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  • Print publication year: 2007
  • Online publication date: August 2009

3 - MHC class I and II pathways for presentation and cross-presentation of bacterial antigens

from I - Dendritic cells and their role in immunity

Summary

DENDRITIC CELLS PRIME ANTI-BACTERIAL CD4+ AND CD8+ T CELLS IN VIVO

It is now widely accepted that dendritic cells (DCs) are crucially required for the priming of T cell responses. Major histo-compatibility complex (MHC) class I and class II presentation pathways ensure the priming of CD8+ and CD4+ T cell, respectively. They thus represent major checkpoints for the induction of adaptative protective immunity toward intracellular bacteria. In this chapter, we will focus on the basic cell biology and physiological regulation of these pathways in the context of bacterial infection. In accordance with the literature, we will refer to “cross presentation” for MHC class I pathways involved in the presentation of non cytosolic antigens.

Listeria, Mycobacteria and Salmonella were shown to actually infect DCs in situ. Some studies have addressed the capacity of DCs purified from infected animals to activate in vitro T cells specific for bacteria-encoded antigens. Intravenous infection of mice with Salmonella and with Mycobacterium bovis BCG (bacillus Calmette-Guérin) leads to the infection of both spleen DC subsets (CD8α CD11c+ and CD8α+ CD11c+). Both subsets display some MHC class I and II complexes formed after the processing of bacteria-encoded antigens. Bacterial infection may also promote apoptosis, resulting in the delivery of bacterial antigens to DCs upon the phagocytosis of infected apoptotic bodies (see Section 3.5).

Whatever may be the mechanism (infection or dead cells cross presentation), the absolute requirement of DCs to induce anti-bacterial T cell priming was elegantly demonstrated in the Listeria model.

REFERENCES
Banchereau, J.et al. (1998). Nature 392(6673), 245–52
Guermonprez, P.et al. (2002). Ann. Rev. Immunol. 20, 620–67
Kolb-Maurer, A.et al. (2000). Infect Immun. 68(6), 3680–8
Pron, B.et al. (2001). Cell Microbiol. 3(5), 331–40
Bodnar, K. A.et al. (2001). Infect. Immun. 69(2), 800–9
Tailleux, L.et al. (2003). J. Exp. Med. 197(1), 121–7
Jiao, X.et al. (2002). J. Immunol. 168(3), 1294–301
Hopkins, S. A.et al. (2000). Cell Microbiol. 2(1), 59–68
Niedergang, F.et al. (2000). Proc. Natl Acad. Sci. U S A 97(26), 14650–5
Yrlid, U.et al. (2002). J. Immunol. 169(1), 108–16
Svensson, M.et al. (2000). Infect. Immun. 68(11), 6311–20
Johansson, C.et al. (2004). J. Immunol. 172(4), 2496–503
Yrlid, B. U.et al. (2000). J. Exp. Med. 191(4), 613–24
Lenz, L. L.et al. (2000). J. Exp. Med. 192(8), 1135–42
Jung, S.et al. (2002). Immunity 17(2), 211–20
Yewdell, J. W.et al. (2003). Nat. Rev. Immunol. 3(12), 952–61
Rock, K. L.et al. (2004). Nat. Immunol. 5(7), 670–7
Kloetzel, P. M. (2004). Nat. Immunol. 5(7), 661–9
Cresswell, P. (2000). Traffic 1(4), 301–5
Macagno, A.et al. (1999). Eur. J. Immunol. 29(12), 4037–42
Lelouard, H.et al. (2002). Nature 417(6885), 177–82
Lelouard, H.et al. (2004). J. Cell Biol. 164(5), 667–75
Canadien, V.et al. (2005). J. Immunol. 174(5), 2471–5
Gil-Torregrosa, B. C.et al. (2004). Eur. J. Immunol. 34(2), 398–407
Ackerman, A. L.et al. (2003). J. Immunol. 170(8), 4178–88
Cella, M.et al. (1999). J. Exp. Med. 189(5), 821–9
Rescigno, M.et al. (1998). Proc. Natl Acad. Sci. U S A 95(9), 5229–34
Delamarre, L.et al. (2003). J. Exp. Med. 198(1), 111–22
Pamer, E. G. (2004). Nat. Rev. Immunol. 4(10), 812–23
Pamer, E. G.et al. (1997). Immunol. Rev. 158, 129–36
Villanueva, M. S.et al. (1994). Immunity 1(6), 479–89
Villanueva, M. S.et al. (1995). J. Immunol. 155(11), 5227–33
Princiotta, M. F.et al. (2003). Immunity 18(3), 343–54
Sijts, A. J.et al. (1997). J. Biol. Chem. 272(31), 19261–8
Shen, H.et al. (1998). Cell 92(4), 535–45
Nakagawa, I.et al. (2004). Science 306(5698), 1037–40
Ogawa, M.et al. (2005). Science 307(5710), 727–31
Rich, K. A.et al. (2003). Cell Microbiol. 5(7), 455–68
Portnoy, D. A.et al. (1989). J. Exp. Med. 170(6), 2141–6
Tvinnereim, A. R.et al. (2004). J. Immunol. 173(3), 1994–2002
Higgins, D. E.et al. (1999). Mol. Microbiol. 31(6), 1631–41
Hess, J.et al. (1998). Proc. Natl Acad. Sci. U S A 95(9), 5299–304
Russmann, H.et al. (1998). Science 281(5376), 565–8
Guermonprez, P.et al. (1999). J. Immunol. 162(4), 1910–16
Pfeifer, J. D.et al. (1993). Nature 361(6410), 359–62
Cheadle, E. J.et al. (2005). Infect. Immun. 73(2), 784–94
Winter, N.et al. (1995). Vaccine 13(5), 471–8
Faassen, H.et al. (2004). J. Immunol. 172(6), 3491–500
Dudani, R.et al. (2002). J. Immunol. 168(11), 5737–45
Wick, M. J.et al. (1996). Eur. J. Immunol. 26(11), 2790–9
Shen, L.et al. (2004). Immunity 21(2), 155–65
Harding, C. V.et al. (1994). J. Immunol. 153(11), 4925–33
Song, R.et al. (1996). J. Immunol. 156(11), 4182–90
Chefalo, P. J.et al. (2003). J. Immunol. 170(12), 5825–33
Chefalo, P. J.et al. (2001). J. Immunol. 167(3), 1274–82
MacAry, P. A.et al. (2001). Proc. Natl Acad. Sci. U S A 98(7), 3982–7
Kleijmeer, M. J.et al. (2001). Traffic 2(2), 124–37
Turley, S. J.et al. (2000). Science 288(5465), 522–7
Lizee, G.et al. (2003). Nat. Immunol. 4(11), 1065–73
McCluskey, J.et al. (1986). EMBO J. 5(10), 2477–83
Vega, M. A.et al. (1989). Proc. Natl Acad. Sci. U S A 86(8), 2688–92
Kleijmeer, M.et al. (2001). J. Cell Biol. 155(1), 53–63
Chow, A.et al. (2002). Nature 418(6901), 988–94
Boes, M.et al. (2002). Nature 418(6901), 983–8
Svensson, M.et al. (1999). Eur. J. Immunol. 29(1), 180–8
Brumell, J. H.et al. (2002). Curr. Biol. 12(1), R15–17
Stamm, L. M.et al. (2003). J. Exp. Med. 198(9), 1361–8
McDonough, K. A.et al. (1993). Infect. Immun. 61(7), 2763–73
Roy, D.et al. (2004). Science 304(5676), 1515–18
Beuzon, C. R.et al. (2000). EMBO. J. 19(13), 3235–49
Teitelbaum, R.et al. (1999). Proc. Natl Acad. Sci. U S A 96(26), 15190–5
Kovacsovics-Bankowski, M.et al. (1995). Science 267(5195), 243–6
Sousa, C. Reis eet al. (1995). J. Exp. Med. 182(3), 841–51
Oh, Y. K.et al. (1997). Vaccine 15(5), 511–18
Norbury, C. C.et al. (1995). Immunity 3(6), 783–91
Norbury, C. C.et al. (1997). Eur. J. Immunol. 27(1), 280–8
Rodriguez, A.et al. (1999). Nat. Cell Biol. 1(6), 362–8
West, M. A.et al. (2004). Science 305(5687), 1153–7
Blander, J. M.et al. (2004). Science 304(5673), 1014–18
Shiratsuchi, A.et al. (2004). J. Immunol. 172(4), 2039–47
Gagnon, E.et al. (2002). Cell 110(1), 119–31
Garin, J.et al. (2001). J. Cell Biol. 152, 165–80
Guermonprez, P.et al. (2003). Nature 425(6956), 397–402
Ackerman, A. L.et al. (2003). Proc. Natl Acad. Sci. USA 100(22), 12889–94
Tsai, B.et al. (2002). Nat. Rev. Mol. Cell Biol. 3(4), 246–55
Tortorella, D.et al. (2000). Annu. Rev. Immunol. 18, 861–926
Wiertz, E. J.et al. (1996). Nature 384(6608), 432–8
Tirosh, B.et al. (2003). J. Biol. Chem. 278(9), 6664–72
Lilley, B. N.et al. (2004). Nature 429(6994), 834–40
Ye, Y.et al. (2004). Nature 429(6994), 841–7
Ye, Y.et al. (2001). Nature 414(6864), 652–6
Houde, M.et al. (2003). Nature 425(6956), 402–6
Ackerman, A. L.et al. (2005). Nat. Immunol. 6(1), 107–13
Roy, C. R. (2005). Proc. Natl Acad. Sci. U S A 102(5), 1271–2
Celli, J.et al. (2003). J. Exp. Med. 198(4), 545–56
Celli, J.et al. (2004). Curr. Opin. Microbiol. 7(1), 93–7
Nagai, H.et al. (2002). Science 295(5555), 679–82
Kagan, J. C.et al. (2004). J. Exp. Med. 199(9), 1201–11
McNew, J. A.et al. (2000). Nature 407(6801), 153–9
Becker, T.et al. (2005). Proc. Natl Acad. Sci. U S A 102(11), 4022–6
Trombetta, E. S.et al. (2005). Annu. Rev. Immunol. 23, 975–1028
Wilson, N. S.et al. (2005). Adv. Immunol. 86, 241–305
Lutz, M. B.et al. (1997). J. Immunol. 159(8), 3707–16
Pierre, P.et al. (1998). Cell 93(7), 1135–45
Trombetta, E. S.et al. (2003). Science 299(5611), 1400–3
Wilson, N. S.et al. (2004). Blood 103(6), 2187–95
Delamarre, L.et al. (2005). Science 307(5715), 1630–4
Ramachandra, L.et al. (1999). J. Immunol. 162(6), 3263–72
Ramachandra, L.et al. (2000). J. Immunol. 164(10), 5103–12
Ramachandra, L.et al. (2001). J. Exp. Med. 194(10), 1421–32
Geginat, G.et al. (2001). J. Immunol. 166(3), 1877–84
Skoberne, M.et al. (2002). J. Immunol. 168(4), 1854–60
Skoberne, M.et al. (2002). J. Immunol. 169(3), 1410–18
Tewari, M. K.et al. (2005). Nat. Immunol. 6(3), 287–94
Dani, A.et al. (2004). J. Cell Sci. 117(Pt 18), 4219–30
Cuervo, A. M.et al. (1998). J. Mol. Med. 76(1), 6–12
Zhou, D.et al. (2005). Immunity 22(5), 571–81
Paludan, C.et al. (2005). Science 307(5709), 593–6
Dengjel, J.et al. (2005). Proc. Natl Acad. Sci. U S A 102(22), 7922–7
Yoshimori, T. (2004). Biochem. Biophys. Res. Commun. 313(2), 453–8
Macpherson, A. J.et al. (2004). Science 303(5664), 1662–5
Macpherson, A. J.et al. (2000). Science 288(5474), 2222–6
Garcia-Del Portillo, F.et al. (2000). Infect. Immun. 68(5), 2985–91
Scott, C. C.et al. (2003). J. Membr. Biol. 193(3), 137–52
Sturgill-Koszycki, S.et al. (1994). Science 263(5147), 678–81
Vergne, I.et al. (2004). Annu. Rev. Cell Dev. Biol. 20, 367–94
Fratti, R. A.et al. (2001). J. Cell Biol. 154(3), 631–44
Fratti, R. A.et al. (2003). Proc. Natl Acad. Sci. U S A 100(9), 5437–42
Vergne, I.et al. (2003). J. Exp. Med. 198(4), 653–9
Vergne, I.et al. (2005). Proc. Natl Acad. Sci. U S A 102(11), 4033–8
Gordon, A. H.et al. (1994). Infect. Immun. 62(10), 4650–1
Harding, C. V.et al. (2003). Curr. Opin. Immunol. 15(1), 112–19
Ramachandra, L.et al. (2005). Infect. Immun. 73(2), 1097–105
Hmama, Z.et al. (1998). J. Immunol. 161(9), 4882–93
Chan, J.et al. (2004). Clin. Immunol. 110(1), 2–12
Jantsch, J.et al. (2003). Cell Microbiol. 5(12), 933–45
Cheminay, C.et al. (2005). J. Immunol. 174(5), 2892–9
Tobar, J. A.et al. (2004). J. Immunol. 173(6), 4058–65
Tailleux, L.et al. (2003). J. Immunol. 170(4), 1939–48
Neild, A. L.et al. (2003). Immunity 18(6), 813–23
Bevan, M. J. (1976). J. Exp. Med. 143(5), 1283–8
Heath, W. R.et al. (2004). Immunol. Rev. 199, 9–26
Yewdell, J. W.et al. (2005). Annu. Rev. Immunol. 23, 651–82
Ramirez, M. C.et al. (2002). J. Immunol. 169(12), 6733–42
Fonteneau, J. F.et al. (2003). Blood 102(13), 4448–55
Guermonprez, P.et al. (2005). Springer Semin. Immunopathol. 26(3), 257–71
Shen, L.et al. (2004). Proc. Natl Acad. Sci. U S A 101(9), 3035–40
Wolkers, M. C.et al. (2004). Science 304(5675), 1314–17
Norbury, C. C.et al. (2004). Science 304(5675), 1318–21
Blachere, N. E.et al. (2005). PLoS Biol. 3(6), e185.
Binder, R. J.et al. (2005). Nat. Immunol. 6(6), 593–9
Srivastava, P. (2002). Nat. Rev. Immunol. 2(3), 185–94
Tobian, A. A.et al. (2004). J. Immunol. 172(9), 5277–86
Schaible, U. E.et al. (2003). Nat. Med. 9(8), 1039–46
Wijburg, O. L.et al. (2002). J. Immunol. 169(6), 3275–83
Wong, P.et al. (2003). Immunity 18(4), 499–511
Janda, J.et al. (2004). J. Immunol. 173(9), 5644–51