Published online by Cambridge University Press: 20 May 2022
This chapter discusses disorders characterized by abnormalities of mood: namely, depression, mania, or mixtures of both. Included here are descriptions of a wide variety of mood disorders that occur over a broad clinical spectrum. Clinical descriptions and criteria for how to diagnose disorders of mood will only be mentioned in passing. The reader should consult standard reference sources for this material. Also included in this chapter is an analysis of how monoamine neurotransmitter systems have long been hypothetically linked to the biological basis of mood disorders. We will also cover more recent advances in neurobiology that link mood disorders to glutamate, GABA (γ-aminobutyric acid), neurotrophic factors, neuroinflammation, and stress.