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20 - Intermittent Explosive Disorder: Clinical Aspects

from Section IV - Sexual and Aggressive Impulses

Published online by Cambridge University Press:  06 July 2010

Elias Aboujaoude
Affiliation:
Stanford University School of Medicine, California
Lorrin M. Koran
Affiliation:
Stanford University School of Medicine, California
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Summary

Intermittent explosive disorder (IED) is a psychiatric diagnosis applied to individuals who repeatedly engage in the acts of impulsive aggression. The IED-integrated research (IR) criteria clearly operationalize the severity and frequency of aggressive behavior required for the diagnosis. The IED-IR criteria allow subjects with borderline and/or antisocial personality disorder (BPD/AsPD) to receive a comorbid IED diagnosis. Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria for AsPD and BPD include anger and aggression. Aggressive outbursts in IED have a rapid onset, often without a recognizable prodromal period. High level of hostility and aggression negatively impact the quality of life across several dimensions, including interpersonal relationships, sleep quality, job satisfaction, and health. Completed analysis of a double-blind, placebo-controlled trial of fluoxetine on impulsive aggressive behavior in 100 subjects with IED demonstrates clear anti-aggressive efficacy for fluoxetine versus placebo.
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Publisher: Cambridge University Press
Print publication year: 2010

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