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  • Print publication year: 2013
  • Online publication date: May 2013

28 - Active and passive avoidance

from Section 5 - Learning and memory
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Behavioral Genetics of the Mouse
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Adriani, W., Felici, A., Sargolini, F., Roullet, P., Usiello, A., Oliverio, A., et al. (1998) N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes. Exp Brain Res 123: 52–59.
Alleva, E. and D’Udine, B. (1988) Early learning capability in rodents: a review. Int J CompPsychol Winter Issue: 107–125.
Ashe, V.M. and McCain, G. (1972) Comparison of one-way and shuttle-avoidance performance of gerbils and rats. J Comp Physiol Psychol 80: 293–296.
Bammer, G. (1982) Pharmacological investigations of neurotransmitter involvement in passive avoidance responding: a review and some new results. Neurosci Biobehav Rev 6: 247–296.
Barros, D.M., Mello, E., Souza, T., de Souza, M.M., Choi, H., DeDavid, E, et al. (2001) LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance. Behav Pharmacol 12: 629–634.
Benus, R.F., Bohus, B., Koolhaas, J.M., and van Oortmerssen, G.A. (1990) Behavioural strategies of aggressive and non-aggressive male mice in response to inescapable shock. Behav Process 21: 127–141.
Bignami, G. (1964) Effects of benactyzine and adiphenine on instrumental avoidance conditioning in a shuttle-box. Psychopharmacologia 5: 264–279.
Bignami, G. (1976) Nonassociative explanations of behavioral changes induced by central cholinergic drugs. Acta Neurobiol Exp (Wars) 36: 5–90.
Bignami, G., Alleva, E., Amorico, L., De Acetis, L., and Giardini, V. (1985) Bidirectional avoidance by mice as a function of CS, US, and apparatus variables. Anim Learn Behav 13: 439–450.
Bignami, G. and Michalek, H. (1978) Cholinergic mechanisms and aversively motivated behaviors. In Anisman, H. and Bignami, G. (eds.), Psychopharmacology of Aversively Motivated Behavior. Plenum Press, New York, pp. 173–255.
Bolles, R.C. (1970) Species-specific defense reactions and avoidance learning. Psychol Rev 71: 32–48.
Bovet, D., Bovet-Nitti, F., and Oliverio, A. (1969) Genetic aspects of learning and memory in mice. Science 163: 139–149.
Brambilla, R., Gnesutta, N., Minichiello, L., White, G., Roylance, A.J., Herron, C.E., et al. (1997) A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 390: 281–286.
Branchi, I., Bichler, Z., Minghetti, L., Delabar, J.M., Malchiodi-Albedi, F., Gonzalez, M.C., et al. (2004) Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol 63: 429–440.
Branchi, I. and Ricceri, L. (2002) Transgenic and knock-out mouse pups: the growing need for behavioral analysis. Genes Brain Behav 1: 135–141.
Brown, R.E., Stanford, L., and Schellinnck, H.M. (2000) Developing standardized behavioral tests for knockout and mutant mice. ILAR J 41: 163–173.
Buselmaier, W., Geiger, S., and Reichert, W. (1978) Monogene inheritance of learning speed in DBA and C3H mice. A behavioral genetic study in the shuttle-box. Hum Genet 40: 209–214.
Cabib, S., Puglisi-Allegra, S., and Ventura, R. (2002) The contribution of comparative studies in inbred strains of mice to the understanding of the hyperactive phenotype. Behav Brain Res 130: 103–109.
Calamandrei, G., Pennazza, S., Ricceri, L., and Valanzano, A. (1996a) Neonatal exposure to anti-nerve growth factor antibodies affects exploratory behavior of developing mice in the hole board. Neurotoxicol Teratol 18: 141–146.
Calamandrei, G., Ricceri, L., and Valanzano, A. (1996b) Systemic administration of anti-NGF antibodies to neonatal mice impairs 24-h retention of an inhibitory avoidance task while increasing ChAT immunoreactivity in the medial septum. Behav Brain Res 78: 81–91.
Capone, F., Puopolo, M., Branchi, I., and Alleva, E. (2002) A new easy accessible and low-cost method for screening olfactory sensitivity in mice: behavioural and nociceptive response in male and female CD-1 mice upon exposure to millipede aversive odour. Brain Res Bull 58: 193–202.
Clark, M.G., Vasilevsky, S., and Myers, T.M. (2003) Air and shock two-way shuttlebox avoidance in C57BL/6J and 129X1/SvJ mice. Physiol Behav 78: 117–123.
Crawley, J.N. and Paylor, R. (1997) A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm Behav 31: 197–211.
Dumery, V., Derer, P., and Blozovski, D. (1988) Enhancement of passive avoidance learning through small doses of intra-amygdaloid physostigmine in the young rat. Its relation to the development of acetylcholinesterase. Dev Psychobiol 21: 553–565.
Eclancher, F. and Karli, P. (1980) Effects of infant and adult amygdaloid lesions upon acquisition of two-way active avoidance by the adult rat: influence of rearing conditions. Physiol Behav 24: 887–893.
Everitt, B.J. and Robbins, T.W. (1997) Central cholinergic systems and cognition. Annu Rev Psychol 48: 649–684.
Galvani, P.F., Riddell, W.I., and Foster, K.M. (1975) Passive avoidance in rats and gerbils as a function of species-specific exploratory tendencies. Behav Biol 13: 277–290.
Garcia, J. and Koelling, R.A. (1966) Relation of cue to consequence in avoidance learning. Psychonomic Sci 4: 123–124.
Gerlai, R. and Clayton, N.S. (1999) Analysing hippocampal function in transgenic mice: an ethological perspective. Trends Neurosci 22: 47–51.
Griebel, G., Belzung, C., Perrault, G., and Sanger, D.J. (2000) Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice. Psychopharmacology (Berl) 148: 164–170.
Holmes, T.M., Aksel, R., and Royce, J.R. (1974) Inheritance of avoidance behavior in Mus musculus. Behav Genet 4: 357–371.
Huang, Y.Y., Bach, M.E., Lipp, H.P., Zhuo, M., Wolfer, D.P., Hawkins, R.D., et al. (1996) Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. Proc Natl Acad Sci USA 93: 8699–8704.
Jarrard, L.E. (1976) Anatomical and behavioral analysis of hippocampal cell fields in rats. J Comp Physiol Psychol 90: 1035–1050.
Jeong, Y.H., Park, C.H., Yoo, J., Shin, K.Y., Ahn, S.M., Kim, H.S., et al. (2006) Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model. FASEB J 20: 729–731.
Kamil, A.C. and Mauldin, J.E. (1988) A comparative-ecological approach to the study of learning. In Bolles, R.C. and Beecher, M.D. (eds.), Evolution and Learning. Lawrence Erlbaum Associates, Hillsdale, NJ, USA, pp. 117–133.
King, S.L., Marks, M.J., Grady, S.R., Caldarone, B.J., Koren, A.O., Mukhin, A.G., et al. (2003) Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. J Neurosci 23: 3837–3843.
Kobayashi, K. and Sano, H. (2000) Dopamine deficiency in mice. Brain Dev 22 (Suppl 1): S54–60.
Leanza, G., Nilsson, O.G., Wiley, R.G., and Bjorklund, A. (1995) Selective lesioning of the basal forebrain cholinergic system by intraventricular 192 IgG-saporin: behavioural, biochemical and stereological studies in the rat. Eur J Neurosci 7: 329–343.
Levine, S. (1966) UCS intensity and avoidance learning. J Exp Psychol 71: 163–164.
Lipp, H.P., Schwegler, H., Crusio, W.E., Wolfer, D.P., Heimrich, B., Driscoll, P., et al. (1989) Using genetically-defined rodent strains for the identification of hippocampal traits relevant for two-way avoidance learning: a non-invasive approach. Experientia 45: 845–859.
Lipp, H.P., Schwegler, H., Heimrich, B., and Driscoll, P. (1988) Infrapyramidal mossy fibers and two-way avoidance learning: developmental modification of hippocampal circuitry and adult behavior of rats and mice. J Neurosci 8: 1905–1921.
Ma, X.M., Kiraly, D.D., Gaier, E.D., Wang, Y., Kim, E.J., Levine, E.S., et al. (2008) Kalirin-7 is required for synaptic structure and function. J Neurosci 28: 12368–12382.
Martin, M., Ledent, C., Parmentier, M., Maldonado, R., and Valverde, O. (2002) Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology (Berl) 159: 379–387.
Martinez, I., Quirarte, G.L., Diaz-Cintra, S., Quiroz, C., and Prado-Alcala, R.A. (2002) Effects of lesions of hippocampal fields CA1 and CA3 on acquisition of inhibitory avoidance. Neuropsychobiology 46: 97–103.
Mathis, C., Paul, S.M., and Crawley, J.N. (1994) Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice. Behav Genet 24: 171–180.
Middei, S., Geracitano, R., Caprioli, A., Mercuri, N., and Ammassari-Teule, M. (2004) Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe. Learn Mem 11: 447–452.
Minichiello, L., Korte, M., Wolfer, D., Kuhn, R., Unsicker, K., Cestari, V., et al. (1999) Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24: 401–414.
Misanin, J.R., Turns, L.E., and Hinderliter, C.F. (1985) Acquisition and retention of active avoidance behavior in previsual rats. Am J Psychol 98: 485–501.
Montag-Sallaz, M. and Montag, D. (2003) Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Genes Brain Behav 2: 20–31.
Myhrer, T. (2003) Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks. Brain Res Brain Res Rev 41: 268–287.
Myslivecek, J. (1997) Inhibitory learning and memory in newborn rats. Prog Neurobiol 53: 399–430.
Nagy, Z.M., Thaller, K., and Mazzaferri, T.A. (1977) Acquisition and retention of a passive-avoidance task as a function of age in mice. Dev Psychobiol 10: 563–573.
Oliverio, A., Castellano, C., and Messeri, P. (1972) Genetic analysis of avoidance, maze, and wheel-running behaviors in the mouse. J Comp Physiol Psychol 79: 459–473.
Oliverio, A. and Messeri, P. (1973) An analysis of single-gene effects on avoidance, maze, wheel running, and exploratory behavior in the mouse. Behav Biol 8: 771–783.
Peeler, D.F. (1987) Active avoidance performance in genetically defined mice. Behav Neural Biol 48: 83–89.
Peeler, D.F. (1995) Shuttlebox performance in BALB/cByJ, C57BL/6ByJ, and CXB recombinant inbred mice – environmental and genetic-determinants and constraints. Psychobiology 23: 161–170.
Podhorna, J. and Brown, R.E. (2002) Strain differences in activity and emotionality do not account for differences in learning and memory performance between C57BL/6 and DBA/2 mice. Genes Brain Behav 1: 96–110.
Prado-Alcala, R.A., Cruz-Morales, S.E., and Lopez-Miro, F.A. (1980) Differential effects of cholinergic blockade of anterior and posterior caudate nucleus on avoidance behaviors. Neurosci Lett 18: 339–345.
Ray, D. and Nagy, Z.M. (1978) Emerging cholinergic mechanisms and ontogeny of response inhibition in the mouse. J Comp Physiol Psychol 92: 335–349.
Ricceri, L. (2003) Behavioral patterns under cholinergic control during development: lessons learned from the selective immunotoxin 192 IgG saporin. Neurosci Biobehav Rev 27: 377–384.
Ricceri, L., Alleva, E., and Calamandrei, G. (1994) Impairment of passive avoidance learning following repeated administrations of antibodies against nerve growth factor in neonatal mice. Neuroreport 5: 1401–1404.
Ricceri, L. and Berger-Sweeney, J. (1998) Postnatal choline supplementation in preweanling mice: sexually dimorphic behavioral and neurochemical effects. Behav Neurosci 112: 1387–1392.
Ricceri, L., Calamandrei, G., and Berger-Sweeney, J. (1997) Different effects of postnatal day 1 versus 7 192 immunoglobulin G-saporin lesions on learning, exploratory behaviors, and neurochemistry in juvenile rats. Behav Neurosci 111: 1292–1302.
Royce, J.R., Yeudall, L.T., and Poley, W. (1971) Diallel analysis of avoidance conditioning in inbred strains of mice. J Comp Physiol Psychol 76: 353–358.
Sarter, M., Hagan, J., and Dudchenko, P. (1992) Behavioral screening for cognition enhancers: from indiscriminate to valid testing: part II. Psychopharmacology (Berl) 107: 461–473.
Schwegler, H. and Lipp, H.P. (1983) Hereditary covariations of neuronal circuitry and behavior: correlations between the proportions of hippocampal synaptic fields in the regio inferior and two-way avoidance in mice and rats. Behav Brain Res 7: 1–38.
Schwegler, H. and Lipp, H.P. (1995) Variations in the morphology of the septo-hippocampal complex and maze learning in rodents: correlation between morphology and behaviour. In Alleva, E., Fasolo, A., Lipp, H.P., Nadel, L. and Ricceri, L. (eds.), Behavioural Brain Research in Naturalistic and Semi-Naturalistic Settings, Vol. 82. Kluwer, Dodrecht, The Netherlands, pp. 259–276.
Schwegler, H., Lipp, H.P., Van der Loos, H., and Buselmaier, W. (1981) Individual hippocampal mossy fiber distribution in mice correlates with two-way avoidance performance. Science 214: 817–819.
Shobe, J. (2002) The role of PKA, CaMKII, and PKC in avoidance conditioning: permissive or instructive? Neurobiol Learn Mem 77: 291–312.
Simmel, E.C. and Eleftheriou, B.E. (1977) Multivariate and behavior genetic analysis of avoidance of complex visual stimuli and activity in recombinant inbred strains of mice. Behav Genet 7: 239–250.
Spear, L.P. (1979) The use of psychopharmacological procedures to analyze the ontogeny of learning and retention: issues and concerns. In Spear, N.E. and Campbell, B.A. (eds.), Ontogeny of Learning and Memory. Lawrence Erlbaum Associates, Hillsdale, NJ, USA, pp. 135–156.
Spear, N.E., Miller, J.S., and Jagielo, J.A. (1990) Animal memory and learning. Annu Rev Psychol 41: 169–211.
Spear, N.E. and Smith, G.J. (1978) Alleviation of forgetting in preweanling rats. Dev Psychobiol 11: 513–529.
Sprott, R.L. (1972) Passive-avoidance conditioning in inbred mice: effects of shock intensity, age, and genotype. J Comp Physiol Psychol 80: 327–334.
Stavnes, K. and Sprott, R.L. (1975) Effects of age and genotype on acquisition of an active avoidance response in mice. Dev Psychobiol 8: 437–445.
Stehouwer, D.J. and Campbell, B.A. (1980) Ontogeny of passive avoidance: role of task demands and development of species-typical behaviors. Dev Psychobiol 13: 385–398.
Suits, E. and Isaacson, R.L. (1968) The effects of scopolamine hydrobromide on one-way and two-way avoidance learning in rats. Int J Neuropharmacol 7: 441–446.
Tzavara, E.T., Bymaster, F.P., Felder, C.C., Wade, M., Gomeza, J., Wess, J., et al. (2003) Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 8: 673–679.
Venable, N. and Kelly, P.H. (1990) Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice. Psychopharmacology (Berl) 100: 215–221.
Walters, G.C. and Abel, E.L. (1971) Passive avoidance learning in rats, mice, gerbils and hamsters. Psychonomic Sci 22: 269–270.
Wilson, W.J. and Cook, J.A. (1994) Cholinergic manipulations and passive avoidance in the rat: effects on acquisition and recall. Acta Neurobiol Exp (Wars) 54: 377–391.