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  • Cited by 6
  • Print publication year: 2010
  • Online publication date: November 2010

17 - Neuropharmacology in stroke recovery

from Section III. - Treatment Strategies


1. FeeneyDM, SuttonRL. Pharmacotherapy for recovery of function after brain injury. Crit Rev Neurobiol. 1987;3:135–97.
2. FeeneyDM, WeisendMP, KlineAE. Noradrenergic pharmacotherapy, intracerebral infusion and adrenal transplantation promote functional recovery after cortical damage. J Neural Transplant Plast. 1993;4:199–213.
3. GoldsteinLB. Basic and clinical studies of pharmacologic effects on recovery from brain injury. J Neural Transplant Plast. 1993;4:175–92.
4. SchallertT, JonesTA, WeaverMS, et al. Pharmacologic and anatomic considerations in recovery of function. Phys Med Rehabil. 1992;6:375–93.
5. GoldsteinLB. Influence of common drugs and related factors on stroke outcome. Curr Opin Neurol. 1997;10:52–7.
6. JonesTA, SchallertT. Subcortical deterioration after cortical damage: effects of diazepam and relation to recovery of function. Behav Brain Res. 1992; 51: 1–13.
7. RedingM, SolomonB, BoruckiS. The effect of dextroamphetamine on motor recovery after stroke. Neurology. 1995;45(Suppl 4):A222.
8. LiepertJ. Pharmacotherapy in restorative neurology. Current Opin Neurol. 2008; 21: 639–43.
9. de BoissezonX, PeranP, de BoyssonC, et al. Pharmacotherapy of aphasia: Myth or reality? Brain Lang. 2007;102:114–25.
10. CrisostomoEA, DuncanPW, PropstM, et al. Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients. Ann Neurol. 1988;23:94–7.
11. Walker-BatsonD, SmithP, CurtisS, et al. Amphetamine paired with physical therapy accelerates motor recovery after stroke. Further evidence. Stroke. 1995;26:2254–9.
12. SondeL, LökkJ. Effects of amphetamine and/or l-dopa and physiotherapy after stroke: A blinded randomized study. Acta Neurol Scand. 2007;115:55–9.
13. SondeL, NordstromM, NilssonCG, et al. A double-blind placebo-controlled study of the effects of amphetamine and physiotherapy after stroke. Cerebrovasc Dis. 2001;12:253–7.
14. MartinssonL, EksborgS, WahlgrenNG. Intensive early physiotherapy combined with dexamphetamine treatment in severe stroke: A randomized, controlled pilot study. Cerebrovasc Dis. 2003;16:338–45.
15. TreigT, WernerC, SachseM, et al. No benefit from d-amphetamine when added to physiotherapy after stroke: A randomized, placebo-controlled study. Clin Rehabil. 2003;17:590–9.
16. PlatzT, KimIH, EngelU, et al. Amphetamine fails to facilitate motor performance and to enhance motor recovery among stroke patients with mild arm paresis: Interim analysis and termination of a double blind, randomised, placebo-controlled trial. Restor Neurol Neurosci. 2005;23:271–80.
17. GladstoneDJ, DanellsCJ, ArmestoA, et al. Subacute therapy with amphetamine and rehabilitation for stroke study investigators. Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: A randomized, double-blind, placebo-controlled trial. Stroke. 2006;37:179–85.
18. MartinssonL, HårdemarkH, EksborgS. Amphetamines for improving recovery after stroke. Cochrane Database Syst Rev 2007:CD002090. A comprehensive review of published and unpublished studies.
19. Walker-BatsonD, CurtisS, NatarajanR, et al. A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia. Stroke. 2001;32:2093–8.
20. WhitingE, CheneryHJ, ChalkJ, et al. Dexamphetamine boosts naming treatment effects in chronic aphasia. J Int Neuropsychol Soc. 2007;13:972–9.
21. GradeC, RedfordB, ChrostowskiJ, et al. Methylphenidate in early poststroke recovery: a double-blind, placebo-controlled study. Arch Phys Med Rehabil. 1998;79:1047–50.
22. TardyJ, ParienteJ, LegerA, et al. Methylphenidate modulates cerebral post-stroke reorganization. Neuroimage. 2006;33:913–22.
23. ScheidtmannK, FriesW, MullerF, et al. Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke: A prospective, randomized, double-blind study. Lancet. 2001;358:787–90.
24. SondeL, LökkJ. Effects of amphetamine and/or l-dopa and physiotherapy after stroke: a blinded randomized study. Acta Neurol Scand. 2007;115:55–9.
25. FloelA, HummelF, BreitensteinC, et al. Dopaminergic effects on encoding of a motor memory in chronic stroke. Neurology. 2005;65:472–4.
26. RestemeyerC, WeillerC, LiepertJ. No effect of a levodopa single dose on motor performance and motor excitability in chronic stroke. A double-blind placebo-controlled cross-over pilot study. Restor Neurol Neurosci. 2007;25:143–50.
27. RosserN, HeuschmannP, WerschingH, et al. Levodopa improves procedural motor learning in chronic stroke patients. Arch Phys Med Rehabil. 2008;89:1633–41.
28. ZittelS, WeillerC, LiepertJ. Citalopram improves dexterity in chronic stroke patients. Neurorehabil Neural Repair. 2008;22:311–4.
29. DamM, ToninP, De BoniA, et al. Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy. Stroke. 1996;27:1211–4.
30. EnderbyP, BroeckxJ, HospersW, et al. Effect of piracetam on recovery and rehabilitation after stroke: A double-blind, placebo-controlled study. Clin Neuropharmacol. 1994;17:320–31.
31. HuberW, WillmesK, PoeckK, et al. Piracetam as an adjuvant to language therapy for aphasia: A randomized double-blind placebo-controlled pilot study. Arch Phys Med Rehabil. 1997;78:245–50.
32. KesslerJ, ThielA, KarbeH, et al. Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic patients. Stroke. 2000;31:2112–6.
33. GreenerJ, EnderbyP, WhurrR. Pharmacological treatment for aphasia following stroke. Cochrane Database Syst Rev. 2001:CD000424.
34. ZittelS, WeillerC, LiepertJ. Reboxetine improves motor function in chronic stroke: A pilot study. J Neurol. 2007;254:197–201.
35. LaskaAC, von ArbinM, KahanT, et al. Long-term antidepressant treatment with moclobemide for aphasia in acute stroke patients: A randomised, double-blind, placebo-controlled study. Cerebrovasc Dis. 2005;19:125–32.
36. BerthierML, GreenC, HiguerasC, et al. A randomized, placebo-controlled study of donepezil in poststroke aphasia. Neurology. 2006;67:1687–9.
37. RobinsonRG, ShoemakerWJ, SchlumpfM, et al. Effect of experimental cerebral infarction in rat brain on catecholamines and behaviour. Nature. 1975;255:332–4.
38. Gerdelat-MasA, LoubinouxI, TombariD, et al. Chronic administration of selective serotonin reuptake inhibitor (SSRI) paroxetine modulates human motor cortex excitability in healthy subjects. Neuroimage. 2005;27:314–22.
39. LoubinouxI, BoulanouarK, RanjevaJP, et al. Cerebral functional magnetic resonance imaging activation modulated by a single dose of the monoamine neurotransmission enhancers fluoxetine and fenozolone during hand sensorimotor tasks. J Cereb Blood Flow Metab. 1999;19:1365–75.
40. LoubinouxI, ParienteJ, BoulanouarK, et al. A single dose of serotonin neurotransmission agonist paroxetine enhances motor output. A double-blind, placebo-controlled, fMRI study in healthy subjects. NeuroImage. 2002;15:26–36.
41. LoubinouxI, ParienteJ, RascolO, et al. Selective serotonin reuptake inhibitor paroxetine modulates motor behavior through practice. A double-blind, placebo-controlled, multi-dose study in healthy subjects. Neuropsychologia. 2002;40:1815–21.
42. LoubinouxI, TombariD, ParienteJ, et al. Modulation of behavior and cortical motor activity in healthy subjects by a chronic administration of a serotonin enhancer. Neuroimage. 2005;27:299–313.
43. PeranP, DemonetJF, CardebatD. Paroxetine-induced modulation of cortical activity supporting language representations of action. Psychopharmacology (Berl). 2008;195:487–96.
44. ParienteJ, LoubinouxI, CarelC, et al. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol. 2001;50:718–29.
45. TombariD, LoubinouxI, ParienteJ, et al. A longitudinal fMRI study: in recovering and then in clinically stable sub-cortical stroke patients. Neuroimage. 2004;23:827–39.
46. ThickbroomGW, ByrnesML, ArcherSA, et al. Motor outcome after subcortical stroke correlates with the degree of cortical reorganization. Clin Neurophysiol. 2004;115:2144–50.
47. ZittelS, BaumerT, LiepertJ. Modulation of intracortical facilitatory circuits of the human primary motor cortex by digital nerve stimulation. Exp Brain Res. 2007;176:425–31.
48. SawakiL, ButlerAJ, XiaoyanL, et al. Constraint-induced movement therapy results in increased motor map area in subjects 3 to 9 months after stroke. Neurorehabil Neural Repair. 2008;22:505–13.
49. JacobsBL, FornalCA. Serotonin and motor activity. Curr Opin Neurobiol. 1997;7:820–5.
50. BangOY, LeeJS, LeePH, et al. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 2005;57:874–82.
51. MeltzerCC, KondziolkaD, VillemagneVL, et al. Serial [18F] fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke. Neurosurgery. 2001;49:586–91; discussion 91–2.
52. KondziolkaD, SteinbergGK, WechslerL, et al. Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg. 2005;103:38–45.
53. NelsonPT, KondziolkaD, WechslerL, et al. Clonal human (hNT) neuron grafts for stroke therapy: Neuropathology in a patient 27 months after implantation. Am J Pathol. 2002;160:1201–06.
54. KondziolkaD, WechslerL, GoldsteinS, et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology. 2000;55:565–9.
55. KornblumHI. Introduction to neural stem cells. Stroke. 2007;38(2 Suppl):810–6.
56. BlissT, GuzmanR, DaadiM, et al. Cell transplantation therapy for stroke. Stroke. 2007;38(2 Suppl):817–26.
57. DobkinBH. Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke. Stroke. 2007;38(2 Suppl):832–9.
58. SavitzSI, DinsmoreJ, WuJ, et al. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: A preliminary safety and feasibility study. Cerebrovasc Dis. 2005;20:101–07.
59. BakayRA. Neural transplantation. J Neurosurg. 2005;103:6–8; discussion.
60. RedmondDE, Jr, FreemanT. The American Society for Neural Transplantation and Repair Considerations and guidelines for studies of human subjects. The practice committee of the society. Approved by council. Cell Transplant. 2001;10:661–4.