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  • Print publication year: 2010
  • Online publication date: August 2012

6 - Immunobiology of the oligodendrocyte



Oligodendrocytes, as the myelin-producing cells of the central nervous system (CNS), are exactly what their Greek-derived name “oligodendroglia” suggests: they, alongside astrocytes, the non-neural microglia and ependymal cells, have been characterized as the “glue” that holds together the intricate apparatus of our brain. The fact that oligodendrocyte and astrocyte cells outnumber neurons by ten to one illustrates their importance, which is particularly highlighted by the oligodendrocyte's role in accelerating transmission of axonal action potentials. On the other hand, oligodendrocytes are involved in a number of serious diseases of viral, metabolic and immunological origin. This chapter tries to shed light on the immunobiological properties of oligodendroglial cells in the healthy and diseased CNS. We will begin with an overview of diseases featuring oligodendrocyte/immune system interactions and will then, in the second part, focus on the molecular repertoire that allows these cells to interact directly or indirectly with immune cells. Subsequently, we will discuss oligodendrocytes as antigen-presenting cells and finally we will present data on direct oligodendroglial/immune cell interactions.


Multiple sclerosis

Multiple sclerosis (MS), which was first described by the French neurologist Jean-Martin Charcot in 1868 (Charcot, 1868), is a chronic inflammatory disease of the CNS of unknown etiology (Hemmer et al., 2006). Although an ideal system for the classification of different MS stages does not yet exist (Van der Valk and De Groot, 2000) there is broad consensus that loss of myelin due to oligodendrocyte damage or death together with axonal degeneration leading to reactive glial scar formation are the key hallmarks of this disease (Trapp and Nave, 2008).