a process that was long believed to be impossible, although it occurs in both nonhuman primates (Gould et al., 1999) and humans (Eriksson et al., 1998). Today, adult neurogenesis has become a prime topic in biomedical research because of its implications for the treatment of neurodegenerative disorders and essentially all diseases that involve a loss of nerve cells (neurons). Because it is the stem cells residing in the adult brain from which new neurons originate in adult neurogenesis, many researchers believe that we might learn from adult neurogenesis how to “grow” stem cells into new neurons for transplantation – in cases of Parkinson's disease, for example (Bjorklund & Lindvall, 2000).

References
Altman, J. (1969). Autoradiographic and histological studies of postnatal neurogenesis: IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. Journal of Comparative Neurology, 137(4), 433–457
Altman, J., & Das, G. D. (1965). Autoradiographic and histologic evidence of postnatal neurogenesis in rats. Journal of Comparative Neurology, 124, 319–335
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nature Medicine, 8 (9), 963–970
Barnea, A., & Nottebohm, F. (1994). Seasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees. Proceedings of the National Academy of Sciences (USA), 91, 11217–11221
Bernhard, T. (1971). Gehen. Frankfurt: Suhrkamp. (in English: Three Novellas: Amras, Playing Watten, Walking, P. Janse, K. Northcott, & B. Evenson, Trans. Chicago:University of Chicago Press, 2003. Available: http://www.conjunctions.com/archives/c31-tb.htm)
Bjorklund, A., & Lindvall, O. (2000). Cell replacement therapies for central nervous system disorders. Nature Neuroscience, 3 (6), 537–544
Boss, B. D., Peterson, G. M., & Cowan, W. M. (1985). On the number of neurons in the dentate gyrus of the rat. Brain Research, 338 (1), 144–150
Cameron, H. A., & Gould, E. (1994). Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience, 61 (2), 203–209
Cameron, H. A., & McKay, R. D. (1999). Restoring production of hippocampal neurons in old age. Nature Neuroscience, 2 (10), 894–897
Cameron, H. A., Woolley, C. S., McEwen, B. S., & Gould, E. (1993). Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience, 56 (2), 337–344
Churchill, J. D., Galvez, R., Colcombe, S., Swain, R. A., Kramer, A. F., & Greenough, W. T. (2002). Exercise, experience and the aging brain. Neurobiology of Aging, 23 (5), 941–955
Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., et al. (2004). Cardiovascular fitness, cortical plasticity, and aging. Proceedings of National Academy of Sciences (USA), 101, 3316–3321
Cotman, C. W. (1985). Synaptic plasticity. New York: Guilford
Crespo, D., Stanfield, B. B., & Cowan, W. M. (1986). Evidence that late-generated granule cells do not simply replace earlier formed neurons in the rat dentate gyrus. Experimental Brain Research, 62 (3), 541–548
D'Sa, C., & Duman, R. S. (2002). Antidepressants and neuroplasticity. Bipolar Disorders, 4 (3), 183–194
Day, M., Langston, R., & Morris, R. G. (2003). Glutamate-receptor-mediated encoding and retrieval of paired-associate learning. Nature, 424 (6945), 205–209
Draganski, B., Gaser, C., Busch, V., Schuierer, G., Bogdahn, U., & May, A. (2004). Neuroplasticity: Changes in grey matter induced by training. Nature, 427 (6972), 311–312
Ehninger, D., & Kempermann, G. (2003). Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex. Cerebral Cortex, 13 (8), 845–851
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A.. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4, 1313–1317
Gage, F. H. (2000). Mammalian neural stem cells. Science, 287 (5457), 1433–1438
Goldman, S. A., & Nottebohm, F. (1983). Neuronal production, migration and differentiation in a vocal control nucleus of the adult female canary brain. Proceedings of the National Academy of Sciences (USA), 80, 2390–2394
Gould, E., Reeves, A. J., Fallah, M., Tanapat, P., Gross, C. G., & Fuchs, E. (1999). Hippocampal neurogenesis in adult old world primates. Proceedings of the National Academy of Sciences (USA), 96, 5263–5267
Greenough, W. T., & Black, J. E. (1992). Induction of brain structure by experience: Substrates for cognitive development. In M. R. Gunnar & C. A. Nelson (Eds.), Developmental behavioral neuroscience (Minnesota Symposia on Child Psychology, Vol. 24, pp. 155–200). Hillsdale, NJ: Erlbaum
Hebb, D. O. (1947). The effects of early experience on problem-solving at maturity. American Psychologist, 2, 306–307
, D. O. (1949). The organization of behavior.New York: Wiley
Jacobs, B. L., Praag, H., & Gage, F. H. (2000). Adult brain neurogenesis and psychiatry: A novel theory of depression. Molecular Psychiatry, 5 (3), 262–269
Kaplan, M. S., & Hinds, J. W. (1977). Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs. Science, 197 (4308), 1092–1094
Kempermann, G. (2002). Why new neurons? Possible functions for adult hippocampal neurogenesis. Journal of Neuroscience, 22 (3), 635–638
Kempermann, G., Brandon, E. P., & Gage, F. H. (1998). Environmental stimulation of 129/SvJ mice results in increased cell proliferation and neurogenesis in the adult dentate gyrus. Current Biology, 8, 939–942
Kempermann, G., & Gage, F. H. (2002). Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance in the water maze task. European Journal of Neuroscience, 16, 129–136
Kempermann, G., Gast, D., & Gage, F. H. (2002). Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Annals of Neurology, 52 (2), 135–143
Kempermann, G., & Kronenberg, G. (2003). Depressed new neurons? Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biological Psychiatry, 54, 499–503
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997a). Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proceedings of the National Academy of Sciences (USA), 94, 10409–10414
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997b). More hippocampal neurons in adult mice living in an enriched environment. Nature, 386, 493–495
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998). Experience-induced neurogenesis in the senescent dentate gyrus. Journal of Neuroscience, 18 (9), 3206–3212
Kempermann, G., & Wiskott, L. (2004). What is the functional role of new neurons in the adult dentate gyrus? In F. H. Gage, A. Björklund, A. Prochiantz, & Y. Christen (Eds.), Stem cells in the nervous system: Functional and clinical implications (pp. 57–65). Berlin:Springer
Kuhn, H. G., Dickinson-Anson, H., & Gage, F. H. (1996). Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. Journal of Neuroscience, 16 (6), 2027–2033
Magavi, S., Leavitt, B., & Macklis, J. (2000). Induction of neurogenesis in the neocortex of adult mice. Nature, 405, 951–955
Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S., et al. (2000). Navigation-related structural change in the hippocampi of taxi drivers. Proceedings of the National Academy of Sciences (USA), 97, 4398–4403
Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F., & Gage, F. H. (1999). Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. Journal of Neuroscience, 19 (19), 8487–8497
Reynolds, B. A., & Weiss, S. (1992). Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science, 255 (5052), 1707–1710
Rosenzweig, M. R., & Bennett, E. L. (1996). Psychobiology of plasticity: Effects of training and experience on brain and behavior. Behavioral Brain Research, 78 (1), 57–65
Sanai, N., Tramontin, A. D., Quinones-Hinojosa, A., Barbaro, N. M., Gupta, N., Kunwar, S., et al. (2004). Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature, 427 (6976), 740–744
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., et al. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301 (5634), 805–809
Stanfield, B. B., & Trice, J. E. (1988). Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections. Experimental Brain Research, 72 (2), 399–406
Praag, H., Kempermann, G., & Gage, F. H. (1999). Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience, 2 (3), 266–270
Weissman, I. L., Anderson, D. J., & Gage, F. (2001). Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annual Review of Cell and Developmental Biology, 17, 387–403
Wilson, R. S., Mendes De Leon, C. F., Barnes, L. L., Schneider, J. A., Bienias, J. L., Evans, D. A.. (2002). Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA, 287 (6), 742–748