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2 - Dementia with Lewy bodies

Published online by Cambridge University Press:  31 July 2009

By
Caroline A. Racine
Edited by
Bruce L. Miller  and
Bradley F. Boeve
Bruce L. Miller
Affiliation:
University of California, San Francisco
Bradley F. Boeve
Affiliation:
Mayo Foundation, Minnesota
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Summary

Introduction

Dementia with Lewy bodies (DLB) is clinical syndrome characterized by progressive dementia, parkinsonism and neuropsychiatric symptoms (McKeith et al.,2004a). Pathologically, DLB is a synuclein disorder with widespread Lewy body pathology in the brainstem and cerebral cortex. Research has suggested that in individuals over 75 years, DLB is the second most common type of neurodegenerative dementia after Alzheimer's disease (AD). Although prevalent, our understanding of this complex disorder is in its relative infancy. The accurate diagnosis of DLB can be difficult owing to its frequent co-occurrence with AD and perceived similarity to other motor disorders such as Parkinson's disease (PD). However, the identification of individuals with DLB is extremely important because of the potential for life-threatening reactions to neuroleptic medications, and more encouraging, their ability to benefit greatly from treatment with anticholinesterase (AChEI) therapies.

Epidemiology

Epidemiological estimates have suggested that after AD, DLB is the second most common dementia in individuals over 75, with a prevalence rate of approximately 22% (Rahkonen et al., 2003). Similarly, estimates of prevalence based on pathological data have suggested that DLB may represent between 15–35% of all dementia cases (Zaccai et al., 2005), while population-based studies have estimated that DLB accounts for 5% of the population (Rahkonen et al., 2003). In a pathologically confirmed sample, Williams et al. (2006) found that DLB was associated with increased mortality rates compared with AD (hazard ratio = 1.88), with a median survival of 78 years in DLB and 85 years in AD.

Type
Chapter
Information
The Behavioral Neurology of Dementia , pp. 7 - 26
Publisher: Cambridge University Press
Print publication year: 2009

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References

Aarsland, D, Ballard, C, Larsen, JP, McKeith, I. (2001). A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia. Int J Geriatr Psychiatry 16(5): 528–36.CrossRefGoogle ScholarPubMed
Aarsland, D, Perry, R, Larsen, JPet al. (2005). Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias. J Clin Psychiatry 66(5): 633–7.CrossRefGoogle ScholarPubMed
Abbas, N, Lucking, CB, Richard, Set al. (1999). A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. Hum Mol Genet 8(4): 567–74.CrossRefGoogle Scholar
Ala, TA, Hughes, LF, Kyrouac, GAet al. (2001). Pentagon copying is more impaired in dementia with Lewy bodies than in Alzheimer's disease. J Neurol Neurosurg Psychiatry 70(4): 483–8.CrossRefGoogle ScholarPubMed
Allan, L, McKeith, I, Ballard, C, Kenny, RA. (2005). Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias. J Am Geriatr Soc 53(10): 1681–7.CrossRefGoogle ScholarPubMed
Allan, LM, Ballard, CG, Burn, DJ, Kenny, RA. (2006). The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life. Dement Geriatr Cogn Disord 22(3): 230–7.CrossRefGoogle ScholarPubMed
Allan, LM, Ballard, CG, Allan, Jet al. (2007). Autonomic dysfunction in dementia. J Neurol Neurosurg Psychiatry 78: 671–7.CrossRefGoogle ScholarPubMed
Almeida, OP, Burton, EJ, McKeith, Iet al. (2003). MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cogn Disord 16(2): 57–63.CrossRefGoogle ScholarPubMed
Ballard, CG, Grace, J, McKeith, I, Holmes, C. (1997). A detailed phenomenological comparison of complex visual hallucinations in dementia with Lewy bodies and Alzheimer's disease. International Psychogeriatrics 9(4): 381–8.CrossRefGoogle ScholarPubMed
Ballard, CG, McKeith, I, Harrison, Ret al. (1998). Neuroleptic sensitivity in dementia with Lewy bodies and Alzheimer's disease. Lancet 351(9108): 1032–3.CrossRefGoogle ScholarPubMed
Ballard, CG, Piggott, M, Johnson, Met al. (2000). Delusions associated with elevated muscarinic binding in dementia with Lewy bodies. Ann Neurol 48(6): 868–76.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Ballard, CG, Aarsland, D, McKeith, Iet al. (2002). Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology 59(11): 1714–20.CrossRefGoogle ScholarPubMed
Ballard, CG, Perry, RH, McKeith, IG, Perry, EK. (2005). Neuroleptics are associated with more severe tangle pathology in dementia with Lewy bodies. Int J Geriatr Psychiatry 20(9): 872–5.CrossRefGoogle ScholarPubMed
Barber, R, Gholkar, A, Scheltens, Pet al. (1999). Medial temporal lobe atrophy on MRI in dementia with Lewy bodies. Neurology 52(6): 1153–8.CrossRefGoogle ScholarPubMed
Barber, R, McKeith, I, Ballard, C, O'Brien, J. (2002). Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia. J Neurol Neurosurg Psychiatry 72(3): 406–7.CrossRefGoogle ScholarPubMed
Benke, T. (2006). Peduncular hallucinosis: a syndrome of impaired reality monitoring. J Neurol 253(12): 1561–71.CrossRefGoogle ScholarPubMed
Boddy, F, Rowan, EN, Lett, Det al. (2007). Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry 22: 529–35.CrossRefGoogle ScholarPubMed
Boeve, BF, Silber, MH, Ferman, TJet al. (1998). REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. Neurology 51(2): 363–70.CrossRefGoogle ScholarPubMed
Boeve, BF, Silber, MH, Parisi, JEet al. (2001). Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord 16(4): 622–30.CrossRefGoogle ScholarPubMed
Boeve, BF, Silber, MH, Ferman, TJ. (2003). Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 61(1): 40–5.CrossRefGoogle ScholarPubMed
Boeve, BF, Silber, MH, Ferman, TJet al. (2004). REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol 17(3): 146–57.CrossRefGoogle ScholarPubMed
Boeve, BF, Silber, MH, Saper, CBet al. (2007). Pathophysiology of REM sleep behavior disorder and relevance to neurodegenerative disease. Brain 130: 2770–88.CrossRefGoogle ScholarPubMed
Bonelli, SB, Ransmayr, G, Steffelbauer, Met al. (2004). l-Dopa responsiveness in dementia with Lewy bodies, Parkinson disease with and without dementia. Neurology 63: 376–8.CrossRefGoogle ScholarPubMed
Borroni, B, Agosti, C, Padovani, A. (2007). Behavioral and psychological symptoms in dementia with Lewy-bodies (DLB): frequency and relationship with disease severity and motor impairment. Arch Gerontol Geriatr 46: 101–6.CrossRefGoogle ScholarPubMed
Bostrom, F, Jonsson, L, Minthon, L, Londos, E. (2006). Patients with Lewy body dementia use more resources than those with Alzheimer's disease. Int J Geriatr Psychiatry 22: 713–19.CrossRefGoogle Scholar
Bozzali, M, Falini, A, Cercignani, Met al. (2002). White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging. J Neurol Neurosurg Psychiatry 72(6): 742–6.CrossRefGoogle ScholarPubMed
Bozzali, M, Falini, A, Franceschi, Met al. (2005). Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain 128(Pt 7): 1595–604.CrossRefGoogle Scholar
Braak, H, Del Tredici, K, Rub, Uet al. (2003). Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24(2): 197–211.CrossRefGoogle ScholarPubMed
Bradshaw, J, Saling, M, Hopwood, Met al. (2004). Fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease is qualitatively distinct. J Neurol Neurosurg Psychiatry 75(3): 382–7.CrossRefGoogle ScholarPubMed
Briel, RC, McKeith, IG, Barker, WAet al. (1999). EEG findings in dementia with Lewy bodies and Alzheimer's disease. J Neurol Neurosurg Psychiatry 66(3): 401–3.CrossRefGoogle ScholarPubMed
Bullock, R, Cameron, A. (2002). Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson's disease: a case series. Curr Med Res Opin 18(5): 258–64.CrossRefGoogle ScholarPubMed
Burke, WJ, Pfeiffer, RF, McComb, RD. (1998). Neuroleptic sensitivity to clozapine in dementia with Lewy bodies. J Neuropsychiatry Clin Neurosci 10(2): 227–9.CrossRefGoogle ScholarPubMed
Burn, D, Emre, M, McKeith, Iet al. (2003). Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: a cross-sectional comparative study. Mov Disord 18(8): 884–9.CrossRefGoogle ScholarPubMed
Burn, DJ, Rowan, EN, Minett, Tet al. (2006). Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease. Mov Disord 21(11): 1899–907.CrossRefGoogle ScholarPubMed
Burton, EJ, Karas, G, Paling, SMet al. (2002). Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. Neuroimage 17(2): 618–30.CrossRefGoogle ScholarPubMed
Collerton, D, Burn, D, McKeith, I, O'Brien, J. (2003). Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dement Geriatr Cogn Disord 16(4): 229–37.CrossRefGoogle ScholarPubMed
Collerton, D, Perry, E, McKeith, I. (2005). Why people see things that are not there: a novel perception and attention deficit model for recurrent complex visual hallucinations. Behav Brain Sci 28(6): 737–57; discussion 757–94.CrossRefGoogle Scholar
Colloby, SJ, Williams, ED, Burn, DJet al. (2005). Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT. Eur J Nucl Med Mol Imaging 32(10): 1176–85.CrossRefGoogle ScholarPubMed
Corder, EH, Saunders, AM, Strittmatter, WJet al. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261(5123): 921–3.CrossRefGoogle ScholarPubMed
Cormack, F, Aarsland, D, Ballard, C, Tovee, MJ. (2004). Pentagon drawing and neuropsychological performance in dementia with Lewy bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia. Int J Geriatr Psychiatry 19(4): 371–7.CrossRefGoogle ScholarPubMed
Cousins, DA, Burton, EJ, Burn, Det al. (2003). Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI study. Neurology 61(9): 1191–5.CrossRefGoogle ScholarPubMed
Crowell, TA, Luis, CA, Cox, , Mullan, M. (2007). Neuropsychological comparison of Alzheimer's disease and dementia with Lewy bodies. Dement Geriatr Cogn Disord 23(2): 120–5.CrossRefGoogle ScholarPubMed
Del Ser, T, McKeith, I, Anand, Ret al. (2000). Dementia with Lewy bodies: findings from an international multicentre study. Int J Geriatr Psychiatry 15(11): 1034–45.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Doran, M, Larner, AJ. (2004). EEG findings in dementia with Lewy bodies causing diagnostic confusion with sporadic Creutzfeldt–Jakob disease. Eur J Neurol 11(12): 838–41.CrossRefGoogle ScholarPubMed
Ellis, HD, Young, AW, Quayle, AH, Pauw, KW. (1997). Reduced autonomic responses to faces in Capgras delusion. Proc Biol Sci 264(1384): 1085–92.CrossRefGoogle ScholarPubMed
Emre, M. (2003). Dementia associated with Parkinson's disease. Lancet Neurol 2(4): 229–37.CrossRefGoogle ScholarPubMed
Farrer, M, Chan, P, Chen, Ret al. (2001). Lewy bodies and parkinsonism in families with parkin mutations. Ann Neurol 50(3): 293–300.CrossRefGoogle ScholarPubMed
Farrer, M, Kachergus, J, Forno, Let al. (2004). Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann Neurol 55(2): 174–9.CrossRefGoogle ScholarPubMed
Ferman, TJ, Boeve, BF, Smith, GEet al. (1999). REM sleep behavior disorder and dementia: cognitive differences when compared with AD. Neurology 52(5): 951–7.CrossRefGoogle ScholarPubMed
Ferman, TJ, Smith, GE, Boeve, BFet al. (2004). DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology 62(2): 181–7.CrossRefGoogle ScholarPubMed
Ferman, TJ, Smith, GE, Boeve, BFet al. (2006). Neuropsychological differentiation of dementia with Lewy bodies from normal aging and Alzheimer's disease. Clin Neuropsychol 20(4): 623–36.CrossRefGoogle ScholarPubMed
Fernandez, HH, Trieschmann, ME, Burke, MA, Friedman, JH. (2002). Quetiapine for psychosis in Parkinson's disease versus dementia with Lewy bodies. J Clin Psychiatry 63(6): 513–5.CrossRefGoogle ScholarPubMed
Ffytche, DH, Howard, RJ, Brammer, MJet al. (1998). The anatomy of conscious vision: an fMRI study of visual hallucinations. Nat Neurosci 1(8): 738–42.CrossRefGoogle ScholarPubMed
Galasko, D, Saitoh, T, Xia, Yet al. (1994). The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease. Neurology 44(10): 1950–1.CrossRefGoogle ScholarPubMed
Galvin, JE, Lee, SL, Perry, Aet al. (2002). Familial dementia with Lewy bodies: clinicopathologic analysis of two kindreds. Neurology 59(7): 1079–82.CrossRefGoogle ScholarPubMed
Galvin, JE, Pollack, J, Morris, JC. (2006). Clinical phenotype of Parkinson disease dementia. Neurology 67(9): 1605–11.CrossRefGoogle ScholarPubMed
Gasser, T, Wszolek, ZK, Trofatter, Jet al. (1994). Genetic linkage studies in autosomal dominant parkinsonism: evaluation of seven candidate genes. Ann Neurol 36(3): 387–96.CrossRefGoogle ScholarPubMed
Gilman, S, Koeppe, RA, Little, Ret al. (2005). Differentiation of Alzheimer's disease from dementia with Lewy bodies utilizing positron emission tomography with [18F]fluorodeoxyglucose and neuropsychological testing. Exp Neurol 191(Suppl 1): S95–103.CrossRefGoogle Scholar
Gnanalingham, KK, Byrne, EJ, Thornton, Aet al. (1997). Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry 62(3): 243–52.CrossRefGoogle ScholarPubMed
Gomez-Tortosa, E, Newell, K, Irizarry, MCet al. (1999). Clinical and quantitative pathologic correlates of dementia with Lewy bodies. Neurology 53(6): 1284–91.CrossRefGoogle ScholarPubMed
Grace, JB, Walker, MP, McKeith, IG. (2000). A comparison of sleep profiles in patients with dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry 15(11): 1028–33.3.0.CO;2-E>CrossRefGoogle ScholarPubMed
Grundman, M, Petersen, RC, Ferris, SHet al. (2004). Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 61(1): 59–66.CrossRefGoogle ScholarPubMed
Guidi, M, Paciaroni, L, Paolini, Set al. (2006). Differences and similarities in the neuropsychological profile of dementia with Lewy bodies and Alzheimer's disease in the early stage. J Neurol Sci 248(1–2): 120–3.CrossRefGoogle ScholarPubMed
Gwinn-Hardy, K. (2002). Genetics of parkinsonism. Mov Disord 17(4): 645–56.CrossRefGoogle ScholarPubMed
Hamilton, JM, Salmon, DP, Galasko, Det al. (2000). Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol 10(3): 378–84.CrossRefGoogle ScholarPubMed
Hamilton, RL. (2004). A comparison of episodic memory deficits in neuropathologically confirmed dementia with Lewy bodies and Alzheimer's disease. J Int Neuropsychol Soc 10(5): 689–97.CrossRefGoogle ScholarPubMed
Harding, AJ, Broe, GA, Halliday, GM. (2002). Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 125(Pt 2): 391–403.CrossRefGoogle ScholarPubMed
Hashimoto, M, Kitagaki, H, Imamura, Tet al. (1998). Medial temporal and whole-brain atrophy in dementia with Lewy bodies: a volumetric MRI study. Neurology 51(2): 357–62.CrossRefGoogle ScholarPubMed
Hirayama, K, Meguro, K, Shimada, Met al. (2003). [A case of probable dementia with Lewy bodies presenting with geographic mislocation and nurturing syndrome.]No To Shinkei 55(9): 782–9.Google Scholar
Hirstein, W, Ramachandran, VS. (1997). Capgras syndrome: a novel probe for understanding the neural representation of the identity and familiarity of persons. Proc Biol Sci 264(1380): 437–44.CrossRefGoogle ScholarPubMed
Hofer, A, Berg, D, Asmus, Fet al. (2005). The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies. J Neural Transm 112(9): 1249–54.CrossRefGoogle ScholarPubMed
Horimoto, Y, Matsumoto, M, Akatsu, Het al. (2003). Autonomic dysfunctions in dementia with Lewy bodies. J Neurol 250(5): 530–3.CrossRefGoogle ScholarPubMed
Imamura, T, Ishii, K, Hirono, Net al. (1999). Visual hallucinations and regional cerebral metabolism in dementia with Lewy bodies (DLB). Neuroreport 10(9): 1903–7.CrossRefGoogle Scholar
Imamura, T, Ishii, K, Hirono, Net al. (2001). Occipital glucose metabolism in dementia with Lewy bodies with and without Parkinsonism: a study using positron emission tomography. Dement Geriatr Cogn Disord 12(3): 194–7.CrossRefGoogle ScholarPubMed
Ishii, K, Imamura, T, Sasaki, Met al. (1998). Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease. Neurology 51(1): 125–30.CrossRefGoogle ScholarPubMed
Ishii, K, Yamaji, S, Kitagaki, Het al. (1999). Regional cerebral blood flow difference between dementia with Lewy bodies and AD. Neurology 53(2): 413–6.CrossRefGoogle ScholarPubMed
Jankovic, J, McDermott, M, Carter, Jet al. (1990). Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group. Neurology 40(10): 1529–34.CrossRefGoogle ScholarPubMed
Johnson, DK, Morris, JC, Galvin, JE. (2005). Verbal and visuospatial deficits in dementia with Lewy bodies. Neurology 65(8): 1232–8.CrossRefGoogle ScholarPubMed
Kaufer, DI, Catt, KE, Lopez, OL, DeKosky, ST. (1998). Dementia with Lewy bodies: response of delirium-like features to donepezil. Neurology 51(5): 1512.CrossRefGoogle ScholarPubMed
Kaufmann, H, Nahm, K, Purohit, D, Wolfe, D. (2004). Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 63(6): 1093–5.CrossRefGoogle ScholarPubMed
Kopito, RR. (2000). Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10(12): 524–30.CrossRefGoogle ScholarPubMed
Kramer, ML, Schulz-Schaeffer, WJ. (2007). Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 27(6): 1405–10.CrossRefGoogle Scholar
Kraybill, ML, Larson, EB, Tsuang, DWet al. (2005). Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology 64(12): 2069–73.CrossRefGoogle Scholar
Kruger, R, Kuhn, W, Leenders, KLet al. (2001). Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers. Neurology 56(10): 1355–62.CrossRefGoogle ScholarPubMed
Lippa, CF, Smith, TW, Saunders, AMet al. (1995). Apolipoprotein E genotype and Lewy body disease. Neurology 45: 97–103.CrossRefGoogle ScholarPubMed
Lippa, CF, Fujiwara, H, Mann, DMet al. (1998). Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 153(5): 1365–70.CrossRefGoogle ScholarPubMed
Lippa, CF, Duda, JE, Grossman, Met al. (2007). DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology 68(11): 812–9.CrossRefGoogle ScholarPubMed
Litvan, I, MacIntyre, A, Goetz, CGet al. (1998). Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. Arch Neurol 55(7): 969–78.CrossRefGoogle ScholarPubMed
Liu, CW, Giasson, BI, Lewis, KAet al. (2005). A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem 280(24): 22670–8.CrossRefGoogle ScholarPubMed
Lobotesis, K, Fenwick, JD, Phipps, Aet al. (2001). Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD. Neurology 56(5): 643–9.CrossRefGoogle Scholar
Lopez, OL, Becker, JT, Kaufer, DIet al. (2002). Research evaluation and prospective diagnosis of dementia with Lewy bodies. Arch Neurol 59(1): 43–6.CrossRefGoogle ScholarPubMed
Mandal, PK, Pettegrew, JW, Masliah, Eet al. (2006). Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochem Res 31(9): 1153–62.CrossRefGoogle ScholarPubMed
Marantz, AG, Verghese, J. (2002). Capgras' syndrome in dementia with Lewy bodies. J Geriatr Psychiatry Neurol 15(4): 239–41.CrossRefGoogle ScholarPubMed
Marui, W, Iseki, E, Kato, Met al. (2002). Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies. J Neurol Sci 195(2): 153–9.CrossRefGoogle ScholarPubMed
Marui, W, Iseki, E, Nakai, Tet al. (2004). Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease. Acta Neuropathol (Berl) 108(2): 121–8.CrossRefGoogle ScholarPubMed
Masliah, E, Rockenstein, E, Veinbergs, Iet al. (2001). Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci USA 98(21): 12245–50.CrossRefGoogle Scholar
Maurage, CA, Ruchoux, MM, Vos, Ret al. (2003). Retinal involvement in dementia with Lewy bodies: a clue to hallucinations?Ann Neurol 54(4): 542–7.CrossRefGoogle ScholarPubMed
McKeith, IG. (2000). Spectrum of Parkinson's disease, Parkinson's dementia, and Lewy body dementia. Neurol Clin 18(4): 865–902.CrossRefGoogle ScholarPubMed
McKeith, IG. (2002). Dementia with Lewy bodies. Br J Psychiatry 180: 144–7.CrossRefGoogle ScholarPubMed
McKeith, IG, Fairbairn, A, Perry, Ret al. (1992). Neuroleptic sensitivity in patients with senile dementia of Lewy body type. BMJ 305(6855): 673–8.CrossRefGoogle ScholarPubMed
McKeith, IG, Galasko, D, Kosaka, Ket al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47(5): 1113–24.CrossRefGoogle Scholar
McKeith, IG, Ballard, CG, Perry, RHet al. (2000a). Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology 54(5): 1050–8.CrossRefGoogle Scholar
McKeith, IG, Del Sero, T, Spano, Pet al. (2000b). Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 356(9247): 2031–6.CrossRefGoogle ScholarPubMed
McKeith, IG, Mintzer, J, Aarsland, Det al. (2004a). Dementia with Lewy bodies. Lancet Neurol 3(1): 19–28.CrossRefGoogle ScholarPubMed
McKeith, IG, Wesnes, KA, Perry, E, Ferrara, R. (2004b). Hallucinations predict attentional improvements with rivastigmine in dementia with Lewy bodies. Dement Geriatr Cogn Disord 18(1): 94–100.CrossRefGoogle ScholarPubMed
McKeith, IG, Dickson, DW, Lowe, Jet al. (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65(12): 1863–72.CrossRefGoogle ScholarPubMed
McKeith, I, O'Brien, J, Walker, Zet al. (2007). Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol 6(4): 305–13.CrossRefGoogle ScholarPubMed
McNaught, KS, Shashidharan, P, Perl, DPet al. (2002). Aggresome-related biogenesis of Lewy bodies. Eur J Neurosci 16(11): 2136–48.CrossRefGoogle ScholarPubMed
Merdes, AR, Hansen, , Jeste, DVet al. (2003). Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies. Neurology 60(10): 1586–90.CrossRefGoogle ScholarPubMed
Middelkoop, HA, Flier, WM, Burton, EJet al. (2001). Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI. Neurology 57(11): 2117–20.CrossRefGoogle Scholar
Molloy, S, McKeith, IG, O'Brien, JT, Burn, DJ. (2005). The role of levodopa in the management of dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 76(9): 1200–3.CrossRefGoogle ScholarPubMed
Molloy, SA, Rowan, EN, O'Brien, JTet al. (2006). Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 77(12): 1323–8.CrossRefGoogle ScholarPubMed
Mori, E, Shimomura, T, Fujimori, Met al. (2000). Visuoperceptual impairment in dementia with Lewy bodies. Arch Neurol 57(4): 489–93.CrossRefGoogle ScholarPubMed
Mori, T, Ikeda, M, Fukuhara, Ret al. (2006). Correlation of visual hallucinations with occipital rCBF changes by donepezil in DLB. Neurology 66(6): 935–7.CrossRefGoogle ScholarPubMed
Morris, JC, Storandt, M, Miller, JPet al. (2001). Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 58(3): 397–405.CrossRefGoogle ScholarPubMed
Mosimann, UP, Rowan, EN, Partington, CEet al. (2006). Characteristics of visual hallucinations in Parkinson disease dementia and dementia with Lewy bodies. Am J Geriatr Psychiatry 14(2): 153–60.CrossRefGoogle ScholarPubMed
Muenter, MD, Forno, LS, Hornykiewicz, Oet al. (1998). Hereditary form of parkinsonism–dementia. Ann Neurol 43(6): 768–81.CrossRefGoogle ScholarPubMed
Murakami, T, Moriwaki, Y, Kawarabayashi, Tet al. (2007). PINK1, a gene product of PARK6, accumulates in α-synucleinopathy brains. J Neurol Neurosurg Psychiatry 78: 653–4.CrossRefGoogle ScholarPubMed
Murman, DL, Kuo, SB, Powell, MC, Colenda, CC. (2003). The impact of parkinsonism on costs of care in patients with AD and dementia with Lewy bodies. Neurology 61(7): 944–9.CrossRefGoogle ScholarPubMed
Nishijima, K, Ishiguro, T. (1989). [Clinical course and CSF monoamine metabolism in neuroleptic malignant syndrome: a study of nine typical cases and five mild cases.]Seishin Shinkeigaku Zasshi [Psychiatr Neurol Jpn] 91(6): 429–56.Google Scholar
O'Brien, JT, Paling, S, Barber, Ret al. (2001). Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia. Neurology 56(10): 1386–8.CrossRefGoogle ScholarPubMed
Ohara, K, Morita, Y. (2006). [Case with probable dementia with Lewy bodies, who shows reduplicative paramnesia and Capgras syndrome.]Seishin Shinkeigaku Zasshi [Psychiatr Neurol Jpn] 108(7): 705–14.Google Scholar
Oka, H, Morita, M, Onouchi, Ket al. (2007). Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease. J Neurol Sci 254(1–2): 72–7.CrossRefGoogle ScholarPubMed
Olson, EJ, Boeve, BF, Silber, MH. (2000). Rapid eye movement sleep behavior disorder: demographic, clinical and laboratory findings in 93 cases. Brain 123 (Pt 2): 331–9.CrossRefGoogle ScholarPubMed
Pankratz, N, Byder, L, Halter, Cet al. (2006). Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia. Mov Disord 21(1): 45–9.CrossRefGoogle Scholar
Papapetropoulos, S, Lieberman, A, Gonzalez, Jet al. (2006). Family history of dementia: dementia with Lewy bodies and dementia in Parkinson's disease. J Neuropsychiatry Clin Neurosci 18(1): 113–6.CrossRefGoogle ScholarPubMed
Perriol, MP, Dujardin, K, Derambure, Pet al. (2005). Disturbance of sensory filtering in dementia with Lewy bodies: comparison with Parkinson's disease dementia and Alzheimer's disease. J Neurol Neurosurg Psychiatry 76(1): 106–8.CrossRefGoogle ScholarPubMed
Perry, EK, Haroutunian, V, Davis, KLet al. (1994). Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease. Neuroreport 5(7): 747–9.CrossRefGoogle ScholarPubMed
Perry, EK, Morris, CM, Court, JAet al. (1995). Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness. Brain Cogn 28(3): 240–58.CrossRefGoogle ScholarPubMed
Perry, EK, Perry, RH. (1995). Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology. Neuroscience 64(2): 385–95.CrossRefGoogle ScholarPubMed
Petersen, RC, Smith, GE, Waring, SCet al. (1999). Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56(3): 303–8.CrossRefGoogle ScholarPubMed
Piggott, MA, Perry, EK, Marshall, EFet al. (1998). Nigrostriatal dopaminergic activities in dementia with Lewy bodies in relation to neuroleptic sensitivity: comparisons with Parkinson's disease. Biol Psychiatry 44(8): 765–74.CrossRefGoogle ScholarPubMed
Piggott, MA, Ballard, CG, Dickinson, HOet al. (2007). Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia. Int J Neuropsychopharmacol 10(2): 231–44.CrossRefGoogle ScholarPubMed
Pletnikova, O, West, N, Lee, MKet al. (2005). Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiol Aging 26(8): 1183–92.CrossRefGoogle ScholarPubMed
Polymeropoulos, MH, Lavedan, C, Leroy, Eet al. (1997). Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276(5321): 2045–7.CrossRefGoogle ScholarPubMed
Rahkonen, T, Eloniemi-Sulkava, U, Rissanen, Set al. (2003). Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older. J Neurol Neurosurg Psychiatry 74(6): 720–4.CrossRefGoogle ScholarPubMed
Rockwell, E, Choure, J, Galasko, Det al. (2000). Psychopathology at initial diagnosis in dementia with Lewy bodies versus Alzheimer disease: comparison of matched groups with autopsy-confirmed diagnoses. Int J Geriatr Psychiatry 15(9): 819–23.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Rosenberg, CK, Cummings, TJ, Saunders, AMet al. (2001). Dementia with Lewy bodies and Alzheimer's disease. Acta Neuropathol (Berl) 102(6): 621–6.CrossRefGoogle ScholarPubMed
Rowan, E, McKeith, IG, Saxby, BKet al. (2007). Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies. Dement Geriatr Cogn Disord 23(3): 161–7.CrossRefGoogle ScholarPubMed
Sadek, J, Rockwood, K. (2003). Coma with accidental single dose of an atypical neuroleptic in a patient with Lewy body dementia. Am J Geriatr Psychiatry 11(1): 112–3.CrossRefGoogle Scholar
Saito, Y, Ruberu, NN, Sawabe, Met al. (2004). Lewy body-related alpha-synucleinopathy in aging. J Neuropathol Exp Neurol 63(7): 742–9.CrossRefGoogle Scholar
Sakakibara, R, Ito, T, Uchiyama, Tet al. (2005). Lower urinary tract function in dementia of Lewy body type. J Neurol Neurosurg Psychiatry 76(5): 729–32.CrossRefGoogle ScholarPubMed
Santhouse, AM, Howard, RJ, ffytche, DH (2000). Visual hallucinatory syndromes and the anatomy of the visual brain. Brain 123(Pt 10): 2055–64.CrossRefGoogle ScholarPubMed
Sauer, J, ffytche, DH, Ballard, Cet al. (2006). Differences between Alzheimer's disease and dementia with Lewy bodies: an fMRI study of task-related brain activity. Brain 129(Pt 7): 1780–8.CrossRefGoogle ScholarPubMed
Schenck, CH, Bundlie, SREttinger, MG, Mahowald, MW. (2002). REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep 25(2): 120–38.CrossRefGoogle ScholarPubMed
Schenck, CH, Mahowald, MW (2002). Chronic behavioral disorders of human REM sleep: a new category of parasomnia. 1986 [classical article]. Sleep 25(2): 293–308.Google Scholar
Schlossmacher, MG, Frosch, MP, Gai, WPet al. (2002). Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol 160(5): 1655–67.CrossRefGoogle ScholarPubMed
Schmidt, ML, Martin, JA, Lee, VM, Trojanowski, JQ. (1996). Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders. Acta Neuropathol (Berl) 91(5): 475–81.CrossRefGoogle ScholarPubMed
Scott, WK, Vance, JM, Haines, JL, Pericak-Vance, MA. (2002). Linkage of parkinsonism and Alzheimer's disease with Lewy body pathology to chromosome 12. Ann Neurol 52(4): 524; author reply 524.CrossRefGoogle ScholarPubMed
Sechi, G, Agnetti, V, Masuri, Ret al. (1996). Acute hyponatremia and neuroleptic malignant syndrome in Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 20(3): 533–42.CrossRefGoogle ScholarPubMed
Sechi, G, Manca, S, Deiana, GAet al. (2000). Risperidone, neuroleptic malignant syndrome and probable dementia with Lewy bodies. Prog Neuropsychopharmacol Biol Psychiatry 24(6): 1043–51.CrossRefGoogle ScholarPubMed
Simard, M, Reekum, R, Cohen, T. (2000). A review of the cognitive and behavioral symptoms in dementia with Lewy bodies. J Neuropsychiatry Clin Neurosci 12(4): 425–50.CrossRefGoogle ScholarPubMed
Singleton, A, Gwinn-Hardy, K, Sharabi, Yet al. (2002). Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies. Dement Geriatr Cogn Disord 14(4): 167–75.CrossRefGoogle ScholarPubMed
Singleton, AB, Wharton, A, O'Brien, KKet al. (2004). Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication. Brain 127(Pt 4): 768–72.CrossRefGoogle ScholarPubMed
Stavitsky, K, Brickman, AM, Scarmeas, Net al. (2006). The progression of cognition, psychiatric symptoms, and functional abilities in dementia with Lewy bodies and Alzheimer disease. Arch Neurol 63(10): 1450–6.CrossRefGoogle ScholarPubMed
Suzuki, M, Kurita, A, Hashimoto, Met al. (2006). Impaired myocardial 123I-metaiodobenzylguanidine uptake in Lewy body disease: comparison between dementia with Lewy bodies and Parkinson's disease. J Neurol Sci 240(1–2): 15–19.CrossRefGoogle ScholarPubMed
Tan, A, Salgado, M, Fahn, S. (1996). Rapid eye movement sleep behavior disorder preceding Parkinson's disease with therapeutic response to levodopa. Mov Disord 11(2): 214–6.CrossRefGoogle Scholar
Thaisetthawatkul, P, Boeve, BF, Benarroch, EEet al. (2004). Autonomic dysfunction in dementia with Lewy bodies. Neurology 62(10): 1804–9.CrossRefGoogle ScholarPubMed
Thomas, DA, Libon, DJ, Ledakis, GE. (2005). Treating dementia patients with vascular lesions with donepezil: a preliminary analysis. Appl Neuropsychol 12(1): 12–18.CrossRefGoogle ScholarPubMed
Tiraboschi, P, Hansen, , Alford, Met al. (2000). Cholinergic dysfunction in diseases with Lewy bodies. Neurology 54(2): 407–11.CrossRefGoogle ScholarPubMed
Trembath, Y, Rosenberg, C, Ervin, JFet al. (2003). Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease. Acta Neuropathol (Berl) 105(5): 484–8.Google ScholarPubMed
Tsuang, DW, Dalan, AM, Eugenio, CJet al. (2002). Familial dementia with Lewy bodies: a clinical and neuropathological study of 2 families. Arch Neurol 59(10): 1622–30.CrossRefGoogle ScholarPubMed
Tsuang, DW, Wilson, RK, Lopez, OLet al. (2005). Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology 64(3): 509–13.CrossRefGoogle ScholarPubMed
Valente, EM, Bentivoglio, AR, Dixon, PHet al. (2001). Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35–p36. Am J Hum Genet 68(4): 895–900.CrossRefGoogle ScholarPubMed
Walker, MP, Ayre, GA, Cummings, JLet al. (2000a). The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale. Two methods to assess fluctuating confusion in dementia. Br J Psychiatry 177: 252–6.CrossRefGoogle ScholarPubMed
Walker, MP, Ayre, GA, Cummings, JLet al. (2000b). Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia. Neurology 54(8): 1616–25.CrossRefGoogle ScholarPubMed
Wenning, GK, Scherfler, C, Granata, Ret al. (1999). Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study. J Neurol Neurosurg Psychiatry 67(5): 620–3.CrossRefGoogle ScholarPubMed
Wesnes, KA, McKeith, I, Edgar, Cet al. (2005). Benefits of rivastigmine on attention in dementia associated with Parkinson disease. Neurology 65(10): 1654–6.CrossRefGoogle ScholarPubMed
Whitwell, JL, Weigand, SD, Shiung, MMet al. (2007). Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain 130(Pt 3): 708–19.CrossRefGoogle ScholarPubMed
Williams, MM, Xiong, C, Morris, JC, Galvin, JE. (2006). Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology 67(11): 1935–41.CrossRefGoogle ScholarPubMed
Yamamoto, T, Imai, T. (1988). A case of diffuse Lewy body and Alzheimer's diseases with periodic synchronous discharges. J Neuropathol Exp Neurol 47(5): 536–48.CrossRefGoogle ScholarPubMed
Yokota, O, Terada, S, Ishizu, Het al. (2002). NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). Acta Neuropathol (Berl) 104(4): 333–41.Google Scholar
Yoshita, M, Taki, J, Yokoyama, Ket al. (2006). Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD. Neurology 66(12): 1850–4.CrossRefGoogle ScholarPubMed
Zaccai, J, McCracken, C, Brayne, C. (2005). A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing 34(6): 561–6.CrossRefGoogle ScholarPubMed
Zarranz, JJ, Alegre, J, Gomez-Esteban, JCet al. (2004). The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55(2): 164–73.CrossRefGoogle ScholarPubMed

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