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  • Print publication year: 2009
  • Online publication date: October 2009

12 - The Role of Preventive Multimodal Analgesia and Impact on Patient Outcome

from SECTION II - Clinical Analgesia

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1. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003;97:534–540.
2. Warfield CA, Kahn CH. Acute pain management: programs in U.S. hospitals and experiences and attitudes among U.S. adults. Anesthesiology. 1995;83:1090–1094.
3. Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. Lancet. 2003;362:1921–1928.
4. Desborough JP. The stress response to trauma and surgery. Br J Anaesth. 2000;85:109–117.
5. Wilmore DW. From Cuthbertson to fast-track surgery: 70 years of progress in reducing stress in surgical patients. Ann Surg. 2002;236:643–648.
6. Holte K, Kehlet H. Postoperative ileus: a preventable event. Br J Surg. 2000;87:1480–1493.
7. Closs SJ. Patients’ night-time pain, analgesic provision and sleep after surgery. Int J Nurs Stud. 1992;29:381–392.
8. Perkins FM, Kehlet H. Chronic pain as an outcome of surgery: a review of predictive factors. Anesthesiology. 2000;93:1123–1133.
9. Descartes R. The passions of the soul. In Descartes R, ed. Key Philosophical Readings. Hertordshire, UK: Wordsworth Editions Limited; 1997:358–383.
10. Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150:971–979.
11. Raja SN, Meyer RA, Campbell JN. Peripheral mechanisms of somatic pain. Anesthesiology. 1988;68:571–590.
12. Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature. 1983;303:686–688.
13. Woolf CJ, Chong MS. Preemptive analgesia – treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg. 1993;77:362–379.
14. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain. 1993;52:259–285.
15. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science. 2000;288:1765–1768.
16. Crile GW. The kinetic theory of shock and its prevention through anoci association (shockless operation). Lancet. 1913;185:7–16.
17. Wall PD. The prevention of postoperative pain. Pain. 1988;33:289–290.
18. Dickenson AH, Sullivan AF: Subcutaneous formalin-induced activity of dorsal horn neurons in the rat: differential response to an intrathecal opiate administered pre or post formalin. Pain. 1987;30:349–360.
19. Coderre TJ, Vaccarino AL, Melzack R. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Res. 1990;535:155–158.
20. Kissin I. Preemptive analgesia. Why its effect is not always obvious. Anesthesiology. 1996;84:1015–1019.
21. Katz J. Pre-emptive analgesia: evidence, current status and future directions. Eur J Anesthesiol. 1995;12:8–13.
22. Moiniche S, Kehlet H, Dahl J. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief-the role of timing of analgesia. Anesthesiology. 2002;96:725–741.
23. Ong CK, Lirk P, Seymour RA, Jenkins BJ. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis. Anesth Analg. 2005;100:757–773.
24. Kissin I. Preemptive analgesia: terminology and clinical relevance. Anesth Analg. 1994;79:809–810. [letter]
25. Katz J, McCartney CJ. Current status of preemptive analgesia. Curr Opin Anaesthesiol. 2002;15:435–441.
26. Katz J, Cohen L. Preventative analgesia is associated with reduced pain disability 3 weeks but not 6 months after major gynecologic surgery by laparotomy. Anesthesiology. 2004;101:169–174.
27. Reuben SS. Preventing the development of complex regional pain syndrome after surgery. Anesthesiology. 2004;101:1215–1224.
28. Phillip BK, Reese PR, Burch SP. The economic impact of opioids on postoperative pain management. J Clin Anesth. 2002;14:354–364.
29. Wheeler M, Oderda GM, Ashburn MA, Lipman AG. Adverse events associated with postoperative analgesia: a systematic review. Clin J Pain. 2002;3:159–180.
30. Phillips DM. JCAHO pain management standards are unveiled. JAMA. 2000;284:4–5.
31. Kehlet H. Postoperative opioid sparing to hasten recovery. What are the issues? Anesthesiology. 2005;102:1083–1085.
32. Taylor S, Voytovich AE, Kozol RA. Has the pendulum swung too far in postoperative pain control? Am J Surg. 2003;186:472–475.
33. Vila H, Smith RA, Augustyniak MJ, et al. The efficacy and safety of pain management before and after implementation of hospital-wide pain management standards: Is patient safety compromised by treatment based solely on numerical pain ratings? Anesth Analg. 2005;101:474–480.
34. Kehlet H, Dahl JB. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth Analg. 1993;77:1048–1056.
35. Dahl JB, Rosenberg J, Dirkes WE, Morgensen T, Kehlet H. Prevention of postoperative pain by balanced analgesia. Br J Anaesth. 1990;64:518–520.
36. Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg. 2002;183:630–641.
37. Buvanendran A, Kroin JS, Tuman KJ, et al. Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor of pain management and recovery of function after knee replacement. JAMA. 2003;290:2411–2418.
38. Reuben SS, Gutta SB, Maciolek H, Sklar J. Effect of initiating a multimodal analgesic regimen upon patient outcomes after anterior cruciate ligament reconstruction for same-day surgery: a 1200-patient case series. Acute Pain. 2004;6:87–93.
39. Reuben SS, Gutta SB, Maciolek H, Sklar J, Redford J. Effect of initiating a preventative multimodal analgesic regimen upon long-term patient outcomes after anterior cruciate ligament reconstruction for same-day surgery: A 1200-patient case series. Acute Pain. 2005;7:65–73.
40. Ashburn MA, Caplan RA, Carr DB, et al. Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists task force on acute pain management. Anesthesiology. 2004;100:1573–1581.
41. United States Acute Pain Management Guideline Panel. Acute Pain Management: Operative or Medical Procedures and Trauma. Pub. no. 92-0032. Rockville, MD:, United States Department of Health and Human Services, Public Health Service Agency for Health Care Policy and Research, 1992.
42. Unnerstall JR, Kopajtic TA, Kuhar MJ. Distribution of alpha 2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Res Rev. 1984;7:69–101.
43. Gaumann DM, Brunet PC, Jirounek P. Clonidine enhances the effects of lidocaine on C-fiber action potential. Anesth Analg. 1992;74:719–725.
44. Butterworth JF, Strichartz GR. The α2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. Anesth Analg. 1993;76:295–301.
45. Gaumann DM, Brunet PC, Jirounek P. Hyperpolarizing after potentials in C fibers and and local anesthetic effects of clonidine and lidocaine. Pharmacology. 1994;48:21–29.
46. Langer SZ, Duval N, Masingham R. Pharmacologic and therapeutic significance of alpha-adrenoceptor subtypes. J Cardiovasc Pharmacol. 1985;7:1–8.
47. Gaumann D, Forster A, Griessen M, Habre W, Poinsot O, Della Santa D. Comparison between clonidine and epinephrine admixture to lidocaine in brachial plexus block. Anesth Analg. 1992;75:69–74.
48. Kroin JS, Buvanendran A, Beck DR, Topic JE, Watts TE, Tuman KJ. Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats is mediated via the hyperpolarization-activated cation current (Ih) not by alpha2-adrenoreceptors. Anesthesiology. 2004;101:488–494.
49. Nakamura M, Ferreira SH. Peripheral analgesic action of clonidine: mediation by release of endogenous enkephaln-like substances. Eur J Pharmacol. 1988;146:223–228.
50. Reuben SS. Stellate ganglion blockade for acute postoperative upper extremity pain. Anesthesiology. 2005;102:288–289.
51. Eisenach JC, DeKock M, Klimscha W. α-2 adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984–1995). Anesthesiology. 1996;85:655–674.
52. Smith H, Elliott J. Alpha2 receptors and agonists in pain management. Curr Opin Anaesthesiol. 2001;14:513–518.
53. Bernard JM, Hommeril JL, Passuti N, Pinaud M. Postoperative analgesia by intravenous clonidine. Anesthesiology. 1991;75:577–582.
54. Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg. 2004;98:153–158.
55. Sites BD, Beach M, Biggs R, et al. Intrathecal clonidine added to a bupivacaine-morphine spinal anesthetic improves postoperative analgesia for total knee arthroplasty. Anesth Analg. 2003;96:1083–1088.
56. Forster JG, Rosenberg PH. Small dose of clonidine mixed with low-dose ropivacaine and fentanyl for epidural analgesia after total knee arthroplasty. Br J Anaesth. 2004;93:670–677.
57. Milligan KR, Convery PN, Weir P, Quinn P, Connolly D. The efficacy and safety of epidural infusions of levobupivacaine with and without clonidine for postoperative pain relief in patients undergoing total hip replacement. Anesth Analg. 2000;91:393–397.
58. Dobrydnjov I, Axelsson K, Gupta A, Lundon A, Holmstrom B, Granath B. Improved analgesia with clonidine when added to local anesthetic during combined spinal-epidural anesthesia for hip arthroplasty: a double-blind, randomized and placebo-controlled study. Acta Anaesthesiol Scand. 2005;49:538–545.
59. Reuben SS, Steinberg RB, Klatt JL, Klatt ML. Intravenous regional anesthesia using lidocaine and clonidine. Anesthesiology. 1999;91:654–658.
60. Lurie SD, Reuben SS, Gibson CS, DeLuca PA, Maciolek HA. Effect of clonidine on upper extremity tourniquet pain in healthy volunteers. Reg Anesth Pain Med. 2000;25:502–505.
61. Reuben SS, Connelly NR. Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine. Anesth Analg. 1999;88:729–733.
62. Joshi W, Reuben SS, Kilaru PK, Sklar J, Maciolek H. Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine and/or morphine. Anesth Analg. 2000;90:1102–1116.
63. Cousins MJ. Acute pain and the injury response: immediate and prolonged effects. Reg Anesth. 1989;14:162–179.
64. McCormack K. Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain. 1994;59:9–43.
65. Souter AJ, Fredman B, White PF. Controversies in the perioperative use of nonsteroidal anti-inflammatory drugs. Anesth Analg. 1994;79:1178–1190.
66. Dahl JB, Kehlet H. Non-steroidal anti-inflammatory drugs: rationale for use in severe postoperative pain. Br J Anaesth. 1991;66:703–712.
67. Reuben SS, Connelly NR, Lurie SD, Klatt ML, Gibson C. Dose-response of ketorolac as an adjunct to patient-controlled analgesia morphine in patients after spinal fusion surgery. Anesth Analg. 1998;87:98–102.
68. Muth-Selbach US, Tegeder I, Brune K, Geisslinger G. Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation. Anesthesiology. 1999;91:231–239.
69. Chandrasekharan NV, Dai H, Roos KL, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA. 2002;99:13926–13931.
70. Hersh EV, Lally ET, Moore PA. Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray? Curr Med Res Opin. 2005;21(8):1217–1226.
71. Pickering G, Loriot MA, Libert F, Eschalier A, Beaune P, Dubray C. Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Ther. 2006;79:371–378.
72. Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth. 2005;94:505–513.
73. Hyllested M, Jones S, Pedersen JL, Kehlet H. Comparative effect of paracetamol, NSAIDs, or their combination in postoperative pain management: a qualitative review. Br J Anaesth. 2002;88:199–214.
74. Sinatra R. Role of COX-2 inhibitors in the evolution of acute pain management. J Pain Symptom Manage. 2002;24:S18–S27.
75. Holmer PP, Owall A, Jakobsson J. Early bioavailability of paracetamol after oral or intravenous administration. Acta Anaesthesiol Scand. 2004;48:867–870.
76. Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal anti-inflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Anesthesiology. 2005;1296–1304.
77. Romsing J, Moniche S. A review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for postoperative pain. Acta Anaesthesiol Scand. 2004;48:525–546.
78. Katz J. Pre-emptive analgesia: importance of timing. Can J Anaesth. 2001;48:105–114.
79. Reuben SS, Bhopatkar S, Maciolek H, et al. The preemptive analgesic effect of rofecoxib after ambulatory arthroscopic knee surgery. Anesth Analg. 2002;94:55–59.
80. Salter MW. Cellular signaling pathways of spinal pain neuroplasticity as targets for analgesic development. Curr Top Med Chem. 2005;5:557–567.
81. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartate acid receptor activation: implication for the treatment of post-injury pain hypersensitivity states. Pain. 1991;44:293–299.
82. Foster AC, Fagg GE. Neurobiology. Taking apart NMDA receptors. Nature. 1987;329:395–396.
83. Schmid RL, Sandler AN, Katz J. Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes. Pain. 1999;82:111–125.
84. Subramaniam K, Subramaniam B, Steinbrook RA. Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review. Anesth Analg. 2004;99:482–495.
85. Tverskoy M, Oren M, Vaskovich M, Dashkovsky I, Kissin I. Ketamine enhances local anesthetic and analgesic effects of bupivacaine by peripheral mechanism: a study in postoperative patients. Neurosci Lett. 1996;215:5–8.
86. Menigaux C, Guignard B, Fletcher D, Dupont X, Guirimand F, Chauvin M. The benefits of intraoperative small-dose ketamine on postoperative pain after anterior cruciate ligament repair. Anesth Analg. 2000;90:129–135.
87. Menigaux C, Guignard B, Fletcher D, Sessler DI, Dupont X, Chauvin M. Intraoperative small-dose ketamine enhances analgesia after outpatient knee arthroscopy. Anesth Analg. 2001;93:606–612.
88. Himmelseher S, Ziegler-Pithamitsis D, Agiriadou H, Martin Jjelen-Esselborn S, Koch E. Small-dose S(+) ketamine reduces postoperative pain when applied with ropivacaine in epidural anesthesia for total knee arthroplasty. Anesth Analg. 2001;92:1290–1295.
89. Adam F, Chauvin M, Du Manoir B, Langlois M, Sessler DI, Fletcher D. Small-dose ketamine infusion improves postoperative analgesia and rehabilitation after total knee arthroplasty. Anesth Analg. 2005;100:475–480.
90. Wong BY, Coulter DA, Choi DW, Prince DA. Dextrorphan and dextromethorphan, common antitussives, are antieleptic and antagonize N-methyl-D-aspartate in brain slices. Neurosci Lett. 1988;85:261–266.
91. LePage KT, Ishmael JT, Low CM, et al. Differential binding properties of [3H] dextrorphan and [3H] MK-801 in heterologously expressed NMDA receptors. Neuropharmacology. 2005;49:1–16.
92. Duedahl TH, Romsing J, Moniche S, Dahl JB. A qualitative systematic review of peri-operative dextromethorphan in post-operative pain. Acta Anaesthesiol Scand. 2006;50:1–13.
93. Cox JA, Lysko PG, Henneberry RC. Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: role of the voltage-dependent magnesium block. Brain Res. 1989;499:267–272.
94. Tramer MR, Schneider J, Mart RA, Rifat K. Role of magnesium sulfate in postoperative analgesia. Anesthesiology. 1996;84:340–347.
95. Konig H, Wallner T, Marhofer P, et al. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesth Analg. 1998;87:206–210.
96. Kara H, Sahin N, Ulusan V, Aydogdu T. Magnesium infusion reduces postoperative pain. Eur J Anaesthesiol. 2002;19:52–56.
97. Levaux CH, Bonhomme V, Dewandre PY, et al. Effect of intra-operative magnesium sulfate on pain relief and patient comfort after major lumbar orthopaedic surgery. Anaesthesia. 2003;58:131–135.
98. Bhatia A, Kashyap L, Pawar DK, Trikha A. Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy. J Clin Anesth. 2004;16:262–265.
99. Sehan TO, Tugrul M, Sungur MO, et al. Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery. Br J Anaesth. 2006;96.
100. Wilder-Smith CH, Knopfli R, Wilder-Smith OH. Perioperative magnesium infusion and postoperative pain. Acta Anesthesiol Scand. 1997;41:1023–1027.
101. Ko SH, Lim HR, Kim DC, et al. Magnesium sulfate does not reduce postoperative analgesic requirements. Anesthesiology. 2001;95:640–646.
102. Paech MJ, Magann EF, Doherty DA, et al. Does magnesium sulfate reduce the short- and long-term requirements for pain relief after caesarean delivery? A double-blind placebo-controlled trial. Am J Obstet Gynecol. 2006;194:1596–1602.
103. McKee JA, Brewer RP, Macy GE, et al. Analysis of the brain bioavailability of peripherally administered magnesium sulfate: a study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med. 2005;33:661–666.
104. McCartney CJ, Sinha A, Katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesth Analg. 2004;98:1385–1400.
105. Skryabina EA, Dunn TS. Disposable infusion pumps. Am J Health Syst Pharm. 2006;63:1260–1268.
106. Chelly JE, Ben-David B, Williams BA, Kentor ML. Anesthesia and postoperative analgesia: outcomes following orthopedic surgery. Orthopedics. 2003;26:S865–S871.
107. Zink W, Graf BM. Local anesthetic myotoxicity. Reg Anesth Pain Med. 2004;29:333–340.
108. Kreitzer JM, Reuben SS. Central nervous system toxicity in a patient receiving continuous intrapleural bupivacaine. J Clin Anesth. 1996;8:666–668.
109. Kulkarni M, Elliot D. Local anaesthetic infusion for postoperative pain. J Hand Surg. 2003;28:300–306.
110. Gomoll AH, Kang RW, Williams JM, Bach BR, Cole BJ. Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy. 2006;22:813–819.
111. Capdevilla X, Barthelet Y, Biboulet P, Ryckwaert Y, Rubenovitch J, d’Athis F. Effects of perioperative analgesic technique on the surgical outcome and duration of rehabilitation after major knee surgery. Anesthesiology. 1999;91:8–15.
112. McCartney CJL, Brull R, Chan VS, et al. Early but no long-term benefit of regional compared with general anesthesia for ambulatory hand surgery. Anesthesiology. 2004;101:461–467.
113. Richman JM, Liu SS, Courpas G, et al. Does continuous peripheral nerve block provide superior pain control to opioids? A meta-analysis. Anesth Analg. 2006;102:248–257.
114. Rathmell JP, Wu CL, Sinatra RS, et al. Acute post-surgical pain management: a critical appraisal of current practice. Reg Anesth Pain Med. 2006;31:1–42.
115. Adams HA, Saatweber P, Schmitz CS, Hecker H. Postoperative pain management in orthopedic patients: no differences in pain score, but improved stress control by epidural anaesthesia. Eur J Anaesthesiol. 2002;19:658–665.
116. Block BM, Liu SS, Rowlingson AJ, Cowan AR, Cowan JA, Wu CL. Efficacy of postoperative epidural analgesia: a meta-analysis. JAMA. 2003;290:2455–2463.
117. De Leon-Casasola OA. When it comes to outcome, we need to define what a perioperative epidural technique is. Anesth Analg. 2003;96:315–318.
118. Reuben SS, Buvanendran A, Kroin JS, et al. Postoperative modulation of central nervous system prostaglandins E2 by cyclooxygenase inhibitors after vascular surgery. Anesthesiology. 2006;104:411–416.
119. Kroin JS, Buvanendran A, McCarthy RJ, et al. Cyclooyxgenase-2 (COX-2) inhibitor potentiates morphine antinociception at the spinal level in a post-operative pain model. Reg Anesth Pain Med. 2002;27:451–455.
120. Dai YQ, Jin DZ, Zhu XZ, et al. Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes. Neuroscience. 2006;55:154–160.
121. Samad TA, Sapirstein A, Woolf CJ. Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol Med. 2002;8:390–396.
122. Buvanendran A, Kroin JS, Berger RA, et al. Up-regulation of prostaglandin E2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans. Anesthesiology. 2006;104:403–410.
123. Walder B, Schafer M, Henzi I, et al. Efficacy and safety of patient-controlled opioid analgesia for acute postoperative pain: a quantitative systematic review. Acta Anaesthesiol Scand. 2001;45:795–804.
124. Chia YT, Liu K, Wang JJ, Kuo MC, Ho ST. Intraoperative high dose fentanyl induces postoperative fentanyl tolerance. Can J Anaesth. 1999;48:872–877.
125. Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology. 2000;93:409–417.
126. Larcher A, Laulin JP, Celerier E, Le Moal M, Simmonnet G. Acute tolerance associated with a single opiate administration: involvement of N-methyl-D-aspartate-dependent pain facilatory systems. Neuroscience. 1998;84:583–589.
127. Mao J. Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy. Pain. 2002;100:213–217.
128. Angst MS, Clark DJ. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology. 2006;104:570–587.
129. Powell KJ, Hosokawa A, Bell A, et al. Comparative effects of cyclo-oxygenase and nitrous oxide synthase inhibition on the development and reversal of spinal opioid tolerance. Br J Pharmacol. 1999;127:631–634.
130. Troster A, Sittl R, Singler B, et al. Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. Anesthesiology. 2006;105:1016–1023.
131. Stein C. Peripheral mechanisms of opioid analgesia. Anesth Analg. 1993;76:182–191.
132. Picard PP Tramer MR, McQuay HJ, Moore RA. Analgesic efficacy of peripheral opioids (all except intra-articular): a qualitative systematic review of randomized controlled trials. Pain. 1997;72:309–318.
133. Kalso E, Smith L, McQuay HJ, Moore RA. No pain, no gain: clinical excellence and scientific rigour-lessons learned from IA morphine. Pain. 2002;98:269–275.
134. Reuben SS, Sklar J. Postoperative pain management for outpatient arthroscopic knee surgery. Current Concepts Review. J Bone Joint Surg. 2000;82:1754–1766.
135. Reichart JA, Daughters RS, Rivard R, Simone DA. Peripheral and preemptive opioid antinociception in a mouse visceral pain model. Pain. 2001;89:221–227.
136. Denti M, Randelli P, Bigoni M, Arino MR, Fraschini N. Pre- and postoperative intra-articular analgesia for arthroscopic surgery of the knee and arthroscopic-assisted anterior cruciate ligament reconstruction. A double-blind randomized prospective study. Knee Surg Sports Traumatol Arthrosc. 1997;5:206–212.
137. Reuben SS, Sklar J, El-Mansouri M. The preemptive analgesic effect of intraarticular bupivacaine and morphine after ambulatory arthroscopic knee surgery. Anesth Analg. 2001;92:923–926.
138. Qin N, Yagel S, Momplaisir ML,Codd EE, D’Andrea MR. Molecular cloning and characterization of the human voltage-gated calcium channel α2δ-4 subunit. Mol Pharmacol. 2002;62:485–496.
139. Gilron I. Is gabapentin a “broad-spectrum” analgesic? Anesthesiology. 2002; 97:537–539.
140. Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G. Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg. 2000;91:185–191.
141. Hurley RW, Chatterjea D, Rose Feng M, Taylor CP, Hammond DL. Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia. Anesthesiology. 2002;97:1263–1273.
142. Gilron I, Orr E, Tu D, O’Neill JP, Zamora JE, Bell AC. A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy. Pain. 2005;113:191–200.
143. Dahl JB, Mathiesen O, Moniche S. “Protective premedication”: an option with gabapentin and related drugs? A review of gabapentin and pregabalin in the treatment of post-operative pain. Acta Anaesthesiol Scand. 2004;48:1130–1136.
144. Hurley RW, Cohen SP, Williams KA, Rowlingson AG, Wu CL. The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis. Reg Anesth Pain Med. 2006;31:237–247.
145. Ho KY, Habib HS. Gabapentin and postoperative pain – a systematic review of randomized controlled trials. Pain. 2006;126:91–101.
146. Reuben SS, Buvanendran A, Kroin JS, Raghunathan K. Evaluation of the analgesic efficacy of administering celecoxib, pregabalin and their combination for spinal fusion surgery. Anesth Analg. 2006;103:1271–1277.
147. Menigaux C, Adam F, Guignard B, Sessler DI, Chauvin M. Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg. 2005;100:1394–1399.
148. Kehlet H, Werner M, Perkins F. Balanced analgesia: what is it and what are its advantages in postoperative pain? Drugs. 1999;58:793–797.
149. Jin F, Chung F. Multimodal analgesia for postoperative pain control. J Clin Anesth. 2001;13:524–539.
150. Joshi GP. Multimodal analgesia techniques and postoperative rehabilitation. Anesthesiol Clin North Am. 2005;23:185–202.
151. Apfelbaum JL, Gan TJ, Zhao S, Hanna DB, Chen C. Reliability and validity of the preoperative opioid-related symptom distress scale. Anesth Analg. 2004;99:699–709.
152. Zhao SZ, Chung F, Hanna DB, Raymundo AL, Cheung RY, Chen C. Dose-response relationship between opioid use and adverse events after ambulatory surgery. J Pain Symptom Manage. 2004;28:35–46.
153. Gan TJ, Joshi GP, Zhao SZ, Hanna DB, Cheung RY, Chen C. Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects. Acta Anaesthesiol Scand. 2004;48:1194–1207.
154. Reuben SS, Raghunathan K, Cheung R. Dose-response relationship between opioid use and adverse events after spinal fusion surgery. Anesthesiology. 2006;105:A1646. [Abstract]
155. Wilmore DW, Kehlet H. Management of patients in fast track surgery. BMJ. 2001;322:473–476.