Cardiac Arrest: The Science and Practice of Resuscitation Medicine

doi:10.1017/CBO9780511544828

Cardiac Arrest is the definitive and most comprehensive reference in advanced life support and resuscitation medicine. This new edition brings the reader completely up-to-date with developments in the field, focusing on practical issues of decision making, clinical management and prevention, as well as providing clear explanations of the science informing the practice. The coverage includes information on the latest pharmacotherapeutic options, the latest chest compression techniques and airway management protocols, all backed by clearly explained, evidence-based scientific research. The content is consistent with the latest guidelines for practice in this area, as detailed by the major international governing organisations. This volume is essential reading for all those working in the hospital environments of emergency medicine, critical care, cardiology and anesthesia, as well as those providing care in the pre-hospital setting, including paramedics and other staff from the emergency services.

British Medical Association 1st Prize Winner in the Cardiology category 2008

'… It is a tribute to the editors of this book, and the contributors they have selected, that they have managed to produce a book of enormous quality on the science of resuscitation medicine.'

Source: The Lancet

'This excellent book, the first of its kind in the field of cardiac arrest, provides a balance of theoretical and clinical information. It achieves a level of authority and sophistication well beyond that of the advanced cardiac life support guidelines and will be of considerable use to all those practicing or teaching clinical resuscitation.'

Source: The New England Journal of Medicine

'The book has virtually everything one would ever want to know about the causes of cardiac arrest, the applied physiology, and its treatment. Physicians and nurses involved in the management of critically ill or injured patients should have Cardiac Arrest in their personal libraries for ready reference.'

Source: Resuscitation

'This is an extremely comprehensive text, covering all aspects of the current knowledge of resuscitation medicine. … I would recommend this book to anyone with a major interest in resuscitation.'

Source: British Journal of Anaesthesia

'The first gut feeling on opening this book is the sheer wealth of expertise and knowledge that the authors are sharing with us. … It achieves what it sets out to do in impressive style and can truly claim to be a comprehensive reference in advanced life support and resuscitation medicine.'

Source: Emergency Medicine Journal

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-x
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List of contributors
pp xi-xxvi
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Foreword
pp xxvii-xxx
- By Myron L. Weisfeldt, M.D.
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Preface
pp xxxi-xxxiv
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Part I - Introduction
pp 1-2
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1 - A history of cardiopulmonary resuscitation
pp 3-25
- By Mickey S. Eisenberg, Department of Medicine, University of Washington, Seattle, WA, USA, Peter Baskett, Formerly Department of Anaesthesia, Frenchay Hospital and the Royal Infirmary, Bristol, UK, Douglas Chamberlain, Prehospital Research Unit, School of Medicine, Cardiff University, UK
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2 - The epidemiology of sudden death
pp 26-48
- By Graham Nichol, University of Washington Clinical Trial Center, Seattle, WA, USA, David Baker, University of Washington Clinical Trial Center, Seattle, WA, USA
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Part II - Basic science
pp 49-50
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3 - Global cellular ischemia/reperfusion during cardiac arrest: critical stress responses and the postresuscitation syndrome
pp 51-69
- By Kimm Hamann, Department of Emergency Medicine, University of Chicago, USA, Dave Beiser, Department of Emergency Medicine, University of Chicago, USA, Terry L. Vanden Hoek, Department of Emergency Medicine, University of Chicago, USA
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4 - Genetics, genomics and proteomics in sudden cardiac death
pp 70-89
- By Lesley A. Kane, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA, Silvia G. Priori, Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy and; Department of Cardiology, University of Pavia, Pavia, Italy, Carlo Napolitano, Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy, Dan E. Arking, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA, Jennifer E. Van Eyk, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA; Department of Medicine and Department of Biomedical Engineering, Johns Hopkins Universtiy, Baltimore, USA
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5 - Intracellular signaling during myocardial ischemia
pp 90-100
- By Peter H. Sugden, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, UK
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6 - Electrophysiology of ventricular fibrillation and defibrillation
pp 101-127
- By Wei Xiong, Department of Medicine, Division of Cardiology, Donald W. Reynolds Cardiovascular Clinical Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Gordon F. Tomaselli, Department of Medicine, Division of Cardiology, Donald W. Reynolds Cardiovascular Clinical Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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7 - The neuroendocrine response to global ischemia and reperfusion
pp 128-162
- By Martin W. Dünser, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria, Stefan Jochberger, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria, Karl-Heinz Stadlbauer, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria, Volker Wenzel, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
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8 - Inflammatory and Immunologic responses to ischemia and reperfusion
pp 163-178
- By Jason S. Haukoos, Department of Emergency Medicine, Denver Health Medical Center, Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA, Ronald J. Korthuis, Department of Medical Pharmacology & Physiology and, The Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA, James T. Niemann, Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
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9 - Methodology of laboratory resuscitation research
pp 179-205
- By Menekhem Zviman, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Henry R. Halperin, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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10 - The methodology of clinical resuscitation research
pp 206-215
- By Johan Herlitz, Department of Cardiology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden, Anouk van Alem, Department of Cardiology, Academic Medical Center, Room B2-238, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands, Volker Wenzel, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria, Karl Wegscheider, Institute for Statistics and Econometry, University of Hamburg, Von-Melle-Park 5, 20146 Hamburg, Germany
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11 - The special problem of consent for resuscitation research
pp 216-226
- By Henry R. Halperin, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Douglas Chamberlain, Prehospital Research Unit, School of Medicine, Cardiff University, UK
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Part III - The pathophysiology of global ischemia and reperfusion
pp 227-228
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12 - The etiology of sudden death
pp 229-235
- By Sunil K. Sinha, Johns Hopkins Hospital, B altimore, MD, USA, Arthur J. Moss, University of Rochester Medical Center, Rochester, NY, USA, Hugh G. Calkins, Johns Hopkins Hospital, B altimore, MD, USA
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13 - Global brain ischemia and reperfusion
pp 236-281
- By Brian J. O'Neil, Department of Emergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA, Raymond C. Koehler, Department of Anesthesiology, Johns Hopkins University, Baltimore, MD, USA, Robert W. Neumar, Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA, Uwe Ebmeyer, Klinik für Anaesthesiologie und Intensivtherapie, Otto-von-Guericke Universität, Magdeburg, Germany, Gary S. Krause, Department of Emergency Medicine, Wayne State University, Detroit, MI, USA
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14 - Reperfusion injury in cardiac arrest and cardiopulmonary resuscitation
pp 282-297
- By Thomas Aversano, Johns Hopkins Hospital, Baltimore, MD, USA
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15 - Visceral organ ischemia and reperfusion in cardiac arrest
pp 298-325
- By Kevin R. Ward, Department of Emergency Medicine Virginia Commonwealth University and Virginia Commonwealth University Reanimation Engineering Shock Center, Andreas W. Prengel, Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Ruhr University Hospital, Bochum, Germany
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16 - Mechanisms of forward flow during external chest compression
pp 326-346
- By Henry R. Halperin, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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17 - Hemodynamics of cardiac arrest
pp 347-368
- By Michael P. Frenneaux, Department of Cardiovascular Medicine, University of Birmingham, UK, Stig Steen, epartment of Cardiothoracic Surgery, University Hospital of Lund, Sweden
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18 - Coronary perfusion pressure during cardiopulmonary resuscitation
pp 369-388
- By Karl B. Kern, University of Arizona Sarver Heart Center, Tucson, AZ, USA, James T. Niemann, Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance CA, USA, Stig Steen, Department of Cardiothoracic Surgery, University Hospital of Lund, Sweden
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19 - Methods to improve cerebral blood flow and neurological outcome after cardiac arrest
pp 389-394
- By Uwe Ebmeyer, Klinik fur Anaesthesiologie und Intensivtherapie, Otto-von-Guericke University, Magdeburg, Germany, Laurence M. Katz, Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, Alan D. Guerci, Klinik fur Anaesthesiologie und Intensivtherapie, Otto-von-Guericke University, Magdeburg, Germany
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20 - Pharmacology of cardiac arrest and reperfusion
pp 395-416
- By Tommaso Pellis, The University Laboratory of Physiology, Oxford, UK, Clinical and Medical Affairs, Biosite Incorporated, San Diego, CA, USA, Jasmeet Soar, The University Laboratory of Physiology, Oxford, UK, Clinical and Medical Affairs, Biosite Incorporated, San Diego, CA, USA, Gavin Perkins, The University Laboratory of Physiology, Oxford, UK, Clinical and Medical Affairs, Biosite Incorporated, San Diego, CA, USA, Raúl J. Gazmuri, The University Laboratory of Physiology, Oxford, UK, Clinical and Medical Affairs, Biosite Incorporated, San Diego, CA, USA
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21 - Analysis and predictive value of the ventricular fibrillation waveform
pp 417-425
- By Trygve Eftestøl, Department of Electrical and Computer Engineering, University of Stavanger, Norway, Hans-Ulrich Strohmenger, Department of Anaesthesiology and Critical Care Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria, Colin Robertson, Department of Emergency Medicine, The Royal Infirmary of Edinburgh, UK
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22 - Etiology, electrophysiology, and myocardial mechanics of pulseless electrical activity
pp 426-446
- By Tom P. Aufderheide, Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
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Cardiac Arrest

The Science and Practice of Resuscitation Medicine

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