Bio-Alcamid (Polymekon) is a nonresorbable polymeric material composed of 4% alkylimide-amide group and 96% apyrogenic water. Alkylimide belongs to the family of acryl derivatives, and its polymeric structure does not contain free monomers. Histologic studies have shown that following implantation, the material is quickly surrounded by a thin collagen capsule, which stabilizes the material and protects it from the host tissues. Bio-Alcamid is indicated for the treatment of congenital and acquired areas of soft tissue depletion. It has been used successfully in the treatment of postliposuction skin irregularities, HIV facial lipoatrophy, Poland's syndrome, pectus excavatum, and posttraumatic soft tissue deficits. Increasingly, Bio-Alcamid is playing an important role in the armamentarium of the aesthetic physician as an alternative to surgical malar and chin augmentation as well as the correction of deep nasolabial folds. Unlike other injectable fillers currently available, Bio-Alcamid can be used to permanently correct large-volume deficits in a single treatment session. Contraindications include cutaneous collagen disease, uncompensated diabetes, and active infectious processes in the area of the implant. Patients are begun on antibiotic therapy aimed at gram-positive organisms one day prior to treatment and for seven days posttreatment. It is recommended that patients avoid direct sun exposure in the area of the implant for six weeks following the procedure to reduce the risk of bruising and edema. It is recommended that patients stop any blood thinning agents two weeks prior to and for one week following treatment.