Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Approach to Autopsy of the Perinatal Nervous System
- Ancillary Studies
- Prosection Techniques
- Chapter 9 Brain Prosection
- Chapter 10 Spinal Cord Prosection
- Chapter 11 Neuromuscular Specimens
- Chapter 12 Eye Specimens
- Tissue Selection
- Reporting
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 12 - Eye Specimens
from Prosection Techniques
Published online by Cambridge University Press: 07 August 2021
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Approach to Autopsy of the Perinatal Nervous System
- Ancillary Studies
- Prosection Techniques
- Chapter 9 Brain Prosection
- Chapter 10 Spinal Cord Prosection
- Chapter 11 Neuromuscular Specimens
- Chapter 12 Eye Specimens
- Tissue Selection
- Reporting
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
In addition to determination of proper ocular development, gross and histopathological exam of fetal eyes may be supportive or even mandatory for the diagnosis of certain inherited syndromes with ocular involvement and/or forensic evaluation. Fetal and infant eyes examination during the routine pediatric autopsy is often complicated by artifacts, which may be caused by either autolysis or incorrect sample manipulation and fixation. Thus proper technical execution of the postmortem eyes exam is pivotal for providing additional diagnostic information that would inform a final classification of an inherited syndrome. In turn, correct diagnosis will allow the appropriate parental genetic counseling with respect to future pregnancies. The fetal eyes autopsy is thus often critical for pediatric diagnostics and should be performed with great care [1, 2].
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- Information
- Perinatal Neuropathology , pp. 56 - 58Publisher: Cambridge University PressPrint publication year: 2021