Skip to main content Accessibility help
×
Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-20T01:34:05.067Z Has data issue: false hasContentIssue false

8 - Fine-Needle Aspiration of Thyroid Gland

Published online by Cambridge University Press:  05 March 2021

Ji-Weon Park
Affiliation:
Rush University, Chicago
Paolo Gattuso
Affiliation:
Rush University, Chicago
Vijaya B. Reddy
Affiliation:
Rush University, Chicago
Shahla Masood
Affiliation:
University of Florida
Get access

Summary

Palpable thyroid nodules are present in approximately 5–7% of the adult population, and of these, 5–10% harbor malignancy. Additional thyroid nodules are found incidentally on imaging for other medical reasons, including screening for malignancies of other organs or evaluation of vasculature. Ultrasound (US) imaging of the neck with evaluation of the thyroid and lymph nodes is typically used and recommended to characterize thyroid nodules. The American Thyroid Association (ATA) classification, and the Thyroid Imaging, Reporting, and Data System (TIRADS) of the American College of Radiology (ACR-TIRADS) risk stratification systems are commonly used.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Primary Sources

Ali, SZ, Cibas, ES, The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria, and Explanatory Notes, 2nd edn. New York: Springer, 2018.Google Scholar
Baloch, ZW, David, S. Cooper, DS, et al. Overview of diagnostic terminology and reporting. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Crothers, BA, Henry, MR, Firat, P, et al. Nondiagnostic/ unsatisfactory. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Haugen, BR, Alexander, EK, Bible, KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016; 26(1): 1133.CrossRefGoogle ScholarPubMed
Jing, X, Michael, CW, Pu, RT. The clinical and diagnostic impact of using standard criteria of adequacy assessment and diagnostic terminology on thyroid nodule fine needle aspiration. Diagn Cytopathol 2008; (36)3:161166.CrossRefGoogle ScholarPubMed
Oertel, YC. Unsatisfactory (vs nondiagnostic) thyroidal aspirates: a semantic issue? Diagn Cytopathol 2006; 34(2): 8788.CrossRefGoogle ScholarPubMed
Pusztaszeri, M, Rossi, E.D, Auger, M, et al. The Bethesda System for Reporting Thyroid Cytopathology: Proposed Modifications and Updates for the Second Edition from an International Panel. Acta Cytologica 2016; 60:399405.Google Scholar
Renshaw, AA. Evidence-based criteria for adequacy in thyroid fine-needle aspiration. Am J Clin Pathol 2002; 118(4)518521.Google Scholar
Zhou, H, Baloch, Z, Nayar, R, et al. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Cancer Cytopath 2018; 126(1): 2026.CrossRefGoogle ScholarPubMed

Secondary Sources

Apel, RL, Ezzat, S, Bapat, BV, et al. Clonality of thyroid nodules in sporadic goiter. Diagn Mol Pathol 1995; 4(2): 113121.CrossRefGoogle ScholarPubMed
Das, DK, Khanna, CM, Tripathi, RP, et al. Solitary nodular goiter. Review of cytomorphologic features in 441 cases. Acta Cytol 1999; 43(4): 563574.Google Scholar
Elsheikh, TM, Cochand-Priollet, B, Hong, SW, Sidawy, MK. Benign. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Frost, AR, Sidawy, MK, Ferfelli, M, et al. Utility of thin-layer preparations in thyroid fine-needle aspiration. Diagnostic accuracy, cytomorphology, and optimal sample preparation. Cancer (Cancer Cytopathol) 1998; 84:1725.Google Scholar
Grant, CS, Hay, ID, Gough, IR, et al. Long-term follow-up of patients with benign thyroid fine-needle aspiration cytologic diagnoses. Surgery 1989; 106:980985.Google Scholar
Harach, HR, Zusman, SB, Saravia Day, E. Nodular goiter: a histo-cytological study with some emphasis on pitfalls of fine-needle aspiration cytology. Diagn Cytopathol 1992; 8(4): 409419.CrossRefGoogle ScholarPubMed
Kung, IT, Yuen, RW. Fine needle aspiration of the thyroid. Distinction between colloid nodules and follicular neoplasms using cell blocks and 21-gauge needles. Acta Cytol 1989; 33(1): 5360.Google Scholar
Layfield, LJ, Wax, T, Jones, C. Cytologic distinction of goiterous nodules from morphologically normal thyroid: analyses of cytomorphologic features. Cancer 2003; 99(4): 217222.Google Scholar
Suen, KC. How does one separate cellular follicular lesions of the thyroid by fine-needle aspiration biopsy? Diagn Cytopathol 1988; 4:7881.Google Scholar
Carson, HJ, Castelli, MJ, Gattuso, P. Incidence of neoplasia in Hashimoto’s thyroiditis: a fine-needle aspiration study. Diagn Cytopathol 1996; 14(1): 3842.Google Scholar
Elsheikh, TM, Cochand-Priollet, B, Hong, SWSidawy, MK. Benign. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Harvey, AM, Truong, LD, Mody, DR. Diagnostic pitfalls of Hashimoto’s/lymphocytic thyroiditis on fine-needle aspirations and strategies to avoid overdiagnosis. Acta Cytol 2012; 56(4): 352360.Google Scholar
Jayaram, G, Marwaha, RK, Gupta, RK, Sharma, SK. Cytomorphologic aspects of thyroiditis. A study of 51 cases with functional, immunologic and ultrasonographic data. Acta Cytol 1987; 31(6): 687693.Google Scholar
Lerma, E, Arguelles, R, Rigla, M, et al. Comparative findings of lymphocytic thyroiditis and thyroid lymphoma. Acta Cytol 2003; 47(4): 575580.CrossRefGoogle ScholarPubMed
Lui, LH, Bakhos, R, Wojcik, EM. Concomitant papillary carcinoma and Hashimoto’s thyroiditis. Semin Diagn Pathol 2001; 18(2): 99103.Google Scholar
MacDonald, K, Yazdi, HM. Fine needle aspiration biopsy of Hashimoto’s thyroiditis. Sources of diagnostic error. Acta Cytol 1999; 43(3): 400406.Google Scholar
Nguygen, GK, Ginsberg, J, Crockford, PMVillanueva, RR. Hashimoto’s thyroiditis: cytodiagnostic accuracy and pitfalls. Diagn Cytopathol 1997; 16(6): 531536.3.0.CO;2-J>CrossRefGoogle Scholar
Poropatich, C, Marcus, D, Oertel, YC. Hashimoto’s thyroiditis: a fine-needle aspiration of 50 asymptomatic cases. Diagn Cytopathol 1994; 11(2): 141145.Google Scholar
Roh, MH, Jo, VY, Stelow, EB, et al. The predictive value of the fine-needle aspiration diagnosis “Suspicious for a follicular neoplasm, Hürthle cell type” in patients with Hashimoto thyroiditis. Am J Clin Pathol 2011; 135: 139145.Google Scholar
Battan, R, Mariuz, P, Raviglione, M., et al. Pneumocystis carinii infection of the thyroid in a hypothyroid patient with AIDS: Diagnosis by fine needle aspiration biopsy. J Clinical Endocrinol Metab 1991; 72: 724726.Google Scholar
Chi, H, Lee, YJ, Chiu, NC, et al. Acute suppurative thyroiditis in children. Pediatr Infect Dis J 2002; 21(5): 384387.Google Scholar
Elsheikh, TM, Cochand-Priollet, B, Hong, SW, Sidawy, MK. Benign. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Fukata, S, Miyauchi, A, Kuma, K, Sugawara, M. Acute suppurative thyroiditis caused by an infected piriform sinus fistula with thyrotoxicosis. Thyroid 2002; 12(2): 175178.Google Scholar
Hopwood, NJ, Kelch, RP. Thyroid masses. Approach to diagnosis and management in childhood and adolescence. Pediatr Rev 1993; 14: 481487.Google Scholar
Lin, JD, Huang, BY, Huang, HS, et al. Ultrasonography and fine needle aspiration cytology of acute suppurative thyroiditis. Changgeng Yi Xue Za Zhi 1993; 16(2): 9398.Google ScholarPubMed
Nishihara, E, Miyauchi, A, Matsuzuka, F, et al. Acute suppurative thyroiditis after fine-needle aspiration causing thyrotoxicosis. Thyroid 2005; 15(10): 11831187.Google Scholar
Shukla, HS. Fine needle aspiration cytology in the management of acute suppurative thyroiditis. Ear Nose Throat J 1994; 73(6): 415417.Google Scholar
Singh, SK, Agrawal, JK, Kumar, M, et al. Thyroid masses. Approach to diagnosis and management in childhood and adolescence. Pediatr Rev 1993; 14: 481487.Google Scholar
Berger, SA, Zonszein, J, Villamena, P, et al. Infectious diseases of the thyroid gland. Rev Infect Dis 1983; 5: 108122.Google Scholar
Chang, TC, Lai, SM, Wen, CY, Hsiao, YL. Three-dimensional cytomorphology in fine needle aspiration biopsy of subacute thyroiditis. Acta Cytol 2004; 48(2): 155160.Google Scholar
Elsheikh, TM, Cochand-Priollet, B, Hong, SW, Sidawy, MK. Benign. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Garcia Solano, J, Gimenez Bascunana, A, Sola Perez, J, et al. Fine-needle aspiration of subacute granulomatous thyroiditis (De Quervain’s thyroiditis): a clinico-cytologic review of 36 cases. Diagn Cytopathol 1997; 16(3): 214220.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Lu, CP, Chang, TC, Wang, CY, Hsiao, YL. Serial changes in ultrasound-guided needle aspiration cytology in subacute thyroiditis. Acta Cytol 1997; 41(2): 238243.Google Scholar
Ofner, C, Hittmair, A, Kroll, I, et al. Fine needle aspiration cytodiagnosis of subacute (de Quervain’s) thyroiditis in an endemic goitre area. Cytopathology 1994; 5(1): 3340.Google Scholar
Shabb, NS, Salti, I. Subacute thyroiditis: fine-needle aspiration cytology of 14 cases presenting with thyroid nodules. Diagn Cytopathol 2006; 34(1): 1823.CrossRefGoogle ScholarPubMed
Shabb, NS, Tawil, A, Gergeos, F, et al. Multinucleated giant cells in fine-needle aspiration of thyroid nodules: their diagnostic significance. Diagn Cytopathol 1999; 21(5): 307312.Google Scholar
Elsheikh, TM, Cochand-Priollet, B, Hong, SW, Sidawy, MK. Benign. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Harigopal, M, Sahoo, S, Recant, WM, DeMay, RM. Fine-needle aspiration of Riedel’s disease: report of a case and review of the literature. Diagn Cytopathol 2004; 30(3): 193197.Google Scholar
Papi, G, Corrado, S, Carapezzi, C, et al. Riedel’s thyroiditis and fibrous variant of Hashimoto’s thyroiditis a clinicopathological and immunohistochemical study. J Endocrinol Invest 2003; 26(5): 444449.Google Scholar
Papi, G, Corrado, S, Cesinaro, AM, et al. Riedel’s thyroiditis: clinical, pathological and imaging features. Int J Clin Pract 2002; 56(1): 65: 7.Google Scholar
Pusztaszeri, M, Triponez, F, Pache, JC, Bongiovanni, M. Riedel’s thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease? Thyroid 2012; 22(9): 964968.CrossRefGoogle ScholarPubMed
Yasmeen, T, Khan, S, Patel, SG, et al. Clinical case seminar: Riedel’s thyroiditis: report of a case complicated by spontaneous hypoparathyroidism, recurrent laryngeal nerve injury, and Horner’s syndrome. J Clin Endocrinol Metab 2002; 87(8): 35433547.Google Scholar
Anderson, SR, Mandel, S, LiVolsi, VA, et al. Can cytomorphology differentiate between benign nodules and tumors arising in Graves’ disease? Diagn Cytopathol 2004; 31(1): 6467.Google Scholar
Cantalamessa, L, Baldini, M, Orsatti, A, et al. Thyroid nodules in Graves’, disease and the risk of thyroid carcinoma. Arch Intern Med 1999; 159(15): 17051708.Google Scholar
Carnell, NE, Valente, WA. Thyroid nodules in Graves’ disease: classification, characterization, and response to treatment. Thyroid 1998; 8(7): 571576.CrossRefGoogle ScholarPubMed
Centeno, BA, Szyfelbein, WM, Daniels, GH, Vickery, AL. Fine-needle aspiration biopsy of the thyroid gland in patients with prior Graves’ disease treated with radioactive iodine: morphologic findings and potential pitfalls. Acta Cytol. 1996; 40:11891197.Google Scholar
Das, DK. Marginal vacuoles (fire-flare appearance) in fine needle aspiration smears of thyroid lesions: Does it represent diffusing out of thyroid hormones at the base of follicular cells? Diagn Cytopathol 2006; 34(4): 277283.Google Scholar
Elsheikh, TM, Cochand-Priollet, B, Hong, SW, Sidawy, MK. Benign. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Jayaram, G, Singh, B, Marwaha, RK. Graves’ disease. Appearance in cytologic smears from fine needle aspirates of the thyroid gland. Acta Cytol 1989; 33(1): 3640.Google Scholar
Liel, Y, Zirkin, HJ, Sobel, RJ. Fine needle aspiration of the hot thyroid nodule. Acta Cytol 1988; 32(6): 866867.Google Scholar
Sahin, M, Guvener, ND, Ozer, F, et al. Thyroid cancer in hyperthyroidism: incidence rates and value of ultrasound-guided fine-needle aspiration biopsy in this patient group. J Endocrinol Invest 2005; 28(9): 815818.Google Scholar
Slowinska-Klencka, D, Klencki, M, Sporny, S, et al. Cytologic appearance of toxic nodular goiter after thyrostatic treatment. A karyometric study. Anal Quant Cytol Histol 2003; 25(1): 3946.Google Scholar
Wang, CY, Chang, TJ, Chang, TC, et al. Thyroidectomy or radioiodine? The value of ultrasonography and cytology in the assessment of nodular lesions in Graves’ hyperthyroidism. Am Surg 2001; 67(8): 721726.Google Scholar
Cibas, ES. Thyroid. In: Cibas, ES, Ducatman, BS, eds. Cytology: Diagnostic Principles and Clinical Correlates, 3rd edn. Philadelphia, PA: Saunders Elsevier: 2009.Google Scholar
Lucas, A, Sanmarti, A, Salinas, I, et al. Amyloid goiter. Diagnosis by fine-needle aspiration biopsy of the thyroid. J Endocrinol Invest 1989; 12(1): 4346.CrossRefGoogle ScholarPubMed
Nijhawan, VS, Marwaha, RK, Sahoo, M, Ravishankar, L. Fine needle aspiration cytology of amyloid goiter. A report of four cases. Acta Cytol 1997; 41(3): 830834.Google Scholar
Alexander, EK, Kennedy, GC, Baloch, ZW, et al. Preoperative diagnosis of benign thyroid nodules with indeterminate cytology. N Engl J Med 2012; 367(8): 705715.Google Scholar
Banizs, AB, Silverman, JF. The utility of combined mutation analysis and microRNA classification in reclassifying cancer risk of cytologically indeterminate thyroid nodules. Diagn Cytopathol 2018; 47(4): 268274.Google Scholar
Bongiovanni, M, Krane, JF, Cibas, ES, Faquin, WC. The atypical thyroid fine-needle aspiration: past, present, and future. Cancer Cytopathol 2012; 120(2): 7386.Google Scholar
Chen, JC, Pace, SC, Chen, BA, et al. Yield of repeat fine-needle aspiration biopsy and rate of malignancy in patients with atypia or follicular lesion of undetermined significance: the impact of the Bethesda System for Reporting Thyroid Cytopathology. Surgery 2012; 152(6): 10371044.CrossRefGoogle ScholarPubMed
Duick, DS, Klopper, J, Diggans, JC, et al. The impact of benign gene expression classifier test results on the endocrinologist-patient decision to operate on patients with thyroid nodules with indeterminate FNA cytopathology. Thyroid 2012; 22(10): 9961001.Google Scholar
Hodak, SP, Rosenthal, DS. American Thyroid Association Clinical Affairs Committee. Information for clinicians: commercially available molecular diagnosis testing in the evaluation of thyroid nodule fine-needle aspiration specimens. Thyroid 2013; 23(2): 131134.Google Scholar
Johnson, DN, Cavallo, AB, Uraizee, I, et al. A proposal for separation of nuclear atypia and architectural atypia in Bethesda Category III (AUS/FLUS) based on differing rates of thyroid malignancy. Am J Clin Pathol 2019; 151(1): 8694.Google Scholar
Krane, J, Nayar, R, Renshaw, A. Atypia of undetermined significance / follicular lesion of undetermined significance. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Labourier, E, Shifrin, A, Busseniers, AE, et al. Molecular testing for miRNA, mRNA, and DNA on fine-needle aspiration improves the preoperative diagnosis of thyroid nodules with indeterminate cytology. J Clin Endocrinol Metab 2015; 100:743750.Google Scholar
Lim, JXY, Nga, ME, Chan, DKH, et al. Subclassification of Bethesda atypical and follicular neoplasm categories according to nuclear and architectural atypia improves discrimination of thyroid malignancy risk. Thyroid 2018; 28:1121.Google Scholar
Nikiforov, YE, Ohori, NP, Hodak, SP, et al. Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples. J Clin Endocrinol Metab 2011; 96(11): 33903397.Google Scholar
Nikiforova, MN, Mercurio, S, Wald, AI, et al. Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules. Cancer 2018; 124(8): 16821690.Google Scholar
Renshaw, AA. Subclassification of atypical cells of undetermined significance in direct smears of fine-needle aspirations of the thyroid: distinct patterns and associated risk of malignancy. Cancer Cytopathol 2011; 119(5): 322327.CrossRefGoogle ScholarPubMed
Rosario, PW, Calsolari, MR. Importance of cytological subclassification of thyroid nodules with Bethesda category III cytology (AUS/FLUS) into architectural atypia only and nuclear atypia: a prospective study. Diagn Cytopathol 2017; 45:04607.Google Scholar
Shi, Y, Ding, X, Klein, M, et al. Thyroid fine-needle aspiration with atypia of undetermined significance: a necessary or optional category? Cancer 2009; 117(5): 298304.Google ScholarPubMed
Sistrunk, JW, Shifrin, A, Frager, M, et al. Clinical impact of testing for mutations and microRNAs in thyroid nodules. Diagn Cytopathol 2019; 47:58764.Google Scholar
Baloch, ZW, Fleisher, S, LiVolsi, VA, Gupta, PK. Diagnosis of “follicular neoplasm”: a gray zone in thyroid fine-needle aspiration cytology. Diagn Cytopathol 2002; 26(1): 4144.Google Scholar
Barbaro, D, Simi, U, Lopane, P, et al. Thyroid nodules with microfollicular findings reported on fine-needle aspiration: invariably surgical treatment? Endocr Pract 2001; 7(5): 352357.Google Scholar
Deandrea, M, Ragazzoni, F, Motta, M, et al. Diagnostic value of a cytomorphological subclassification of follicular patterned thyroid lesions: a study of 927 consecutive cases with histological correlation. Thyroid 2010; 20(10): 10771083.Google Scholar
Ersoz, C, Firat, P, Uguz, A, Kuzey, GM. Fine-needle aspiration cytology of solitary thyroid nodules: how far can we go in rendering differential cytologic diagnoses? Cancer 2004; 102(5): 302307.Google Scholar
Faquin, WC, Wong, LQ, Afrogheh, AH, et al. Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in The Bethesda System for Reporting Thyroid Cytopathology. Cancer Cytopathol 2016; 124:81–7.Google Scholar
Giordano, TJ. Genomic hallmarks of thyroid neoplasia. Annu Rev Pathol Mech Dis 2018; 13: 141–62.Google Scholar
Giordano, TJ, Beaudenon-Huibregtse, S, Shinde, R, et al. Molecular testing for oncogenic gene mutations in thyroid lesions: a case-control validation study in 413 postsurgical specimens. Hum Pathol 2014; 45(7): 13391347.Google Scholar
Giorgadze, T, Rossi, ED, Fadda, G, et al. Does the fine-needle aspiration diagnosis of “Hürthle-cell neoplasm/follicular neoplasm with oncocytic features” denote increased risk of malignancy? Diagn Cytopathol 2004; 31(5): 307312.CrossRefGoogle ScholarPubMed
Greaves, TS, Olvera, M, Florentine, BD, et al. Follicular lesions of thyroid: a 5-year fine-needle aspiration experience. Cancer 2000; 90(6): 335341.Google Scholar
Henry, MR, Westra, WH, Krane, JF. Follicular neoplasm/suspicious for follicular neoplasm. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Johnson, DN, Furtado, LV, Long, B, et al. Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs) are genetically and biologically similar to adenomatous nodules and distinct from papillary thyroid carcinomas with extensive follicular growth. Arch Pathol Lab Med 2018; 142(7): 838850.Google Scholar
Krane, JF, Alexander, EK, Cibas, ES, Barletta, JA. Coming to terms with NIFTP: A provisional approach for cytologists. Cancer 2016; 124(11): 767772.Google Scholar
LiVolsi, V, et al. Follicular thyroid carcinoma. In: Lloyd, RV, Osamura, RY, Klöppel, G, Rosai, J, eds. WHO Classification of Tumours of Endocrine Organs, 4th edn. Lyon, France: IARC, 2017: 9295.Google Scholar
Najafian, A, Noureldine, S, Azar, F, et al. RAS mutations, and RET/PTC and PAX8/PPAR-gamma chromosomal rearrangements are also prevalent in benign thyroid lesions: implications thereof and a systematic review. Thyroid 2017; 27(1): 3948.Google Scholar
Schulten, H-J, Salama, S, Al-Ahmadi, A, et al. Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population. Anticancer Res 2013; 33(11): 47794784.Google Scholar
Sidawy, MK, Del Vecchio, DM, Knoll, SM. Fine-needle aspiration of thyroid nodules: correlation between cytology and histology and evaluation of discrepant cases. Cancer 1997; 81(4): 253259.Google Scholar
Tulecke, MA, Wang, HH. ThinPrep for cytologic evaluation of follicular thyroid lesions: correlation with histologic findings. Diagn Cytopathol 2004; 30(1): 713.Google Scholar
Wu, HH. The impact of NIFTP on FNA cytology: Can we still diagnose papillary thyroid carcinoma? J Basic Clin Med 2017; 6(1): 6162.Google Scholar
Zeppa, P, Benincasa, G, Lucariello, A, Palombini, L. Association of different pathologic processes of the thyroid gland in fine needle aspiration samples. Acta Cytol 2001; 45(3): 347352.Google Scholar
Alaedeen, DI, Khiyami, A, McHenry, CR. Fine-needle aspiration biopsy specimen with a predominance of Hürthle cells: a dilemma in the management of nodular thyroid disease. Surgery 2005; 138(4): 650656: discussion 656–657.Google Scholar
Blumenfeld, W, Nair, R, Mir, R. Diagnostic significance of papillary structures and intranuclear inclusions in Hürthle-cell neoplasms of the thyroid. Diagn Cytopathol 1999; 20(4): 185189.Google Scholar
Faquin, WC, Michael, CW, Renshaw, A, Vielh, P. Fine-needle aspiration biopsy of Hürthle cell lesions of the thyroid gland: a cytomorphologic study of 139 cases with statistical analysis. Cancer 2006; 108(2): 102109.Google Scholar
Faquin, WC, Michael, CW, Renshaw, AA, Vielh, P. Follicular neoplasm, Hürthle cell type / suspicious for a follicular neoplasm, Hürthle cell type. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Giorgadze, T, Rossi, ED, Fadda, G, et al. Does the fine-needle aspiration diagnosis of “Hürthle -cell neoplasm/follicular neoplasm with oncocytic features” denote increased risk of malignancy? Diagn Cytopathol 2004; 31(5): 307312.Google Scholar
Gonzalez, JL, Wang, HH, Ducatman, BS. Fine-needle aspiration of Hürthle cell lesions. A cytomorphologic approach to diagnosis. Am J Clin Pathol 1993; 100(3): 231235.Google Scholar
Kini, SR, Miller, JM, Hamburger, JI. Cytopathology of Hürthle cell lesions of the thyroid gland by fine needle aspiration. Acta Cytol 1981; 25(6): 647652.Google Scholar
LiVolsi, V, et al. Follicular thyroid carcinoma. In: Lloyd, RV, Osamura, RY, Klöppel, G, Rosai, J, eds. WHO Classification of Tumours of Endocrine Organs, 4th edn. Lyon, France: IARC, 2017: 9295.Google Scholar
Nguyen, GK, Husain, M, Akin, MR. Cytodiagnosis of benign and malignant Hürthle cell lesions of the thyroid by fine-needle aspiration biopsy. Diagn Cytopathol 1999; 20(5): 261265.Google Scholar
Renshaw, AA. Hürthle cell carcinoma is a better gold standard than Hürthle cell neoplasm for fine-needle aspiration of the thyroid: defining more consistent and specific cytologic criteria. Cancer 2002; 96(5): 261266.Google Scholar
Roh, MH, Jo, VY, Stelow, EB, et al. The predictive value of the fine-needle aspiration diagnosis “suspicious for a follicular neoplasm, Hürthle cell type” in patients with Hashimoto thyroiditis. Am J Clin Pathol 2011; 135(1): 139145.Google Scholar
Yang, YJ, Khurana, KK. Diagnostic utility of intracytoplasmic lumen and transgressing vessels in evaluation of Hürthle cell lesions by fine-needle aspiration. Arch Pathol Lab Med 2001; 125(8): 10311035.Google Scholar
Castro-Gomez, L, Cordova-Ramirez, S, Duarte-Torres, R, et al. Cytologic criteria of cystic papillary carcinoma of the thyroid. Acta Cytol 2003; 47(4): 590594.Google Scholar
Chhieng, DC, Cohen, JM, Cangiarella, JF. Cytology and immunophenotyping of low- and intermediate-grade B-cell non-Hodgkin’s lymphomas with a predominant small-cell component: a study of 56 cases. Diagn Cytopathol 2001; 24(2): 9097.Google Scholar
Faquin, WC, Cibas, ES, Renshaw, AA. “Atypicalcells in fine-needle aspiration biopsy specimens of benign thyroid cysts. Cancer 2005; 105(2): 7179.Google Scholar
Granter, SR, Cibas, ES. Cytologic findings in thyroid nodules after 131iodine treatment of hyperthyroidism. Am J Clin Pathol 1997; 107: 2025.Google Scholar
Hodak, SP, Rosenthal, DS. American Thyroid Association Clinical Affairs Committee. Information for clinicians: commercially available molecular diagnosis testing in the evaluation of thyroid nodule fine-needle aspiration specimens. Thyroid 2013; 23(2): 131134.Google Scholar
Johnson, DN, Furtado, LV, Long, B. Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs) are genetically and biologically similar to adenomatous nodules and distinct from papillary thyroid carcinomas with extensive follicular growth. Arch Pathol Lab Med 2018; 142(7): 838850.Google Scholar
Lerma, E, Arguelles, R, Rigla, M. et al. Comparative findings of lymphocytic thyroiditis and thyroid lymphoma. Acta Cytol 2003; 47(4): 575580.Google Scholar
Mahajan, A, Lin, X, Nayar, R. Thyroid Bethesda reporting category, ‘suspicious for papillary thyroid carcinoma’, pitfalls and clues to optimize the use of this category. Cytopathology 2013; 24(2): 8591.Google Scholar
Renshaw, AA. “Histiocytoid” cells in fine-needle aspirations of papillary carcinoma of the thyroid: frequency and significance of an under-recognized cytologic pattern. Cancer 2002; 96(4): 240243.Google Scholar
VanderLaan, PA, Chandra, A, Filie, AC, et al., Suspicious for malignancy. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Wang, HH, Filie, AC, Clark, DP, Powers, CNSuspicious for malignancy. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 1st edn. New York: Springer, 2010: 7590.Google Scholar
Weber, D, Brainard, J, Chen, L. Atypical epithelial cells, cannot exclude papillary carcinoma, in fine needle aspiration of the thyroid. Acta Cytol 2008; 52(3): 320324.Google Scholar
Zhang, Y, Fraser, JL, Wang, HH. Morphologic predictors of papillary carcinoma on fine-needle aspiration of the thyroid with ThinPrep preparations. Diagn Cytopathol 2001; 24(6): 378383.Google Scholar
Brandwein-Gensler, M, Urken, M, Wang, B. Collision tumor of the thyroid: a case report of metastatic liposarcoma plus papillary thyroid carcinoma. Head Neck 2004; 26(7): 637641.Google Scholar
Chuah, KL, Hwang, JS, Ng, SB, et al. Cytologic features of cribriform-morular variant of papillary carcinoma of the thyroid: a case report. Acta Cytol 2005; 49(1): 7580.Google Scholar
Das, DK, Mallik, MK, Sharma, P, et al. Papillary thyroid carcinoma and its variants in fine needle aspiration smears. A cytomorphologic study with special reference to tall cell variant. Acta Cytol 2004; 48(3): 325336.Google Scholar
Das, DK, Sharma, PN. Diagnosis of papillary thyroid carcinoma in fine needle aspiration smears: factors that affect decision making. Acta Cytol 2009; 53(5): 497506.Google Scholar
Khurana, KK, Truong, LD, LiVolsi, VA, Baloch, ZW. Cytokeratin 19 immunolocalization in cell block preparation of thyroid aspirates. An adjunct to fine-needle aspiration diagnosis of papillary thyroid carcinoma. Arch Pathol Lab Med 2003; 127(5): 579583.Google Scholar
Mesonero, CE, Jugle, JE, Wilbur, DC, Nayar, R. Fine-needle aspiration of the macrofollicular and microfollicular subtypes of the follicular variant of papillary carcinoma of the thyroid. Cancer 1998; 84(4): 235244.Google Scholar
Moreira, AL, Waisman, J, Cangiarella, JF. Aspiration cytology of the oncocytic variant of papillary adenocarcinoma of the thyroid gland. Acta Cytol 2004; 48(2): 137141.Google Scholar
Ohori, NP, Schoedel, KE. Cytopathology of high-grade papillary thyroid carcinomas: tall-cell variant, diffuse sclerosing variant, and poorly differentiated papillary carcinoma. Diagn Cytopathol 1999; 20(1): 1923.Google Scholar
Pusztaszeri, MP, Auger, M, Stelow, EB, et al. Papillary thyroid carcinoma and variants. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Solomon, A, Gupta, P. Baloch, Z, LiVolsi, V. Distinguishing tall cell variant of papillary thyroid carcinoma from usual variant of papillary thyroid carcinoma in cytologic specimens. Diagn Cytopathol 2002; 27(3): 143148.Google Scholar
Wu, HH, Jones, JN, Grzybicki, DM, Elsheikh, TM. Sensitive cytologic criteria for the identification of follicular variant of papillary thyroid carcinoma in fine-needle aspiration biopsy. Diagn Cytopathol 2003; 29(5): 262266.Google Scholar
Ylagan, LR, Dehner, LP, Huettner, PC, Lu, D. Columnar cell variant of papillary thyroid carcinoma. Report of a case with cytologic findings. Acta Cytol 2004; 48(1): 7377.Google Scholar
Aulicino, MR, Szporn, AH, Dembitzer, R, et al. Cytologic findings in the differential diagnosis of C-cell hyperplasia and medullary carcinoma by fine needle aspiration. A case report. Acta Cytol 1998; 42(4): 963967.Google Scholar
Cakir, M, Altunbas, H, Balci, MK, et al. Medullary thyroid carcinoma, follicular variant. Endocr Pathol 2002; 13(1): 7579.Google Scholar
Dedivitis, RA, Di Giovanni, JH, Silva, GF, et al. [Oncocytic variant of medullary thyroid carcinoma: case report]. Arq Bras Endocrinol Metabol 2004; 48(2): 315317.Google Scholar
Duskova, J, Janotova, D, Svobodova, E, et al. Fine needle aspiration biopsy of mixed medullary-follicular thyroid carcinoma. A report of two cases. Acta Cytol 2003; 47(1): 7177.Google Scholar
Dustin, SM, Jo, VY, Hanley, KZ, Stelow, EB. High sensitivity and positive predictive value of fine-needle aspiration for uncommon thyroid malignancies. Diagn Cytopathol 2012; 40(5): 416421.Google Scholar
Forrest, CH, Frost, FA, de Boer, WB, et al. Medullary carcinoma of the thyroid: accuracy of diagnosis of fine-needle aspiration cytology. Cancer 1998; 84(5): 295302.Google Scholar
Ibarrola de, AC, Castellano Megias, VM, Ballestin Carcavilla, C, et al. Hepatic metastases from the spindle cell variant of medullary thyroid carcinoma: report of a case with diagnosis by fine needle aspiration biopsy. Acta Cytol 2001; 45(6): 10221026.Google Scholar
Kakudo, K, Miyauchi, A, Ogihara, T, et al. Medullary carcinoma of the thyroid. Giant cell type. Arch Pathol Lab Med 1978; 102(9): 445–7.Google Scholar
Kini, SR, Miller, JM, Hamburger, JI, et al. Cytopathologic features of medullary carcinoma of the thyroid. Arch Pathol Lab Med 1984; 108: 156159.Google Scholar
Nishino, M, Pusztaszeri, MP, Pitman, MB. Medullary thyroid carcinoma and variants. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Pigman, MB, Oertel, YC, Geisinger, KR. Medullary thyroid carcinoma. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 1st edn. New York: Springer, 2010, 117128.Google Scholar
Trimboli, P, Rossi, F, Baldelli, R, et al. Measuring calcitonin in washout of the needle in patients undergoing fine needle aspiration with suspicious medullary thyroid cancer. Diagn Cytopathol 2012; 40(5): 394398.Google Scholar
Bongiovanni, M, Fadda, G, Faquin, WC. Poorly differentiated thyroid carcinoma. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Guiter, GE, Auger, M, Ali, SZ, et al. Cytopathology of insular carcinoma of the thyroid. Cancer 1999; 87(4): 196202.Google Scholar
Kuhel, WI, Kutler, DI, Santos-Buch, CA. Poorly differentiated insular thyroid carcinoma. A case report with identification of intact insulae with fine needle aspiration biopsy. Acta Cytol 1998; 42(4): 991997.Google Scholar
Layfield, LJ, Gopez, EV. Insular carcinoma of the thyroid: report of a case with intact insulae and microfollicular structures. Diagn Cytopathol 2000; 23(6): 409413.Google Scholar
Pereira, EM, Maeda, SA, Alves, F, Schmitt, FC. Poorly differentiated carcinoma (insular carcinoma) of the thyroid diagnosed by fine needle aspiration (FNA). Cytopathology 1996; 7(1): 6165.Google Scholar
Pietribiasi, F, Sapino, A, Papotti, M, Bussolati, G. Cytologic features of poorly differentiated ‘insular’ carcinoma of the thyroid, as revealed by fine-needle aspiration biopsy. Am J Clin Pathol 1990; 94(6): 687692.Google Scholar
Sironi, M, Collini, P, Cantaboni, A. Fine needle aspiration cytology of insular thyroid carcinoma. A report of four cases. Acta Cytol 1992; 36(3): 435439.Google Scholar
Bauman, ME, Tao, LC. Cytopathology of papillary carcinoma of the thyroid with anaplastic transformation. A case report. Acta Cytol 1995; 39(3): 525529.Google Scholar
Cameselle-Teijeiro, J, Febles-Perez, C, Sobrinho-Simoes, M. Cytologic features of fine needle aspirates of papillary and mucoepidermoid carcinoma of the thyroid with anaplastic transformation. A case report. Acta Cytol 1997; 41(4 Suppl): 13561360.Google Scholar
Dustin, SM, Jo, VY, Hanley, KZ, Stelow, EB. High sensitivity and positive predictive value of fine-needle aspiration for uncommon thyroid malignancies. Diagn Cytopathol 2012; 40(5): 416421.Google Scholar
Fortson, JK, Durden, FL Jr, Patel, V, Darkeh, A. The coexistence of anaplastic and papillary carcinomas of the thyroid: a case presentation and literature review. Am Surg 2004; 70(12): 11161119.Google Scholar
Guarda, LA, Peterson, CE, Hall, W, Baskin, HJ. Anaplastic thyroid carcinoma: cytomorphology and clinical implications of fine-needle aspiration. Diagn Cytopathol 1991; 7(1): 6367.Google Scholar
Kumar, PV, Torabinejad, S, Omrani, GH. Osteoclastoma-like anaplastic carcinoma of the thyroid gland diagnosed by fine needle aspiration cytology. Report of two cases. Acta Cytol 1997; 41(4 Suppl): 13451348.Google Scholar
Luze, T, Totsch, M, Bangerl, I, et al. Fine needle aspiration cytodiagnosis of anaplastic carcinoma and malignant haemangioendothelioma of the thyroid in an endemic goitre area. Cytopathology 1990; 1(5): 305310.Google Scholar
Mai, DD, Mai, KT, Shamji, FM. Fine needle aspiration biopsy of anaplastic thyroid carcinoma developing from a Hürthle cell tumor: a case report. Acta Cytol 2001; 45(5): 761764.Google Scholar
Saunders, CA, Nayar, R. Anaplastic spindle-cell squamous carcinoma arising in association with tall-cell papillary cancer of the thyroid: A potential pitfall. Diagn Cytopathol 1999; 21(6): 413418.Google Scholar
Staerkel, GA, Bishop, JA,. Shidham, VB, Zarka, MA. Undifferentiated (anaplastic) thyroid carcinoma. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Staerkel, GA, Ljung, BE, Shidham, V, Frable, WJ, Rosai, J. Undifferentiated (anaplastic) carcinoma and squamous cell carcinoma of the thyroid. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 1st edn. New York: Springer, 2018: 139152.Google Scholar
Al-Marzooq, YM, Chopra, R, Younis, M, et al. Thyroid low-grade B-cell lymphoma (MALT type) with extreme plasmacytic differentiation: report of a case diagnosed by fine-needle aspiration and flow cytometric study. Diagn Cytopathol 2004; 31(1): 5256.Google Scholar
Cha, C, Chen, H, Westra, WH, Udelsman, R. Primary thyroid lymphoma: can the diagnosis be made solely by fine-needle aspiration? Ann Surg Oncol. 2002; 9(3): 298302.Google Scholar
Das, DK, Gupta, SK, Francis, IM, Ahmed, MS. Fine-needle aspiration cytology diagnosis of non-Hodgkin lymphoma of thyroid: a report of four cases. Diagn Cytopathol 1993; 9(6): 639645.Google Scholar
Dustin, SM, Jo, VY, Hanley, KZ, Stelow, EB. High sensitivity and positive predictive value of fine-needle aspiration for uncommon thyroid malignancies. Diagn Cytopathol 2012; 40(5): 416421.Google Scholar
Gupta, N, Nijhawan, R, Srinivasan, R, et al. Fine needle aspiration cytology of primary thyroid lymphoma: a report of ten cases. Cytojournal 2005; 9(2): 21.Google Scholar
Layfield, LJ, Kakudo, K. Metastatic tumors, lymphomas and rare tumors of the thyroid. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Layfield, LJ, Waisman, J, Atkins, KA. Metastatic tumors and lymphomas. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 1st edn. New York: Springer, 2018: 153166.Google Scholar
Lu, JY, Lin, CW, Chang, TC, Chen, YC. Diagnostic pitfalls of fine-needle aspiration cytology and prognostic impact of chemotherapy in thyroid lymphoma. J Formos Med Assoc 2001; 100(8): 519525.Google Scholar
Matsuzuka, F, Miyauchi, A, Katayama, S, et al. Clinical aspects of primary thyroid lymphoma: diagnosis and treatment based on our experience of 119 cases. Thyroid 1993; 3(2): 9399.Google Scholar
Morgen, EK, Geddie, W, Boerner, S, et al. The role of fine-needle aspiration in the diagnosis of thyroid lymphoma: a retrospective study of nine cases and review of published series. J Clin Pathol 2010; 63(2): 129133.Google Scholar
Sangalli, G, Serio, G, Zampatti, C, et al. Fine needle aspiration cytology of primary lymphoma of the thyroid: a report of 17 cases. Cytopathology 2001; 12(4): 257263.Google Scholar
Bozbora, A, Barbaros, U, Kaya, H, et al. Thyroid metastasis of malignant melanoma. Am J Clin Oncol 2005; 28(6): 642643.Google Scholar
Hanna, WC, Ponsky, TA, Trachiotis, GD, Knoll, SM. Colon cancer metastatic to the lung and the thyroid gland. Arch Surg 2006; 141(1): 9396.Google Scholar
Kihara, M, Yokomise, H, Yamauchi, A. Metastasis of renal cell carcinoma to the thyroid gland 19 years after nephrectomy: a case report. Auris Nasus Larynx 2004; 31(1): 95100.Google Scholar
Layfield, LJ, Kakudo, K. Metastatic tumors, lymphomas and rare tumors of the thyroid. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 2nd edn. New York: Springer, 2018.Google Scholar
Layfield, LJ, Waisman, J, Atkins, KA. Metastatic tumors and lymphomas. In: Ali, SZ, Cibas, ES, eds. The Bethesda System for Reporting Thyroid Cytopathology, 1st edn. New York: Springer, 2010: 153166.Google Scholar
Loo, CK, Burchett, IJ. Fine needle aspiration biopsy of neuroendocrine breast carcinoma metastatic to the thyroid. A case report. Acta Cytol 2003; 47(1): 8387.Google Scholar
Maly, A, Meir, K, Maly, B. Isolated carcinoid tumor metastatic to the thyroid gland: report of a case initially diagnosed by fine needle aspiration cytology. Acta Cytol 2006; 50(1): 8487.Google Scholar
Michelow, PM, Leiman, G. Metastases to the thyroid gland: diagnosis by aspiration cytology. Diagn Cytopathol 1995; 13(3): 209213.Google Scholar
Nenkov, R, Radev, R, Hristosov, K, et al. Locally advanced papillary thyroid carcinoma with coexistent metastasis from hepatocellular carcinoma in the thyroid gland and parathyroid adenoma. Thyroid 2005; 15(12): 14151416.Google Scholar
Owens, CL, Basaria, S, Nicol, TL. Metastatic breast carcinoma involving the thyroid gland diagnosed by fine-needle aspiration: a case report. Diagn Cytopathol 2005; 33(2): 110115.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×