Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- Part II Cell Death in Tissues and Organs
- 11 Cell Death in Nervous System Development and Neurological Disease
- 12 Role of Programmed Cell Death in Neurodegenerative Disease
- 13 Implications of Nitrosative Stress-Induced Protein Misfolding in Neurodegeneration
- 14 Mitochondrial Mechanisms of Neural Cell Death in Cerebral Ischemia
- 15 Cell Death in Spinal Cord Injury – An Evolving Taxonomy with Therapeutic Promise
- 16 Apoptosis and Homeostasis in the Eye
- 17 Cell Death in the Inner Ear
- 18 Cell Death in the Olfactory System
- 19 Contribution of Apoptosis to Physiologic Remodeling of the Endocrine Pancreas and Pathophysiology of Diabetes
- 20 Apoptosis in the Physiology and Diseases of the Respiratory Tract
- 21 Regulation of Cell Death in the Gastrointestinal Tract
- 22 Apoptosis in the Kidney
- 23 Physiologic and Pathological Cell Death in the Mammary Gland
- 24 Therapeutic Targeting Apoptosis in Female Reproductive Biology
- 25 Apoptotic Signaling in Male Germ Cells
- 26 Cell Death in the Cardiovascular System
- 27 Cell Death Regulation in Muscle
- 28 Cell Death in the Skin
- 29 Apoptosis and Cell Survival in the Immune System
- 30 Cell Death Regulation in the Hematopoietic System
- 31 Apoptotic Cell Death in Sepsis
- 32 Host–Pathogen Interactions
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
11 - Cell Death in Nervous System Development and Neurological Disease
from Part II - Cell Death in Tissues and Organs
Published online by Cambridge University Press: 07 September 2011
Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- Part II Cell Death in Tissues and Organs
- 11 Cell Death in Nervous System Development and Neurological Disease
- 12 Role of Programmed Cell Death in Neurodegenerative Disease
- 13 Implications of Nitrosative Stress-Induced Protein Misfolding in Neurodegeneration
- 14 Mitochondrial Mechanisms of Neural Cell Death in Cerebral Ischemia
- 15 Cell Death in Spinal Cord Injury – An Evolving Taxonomy with Therapeutic Promise
- 16 Apoptosis and Homeostasis in the Eye
- 17 Cell Death in the Inner Ear
- 18 Cell Death in the Olfactory System
- 19 Contribution of Apoptosis to Physiologic Remodeling of the Endocrine Pancreas and Pathophysiology of Diabetes
- 20 Apoptosis in the Physiology and Diseases of the Respiratory Tract
- 21 Regulation of Cell Death in the Gastrointestinal Tract
- 22 Apoptosis in the Kidney
- 23 Physiologic and Pathological Cell Death in the Mammary Gland
- 24 Therapeutic Targeting Apoptosis in Female Reproductive Biology
- 25 Apoptotic Signaling in Male Germ Cells
- 26 Cell Death in the Cardiovascular System
- 27 Cell Death Regulation in Muscle
- 28 Cell Death in the Skin
- 29 Apoptosis and Cell Survival in the Immune System
- 30 Cell Death Regulation in the Hematopoietic System
- 31 Apoptotic Cell Death in Sepsis
- 32 Host–Pathogen Interactions
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
Summary
Naturally occurring neuronal cell death is common during the development of the nervous system. Depending on the neuronal population, as many as 20% to 80% of all neurons produced during embryogenesis die before the animal reaches adulthood. This regressive event functions to primarily adjust the magnitude of each neuronal population to the size or functional needs of its target field and has been recognized as a major player in establishing the definitive form of adult nervous system. Although immature neurons die physiologically in large numbers during development, mature neurons are among the most long-lived cell types in mammals. Under pathological conditions, mature neurons might activate cell death mechanisms that are known to occur in various acute and chronic neurodegenerative diseases. Pathological neuronal cell death, however, occurs through more diversified pathways than that during development. In this chapter, we review the evidence that supports the role of apoptosis during neuronal development, as well as the possible role of nonapoptotic cell death in the nervous system. We discuss the relevance of different cell death mechanisms in several neurodegenerative diseases and the potential neuroprotective targets for treatment of these diseases.
- Type
- Chapter
- Information
- ApoptosisPhysiology and Pathology, pp. 123 - 134Publisher: Cambridge University PressPrint publication year: 2011
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