Book contents
- Frontmatter
- Contents
- List of Contributors
- Foreword by Daniel R. Salomon
- Foreword by Robin Marks
- Foreword by Kathy Schwab
- Preface
- Acknowledgments
- SECTION ONE TRANSPLANT DERMATOLOGY: AN EVOLVING DYNAMIC FIELD
- Section Two Transplant Medicine and Dermatology
- 2 The History of Organ Transplantation
- 3 The Development of Modern Immunosuppressive Medications
- 4 Organ Transplantation: Current Status and Practice
- 5 The Immunology of Transplantation and Allograft Rejection
- 6 Allograft-Specific Considerations in Transplant Dermatology
- 7 Dermatologic Disease from the Transplant Perspective
- Section Three Pathogenic Factors in Transplant Dermatology
- Section Four Cutaneous Effects of Immunosuppressive Medications
- Section Five Infectious Diseases of the Skin in Transplant Dermatology
- Section Six Benign and Inflammatory Skin Diseases in Transplant Dermatology
- Section Seven Cutaneous Oncology in Transplant Dermatology
- Section Eight Special Scenarios in Transplant Cutaneous Oncology
- Section Nine Educational, Organizational, and Research Efforts in Transplant Dermatology
- Index
5 - The Immunology of Transplantation and Allograft Rejection
from Section Two - Transplant Medicine and Dermatology
Published online by Cambridge University Press: 18 January 2010
- Frontmatter
- Contents
- List of Contributors
- Foreword by Daniel R. Salomon
- Foreword by Robin Marks
- Foreword by Kathy Schwab
- Preface
- Acknowledgments
- SECTION ONE TRANSPLANT DERMATOLOGY: AN EVOLVING DYNAMIC FIELD
- Section Two Transplant Medicine and Dermatology
- 2 The History of Organ Transplantation
- 3 The Development of Modern Immunosuppressive Medications
- 4 Organ Transplantation: Current Status and Practice
- 5 The Immunology of Transplantation and Allograft Rejection
- 6 Allograft-Specific Considerations in Transplant Dermatology
- 7 Dermatologic Disease from the Transplant Perspective
- Section Three Pathogenic Factors in Transplant Dermatology
- Section Four Cutaneous Effects of Immunosuppressive Medications
- Section Five Infectious Diseases of the Skin in Transplant Dermatology
- Section Six Benign and Inflammatory Skin Diseases in Transplant Dermatology
- Section Seven Cutaneous Oncology in Transplant Dermatology
- Section Eight Special Scenarios in Transplant Cutaneous Oncology
- Section Nine Educational, Organizational, and Research Efforts in Transplant Dermatology
- Index
Summary
OVERVIEW OF THE DEVELOPMENT AND CURRENT STATUS OF TRANSPLANT IMMUNOLOGY
Many of the historical and persistent barriers to successful transplantation derive from the complex immunological events that are set in motion once an organ or tissue from one individual is placed within the body of another. From a clinical standpoint, the immune interface between transplanted organs and their hosts dictates much of the need for pretransplant tissue typing and cross-match testing, lifelong posttransplant immunosuppressive therapy, regular monitoring of allograft function, and intermittent histological sampling of the graft. From a scientific perspective, the fields of immunology and transplantation have developed together in symbiotic fashion over the past century with experimentation and discovery in each influencing the other. Among the major immunological insights that have arisen partly or entirely from transplant-related experiments are the biology of natural and acquired antibodies, the significance of major histocompatibility complex (MHC) genetic diversity, the function of the thymus and other lymphoid organs, the nature of antigen presentation, the role of costimulation in T-Cell activation, and the mechanisms underlying self-tolerance. Recently, the parallel progress of the two fields has entered a new stage of productivity, the translation of mechanistic immunological discovery into novel targeted interventions, and treatment strategies for improving overall success in human transplantation. The purposes of this chapter are to succinctly describe our current understanding of the major elements of human protective immunity and to link these pathways with important aspects of the immune response to allogeneic organ transplants.
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- Chapter
- Information
- Skin Disease in Organ Transplantation , pp. 29 - 38Publisher: Cambridge University PressPrint publication year: 2008