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Chapter 13 - Therapeutic innovations

Published online by Cambridge University Press:  05 May 2016

Christopher M. Filley
University of Colorado School of Medicine
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White Matter Dementia , pp. 162 - 171
Publisher: Cambridge University Press
Print publication year: 2016

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Albert, M, Antel, J, Brück, W, Stadelmann, C. Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol 2007; 17: 129138.CrossRefGoogle ScholarPubMed
Barnes, DE, Yaffe, K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol 2011; 10: 819828.CrossRefGoogle ScholarPubMed
Bartzokis, G. Alzheimer’s disease as homeostatic responses to age-related myelin breakdown. Neurobiol Aging 2011; 32: 13411371.CrossRefGoogle ScholarPubMed
Ben-Hur, T. Cell therapy for multiple sclerosis. Neurotherapeutics 2011; 8: 625642.CrossRefGoogle ScholarPubMed
Bettcher, BM, Yaffe, K, Boudreau, RM, et al. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging 2015; 36: 948954.CrossRefGoogle ScholarPubMed
Braun, SM, Jessberger, S. Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function. Neuropathol Appl Neurobiol 2014; 40: 312.CrossRefGoogle ScholarPubMed
Breteler, MM. Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective. Neurobiol Aging 2000; 21: 153160.CrossRefGoogle Scholar
Bu, G. Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 2009; 10: 333344.CrossRefGoogle ScholarPubMed
Bucks, RS, Olaithe, M, Eastwood, P. Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology 2013; 18: 6170.CrossRefGoogle ScholarPubMed
Castronovo, V, Scifo, P, Castellano, A, et al. White matter integrity in obstructive sleep apnea before and after treatment. Sleep 2014; 37: 14651475.CrossRefGoogle ScholarPubMed
Chaddock-Heyman, L, Erickson, KI, Holtrop, JL, et al. Aerobic fitness is associated with greater white matter integrity in children. Front Hum Neurosci 2014; 8: 584.CrossRefGoogle ScholarPubMed
Chang, A, Staugaitis, SM, Dutta, R, et al. Cortical remyelination: a new target for repair therapies in multiple sclerosis. Ann Neurol 2012; 72: 918926.CrossRefGoogle ScholarPubMed
Chen, J, Zuo, S, Wang, J, et al. Aspirin promotes oligodendrocyte precursor cell proliferation and differentiation after white matter lesion. Front Aging Neurosci 2014; 6: 7.CrossRefGoogle ScholarPubMed
Chen, Y, Chen, K, Zhang, J, et al. Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele. Neuropsychopharmacology 2015; 40: 11811191.CrossRefGoogle ScholarPubMed
Cheng, CY, Tsai, CF, Wang, SJ, et al. Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia. J Geriatr Psychiatry Neurol 2013; 26: 158164.CrossRefGoogle ScholarPubMed
Chiang, GC, Zhan, W, Schuff, N, Weiner, MW. White matter alterations in cognitively normal apoE ε2 carriers: insight into Alzheimer resistance? AJNR 2012; 33: 13921397.CrossRefGoogle ScholarPubMed
Dammann, O, Bueter, W, Leviton, A, et al. Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage. Neonatology 2008; 93: 182187.CrossRefGoogle ScholarPubMed
Evin, G, Barakat, A, Masters, CL. BACE: therapeutic target and potential biomarker for Alzheimer’s disease. Int J Biochem Cell Biol 2010; 42: 19231926.CrossRefGoogle ScholarPubMed
Filley, CM. Alzheimer’s Disease prevention: new optimism. Neurol Clin Pract 2015; 5: 193200.CrossRefGoogle ScholarPubMed
Folstein, MF, Folstein, SE, McHugh, PR. “Mini-Mental State”: a practical method of grading the cognitive state of patients for the clinician. J Psychiat Res 1975; 12: 189198.CrossRefGoogle ScholarPubMed
Forette, F, Seux, ML, Staessen, JA, et al. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002; 162: 20462052.CrossRefGoogle ScholarPubMed
Franklin, RJ, Ffrench-Constant, C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008; 9: 839855.CrossRefGoogle Scholar
Franklin, RJ, Goldman, SA. Glia disease and repair-remyelination. Cold Spring Harb Perspect Biol 2015; 2015; 7 (7). pii: a020594.CrossRefGoogle ScholarPubMed
Goldman, SA, Schanz, S, Windrem, MS. Stem cell–based strategies for treating pediatric disorders of myelin. Hum Mol Genet 2008; 17: 876883.CrossRefGoogle ScholarPubMed
Gons, RA, Tuladhar, AM, de Laat, KF, et al. Physical activity is related to the structural integrity of cerebral white matter. Neurology 2013; 81: 971976.CrossRefGoogle ScholarPubMed
Hu, X, Hicks, CW, He, W, et al. Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci 2006; 9: 15201525.CrossRefGoogle ScholarPubMed
Huang, JK, Jarjour, AA, Nait Oumesmar, B, et al. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci 2011; 14: 4553.CrossRefGoogle ScholarPubMed
Johnson, NF, Kim, C, Clasey, JL, et al. Cardiorespiratory fitness is positively correlated with cerebral white matter integrity in healthy seniors. Neuroimage 2012; 59: 15141523.CrossRefGoogle ScholarPubMed
Karussis, D, Karageorgiou, C, Vaknin-Dembinsky, C, et al. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol 2010; 67: 11871194.CrossRefGoogle ScholarPubMed
Keough, MB, Yong, VW. Remyelination therapy for multiple sclerosis. Neurotherapeutics 2013; 10: 4454.CrossRefGoogle ScholarPubMed
Kim, H, Yun, CH, Thomas, RJ, et al. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. Sleep 2013; 36: 709715B.Google Scholar
Lassmann, H, Brück, W, Lucchinetti, C, Rodriguez, M. Remyelination in multiple sclerosis. Mult Scler 1997; 3: 133136.CrossRefGoogle ScholarPubMed
Leung, TW, Wang, L, Soo, YO, et al. Evolution of intracranial atherosclerotic disease under modern medical therapy. Ann Neurol 2015; 77: 478486.CrossRefGoogle ScholarPubMed
Levine, JM, Reynolds, R, Fawcett, JW. The oligodendrocyte precursor cell in health and disease. Trends Neurosci 2001; 24: 3947.CrossRefGoogle ScholarPubMed
Lundgaard, I, Luzhynskaya, A, Stockley, JH, et al. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol 2013; 11: e1001743.CrossRefGoogle ScholarPubMed
Lunn, JS, Sakowski, SA, Hur, J, Feldman, EL. Stem cell technology for neurodegenerative diseases. Ann Neurol 2011; 70: 353361.CrossRefGoogle ScholarPubMed
Maki, T, Liang, AC, Miyamoto, N, et al. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci 2013; 7: 275.CrossRefGoogle ScholarPubMed
Matthews, FE, Arthur, A, Barnes, LE, et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet 2013; 382: 14051412.CrossRefGoogle ScholarPubMed
McKee, AC, Cantu, RC, Nowinski, CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68: 709735.CrossRefGoogle ScholarPubMed
Mei, L, Nave, KA. Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron 2014; 83: 2749.CrossRefGoogle ScholarPubMed
Mi, S, Pepinsky, RB, Cadavid, D. Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic. CNS Drugs 2013; 27: 493503.CrossRefGoogle ScholarPubMed
Ming, GL, Song, H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 2011; 70: 687702.CrossRefGoogle ScholarPubMed
Mitew, S, Hay, CM, Peckham, H, et al. Mechanisms regulating the development of oligodendrocytes and central nervous system myelin. Neuroscience 2014; 276: 2947.CrossRefGoogle ScholarPubMed
Morandi, A, Rogers, BP, Gunther, ML, et al. The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study. Crit Care Med 2012; 40: 21822189.CrossRefGoogle ScholarPubMed
Ngandu, T, Lehtisalo, J, Solomon, A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015; 385: 22552263.CrossRefGoogle ScholarPubMed
Pandharipande, PP, Girard, TD, Jackson, JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013; 369: 13061316.CrossRefGoogle ScholarPubMed
Peters, A. The effects of normal aging on myelinated nerve fibers in monkey central nervous system. Front Neuroanat 2009; 3: 11.CrossRefGoogle ScholarPubMed
Peters, A, Sethares, C. Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey. J Comp Neurol 2002; 442: 277291.CrossRefGoogle ScholarPubMed
Prins, ND, Scheltens, P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol 2015; 11: 157165.CrossRefGoogle ScholarPubMed
Qiu, C, Kivipelto, M, von Strauss, E. Epidemiology of Alzheimer’s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 2009; 11: 111128.Google ScholarPubMed
Qiu, C, von Strauss, E, Bäckman, L, et al. Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology 2013; 80: 18881894.CrossRefGoogle ScholarPubMed
Ready, RE, Baran, B, Chaudhry, M, et al. Apolipoprotein E-e4, processing speed, and white matter volume in a genetically enriched sample of midlife adults Am J Alzheimers Dis Other Demen 2011; 26: 463468.CrossRefGoogle Scholar
Rocca, WA, Petersen, RC, Knopman, DS, et al. Trends in the incidence and prevalence of Alzheimer’s disease, dementia, and cognitive impairment in the United States. Alzheimers Dement 2011; 7: 8093.CrossRefGoogle ScholarPubMed
Ryan, L, Walther, K, Bendlin, BB, et al. Age-related differences in white matter integrity and cognitive function are related to APOE status. Neuroimage 2011; 54: 15651577.CrossRefGoogle ScholarPubMed
Salat, DH. Imaging small vessel–associated white matter changes in aging. Neuroscience 2014; 276: 174186.CrossRefGoogle Scholar
Shi, H, Hu, X, Leak, RK, Shi, Y, et al. Demyelination as a rational therapeutic target for ischemic or traumatic brain injury. Exp Neurol 2015 Mar 24. [Epub ahead of print]
Spira, AP, Gamaldo, AA, An, Y, et al. Self-reported sleep and β-amyloid deposition in community-dwelling older adults. JAMA Neurol 2013; 70: 15371543.Google ScholarPubMed
Valenzuela, M, Esler, M, Ritchie, K, Brodaty, H. Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention. Transl Psychiatry 2012; 2: e107.CrossRefGoogle ScholarPubMed
Vanderver, A, Tonduti, D, Schiffmann, R, et al. Leukodystrophy overview. In: Pagon, RA, Adam, MP, Ardinger, HH, Wallace, SE, Amemiya, A, Bean, LJH, Bird, TD, Dolan, CR, Fong, CT, Smith, RJH, Stephens, K, eds. GeneReviews® [Internet]. Seattle: University of Washington, Seattle; 19932015. 2014 Feb 6.Google Scholar
Verhaaren, BF, Vernooij, MW, de Boer, R, et al. High blood pressure and cerebral white matter lesion progression in the general population. Hypertension 2013; 61: 13541359.CrossRefGoogle ScholarPubMed
Voss, MW, Heo, S, Prakash, RS, et al. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp 2013; 34: 29722985.CrossRefGoogle ScholarPubMed
Wang, R, Fratiglioni, L, Laukka, EJ, et al. Effects of vascular risk factors and APOE ε4 on white matter integrity and cognitive decline. Neurology 2015; 84: 11281135.CrossRefGoogle ScholarPubMed
Xie, L, Kang, H, Xu, Q, et al. Sleep drives metabolite clearance from the adult brain. Science 2013; 342: 373377.CrossRefGoogle ScholarPubMed
Xiong, Y, Mahmood, A, Chopp, M. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs 2010; 11: 298308.Google ScholarPubMed
Yaffe, K. Metabolic syndrome and cognitive disorders: is the sum greater than its parts? Alzheimer Dis Assoc Disord 2007; 21: 167171.CrossRefGoogle ScholarPubMed
Zhang, R, Chopp, M, Zhang, ZG. Oligodendrogenesis after cerebral ischemia. Front Cell Neurosci 2013; 7: 201.CrossRefGoogle ScholarPubMed

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