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5 - The Genetic Background of Atherosclerosis in Ancient Mummies

from Part I - Evidence from Mummified Tissues

Published online by Cambridge University Press:  31 March 2023

By
Albert Zink ,
Christina Wurst ,
Frank Maixner ,
Samuel Wann ,
Randall C. Thompson  and
Gregory S. Thomas
Edited by
Michaela Binder ,
Charlotte A. Roberts  and
Daniel Antoine
Michaela Binder
Affiliation:
Novetus GmbH Archaeological Services
Charlotte A. Roberts
Affiliation:
Durham University
Daniel Antoine
Affiliation:
British Museum, London
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Summary

This chapter aims to outline current knowledge concerning the genetic background of cardiovascular disease (CVD) and its study in ancient human remains. This is demonstrated by the application of a palaeogenetic analysis to the mummy of the Tyrolean Iceman, who presented with both arterial calcifications and a strong genetic predisposition for heart disease. Further discussion highlights how the study of ancient humans can provide new insights into the genetic background of CVD and its intersection with risk factors related to lifestyle.

Type
Chapter
Information
The Bioarchaeology of Cardiovascular Disease , pp. 81 - 97
Publisher: Cambridge University Press
Print publication year: 2023

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