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Chapter 15 - Use of GnRH Analogs for Prevention of Chemotherapy-Induced Gonadotoxicity

from Section 5 - Fertility Preservation Strategies in the Female: Medical/Surgical

Published online by Cambridge University Press:  27 March 2021

By
Matteo Lambertini ,
Florence Horicks  and
Isabelle Demeestere
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
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Summary

Although cancer remains a public health problem worldwide, survival has significantly improved over the past years thanks to major advances in both early detection and use of more effective anticancer treatments [1]. Progress has been especially rapid for hematological malignancies but has also concerned the majority of solid tumors [1]. Therefore, nowadays, addresing survivorship issues as early as possible is of crucial importance to avoid the potential serious long-term consequences of anticancer treatments [2]. On this regard, chemotherapy-induced gonadotoxicity is of particular concern for newly diagnosed premenopausal patients being associated with negative side effects including menopause-related symptoms and other negative sequelae such as the possible risk of infertility [3]. Therefore, at the time of diagnosis, all premenopausal women should be informed about the potential gonadotoxicity of chemotherapy as well as on the strategies available to counteract the risk of developing this side effect and its negative consequences [4–8].

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 171 - 181
Publisher: Cambridge University Press
Print publication year: 2021

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