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Chapter 7 - Drugs to Treat Depression

from Part 2 - Psychopharmacology of the Main Psychotropic Drug Groups

Published online by Cambridge University Press:  29 May 2020

Peter M. Haddad
Affiliation:
Hamad Medical Corporation, Qatar
David J. Nutt
Affiliation:
Centre for Neuropsychopharmacology, Division of Psychiatry, Department of Brain Sciences, Imperial College London
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Summary

This chapter reviews the main drugs used in the treatment of unipolar depressive disorders. At the outset it should be noted that the term ‘antidepressant’ is problematic given that drugs traditionally regarded as ‘antidepressants’ are effective in treating psychiatric syndromes other than depression, most notably various anxiety disorders. Furthermore, some drugs not traditionally classified as ‘antidepressants’ are effective in treating depression either in monotherapy or as adjunctive agents to antidepressants. Examples of the former include lamotrigine and quetiapine, which have efficacy in treating bipolar depression, and lithium and some antipsychotics which are effective in augmenting the efficacy of reuptake inhibiting antidepressants in major depressive disorder. Despite these issues, the term ‘antidepressant’ is widely used and is likely to remain so.

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Publisher: Cambridge University Press
Print publication year: 2020

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