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  • Print publication year: 2015
  • Online publication date: June 2015

1 - Classification of chemical messengers


Hormones, the brain and behavior

Neuroendocrinology is the study of how the brain controls the endocrine systems that keep us alive and able to reproduce. However, an essential and critical characteristic of this neural control of the endocrine systems is that endocrine hormones in turn have profound effects on brain function through feedback systems. Research on hormones and the brain is intensive and covers many fields: from cell and molecular biology and genetics to anatomy, physiology, pharmacology, biochemistry, medicine, psychiatry and psychology. This book will examine the interactions between hormones, the brain and behavior. Thus, the primary focus will be on how the endocrine and nervous systems affect each other to produce an integrated functional neuroendocrine system that influences physiological and behavioral responses. As preliminary background reading, students are referred to any modern text on Human Physiology (see “Further reading” at the end of this chapter).

When you hear the term “hormone,” for example steroid hormone, you think of the endocrine glands and how their secretions influence physiological responses in the body, but this is only part of the picture. Many of the endocrine glands (although not all of them) are influenced by the pituitary gland, the so-called “master gland,” and the pituitary is itself controlled by various hormones secreted from the hypothalamus, a part of the brain situated directly above the pituitary gland. The release of hypothalamic hormones is in turn regulated by neurotransmitters released from nerve cells (neurons) in the brain. Some neurotransmitters released within the brain also control behavior, and the secretion of neurotransmitters from specific nerve cells can be modulated by the level of specific endocrine hormones in the circulation. This is called hormone feedback. Thus, neurotransmitter release influences both hormones and behavior and, in turn, hormones regulate the release of neurotransmitters. This interaction between hormones, the brain and behavior involves a wide variety of chemical messengers which are described in this chapter.

Broberger, C. (2005). “Brain regulation of food intake and appetite: molecules and networks,” J Intern Med 258, 301–327.
Farooqi, I. S. (2011). “Genetic, molecular and physiological insights into human obesity,” Europ J Clin Invest 41, 451–455.
Glaser, R. and Kiecolt-Glaser, J. K. (2005). “Stress-induced immune dysfunction: implications for health,” Nat Rev Immunol 5, 243–251.
Grimm, D. (2014). “Male scent may compromise biomedical studies,” Science 344, 461.
Hyman, S. E. (2009). “How adversity gets under the skin,” Nat Neurosci 12, 241–243.
Labrie, F., Luu-The, V., Labrie, C. and Simard, J. (2001). “DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology,” Front Neuroendocrinol 22, 185–212.
Minorsky, P. V. (2002). “Abscisic acid: a universal signalling factor?”Plant Physiol 128, 788–789.
Murata, K., Tamogami, S., Itou, M., Ohkubo, Y., Wakabayashi, Y., Watanabe, H., Okamura, H., Takeuchi, Y. and Mori, Y. (2014). “Identification of an olfactory signal molecule that activates the central regulator of reproduction in goats,” Curr Biol 24, 681–686.
Nussey, S. S. and Whitehead, S. A. (2001). Endocrinology: An Integrated Approach (Oxford: Bios Scientific Publishers),
Ryan, K. K. and Seeley, R. J. (2013). “Food as a hormone,” Science 339, 918–919.
Smythies, J. R. (1976). “Perspectives in psychoneuroendocrinology,” Psychoneuroendocr 1, 317–319.
Widmaier, E. P., Raff, H. and Strang, K. T. (2010). Vander's Human Physiology: The Mechanisms of Body Function, th edn. (New York: McGraw-Hill).
Wikipedia definition of “psychoneuroimmunology”,