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Chapter 13 - Thromboprophylaxis in Pregnancy

from Section 5 - Thromboembolism and Anticoagulation

Published online by Cambridge University Press:  01 February 2018

Sue Pavord
Affiliation:
University of Oxford
Beverley Hunt
Affiliation:
King's College London
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Publisher: Cambridge University Press
Print publication year: 2018

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References

Royal College of Obstetricians and Gynecologists. Reducing the Risk of Thrombosis and Embolism during Pregnancy and Puerperium. Green-Top Guideline No. 37a. London: Royal College of Obstetricians and Gynecologists; 2015.
Lewis, G, ed. The Confidential Enquiry into Maternal and Child Health (CEMACH) – Saving Mothers’ Lives: Reviewing Maternal Deaths to Make Motherhood Safer – 2003–2005. The Seventh Report on Confidential Enquiries into Maternal Deaths in the United Kingdom. London: CEMACH; 2007.Google Scholar
Center for Maternal and Child Enquiries (CMACE). Saving Mothers’ Lives: Reviewing maternal deaths to make motherhood safer: 2006–08. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG: An International Journal of Obstetrics and Gynecology 2011; 118 (Suppl 1): 1203.
MBRRACE. Saving Lives, Improving Mothers’ Care – Lessons learned to inform future maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009–12. Oxford: National Perinatal Epidemiology Unit, University of Oxford; 2014.
Knight, M; UKOSS. Antenatal pulmonary embolism: risk factors, management and outcomes. BJOG: An International Journal of Obstetrics and Gynecology 2008; 115: 453461.CrossRefGoogle ScholarPubMed
Royal College of Obstetricians and Gynecologists. Thromboprophylaxis during Pregnancy, Labor and After Normal Vaginal Delivery. Green-Top Guideline no. 37. London: Royal College of Obstetricians and Gynecologists; 2004.
Royal College of Obstetricians and Gynecologists. Reducing the risk of Thrombosis and Embolism during Pregnancy and Puerperium. Green-Top Guideline No. 37a. London: Royal College of Obstetricians and Gynecologists; 2009.
Heit, JA, Kobbervig, CE, James, AH et al. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Annals of Internal Medicine 2005; 143: 697706.CrossRefGoogle ScholarPubMed
Jacobsen, AF, Skjeldestad, FE, Sandset, PM. Ante- and postnatal risk factors of venous thrombosis: a hospital-based case–control study. Journal of Thrombosis and Hemostasis 2008; 6: 905912.CrossRefGoogle ScholarPubMed
James, AH. Prevention and management of venous thrombo-embolism in pregnancy. American Journal of Medicine 2007; 120: S2634.CrossRefGoogle Scholar
Lindqvist, P, Dahlbäck, B, MarŜál, K. Thrombotic risk during pregnancy: a population study. BJOG: An International Journal of Obstetrics and Gynecology 1999; 94: 595599.Google ScholarPubMed
Kane, EV, Calderwood, C, Dobbie, R et al. A population-based study of venous thrombosis in pregnancy in Scotland 1980–2005. European Journal of Obstetrics & Gynecology and Reproductive Biology 2013; 169: 223229.CrossRefGoogle ScholarPubMed
Sultan, AA, West, J, Tata, LJ et al. Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study. British Journal of Haematology 2012; 156: 366373.CrossRefGoogle ScholarPubMed
Pomp, ER, Lenselink, AM, Rosendaal, FR, Doggen, CJ. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. Journal of Thrombosis and Haemostasis 2008; 6: 632637.CrossRefGoogle ScholarPubMed
Nelson, SM, Greer, IA. Thrombophilia and the risk for venous thromboembolism during pregnancy, delivery, and puerperium. Obstetric Gynecologic Clinics of North America 2006; 33: 413427.CrossRefGoogle ScholarPubMed
Bates, SM, Greer, IA, Middeldorp, S et al.; American College of Chest Physicians. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141 (2 Suppl): e691S736S.CrossRefGoogle ScholarPubMed
Jackson, E, Curtis, KM, Gaffield, ME. Risk of venous thromboembolism during the postpartum period: a systematic review. Obstetrics and Gynecology 2011; 117: 691703.CrossRefGoogle ScholarPubMed
National Institute for Health and Clinical Excellence. Venous Thromboembolism: Reducing the Risk. Reducing the risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital. NICE Clinical Guideline 92. London: NICE; 2010.
Lindqvist, PG, Bremme, K, Hellgren, M. Swedish Society of Obstetrics and Gynecology (SFOG) Working Group on Hemostatic Disorders (Hem-ARG). Efficacy of obstetric thromboprophylaxis and long-term risk of recurrence of venous thromboembolism. Acta Obstetricia et Gynecologica Scandinavica 2011; 90: 648653.CrossRefGoogle Scholar
Hunt, BJ, Gattens, M, Khamashta, M, Nelson-Piercy, C, Almeida, A. Thromboprophylaxis with unmonitored intermediate-dose low molecular weight heparin in pregnancies with a previous arterial or venous thrombotic event. Blood Coagulation and Fibrinolysis 2003; 14: 735739.CrossRefGoogle ScholarPubMed
Virchow, R. Thrombose und Embolie. Gefässentzündung und septische Infektion: Gesammelte Abhandlungen zur wissenschaftlichen Medicin [in German]. Frankfurt am Main: Von Meidinger & Sohn. 1856: 219732.Google Scholar
McColl, MD, Walker, ID, Greer, IA. The role of inherited thrombophilia in venous thromboembolism associated with pregnancy. British Journal of Obstetrics and Gynaecology 1999; 106: 756766.CrossRefGoogle ScholarPubMed
James, AH, Jamison, MG, Brancazio, LR, Myers, ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. American Journal of Obstetrics and Gynecology 2006; 194: 13111315.CrossRefGoogle ScholarPubMed
Jamison, MG, Brancazio, LR, Myers, ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. American Journal of Obstetrics and Gynecology 2006; 194: 13111315.Google Scholar
Nelson-Piercy, C. Handbook of Obstetric Medicine, 5th edn. Florida: CRC Press, Taylor & Francis Group; 2015: 4960.Google Scholar
Larsen, TB, Sorensen, HT, Gislum, M, Johnsen, SP. Maternal smoking, obesity, and risk of venous thromboembolism during pregnancy and the puerperium: a population-based nested case-control study. Thrombosis Research 2007; 120: 505509.CrossRefGoogle ScholarPubMed
Simpson, EL, Lawrenson, RA, Nightingale, AL, Farmer, RD. Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database. BJOG: An International Journal of Obstetrics and Gynecology 2001; 108: 5660.Google ScholarPubMed
De Stefano, V, Martinelli, I, Rossi, E et al. The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis. British Journal of Haematology 2006; 135: 386391.CrossRefGoogle ScholarPubMed
Baglin, T, Gray, E, Greaves, M et al. British Committee for Standards in Hematology. Clinical guidelines for testing for heritable thrombophilia. British Journal of Haematology 2010; 149: 209220.CrossRefGoogle Scholar
Bramham, K, Retter, A, Robinson, SE. How I treat heterozygous hereditary antithrombin deficiency in pregnancy. Thrombosis and Haemostasis 2013; 110: 550559.CrossRefGoogle ScholarPubMed
Rogenhofer, N, Bohlmann, MK, Beuter-Winkler, P et al. Prevention, management and extent of adverse pregnancy outcomes in women with hereditary antithrombin deficiency. Annals of Hematology 2014; 93: 385392.CrossRefGoogle ScholarPubMed
Liu, S, Rouleau, J, Joseph, KS et al. Maternal Health Study Group of the Canadian Perinatal Surveillance System. Epidemiology of pregnancy-associated venous thromboembolism: a population-based study in Canada. Journal of Obstetrics and Gynecology Canada 2009; 31: 611620.CrossRefGoogle Scholar
National Collaborating Center for Women’s and Children’s Health. Antenatal Care: Routine Care for the Healthy Pregnant Woman. London: RCOG Press; 2008.PubMed
Royal College of Obstetricians and Gynecologists. Air Travel and Pregnancy. Scientific Impact Paper No. 1. London: RCOG; 2013.
Hezelgrave, NL, Whitty, CJ, Shennan, AH, Chappell, LC. Advising on travel during pregnancy. BMJ 2011; 342: d2506.CrossRefGoogle ScholarPubMed
Sultan, AA, Tata, LJ, West, J et al. Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom. Blood 2013; 121: 39533961.CrossRefGoogle ScholarPubMed
James, AH, Tapson, VF, Goldhaber, SZ. Thrombosis during pregnancy and the postpartum period. American Journal of Obstetrics and Gynecology 2005; 193: 216219.CrossRefGoogle ScholarPubMed
Stone, S, Hunt, BJ, Khamashta, MA, Bewley, SJ, Nelson-Piercy, C. Primary antiphospholipid syndrome in pregnancy: an analysis of outcome in a cohort of 33 women treated with a rigorous protocol. Journal of Thrombosis and Haemostasis 2005; 3: 243245.CrossRefGoogle Scholar
Casele, H, Grobman, WA. Cost-effectiveness of thromboprophylaxis with intermittent pneumatic compression at Cesarean delivery. Obstetrics and Gynecology 2006; 108: 535540.CrossRefGoogle ScholarPubMed
Rogenhofer, N, Bohlmann, MK, Beuter-Winkler, P et al. Prevention, management and extent of adverse pregnancy outcomes in women with hereditary antithrombin deficiency. Annals of Hematology 2014; 93: 385392.CrossRefGoogle ScholarPubMed
Bates, SM, Greer, IA, Pabinger, I et al. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edn). Chest 2008; 133: 844S886S.CrossRefGoogle Scholar
Clark, NP, Delate, T, Witt, DM, Parker, S, McDuffie, R. A descriptive evaluation of unfractionated heparin use during pregnancy. Journal of Thrombosis and Thrombolysis 2009; 27: 267273.CrossRefGoogle ScholarPubMed
Andersen, AS, Berthelsen, JG, Bergholt, T. Venous thrombo-embolism in pregnancy: prophylaxis and treatment with low molecular weight heparin. Acta Obstetricia et Gynecologica Scandinavica 2010; 89: 1521.CrossRefGoogle Scholar
Greer, IA, Nelson-Piercy, C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 2005; 106: 401407.CrossRefGoogle ScholarPubMed
Lindhoff-Last, E, Bauersachs, R. Heparin-induced thrombocytopenia-alternative anticoagulation in pregnancy and lactation. Seminars in Thrombosis and Hemostasis 2002; 28: 439446.CrossRefGoogle ScholarPubMed
Gerhardt, A, Zotz, RB, Stockschleder, M, Scharf, RE. Fondaparinux is an effective alternative anticoagulant in pregnant women with high risk of venous thromboembolism and intolerance to low-molecular-weight heparins and heparinoids. Thrombosis and Haemostasis 2007; 97: 496497.Google ScholarPubMed
Bomke, B, Hoffmann, T, Dücker, C, Scharf, RE. P01-09 Successful prevention or treatment of venous thromboembolism (VTE) with fondaparinux in pregnant women with allergic skin reactions to low-molecular-weight heparins (LMWHs) and danaparoid. Hämostaseologie 2010; 30 (Suppl): A35.Google Scholar
Lagrange, F, Vergnes, C, Brun, JL, et al. Absence of placental transfer of pentasaccharide (Fondaparinux, Arixtra®) in the dually perfused human cotyledon in vitro. Thrombosis and Haemostasis 2002; 87: 831835.Google Scholar
Holzgreve, W, Carey, JC, Hall, BD. Warfarin-induced fetal abnormalities. Lancet 1976; ii: 914–5.Google Scholar
Born, D, Martinez, EE, Almeida, PA et al. Risk of warfarin during pregnancy with mechanical valve prostheses. Obstetrics and Gynecology 2002; 99: 3540.Google Scholar
Sbarouni, E, Oakley, CM. Outcome of pregnancy in women with valve prostheses. British Heart Journal 1994; 71: 196201.CrossRefGoogle ScholarPubMed
Born, D, Martinez, EE, Almeida, PA. Pregnancy in patients with prosthetic heart valves: the effects of anticoagulation on mother, fetus, and neonate. American Heart Journal 1992; 124: 413417.CrossRefGoogle ScholarPubMed
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