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Chapter 10 - Diabetes Mellitus and the Metabolic Syndrome

from Section 2 - Pathophysiology of Obesity

Published online by Cambridge University Press:  24 September 2018

Christopher Bouch
Affiliation:
Leicester Royal Infirmary
Jonathan Cousins
Affiliation:
Hammersmith Hospital
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References

Further Reading

Alberti, KG, Eckel, RH, Grundy, SM, et al. Harmonizing the metabolic syndrome: a joint interim statement. Circulation. 2009;120(16):1640–5.Google Scholar
Berg, AH, Scherer, PE Adipose tissue, inflammation, and cardiovascular disease. Circul Res. 2005;96(9):939–49.Google Scholar
Brownlee, M The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615–25.Google Scholar
Cooper, SA, Whaley-Connell, A, Habibi, J, et al.Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance. Am J Physiol Heart Circul Physiol. 2007;293(4):2009–23.Google Scholar
Dandona, P, Aljada, A, Chaudhuri, A, Mohanty, P, Garg, RMetabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005;111(11):1448–54.Google Scholar
Day, C, Bailey, CJ Obesity in the pathogenesis of type 2 diabetes. Br J Diabetes Vasc Dis. 2011;11(2):5561.Google Scholar
Després, JP, Lemieux, I Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881–7.Google Scholar
Hajer, GR, van Haeften, TW, Visseren, FL Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008;29(24):2959–71.Google Scholar
Kahn, SE, Hull, RL, Utzschneider, KM Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840–6.Google Scholar
Kershaw, EE, Flier, JS Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89(6):2548–56.Google Scholar
Petersen, KF, Shulman, GI Etiology of insulin resistance. Am J Med. 2006;119(5 Suppl 1): S10S16.Google Scholar
Qatanani, M, Lazar, MA Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Develop. 2007;21(12):1443–55.Google Scholar
Redinger, RN The pathophysiology of obesity and its clinical manifestations. Gastroenterol Hepatol. 2007;3(11):856–63.Google Scholar
Shoelson, SE, Lee, J, Goldfine, AB Inflammation and insulin resistance. J Clin Invest. 2006;116(7):1793–801.Google Scholar
Unger, RH Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes. 1995;44(8):863–70.Google Scholar

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