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Chapter 23 - Testosterone therapy and Alzheimer's disease: potential for treatment and prevention in women

from Section 5 - Testosterone, estradiol and men, and sex hormone binding globulin

Published online by Cambridge University Press:  06 July 2010

Eef Hogervorst
Affiliation:
Loughborough University
Victor W. Henderson
Affiliation:
Stanford University, California
Robert B. Gibbs
Affiliation:
University of Pittsburgh
Roberta Diaz Brinton
Affiliation:
University of Southern California
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Summary

Editors' introduction

Testosterone, an androgen, is viewed as a male hormone and for this reason is less studied in women than in men. In postmenopausal women, testosterone concentrations are affected by a number of factors, including age and whether a woman has undergone oophorectomy. Past hormonal exposures may also be relevant. In this chapter, Wharton, Asthana, and Gleason review research indicating that testosterone affects function of the hippocampus and other brain regions, and that testosterone has actions that might be expected to reduce Alzheimer's disease (AD) risk in women as well as men. Some studies in women suggest a relation between testosterone therapy or testosterone concentrations and performance on cognitive tasks involving visuospatial abilities. Unfortunately, few data are available on testosterone administration in women at risk for AD or with symptoms of this disorder. The authors conclude that further research is warranted on the cognitive effects of testosterone administration in older women, perhaps concurrently with estradiol and perhaps particularly in women who have experienced surgical menopause.

Type
Chapter
Information
Hormones, Cognition and Dementia
State of the Art and Emergent Therapeutic Strategies
, pp. 220 - 227
Publisher: Cambridge University Press
Print publication year: 2009

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