REFERENCES
1. Reisine T, Pasternak G. Opioid analgesics and antagonists. In Goodman LS, Gilman A, eds. The Pharmacologic Basis of Therapeutics. 9th ed. New York, NY: Macmillan; 1997.
2. Gutstein HB, Akil H. Opioid analgesics. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill; 2002:569–619.
3. Pasero C, Portenoy RK, McCaffery M. Opioid analgesics. In: McCaffery M, Pasero C, eds. Pain Clinical Manual. St. Louis, MO: Mosby Inc, 1999:161–299.
4. Sinatra RS. Opioid analgesics in primary care: challenges and new advances in the management of noncancer pain. Journal of the American Board of Family Medicine. 2006;19(2):165–177.
5. Meldrum ML. A capsule history of pain management. JAMA. 2003;290:2470–2475.
6. Gilson AM, Joranson DE. Controlled substances and pain management: changes in knowledge and attitudes of state medical regulators. J Pain Symptom Manage. 2001;21:227–237.
7. Gilson AM, Joranson DE. U.S. policies relevant to the prescribing of opioid analgesics for the treatment of pain in in patients with addictive disease. Clin J Pain. 2002;18:S91–S98.
8. American Society of Anesthesiologists. A report by the American Society of Anesthesiologists Task Force on Pain Management, Chronic Pain Section. Anesthesiology. 1997;86:995–1004.
9. Joint Commission on Accreditation of Healthcare Organizations. JCAHO Standards for Pain Management [referenced from the Comprehensive Accreditation Manual for Hospitals, Update 3, 1999 (effective January 1, 2001)]. Available at:
//www.texmed.org/has/prs/pop/jps.asp. Accessed August 5, 2003.
11. Sinatra RS, Bigham M: The anatomy and pathophysiology of acute pain. In: Grass JA, ed. Problems in Anesthesiology. Vol. 10. Philadelphia, PA: Lippincott-Raven; 1997:8–22.
12. Bonica JJ. Biochemistry and modulation of nociception and pain. In: Bonica, JJ, ed. The Management of Pain. 2nd ed. Philadelphia, PA: Lea & Febiger; 1990:94–121.
13. Beecher H. Pain in men wounded in battle. Ann Surg. 1946;123:96–105.
14. Way WL, Fields HL, Schumaker MA. Chapter 31- Opioid Analgesics. In: Katsung BG, ed. Basic & Clinical Pharmacology. 9th ed. New York, NY: Lange Medical Books/McGraw-Hill; 2004.
15. Zastrow M, Svingos A, Haberstock H, et al. Regulatory endocytosis of opioid receptors: cellular mechanisms and proposed role in physiological adaptation to opiate drugs. Curr Opin Neurobiol. 2003;13:348–353.
16. Nestler EJ, Aghajanian GK. Molecular and cellular basis of addiction. Science. 1997;278:58–63.
17. Angst MS, Clark JD. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology. 2006;104(3):570–587.
18. Galer BS, Coyle N, Pasternak GW, Portenoy RK. Individual variability in the response to different opioids: report of five cases. Pain. 1992;49:87–91.
19. Mogil JS. The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proc Natl Acad Sci USA. 1999;96:7744–7751.
20. Pan YX, Xu J, Bolan E, Moskowitz HS, Pasternak GW. Identification of four novel exon 5 splice variants of the mouse mu opioid receptor gene. Mol Pharmacol. 2005;68:866–875.
21. Uhl GR, Sora I, Wang Z. The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Proc Natl Acad Sci USA. 1999;96:7752–7755.
22. Chou WY, Yang LC, Lu HF, Ko JY, Wang CH, Lin SH, Lee TH, Concejero A, Hsu CJ. Association of μ-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty Acta Anaesth Scand. 2006;50:787–792.
23. Reyes Gibby CC, Shete S, et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain; OPRM1 and COMT gene. Pain. 2007;130:25–30.
24. Klepstad P, Dale O, Skorpen F, et al. Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand. 2005;49:902–908.
25. Park HJ, Shinn HK, Lee HS et al. Genetic polymorphism in the ABCB1 gene and the effects of fentanyl in Koreans. Clin Pharm Therapeut. 2007;81:539–546.
26. Hamabe W, Maeda T, Fukazawa Y, et al. Polymorphism in the ABCB1 transporter. Pharmacol Biochem Behav. 2006:85:629–636.
27. Ross JR, et al. Pharmacogenetics J. 2005;5:324–336. Goodman & Gilman's Pharmacology. 11th ed. McGraw-Hill. 2006.
28. Mercadante S. Opioid rotation for cancer pain: rationale and clinical aspects. Cancer. 1999;86:1856–1866.
29. Evans DA, Mahgoub A, Sloan TP, Idle JR, Smith RL. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet. 1980;17:102–105.
30. Portenoy RK. Opioid therapy for chronic nonmalignant pain: a review of the critical issues. J Pain Sympt Manag. 1996;11:203–217.
31. Gan TJ, Ginsberg B, Glass PSA, et al. Opioid sparing effects of a low-dose infusion of naloxone in patient administered morphine sulphate. Anesthesiology. 1997;87(5):1075–1081.
32. Mahowald ML, Singh JA, Majeski P. Opioid use by patients in an orthopedics spine clinic. Arthritis Rheum. 2005;52:312–321.
33. Fine PG, Portenoy RK. A Clinical Guide to Opioid Analgesia. New York, NY: McGraw-Hill; 2004.
34. Yeh SY, Gorodetzky CW, Krebs HA. Isolation and identification of morphine-3 and 6-glucuronides, morphine 3,6 diglucuronide, morphine 3 ethereal sulfate, normorphine and normorphine 6-glucuronide as morphine metabolites in humans. J Pharm Sci. 1977;66:1288–1293.
35. Marco CA, Plewa MC, Buderer N, Black C, Roberts A. Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial. Acad Emerg Med. 2005;12:282–288.
36. Ross FB, Smith MT. The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated. Pain. 1997;73:151–157.
37. Otton SV, Schadel M, Cheung SW, Kaplan HL: CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone. J Clin Therapeut. 1993;54:463–472.
38. Combunox [package insert]. St Louis, MO: Forest Pharmaceuticals Inc.; 2004.
39. Stambaugh JE, Reder RF, Stambaugh MD, Stambaugh H, Davis M. Double-blind, randomized comparison of the analgesic and pharmacokinetic profiles of controlled- and immediate-release oral oxycodone in cancer pain patients. J Clin Pharmacol. 2001;41:500–506.
40. Mahler DL, Forrest WH. Relative analgesic potencies of morphine and hydromorphone in postoperative pain. Anesthesiology. 1975;42:602–607.
41. Inturrisi C, Portenoy R, Stillman M, et al. Hydromorphone bioavailability and pharmacokinetic-pharmacodynamic relationships. Clin Pharm Ther. 1988;43:162–169.
42. Keeri-Szanto M. Anesthesia time/dose curves IX: the use of hydromorphone in surgical anesthesia and post operative pain relief in comparison to morphine. Can Anesth Soc J. 1976;23:587–595.
43. Ritschel WA. Absolute bioavailability of hydromorphone after oral and rectal administration in humans. J Clin Pharmacol. 1987;27:647–653.
44. Babul N. Darke AC, Hagen N. Hydromorphone metabolite accumulation in renal failure. J Pain Symptom Manage. 1995;10(3):184–186.
45. Peng PW, Sandler AN. Fentanyl for postoperative analgesia: a review. Anesthesiology. 1999;90:576–599.
46. Sinatra RS, Harrison DM, Hyde N. Oxymorphone revisited. In: Katz R, ed. Essays in Anesthesiology. Vol. 8. 1988:208–215.
47. Opana ER(R) [package insert]. Chadds Ford, PA: Endo Pharmaceuticals Inc;). 2005.
48. Anderson A, Saiers JH, Abram S, Schlicht C. Accuracy in equianalgesic: dosing conversion dilemmas. J Pain Symptom Manage. 2001;21:397–406.
49. Wadam EF, Bigelow GE. Johnson RE, Nuzzo PA, Haigney MC. Qt interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial. Arch Intern Med. 2007;167:2469–2475.
50. Latta K, Ginsberg B, Barken K. Meperidine: a critical review. Am J Therapeut. 2002;9:53–68.
51. Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, Levine JD. Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med. 1996;2:1248–1250.
52. Sinatra RS, Sramcik J. Tramadol: its use in pain management. In: Hines RL, ed. Anesthesiology Clinics of North America. Vol. 2. Philadelphia, PA: Saunders, 1998;53–69.
53. Dayer P, Desmules J, Collart L. Pharmacology of tramadol. Drugs. 1997;53(Suppl 2):18–24.
54. Alford DP, Compton P, Samet JH. Acute pain management for patients receiving methadone or burenorphine therapy. Arch Int Med. 2006;144:127–134.
55. Sinatra RS, Torres J, Bustos AM. Pain management after major orthopaedic surgery: current strategies and new concepts. J Am Acad Orthop Surg. 2002;10:117–129.
56. Sinatra RS. Treatment guidelines and unpublished observations. Yale University Pain Management Service 2007.
57. Coda BA, Tanaka A, Jacobson RC: Hydromorphone analgesia after intravenous bolus administration. Pain. 1997;71:41–48.
58. Sinatra RS, Harrison DM. A comparison of oxymorphone and fentanyl as narcotic supplements in general anesthesia. J Clin Anesth. 1989;1:253–258.
59. Sinatra RS, Lodge K, Sibert K, et al. A comparison of morphine, meperidine, and oxymorphone as utilized in patient-controlled analgesia following cesarean delivery. Anesthesiology. 1989;70:585–590.
60. Richlin DM, Reuben SS. Postoperative pain control with methadone following abdominal surgery. J Clin Anesthes. 1991;3:112–116.
61. Chui PT Gin T. A double blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine. Anesthesia Intensive Care 1992;20:46–51.
62. Shir Y, Rosen G, Zeiden A, Davidson M. Methadone is safe for treating hospitalized patients. Can J Anesthes. 2001;48:1109–1113.
63. Rowbotham MC, Twilling L, Davies PS, Reisner L, Taylor K, Mohr D. Oral opioid therapy for chronic peripheral and central neuropathic pain. N Engl J Med. 2003;348:1223–1232.
64. Mitra S, Sinatra RS: Perioperative management of acute pain in the opioid-dependent patient. Anesthesiology. 2004;101:212–227.
65. Guinard JP Maurocordatos P Carpenter RL: A randomized comparison of intravenous versus lumbar and thoracic epidural infusions of fentanyl after Thoracotomy. Anesthesiology. 1992;77:1108–1115.
66. Abrahamsson J, Niemand D, Olsson AK, Tornebrandt K. Buprenorphine (Temgesic) as a perioperative analgesic: a multicenter sudy. Anaesthesist. 1983;32(2):75–79.
67. Ho ST, Wang JJ, Liu HS, Tzeng JI, Liaw WJ. The analgesic effect of PCA buprenorphine in Taiwan's gynecologic patients. Acta Anaesthesiol Sin. 1997;35(4):195–199.
68. Bullingham RE, McQuay HJ, Dwyer D, Allen MC, Moore RA. Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis. Br J Clin Pharmacol. 1981;12(2):117–122.
69. McCormack JP, Warnier CB, Levine M, Glick N. A comparison of oral dosed morphine sulfate and on demand IM morphine in the treatment of postoperative pain. Can J Anesthes. 1993;40:819–824.
70. Silvasti M, Rosenberg P, Seppala T, Svartling N, Pitkanen M. Comparison of analgesic efficacy of oxycodone and morphine in postoperative intravenous patient-controlled analgesia. Acta Anaesthesiol Scand. 1998;42:576–580.
71. Singla N, Pong A, Newman K. Combination oxycodone 5mg/ibuprofen 400mg for the treatment of pain after abdominal surgery in women. Clin Therapeut. 2005;27:45–57.
72. Palangio M, Wideman GL, Keffer M, Landau CJ. Combination hydrocodone and ibuprofen versus oxycodone and acetaminophen in the treatment of postoperative obstetric or gynecologic pain. Clin Therapeut. 2000;22:600–612.
73. Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology. 2005;102:1249–1260.
74. Aqua K, Gimbel JS, Singla N, Ma T, Ahdieh H. Efficacy and tolerability of oxymorphone IR, for acute postoperative pain after abdominal surgery. Clin Therapeut. 2007;29:1000–1012.
75. Gimbel J, Ahdieh H. The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain. Anesth Analg. 2004;99:1472–1477.
76. McCarberg BH, Barkin RL. Long-acting opioids for chronic pain: pharmacotherapeutic opportunities to enhance compliance, quality of life, and analgesia. Am J Ther. 2001;8:181–186.
77. Gabrail NY, Dvergsten C, Ahdieh H. Establishing the dosage equivalency of oxymorphone extended release and oxycodone controlled release in patients with cancer pain: a randomized controlled study. Curr Med Res Opin. 2004;20:911–918.
78. Reuben SS, Connelly NR, Maciolek H. Postoperative analgesia with controlled release oxycodone for outpatient anterior cruciate ligament surgery. Anesth Analg. 1999;48:1286–1291.
79. Ginsberg B, Sinatra RS, Adler LJ, et al. Conversion to oral controlled-release oxycodone from intravenous opioid analgesic in the postoperative setting. Pain Med. 2003;4(1):31–38.
80. Fricke JR, Karim R, Jordan D, Rosenthal N: A double-blind single-dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets and placebo after oral surgery. Clin Ther. 2002;24:953–968.
81. Gordon D, Stevenson K, Griffie J, et al. Opioid equianalgesic calculations. J Palliat Med. 1999;2:209–221.
82. Cherny N, Ripamonti C, Pereira J, et al. Strategies to manage the adverse effects of oral morphine: an evidence-based report. J Clin Oncol. 2001;19:2542–2554.
83. Wheeler M, Oderda GM, Asburn MA, Lipman AG. Adverse events associated with postoperative opioid analgesia: a systematic review. J Pain. 2002;3:159–180.
84. Zofran [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2004.
85. National Institutes of Health. The NIH Guide: New Directions in Pain Research I. Washington, DC: U.S. Government Printing Office; 1998.
86. Mather LE, Woodhouse A, Ward ME, Farr SJ. Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis. Br J Anaesth. 1998;46:37–43.
87. Romberg R, van Dorp E, Hollander J et al. A randomized double-blind placebo-controlled pilot study of morphine-6-glucoronide for postoperative pain relief after knee replacement surgery. Clin J Pain. 2007;23:197–203.